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phenol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4266	108-95-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: phenol hydroxybenzene	An antiseptic and disinfectant aromatic alcohol. Molecular weight: 94.11 Formula: C6H6O CLOGP: 1.48 LIPINSKI: 0 HAC: 1 HDO: 1 TPSA: 20.23 ALOGS: -0.31 ROTB: 0

Molecule

Description

Molfile Inchi Smiles

Synonyms:

phenol
hydroxybenzene

An antiseptic and disinfectant aromatic alcohol.

Molecular weight: 94.11
Formula: C6H6O
CLOGP: 1.48
LIPINSKI: 0
HAC: 1
HDO: 1
TPSA: 20.23
ALOGS: -0.31
ROTB: 0

Drug dosage:

None

ADMET properties:

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Property	Value	Reference
S (Water solubility)	15.40 mg/mL	Bocci G, Oprea TI, Benet LZ
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Bocci G, Oprea TI, Benet LZ

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Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Cystitis-like symptom	25.52	22.38	3	1180	9	63487830

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FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Urticaria pressure	22.24	21.67	3	1395	35	79742955

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	C05BB05	CARDIOVASCULAR SYSTEM VASOPROTECTIVES ANTIVARICOSE THERAPY Sclerosing agents for local injection
ATC	D08AE03	DERMATOLOGICALS ANTISEPTICS AND DISINFECTANTS ANTISEPTICS AND DISINFECTANTS Phenol and derivatives
ATC	N01BX03	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, LOCAL Other local anesthetics
ATC	R02AA19	RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Antiseptics
CHEBI has role	CHEBI:48218	antiseptics
CHEBI has role	CHEBI:48219	disinfectants
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76967	human xenobiotic metabolites
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000891	Anti-Infective Agents, Local

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Skin irritation	indication	367466007
Itching of skin	indication	418363000
Minor Skin Wound Pain	indication
Mouth Irritation	indication
Herpes zoster	contraindication	4740000	DOID:8536
Bacterial septicemia	contraindication	10001005	DOID:0040085
Infection of skin AND/OR subcutaneous tissue	contraindication	19824006
Progressive multifocal leukoencephalopathy	contraindication	22255007	DOID:643
Shock	contraindication	27942005
Cytomegalovirus infection	contraindication	28944009

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	9.68	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN	Ki	5.26	CHEMBL
Carbonic anhydrase 1	Enzyme	P00915	CAH1_HUMAN	Ki	5	CHEMBL
Carbonic anhydrase 4	Enzyme	P22748	CAH4_HUMAN	Ki	5.02	CHEMBL
Carbonic anhydrase 9	Enzyme	Q16790	CAH9_HUMAN	Ki	5.06	CHEMBL
Carbonic anhydrase 12	Enzyme	O43570	CAH12_HUMAN	Ki	5.04	CHEMBL
Carbonic anhydrase 3	Enzyme	P07451	CAH3_HUMAN	Ki	5.57	CHEMBL
Carbonic anhydrase 14	Enzyme	Q9ULX7	CAH14_HUMAN	Ki	4.94	CHEMBL
Endolysin	Enzyme		ENLYS_BPT4	Kd	4.04	CHEMBL
Carbonic anhydrase 15	Enzyme		CAH15_MOUSE	Ki	4.98	CHEMBL
Carbonic anhydrase	Enzyme		CAN_CANAL	Ki	4.76	CHEMBL

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External reference:

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ID	Source
IPH	PDB_CHEM_ID
003172	NDDF
003199	NDDF
11515	MMSL
116613007	SNOMEDCT_US
33290	RXNORM
339NCG44TV	UNII
354036003	SNOMEDCT_US
4017412	VUID
4017412	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ambix First Aid	HUMAN OTC DRUG LABEL	2	10038-250	CREAM	0.01 g	TOPICAL	OTC monograph not final	11 sections
Blistex con Medicacion Crema Labial	HUMAN OTC DRUG LABEL	2	10157-9926	STICK	0.45 g	TOPICAL	EXPORT ONLY	1 sections
Blistex Lip Medex	HUMAN OTC DRUG LABEL	4	10157-8407	PASTE	0.60 g	TOPICAL	OTC MONOGRAPH NOT FINAL	12 sections
Blistex Lip Medex	HUMAN OTC DRUG LABEL	4	10157-8407	PASTE	0.60 g	TOPICAL	OTC MONOGRAPH NOT FINAL	12 sections
Blistex Medicated	HUMAN OTC DRUG LABEL	4	10157-9951	OINTMENT	0.50 g	TOPICAL	OTC MONOGRAPH NOT FINAL	12 sections
Calamine Phenolated Topical Suspension	HUMAN OTC DRUG LABEL	2	0395-0407	LOTION	10 mg	TOPICAL	OTC monograph final	11 sections
Calamine Phenolated Topical Suspension	HUMAN OTC DRUG LABEL	2	0395-0407	LOTION	10 mg	TOPICAL	OTC monograph final	11 sections
Calamine Phenolated Topical Suspension	HUMAN OTC DRUG LABEL	2	0395-9109	LOTION	10 mg	TOPICAL	OTC monograph final	12 sections
Calamine Phenolated Topical Suspension	HUMAN OTC DRUG LABEL	2	24385-407	LOTION	10 mg	TOPICAL	OTC monograph final	12 sections
CHAPSTICK MEDICATED	HUMAN OTC DRUG LABEL	4	0573-0720	STICK	5 mg	TOPICAL	OTC monograph not final	13 sections

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