hexylresorcinol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
1374 136-77-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hexylresorcinol
  • 4-Hexylresorcinol
  • antascarin
  • ascaricid
  • ascarinol
A substituted dihydroxybenzene used topically as an antiseptic for the treatment of minor skin infections.
  • Molecular weight: 194.27
  • Formula: C12H18O2
  • CLOGP: 3.90
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -2.63
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC R02AA12 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Antiseptics
MeSH PA D000871 Anthelmintics
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Methemoglobinemia contraindication 38959009 DOID:10783
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.32 acidic
pKa2 11.99 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Arachidonate 5-lipoxygenase Enzyme IC50 5.55 CHEMBL
Tyrosinase Enzyme IC50 6.25 CHEMBL
Polyphenol oxidase 2 Enzyme IC50 6.01 CHEMBL

External reference:

IDSource
N0000166594 NUI
D04441 KEGG_DRUG
C0019497 UMLSCUI
CHEBI:93749 CHEBI
CHEMBL443605 ChEMBL_ID
DB11254 DRUGBANK_ID
D006604 MESH_DESCRIPTOR_UI
3610 PUBCHEM_CID
R9QTB5E82N UNII
5321 RXNORM
15077 MMSL
002976 NDDF
411201006 SNOMEDCT_US
54086007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Myxcin-C HUMAN OTC DRUG LABEL 1 52426-520 SOLUTION 1.10 mg TOPICAL OTC MONOGRAPH NOT FINAL 14 sections
S.T.37 HUMAN OTC DRUG LABEL 1 69846-860 SOLUTION 1.10 mg ORAL unapproved drug other 16 sections
MUCINEX INSTASOOTHE SORE THROAT PLUS SOOTHING COMFORT HUMAN OTC DRUG LABEL 1 72854-261 LOZENGE 2.40 mg ORAL OTC monograph not final 15 sections
MUCINEX INSTASOOTHE SORE THROAT PLUS PAIN RELIEF HUMAN OTC DRUG LABEL 1 72854-262 LOZENGE 2 mg ORAL OTC MONOGRAPH NOT FINAL 15 sections
MUCINEX INSTASOOTHE SORE THROAT PLUS COUGH RELIEF HUMAN OTC DRUG LABEL 2 72854-263 LOZENGE 2 mg ORAL OTC monograph not final 16 sections
AnubisMed HUMAN OTC DRUG LABEL 14 83021-401 LIQUID 1 g TOPICAL OTC monograph final 9 sections