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ribostamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, produced by Streptomyces strains | 3526 | 25546-65-0 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 1 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| Vd (Volume of distribution) | 0.25 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.50 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.50 hours | Lombardo F, Berellini G, Obach RS |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,CAMK2D,CDK4,CDK5,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,NTRK1,NTRK2,PDK2,PDK4,PRKDC,TEK | 21 | |||
| kinase-selectivity-class | CHUK,MAP2K6,PDK1 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01GB10 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE AMINOGLYCOSIDE ANTIBACTERIALS Other aminoglycosides |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
| CHEBI has role | CHEBI:25212 | metabolite |
Related Drugs by ATC class:
J01GB Other aminoglycosides 12 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 12.57 | acidic |
| pKa2 | 13.56 | acidic |
| pKa3 | 13.9 | acidic |
| pKa4 | 8.21 | Basic |
| pKa5 | 7.69 | Basic |
| pKa6 | 6.31 | Basic |
| pKa7 | 5.7 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D02209 | KEGG_DRUG |
| 53797-35-6 | SECONDARY_CAS_RN |
| C0035554 | UMLSCUI |
| CHEBI:45257 | CHEBI |
| RIO | PDB_CHEM_ID |
| CHEMBL221572 | ChEMBL_ID |
| D012271 | MESH_DESCRIPTOR_UI |
| DB03615 | DRUGBANK_ID |
| 12161 | IUPHAR_LIGAND_ID |
| 3197 | INN_ID |
| 2Q5JOU7T53 | UNII |
| 33042 | PUBCHEM_CID |
| 010978 | NDDF |
| 010979 | NDDF |
| 2Q5JOU7T53 | INXIGHT DRUGS |
Pharmaceutical products:
None