bekanamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 1520 4696-76-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bekanamycin
  • Kanamycin B
  • aminodeoxykanamycin
  • kanendomycin
  • Nebramycin V
kanendomycin is the sulfate of bekanamycin; RN given refers to parent cpd; structure
  • Molecular weight: 483.52
  • Formula: C18H37N5O10
  • CLOGP: -3.85
  • LIPINSKI: 2
  • HAC: 15
  • HDO: 11
  • TPSA: 288.40
  • ALOGS: -0.80
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.60 g P

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01GB13 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
AMINOGLYCOSIDE ANTIBACTERIALS
Other aminoglycosides
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.0 acidic
pKa2 13.56 acidic
pKa3 13.99 acidic
pKa4 8.03 Basic
pKa5 7.6 Basic
pKa6 7.07 Basic
pKa7 6.11 Basic
pKa8 5.41 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
3-oxoacyl-[acyl-carrier-protein] synthase 3 Enzyme IC50 5.20 CHEMBL
3-oxoacyl-[acyl-carrier-protein] synthase 3 Unclassified IC50 5.25 CHEMBL

External reference:

IDSource
D07497 KEGG_DRUG
C0053076 UMLSCUI
CHEBI:28098 CHEBI
9CS PDB_CHEM_ID
CHEMBL176 ChEMBL_ID
DB13673 DRUGBANK_ID
C001495 MESH_SUPPLEMENTAL_RECORD_UI
12182 IUPHAR_LIGAND_ID
2838 INN_ID
15JT14C3GI UNII
439318 PUBCHEM_CID

Pharmaceutical products:

None