isepamicin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| aminoglycosides, antibiotics obtained from various Micromonospora | 1486 | 58152-03-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.40 | g | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 26.33 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| Vd (Volume of distribution) | 0.32 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 1.30 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.95 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 24 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 1, 1988 | YEAR INTRODUCED |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01GB11 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE AMINOGLYCOSIDE ANTIBACTERIALS Other aminoglycosides |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 10.34 | acidic |
| pKa2 | 13.11 | acidic |
| pKa3 | 13.71 | acidic |
| pKa4 | 9.0 | Basic |
| pKa5 | 8.3 | Basic |
| pKa6 | 7.7 | Basic |
| pKa7 | 7.0 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Macrolide 2'-phosphotransferase II; Macrolide 2'-phosphotransferase II protein MphB; Macrolide 2-phosphotransferase, mph(B) | Enzyme | Km | 4.87 | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| D01826 | KEGG_DRUG |
| 393574-17-9 | SECONDARY_CAS_RN |
| C1148065 | UMLSCUI |
| CHEBI:31722 | CHEBI |
| CHEMBL272080 | ChEMBL_ID |
| DB13540 | DRUGBANK_ID |
| C016927 | MESH_SUPPLEMENTAL_RECORD_UI |
| 12136 | IUPHAR_LIGAND_ID |
| 5849 | INN_ID |
| G7K224460P | UNII |
| 3037209 | PUBCHEM_CID |
| 005264 | NDDF |
| 005265 | NDDF |
| 725577008 | SNOMEDCT_US |
Pharmaceutical products:
None