tertatolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| beta-adrenoreceptor antagonists | 2605 | 83688-84-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 5 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C07AA16 | CARDIOVASCULAR SYSTEM BETA BLOCKING AGENTS BETA BLOCKING AGENTS Beta blocking agents, non-selective |
| MeSH PA | D018663 | Adrenergic Agents |
| MeSH PA | D018674 | Adrenergic Antagonists |
| MeSH PA | D000319 | Adrenergic beta-Antagonists |
| MeSH PA | D000889 | Anti-Arrhythmia Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D018377 | Neurotransmitter Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.31 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 8.09 | PDSP | |||||
| Beta-3 adrenergic receptor | GPCR | ANTAGONIST | Ki | 8.60 | IUPHAR | ||||
| 5-hydroxytryptamine receptor 1A | GPCR | Ki | 8.11 | CHEMBL | |||||
| Beta-3 adrenergic receptor | GPCR | ANTAGONIST | Ki | 7 | IUPHAR | ||||
| Beta-3 adrenergic receptor | GPCR | ANTAGONIST | Ki | 7 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| D07182 | KEGG_DRUG |
| C0076166 | UMLSCUI |
| CHEBI:135244 | CHEBI |
| CHEMBL434200 | ChEMBL_ID |
| DB13775 | DRUGBANK_ID |
| C005632 | MESH_SUPPLEMENTAL_RECORD_UI |
| 36920 | PUBCHEM_CID |
| 571 | IUPHAR_LIGAND_ID |
| 5211 | INN_ID |
| 9ZO341YQXP | UNII |
| 37840 | RXNORM |
| 005762 | NDDF |
| 716124003 | SNOMEDCT_US |
Pharmaceutical products:
None