mepindolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 1697 23694-81-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betagon
  • mepindolol sulphate
  • mepindolol sulfate
  • mepindolol
  • (+/-)-Mepindolol
2-methyl deriv of pindolol; RN given refers to parent cpd; structure
  • Molecular weight: 262.35
  • Formula: C15H22N2O2
  • CLOGP: 2.17
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 57.28
  • ALOGS: -2.87
  • ROTB: 6

Drug dosage:

DoseUnitRoute
5 mg O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 82 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 2.17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.83 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.51 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.61 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07AA14 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, non-selective
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.59 acidic
pKa2 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07181 KEGG_DRUG
56396-94-2 SECONDARY_CAS_RN
C0065961 UMLSCUI
CHEBI:135082 CHEBI
CHEMBL65717 ChEMBL_ID
CHEMBL400962 ChEMBL_ID
CHEMBL251477 ChEMBL_ID
DB13530 DRUGBANK_ID
C015340 MESH_SUPPLEMENTAL_RECORD_UI
71698 PUBCHEM_CID
4001 INN_ID
00Q31ER368 UNII
236904 RXNORM
007144 NDDF
007145 NDDF

Pharmaceutical products:

None