risedronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 2387 105462-24-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • risedronate sodium hemi-pentahydrate
  • risedronate sodium monohydrate
  • risedronate sodium anhydrous
  • risedronate sodium hydrate
  • sodium risedronate
  • sodium risedronate hydrate
  • risedronic acid
  • risedronate
  • risedronate sodium
  • actonel
  • risedronic acid monosodium salt
  • risedronic acid monohydrate
A pyridine and diphosphonic acid derivative that acts as a CALCIUM CHANNEL BLOCKER and inhibits BONE RESORPTION.
  • Molecular weight: 283.11
  • Formula: C7H11NO7P2
  • CLOGP: -0.77
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 5
  • TPSA: 148.18
  • ALOGS: -1.43
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O
5 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 87 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.29 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 1 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 6.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.50 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.76 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 200 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 5 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MTOR,NTRK1,NTRK2,PDK1,PDK2,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1 52
kinase-selectivity-class AURKA,AURKB,AXL,BMX,BRAF,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,JAK2,MAP2K6,MAP3K14,MAP3K2,MAPK7,MAPK8,PIK3CB,PIK3CD,PIK3CG,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70 27
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
March 27, 1998 FDA WARNER CHILCOTT LLC

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Atypical femur fracture 670.21 10.55 307 187424 6114 90434602
Oedema 644.66 10.55 1337 186394 198958 90241758
Femur fracture 623.17 10.55 613 187118 45469 90395247
Wheezing 494.52 10.55 1340 186391 236740 90203976
Asthma 493.06 10.55 1353 186378 240807 90199909
Low turnover osteopathy 410.09 10.55 192 187539 4026 90436690
Rheumatoid arthritis 376.74 10.55 1618 186113 360996 90079720
Stress fracture 358.22 10.55 223 187508 8388 90432328
Drug hypersensitivity 338.74 10.55 1870 185861 461739 89978977
Toxicity to various agents 338.66 10.55 89 187642 287757 90152959
Osteonecrosis of jaw 332.95 10.55 408 187323 38695 90402021
Death 323.66 10.55 282 187449 456269 89984447
Pulmonary fibrosis 294.55 10.55 673 187058 106830 90333886
Nasal oedema 282.74 10.55 174 187557 6410 90434306
Fracture displacement 271.18 10.55 101 187630 1155 90439561
Osteoarthritis 266.00 10.55 951 186780 194779 90245937
Completed suicide 256.68 10.55 10 187721 145048 90295668
Mobility decreased 238.27 10.55 1090 186641 249644 90191072
Neutropenia 220.19 10.55 95 187636 224809 90215907
Nodule 204.18 10.55 264 187467 26422 90414294
Disease progression 198.83 10.55 41 187690 156574 90284142
Eosinophilic bronchitis 192.94 10.55 66 187665 577 90440139
Lower limb fracture 188.83 10.55 491 187240 84522 90356194
Pathological fracture 188.55 10.55 158 187573 9502 90431214
Product dose omission issue 185.75 10.55 198 187533 291489 90149227
Injection site pain 185.53 10.55 64 187667 173635 90267081
Rheumatoid factor positive 181.77 10.55 771 186960 170879 90269837
Fracture 176.14 10.55 223 187508 21853 90418863
Intentional overdose 174.93 10.55 4 187727 93830 90346886
Osteoporosis 171.50 10.55 514 187217 96017 90344699
Gastrooesophageal reflux disease 170.62 10.55 740 186991 165597 90275119
Acute kidney injury 163.29 10.55 257 187474 320130 90120586
Drug interaction 162.63 10.55 200 187531 276253 90164463
Foot fracture 156.66 10.55 232 187499 26374 90414342
Rheumatoid nodule 151.93 10.55 198 187533 19968 90420748
Osteonecrosis 149.06 10.55 225 187506 26016 90414700
Jaw disorder 147.54 10.55 109 187622 5450 90435266
Bone disorder 146.90 10.55 209 187522 22911 90417805
Bedridden 146.58 10.55 152 187579 11996 90428720
Blood pressure systolic increased 146.37 10.55 353 187378 57992 90382724
Respiratory tract infection 143.48 10.55 353 187378 58725 90381991
COVID-19 143.29 10.55 86 187645 168757 90271959
Febrile neutropenia 142.51 10.55 75 187656 158274 90282442
Joint destruction 142.20 10.55 156 187575 13131 90427585
Drug tolerance 141.39 10.55 180 187551 17736 90422980
Foot deformity 141.25 10.55 353 187378 59298 90381418
Malignant neoplasm progression 139.79 10.55 26 187705 106844 90333872
Fracture nonunion 139.51 10.55 76 187655 2216 90438500
Drug abuse 135.17 10.55 9 187722 82338 90358378
Red blood cell sedimentation rate abnormal 132.49 10.55 204 187527 24000 90416716
Systemic lupus erythematosus rash 131.13 10.55 74 187657 2315 90438401
Osteoporotic fracture 130.52 10.55 95 187636 4641 90436075
Somnolence 129.66 10.55 145 187586 208939 90231777
Obstructive airways disorder 127.75 10.55 208 187523 25661 90415055
Polyarthritis 119.72 10.55 168 187563 18182 90422534
Osteomyelitis 119.10 10.55 210 187521 27636 90413080
Cardiac arrest 118.54 10.55 35 187696 104900 90335816
Atypical fracture 117.96 10.55 51 187680 880 90439836
Sepsis 114.47 10.55 122 187609 179692 90261024
Type 2 diabetes mellitus 113.20 10.55 765 186966 202479 90238237
Ulcer haemorrhage 110.64 10.55 197 187534 26124 90414592
Liver injury 110.41 10.55 667 187064 169900 90270816
Deep vein thrombosis postoperative 108.24 10.55 358 187373 70451 90370265
Overdose 107.26 10.55 101 187630 157608 90283108
Osteopenia 105.61 10.55 179 187552 22823 90417893
Synovitis 102.45 10.55 1089 186642 328663 90112053
Fracture delayed union 101.97 10.55 64 187667 2442 90438274
Seizure 100.03 10.55 101 187630 152528 90288188
Injection site erythema 98.94 10.55 40 187691 98462 90342254
Fatigue 96.43 10.55 1748 185983 1152275 89288441
Fibromyalgia 96.18 10.55 744 186987 205525 90235191
Bursitis 95.72 10.55 531 187200 131123 90309593
Musculoskeletal stiffness 95.25 10.55 986 186745 295546 90145170
Thrombocytopenia 94.80 10.55 180 187551 208545 90232171
Swollen joint count increased 93.54 10.55 467 187264 110739 90329977
Joint range of motion decreased 92.63 10.55 538 187193 135105 90305611
Dehydration 92.48 10.55 163 187568 194284 90246432
Arthropathy 92.09 10.55 1161 186570 365081 90075635
Suicide attempt 91.11 10.55 22 187709 75377 90365339
Obesity 90.82 10.55 446 187285 105061 90335655
Anaemia 90.63 10.55 399 187332 352403 90088313
Arthralgia 90.06 10.55 2178 185553 776344 89664372
Pleural fibrosis 89.84 10.55 68 187663 3528 90437188
Lip dry 89.23 10.55 430 187301 100525 90340191
White blood cell count decreased 88.96 10.55 130 187601 166979 90273737
Psoriatic arthropathy 88.50 10.55 790 186941 227545 90213171
Presbyacusis 88.36 10.55 63 187668 2979 90437737
Tooth disorder 87.71 10.55 197 187534 30893 90409823
Myelosuppression 87.53 10.55 6 187725 53585 90387131
Blood parathyroid hormone decreased 87.48 10.55 117 187614 12099 90428617
Adrenal insufficiency 87.12 10.55 192 187539 29729 90410987
C-reactive protein 86.54 10.55 197 187534 31170 90409546
Autoimmune disorder 83.72 10.55 348 187383 76396 90364320
Therapy interrupted 83.66 10.55 5 187726 50103 90390613
Ankle arthroplasty 83.08 10.55 59 187672 2772 90437944
C-reactive protein abnormal 82.24 10.55 498 187233 126931 90313785
Intramedullary rod insertion 82.23 10.55 53 187678 2119 90438597
Pruritus 82.04 10.55 722 187009 540803 89899913
Sciatica 81.93 10.55 421 187310 100961 90339755
Peripheral venous disease 81.93 10.55 368 187363 83553 90357163
Therapy non-responder 81.20 10.55 523 187208 136181 90304535
Periodontal disease 80.61 10.55 48 187683 1664 90439052
Anti-cyclic citrullinated peptide antibody positive 80.13 10.55 795 186936 235638 90205078
Bone sequestrum 79.73 10.55 45 187686 1408 90439308
Liver disorder 79.58 10.55 476 187255 120793 90319923
Loss of personal independence in daily activities 79.18 10.55 518 187213 135587 90305129
Chest pain 78.92 10.55 1010 186721 318635 90122081
Blood pressure diastolic decreased 77.94 10.55 172 187559 26654 90414062
Suicidal ideation 77.48 10.55 28 187703 73827 90366889
Immobile 77.09 10.55 80 187651 6318 90434398
Anaemia postoperative 76.46 10.55 51 187680 2162 90438554
Neutrophilia 76.46 10.55 76 187655 5702 90435014
Total lung capacity decreased 75.99 10.55 63 187668 3732 90436984
Foetal exposure during pregnancy 75.87 10.55 3 187728 42972 90397744
Off label use 75.73 10.55 1724 186007 1100528 89340188
Dental caries 75.32 10.55 105 187626 11292 90429424
Wrong technique in product usage process 75.31 10.55 27 187704 71544 90369172
Blood cholesterol increased 75.19 10.55 709 187022 207303 90233413
Lung disorder 75.13 10.55 550 187181 149333 90291383
Osteogenesis imperfecta 74.65 10.55 37 187694 883 90439833
Platelet count decreased 74.43 10.55 105 187626 136864 90303852
Anaphylactic reaction 73.64 10.55 45 187686 87479 90353237
Alanine aminotransferase abnormal 72.97 10.55 72 187659 5354 90435362
Constipation 72.66 10.55 316 187415 280079 90160637
Blood pressure diastolic abnormal 72.52 10.55 140 187591 19741 90420975
Coma 72.12 10.55 30 187701 72602 90368114
Pleural thickening 71.53 10.55 57 187674 3191 90437525
Accidental exposure to product 71.42 10.55 4 187727 42362 90398354
Intentional product misuse 71.40 10.55 49 187682 89555 90351161
Prescribed overdose 71.11 10.55 394 187337 97231 90343485
Foot operation 70.34 10.55 90 187641 8911 90431805
Respiratory failure 70.28 10.55 85 187646 118333 90322383
Peri-implantitis 69.90 10.55 19 187712 67 90440649
Abortion spontaneous 68.89 10.55 14 187717 54042 90386674
Granuloma skin 68.51 10.55 97 187634 10583 90430133
Panniculitis 68.35 10.55 114 187617 14344 90426372
Tachycardia 68.11 10.55 140 187591 157533 90283183
Injection site swelling 67.50 10.55 20 187711 59819 90380897
Night sweats 66.54 10.55 476 187255 128290 90312426
Feeling abnormal 65.26 10.55 157 187574 167078 90273638
Bronchopulmonary aspergillosis allergic 64.17 10.55 57 187674 3709 90437007
Rash 64.05 10.55 1213 186518 794887 89645829
Dry mouth 63.85 10.55 622 187109 183437 90257279
Inappropriate schedule of product administration 63.18 10.55 135 187596 149798 90290918
Musculoskeletal pain 63.02 10.55 586 187145 170665 90270051
Blood magnesium increased 62.94 10.55 54 187677 3354 90437362
Mucosal inflammation 61.90 10.55 21 187710 57604 90383112
Hyperhidrosis 61.47 10.55 118 187613 136187 90304529
Basal cell carcinoma 61.36 10.55 180 187551 33209 90407507
Osteosclerosis 61.23 10.55 59 187672 4261 90436455
Drug ineffective for unapproved indication 60.78 10.55 31 187700 66613 90374103
Drug tolerance decreased 60.77 10.55 175 187556 31955 90408761
Injection site pruritus 60.71 10.55 18 187713 53816 90386900
Polyp 60.63 10.55 77 187654 7567 90433149
Sedation 60.31 10.55 13 187718 48158 90392558
Bradycardia 60.23 10.55 51 187680 83796 90356920
Comminuted fracture 60.23 10.55 27 187704 510 90440206
Illness 59.94 10.55 49 187682 81920 90358796
Neutrophil count decreased 59.87 10.55 37 187694 71495 90369221
Skin exfoliation 59.86 10.55 33 187698 67880 90372836
Resorption bone increased 59.55 10.55 35 187696 1184 90439532
Rheumatic fever 59.41 10.55 530 187201 152591 90288125
Headache 59.24 10.55 1349 186382 861397 89579319
Dry skin 59.17 10.55 57 187674 88016 90352700
Pelvic fracture 59.01 10.55 110 187621 15109 90425607
Blood pressure systolic abnormal 58.99 10.55 127 187604 19351 90421365
Salpingo-oophorectomy unilateral 58.65 10.55 32 187699 936 90439780
Impaired healing 58.61 10.55 742 186989 233457 90207259
Lactic acidosis 58.52 10.55 16 187715 50447 90390269
Sinusitis fungal 57.80 10.55 41 187690 1923 90438793
Ulna fracture 57.54 10.55 35 187696 1262 90439454
Lung opacity 57.39 10.55 67 187664 6035 90434681
Periodontitis 57.23 10.55 54 187677 3799 90436917
Tooth infection 57.11 10.55 128 187603 20042 90420674
Adjustment disorder with depressed mood 56.99 10.55 251 187480 56502 90384214
Premature delivery 56.23 10.55 7 187724 38755 90401961
Deafness neurosensory 55.99 10.55 70 187661 6771 90433945
Red blood cell sedimentation rate increased 55.98 10.55 327 187404 82268 90358448
Skin necrosis 55.43 10.55 114 187617 16827 90423889
Depressed level of consciousness 55.12 10.55 42 187689 72742 90367974
Bone cyst 55.10 10.55 43 187688 2335 90438381
Spinal fracture 54.98 10.55 133 187598 21883 90418833
Tooth extraction 54.72 10.55 91 187640 11422 90429294
Syncope 54.61 10.55 121 187610 132542 90308174
Drug ineffective 54.42 10.55 2331 185400 1381967 89058749
Wound infection 54.20 10.55 392 187339 106010 90334706
Neoplasm progression 53.71 10.55 13 187718 44473 90396243
Inflammation 53.61 10.55 586 187145 178006 90262710
Breast cancer stage III 53.19 10.55 328 187403 84119 90356597
Nausea 52.03 10.55 1831 185900 1108485 89332231
Therapy cessation 51.70 10.55 7 187724 36354 90404362
Injection site bruising 51.30 10.55 22 187709 52285 90388431
Hypocholesterolaemia 51.21 10.55 65 187666 6384 90434332
Infection 50.84 10.55 1042 186689 361052 90079664
Taste disorder 50.70 10.55 257 187474 61289 90379427
Arthritis 50.68 10.55 550 187181 166765 90273951
Joint swelling 50.68 10.55 1383 186348 501917 89938799
Exposure during pregnancy 50.65 10.55 288 187443 238122 90202594
Agitation 50.45 10.55 39 187692 67059 90373657
Pancytopenia 50.07 10.55 109 187622 120154 90320562
Diverticulum 50.06 10.55 90 187641 12023 90428693
Multiple sclerosis relapse 49.72 10.55 23 187708 52282 90388434
Electrocardiogram QT prolonged 49.72 10.55 46 187685 72410 90368306
Colitis 49.68 10.55 43 187688 69899 90370817
Road traffic accident 49.45 10.55 387 187344 107239 90333477
Dental fistula 48.42 10.55 25 187706 652 90440064
Ulcer 48.24 10.55 164 187567 32718 90407998
Immunodeficiency 47.10 10.55 196 187535 43038 90397678
Drug reaction with eosinophilia and systemic symptoms 46.95 10.55 15 187716 42743 90397973
Bone density decreased 46.81 10.55 108 187623 17237 90423479
Nerve injury 46.51 10.55 83 187648 11023 90429693
Serotonin syndrome 45.88 10.55 11 187720 37876 90402840
Prescribed underdose 45.75 10.55 289 187442 74730 90365986
Open reduction of fracture 45.59 10.55 29 187702 1133 90439583
Muscle fatigue 45.39 10.55 42 187689 2882 90437834
Cardiac failure 44.96 10.55 100 187631 109396 90331320
Hyperkalaemia 44.86 10.55 41 187690 64923 90375793
Adverse event 44.81 10.55 405 187326 117013 90323703
Malaise 44.56 10.55 1556 186175 584430 89856286
Drug intolerance 44.49 10.55 1228 186503 446363 89994353
Osteonecrosis of external auditory canal 44.18 10.55 16 187715 168 90440548
Respiratory symptom 43.91 10.55 49 187682 4203 90436513
Injury 43.45 10.55 611 187120 196738 90243978
Cytokine release syndrome 43.26 10.55 4 187727 27969 90412747
Blepharospasm 43.23 10.55 228 187503 55217 90385499
Wheelchair user 43.14 10.55 66 187665 7719 90432997
Drug resistance 42.97 10.55 6 187725 30443 90410273
Hypercalcaemia 42.75 10.55 162 187569 34078 90406638
Therapeutic product effect variable 42.70 10.55 31 187700 1508 90439208
Jaw fracture 42.61 10.55 39 187692 2639 90438077
Blood pressure fluctuation 42.57 10.55 218 187513 52195 90388521
Blood pressure inadequately controlled 42.12 10.55 58 187673 6166 90434550
Abdominal pain upper 42.07 10.55 943 186788 331731 90108985
Full blood count decreased 41.54 10.55 6 187725 29683 90411033
Bone formation decreased 41.41 10.55 13 187718 84 90440632
Oral cavity fistula 41.00 10.55 22 187709 622 90440094
Dislocation of vertebra 40.82 10.55 226 187505 55742 90384974
Dysarthria 40.54 10.55 32 187699 54450 90386266
Gingivitis 40.50 10.55 71 187660 9298 90431418
Contraindicated product administered 40.33 10.55 907 186824 319232 90121484
Vaginal haemorrhage 40.05 10.55 8 187723 31263 90409453
Influenza 39.78 10.55 151 187580 139113 90301603
Multiple organ dysfunction syndrome 39.54 10.55 50 187681 68286 90372430
Hallucination 39.50 10.55 47 187684 65912 90374804
Sputum increased 39.32 10.55 39 187692 2918 90437798
Spinal compression fracture 39.31 10.55 93 187638 15085 90425631
Angioedema 39.09 10.55 46 187685 64830 90375886
Exercise tolerance decreased 39.03 10.55 62 187669 7489 90433227
Device failure 38.97 10.55 59 187672 6838 90433878
Epigastric discomfort 38.93 10.55 62 187669 7506 90433210
Hypertension 38.86 10.55 1231 186500 456301 89984415
Vision blurred 38.84 10.55 109 187622 110184 90330532
Neuropathy peripheral 38.81 10.55 149 187582 136821 90303895
Hypervolaemia 38.72 10.55 10 187721 32747 90407969
Exostosis of jaw 38.56 10.55 27 187704 1240 90439476
Palmar-plantar erythrodysaesthesia syndrome 38.44 10.55 6 187725 28017 90412699
Therapeutic response decreased 38.15 10.55 317 187414 89412 90351304
Eosinophil count increased 38.14 10.55 84 187647 12997 90427719
Encephalopathy 37.53 10.55 25 187706 46419 90394297
Pain in extremity 37.44 10.55 1209 186522 449320 89991396
Pulmonary embolism 37.26 10.55 142 187589 130678 90310038
Live birth 37.19 10.55 286 187445 78821 90361895
Red blood cell sedimentation rate 37.07 10.55 47 187684 4611 90436105
Treatment failure 37.01 10.55 857 186874 303071 90137645
Flushing 37.00 10.55 80 187651 88411 90352305
Tooth fracture 36.84 10.55 81 187650 12519 90428197
Bone graft 36.43 10.55 24 187707 996 90439720
Muscle spasticity 36.03 10.55 14 187717 35308 90405408
Incorrect dose administered 35.87 10.55 68 187663 78862 90361854
Rales 35.72 10.55 92 187639 15735 90424981
Renal failure 35.54 10.55 145 187586 130862 90309854
Vomiting 35.24 10.55 1982 185749 786311 89654405
Bone fragmentation 34.80 10.55 21 187710 746 90439970
Lethargy 34.69 10.55 48 187683 63091 90377625
Purulent discharge 34.54 10.55 49 187682 5356 90435360
Embolism venous 34.47 10.55 40 187691 3580 90437136
Respiratory arrest 34.31 10.55 13 187718 33298 90407418
Metabolic acidosis 34.06 10.55 39 187692 55637 90385079
Eye injury 33.54 10.55 72 187659 10948 90429768
Gingival ulceration 33.54 10.55 23 187708 1021 90439695
Acute respiratory failure 33.49 10.55 24 187707 42894 90397822
Neurotoxicity 33.38 10.55 3 187728 21464 90419252
Pyrexia 33.19 10.55 1079 186652 659406 89781310
Diarrhoea 33.19 10.55 1599 186132 937591 89503125
Fistula discharge 32.93 10.55 23 187708 1052 90439664
Pulmonary arterial hypertension 32.92 10.55 7 187724 26180 90414536
Withdrawal syndrome 32.84 10.55 4 187727 22520 90418196
Dental necrosis 32.72 10.55 12 187719 131 90440585
Tendonitis 32.60 10.55 108 187623 21264 90419452
Visual impairment 32.56 10.55 152 187579 132213 90308503
Thrombosis 32.51 10.55 64 187667 73187 90367529
Pneumonia 32.45 10.55 1624 186107 636435 89804281
Bronchiectasis 32.43 10.55 111 187620 22219 90418497
Bone loss 32.27 10.55 38 187693 3454 90437262
Disturbance in attention 32.21 10.55 30 187701 47079 90393637
Limb discomfort 32.10 10.55 160 187571 37900 90402816
Tremor 32.00 10.55 186 187545 152987 90287729
Limb asymmetry 31.96 10.55 21 187710 868 90439848
Skin ulcer 31.84 10.55 195 187536 49880 90390836
Groin pain 31.81 10.55 75 187656 12138 90428578
Loose tooth 31.76 10.55 39 187692 3704 90437012
Impaired quality of life 31.64 10.55 5 187726 23139 90417577
Acute respiratory distress syndrome 31.61 10.55 10 187721 28676 90412040
Leukopenia 31.56 10.55 105 187626 100605 90340111
Lower respiratory tract infection 31.50 10.55 710 187021 249949 90190767
Periprosthetic fracture 31.50 10.55 18 187713 577 90440139
Gingival disorder 31.33 10.55 40 187691 3951 90436765
Gait inability 31.25 10.55 451 187280 146005 90294711
Anal abscess 31.08 10.55 48 187683 5660 90435056
Sputum discoloured 31.06 10.55 103 187628 20288 90420428
Mental disorder 31.05 10.55 14 187717 32304 90408412
Abnormal behaviour 30.69 10.55 5 187726 22623 90418093
Coordination abnormal 30.63 10.55 4 187727 21352 90419364
Hepatic enzyme 30.60 10.55 46 187685 5298 90435418
Haematochezia 30.58 10.55 63 187668 70850 90369866
Rash erythematous 30.55 10.55 55 187676 65049 90375667
Hepatotoxicity 30.40 10.55 30 187701 45812 90394904
Ill-defined disorder 30.32 10.55 545 187186 184346 90256370
Bunion operation 30.27 10.55 24 187707 1334 90439382
Breath sounds abnormal 30.26 10.55 85 187646 15301 90425415
Palpitations 30.21 10.55 163 187568 136565 90304151
Device malfunction 29.92 10.55 4 187727 20973 90419743
Fear of injection 29.88 10.55 59 187672 8456 90432260
Cardiogenic shock 29.83 10.55 7 187724 24461 90416255
Metastases to bone 29.74 10.55 8 187723 25497 90415219
Food allergy 29.69 10.55 8 187723 25470 90415246
Therapy partial responder 29.61 10.55 5 187726 22038 90418678
Oral infection 29.59 10.55 45 187686 5235 90435481
Foetal death 29.44 10.55 4 187727 20719 90419997
Adverse drug reaction 29.27 10.55 370 187361 116331 90324385
Blue toe syndrome 29.26 10.55 16 187715 470 90440246
Blood calcium increased 29.21 10.55 72 187659 11986 90428730
Hypotension 29.17 10.55 486 187245 324911 90115805
Sleep disorder 29.12 10.55 574 187157 197456 90243260
Maternal exposure during pregnancy 29.03 10.55 548 187183 359515 90081201
Acute phase reaction 28.88 10.55 14 187717 318 90440398
Deformity 28.78 10.55 72 187659 12098 90428618
Hypersomnia 28.66 10.55 5 187726 21526 90419190
Metaphyseal corner fracture 28.64 10.55 8 187723 32 90440684
Drug eruption 28.56 10.55 147 187584 35260 90405456
Urinary tract infection 28.55 10.55 453 187278 305179 90135537
Calcium deficiency 28.52 10.55 23 187708 1310 90439406
Therapeutic product effect decreased 28.52 10.55 765 186966 276806 90163910
Hyponatraemia 28.51 10.55 161 187570 133377 90307339
Rotator cuff syndrome 28.47 10.55 85 187646 15834 90424882
Lupus vulgaris 28.36 10.55 175 187556 44884 90395832
Myopathy toxic 28.35 10.55 17 187714 597 90440119
Swollen tongue 28.32 10.55 32 187699 45924 90394792
Sopor 28.23 10.55 8 187723 24636 90416080
Intentional product use issue 28.08 10.55 617 187114 216275 90224441
Carpal tunnel syndrome 28.07 10.55 111 187620 23817 90416899
Posterior reversible encephalopathy syndrome 28.02 10.55 6 187725 22333 90418383
Irritability 27.75 10.55 20 187711 35642 90405074
Coagulopathy 27.73 10.55 7 187724 23282 90417434
Mental status changes 27.65 10.55 31 187700 44648 90396068
Coeliac disease 27.56 10.55 31 187700 44579 90396137
Arteriovenous fistula occlusion 27.40 10.55 14 187717 357 90440359
Fracture malunion 27.34 10.55 11 187720 157 90440559
Epistaxis 27.19 10.55 88 187643 85037 90355679
Diastolic dysfunction 27.19 10.55 52 187679 7281 90433435
No adverse event 27.16 10.55 63 187668 67919 90372797
Neutropenic sepsis 26.98 10.55 3 187728 18127 90422589
Affect lability 26.85 10.55 3 187728 18060 90422656
Gastroenteritis viral 26.59 10.55 129 187602 30226 90410490
Acute hepatic failure 26.45 10.55 7 187724 22554 90418162
Meniscus injury 26.44 10.55 55 187676 8182 90432534
Skin haemorrhage 26.30 10.55 6 187725 21374 90419342
Tenosynovitis 26.26 10.55 78 187653 14489 90426227
Tachypnoea 26.17 10.55 6 187725 21303 90419413
Product prescribing error 26.06 10.55 15 187716 30130 90410586
Unevaluable event 26.04 10.55 46 187685 54802 90385914
General physical health deterioration 25.95 10.55 939 186792 354176 90086540
Spinal osteoarthritis 25.92 10.55 93 187638 19055 90421661
Cerebrovascular accident 25.80 10.55 150 187581 123383 90317333
Rash maculo-papular 25.78 10.55 28 187703 40905 90399811
Haemoglobin decreased 25.76 10.55 213 187518 161743 90278973
Cardiac failure congestive 25.67 10.55 111 187620 98583 90342133
Injection site mass 25.62 10.55 7 187724 22083 90418633
Malocclusion 25.49 10.55 10 187721 133 90440583
Generalised tonic-clonic seizure 25.34 10.55 21 187710 34882 90405834
Dyskinesia 25.29 10.55 23 187708 36511 90404205
Macular degeneration 25.01 10.55 25 187706 37945 90402771
Psychotic disorder 24.98 10.55 17 187714 31213 90409503
Hunger 24.90 10.55 47 187684 6516 90434200
Ventricular tachycardia 24.86 10.55 10 187721 24698 90416018
Nasal congestion 24.76 10.55 89 187642 83325 90357391
Swelling face 24.68 10.55 86 187645 81266 90359450
Polyneuropathy 24.66 10.55 5 187726 19336 90421380
Hiatus hernia 24.58 10.55 111 187620 25250 90415466
Dystonia 24.49 10.55 3 187728 16816 90423900
Abdominal distension 24.48 10.55 164 187567 130437 90310279
Burning sensation 24.40 10.55 60 187671 63392 90377324
Amnesia 24.30 10.55 337 187394 108168 90332548
Bone density abnormal 24.22 10.55 36 187695 4104 90436612
Blood pressure diastolic increased 24.12 10.55 70 187661 12836 90427880
Product quality issue 24.11 10.55 261 187470 79064 90361652
Cardio-respiratory arrest 24.05 10.55 60 187671 63080 90377636
Breast cancer stage II 24.00 10.55 140 187591 35194 90405522
Drug withdrawal syndrome 23.84 10.55 15 187716 28708 90412008
Status epilepticus 23.82 10.55 5 187726 18869 90421847
Fluid retention 23.57 10.55 98 187633 87993 90352723
Cytomegalovirus infection 23.33 10.55 13 187718 26589 90414127
Mood swings 23.20 10.55 7 187724 20695 90420021
Emotional distress 23.17 10.55 25 187706 36637 90404079
Chronic kidney disease 23.01 10.55 43 187688 50148 90390568
Cyst 22.90 10.55 81 187650 16480 90424236
Pulmonary oedema 22.87 10.55 60 187671 62020 90378696
Ascites 22.69 10.55 40 187691 47700 90393016
Enthesopathy 22.62 10.55 56 187675 9348 90431368
Pancreatitis acute 22.49 10.55 20 187711 32095 90408621
Abscess jaw 22.46 10.55 21 187710 1460 90439256
Device issue 22.42 10.55 17 187714 29520 90411196
Product storage error 22.40 10.55 7 187724 20234 90420482
Tongue disorder 22.35 10.55 61 187670 10799 90429917
Respiratory depression 22.14 10.55 3 187728 15572 90425144
Hypocalcaemia 22.09 10.55 157 187574 42211 90398505
Hepatic failure 22.03 10.55 30 187701 39698 90401018
Aggression 22.03 10.55 14 187717 26654 90414062
Mass excision 21.99 10.55 12 187719 351 90440365
Unresponsive to stimuli 21.94 10.55 28 187703 38093 90402623
Pneumonitis 21.92 10.55 36 187695 44134 90396582
Aspiration 21.91 10.55 77 187654 15616 90425100
Oropharyngeal pain 21.91 10.55 144 187587 115043 90325673
Emphysema 21.83 10.55 65 187666 12090 90428626
Facet joint syndrome 21.79 10.55 305 187426 98084 90342632
Exostosis 21.67 10.55 186 187545 52948 90387768
C-reactive protein increased 21.60 10.55 510 187221 180879 90259837
Tooth loss 21.45 10.55 48 187683 7506 90433210
Injection site warmth 21.37 10.55 5 187726 17510 90423206
Multiple allergies 21.33 10.55 3 187728 15143 90425573
Caesarean section 21.33 10.55 6 187725 18571 90422145
Metastases to liver 21.33 10.55 17 187714 28790 90411926
Respiratory distress 21.00 10.55 30 187701 38916 90401800
Injection site rash 20.93 10.55 12 187719 24161 90416555
Sinus tachycardia 20.90 10.55 17 187714 28496 90412220
Pericarditis 20.88 10.55 719 187012 269432 90171284
Urosepsis 20.71 10.55 9 187722 21223 90419493
Polymyalgia rheumatica 20.59 10.55 37 187694 4940 90435776
Sensory loss 20.46 10.55 6 187725 18069 90422647
Sneezing 20.45 10.55 19 187712 29850 90410866
Hypoglycaemia 20.42 10.55 75 187656 69773 90370943
Bone marrow failure 20.33 10.55 22 187709 32199 90408517
Temperature regulation disorder 20.27 10.55 3 187728 14576 90426140
Bursitis infective 20.24 10.55 20 187711 1490 90439226
Thrombotic microangiopathy 20.22 10.55 4 187727 15739 90424977
X-ray abnormal 20.12 10.55 162 187569 45262 90395454
Oral herpes 19.73 10.55 128 187603 33396 90407320
Hepatic cytolysis 19.63 10.55 21 187710 30895 90409821
Lip swelling 19.60 10.55 31 187700 38579 90402137
Gait disturbance 19.55 10.55 691 187040 259805 90180911
Atrophy 19.55 10.55 23 187708 2089 90438627
Blood potassium increased 19.50 10.55 90 187641 20659 90420057
Temporomandibular joint syndrome 19.43 10.55 32 187699 3985 90436731
Altered state of consciousness 19.38 10.55 22 187709 31510 90409206
Endometrial disorder 19.36 10.55 15 187716 806 90439910
Proctitis 19.34 10.55 4 187727 15255 90425461
Radius fracture 19.27 10.55 32 187699 4012 90436704
Bone erosion 19.27 10.55 181 187550 52840 90387876
Drug-induced liver injury 19.22 10.55 109 187622 90209 90350507
Hysterectomy 18.99 10.55 60 187671 11524 90429192
Right ventricular failure 18.95 10.55 8 187723 19197 90421519
Lymphopenia 18.92 10.55 12 187719 22869 90417847
Vitamin B12 decreased 18.89 10.55 37 187694 5273 90435443
Tibia fracture 18.79 10.55 40 187691 6047 90434669
Fracture pain 18.78 10.55 17 187714 1134 90439582
Tubulointerstitial nephritis 18.71 10.55 15 187716 25328 90415388
Product use in unapproved indication 18.63 10.55 542 187189 335694 90105022
Heart rate decreased 18.62 10.55 181 187550 53324 90387392
Blood creatine phosphokinase MB 18.49 10.55 4 187727 3 90440713
Dysgeusia 18.46 10.55 52 187679 52508 90388208
Device dislocation 18.25 10.55 23 187708 31459 90409257
Multiple drug therapy 18.21 10.55 43 187688 6966 90433750
Muscle injury 18.17 10.55 487 187244 176167 90264549
Thoracic vertebral fracture 18.10 10.55 37 187694 5437 90435279
Circulatory collapse 18.06 10.55 15 187716 24889 90415827
International normalised ratio increased 17.99 10.55 45 187686 47271 90393445
Pneumonia aspiration 17.97 10.55 36 187695 40904 90399812
Anti-cyclic citrullinated peptide antibody 17.94 10.55 107 187624 27114 90413602
Patellofemoral pain syndrome 17.85 10.55 14 187717 766 90439950
Vaginal discharge 17.83 10.55 9 187722 19455 90421261
Spondylolisthesis 17.77 10.55 31 187700 4044 90436672
Aphasia 17.65 10.55 39 187692 42773 90397943
Ejection fraction decreased 17.62 10.55 17 187714 26236 90414480
Toxic epidermal necrolysis 17.60 10.55 25 187706 32503 90408213
Disorientation 17.53 10.55 41 187690 44073 90396643
Eosinophil count decreased 17.47 10.55 27 187704 3185 90437531
Motor dysfunction 17.45 10.55 9 187722 19221 90421495
Drug dependence 17.45 10.55 21 187710 29306 90411410
Peripheral vascular disorder 17.30 10.55 40 187691 6391 90434325
Tuberculin test positive 17.11 10.55 29 187702 3696 90437020
Skin fissures 17.08 10.55 11 187720 20798 90419918
Gastrointestinal haemorrhage 17.07 10.55 113 187618 90135 90350581
Ataxia 17.04 10.55 8 187723 18034 90422682
Pleuritic pain 16.98 10.55 54 187677 10407 90430309
Nail disorder 16.88 10.55 192 187539 58875 90381841
Cough 16.87 10.55 930 186801 368032 90072684
Haemorrhage 16.85 10.55 80 187651 69289 90371427
Acute myeloid leukaemia 16.82 10.55 11 187720 20629 90420087
Pallor 16.81 10.55 28 187703 34137 90406579
Femoral neck fracture 16.77 10.55 53 187678 10180 90430536
Myocarditis 16.73 10.55 4 187727 13802 90426914
Bacteraemia 16.71 10.55 13 187718 22287 90418429
Hot flush 16.66 10.55 65 187666 59423 90381293
Pseudarthrosis 16.65 10.55 11 187720 459 90440257
Intentional dose omission 16.62 10.55 8 187723 17775 90422941
Skin burning sensation 16.61 10.55 10 187721 19601 90421115
Orthostatic hypotension 16.52 10.55 39 187692 41788 90398928
Pulmonary hypertension 16.51 10.55 40 187691 42483 90398233
Rhinorrhoea 16.50 10.55 111 187620 88205 90352511
Blister 16.40 10.55 665 187066 254333 90186383
Rash papular 16.39 10.55 11 187720 20344 90420372
Skin reaction 16.37 10.55 9 187722 18544 90422172
Rheumatoid lung 16.34 10.55 30 187701 4073 90436643
Diabetic ketoacidosis 16.15 10.55 16 187715 24391 90416325
Granuloma 16.13 10.55 38 187693 6147 90434569
Respiratory tract inflammation 16.10 10.55 12 187719 608 90440108
Migraine 16.05 10.55 512 187219 189880 90250836
Spinal disorder 16.05 10.55 57 187674 11622 90429094
Tooth abscess 16.03 10.55 72 187659 16341 90424375
Haemophagocytic lymphohistiocytosis 15.98 10.55 6 187725 15453 90425263
Walking aid user 15.93 10.55 127 187604 35379 90405337
Eye disorder 15.89 10.55 20 187711 27370 90413346
Urinary retention 15.88 10.55 34 187697 37710 90403006
Giant cell arteritis 15.84 10.55 25 187706 3004 90437712
Feeling jittery 15.83 10.55 6 187725 15365 90425351
Rheumatoid factor 15.75 10.55 11 187720 503 90440213
Oral candidiasis 15.71 10.55 31 187700 35424 90405292
Toothache 15.70 10.55 89 187642 22141 90418575
Rash macular 15.67 10.55 24 187707 30256 90410460
Pericardial effusion 15.64 10.55 33 187698 36800 90403916
Bronchospasm 15.61 10.55 12 187719 20697 90420019
Episcleral hyperaemia 15.55 10.55 3 187728 0 90440716
Weight bearing difficulty 15.53 10.55 24 187707 2832 90437884
Fractured sacrum 15.50 10.55 22 187709 2405 90438311
Stevens-Johnson syndrome 15.48 10.55 23 187708 29353 90411363
Vascular device infection 15.43 10.55 3 187728 11949 90428767
Bone marrow oedema 15.35 10.55 17 187714 1446 90439270
Parkinsonism 15.32 10.55 5 187726 14060 90426656
Mastication disorder 15.30 10.55 22 187709 2434 90438282
Mydriasis 15.23 10.55 6 187725 15006 90425710
Hip arthroplasty 15.20 10.55 232 187499 75976 90364740
Restlessness 15.17 10.55 32 187699 35688 90405028
Splenomegaly 15.17 10.55 4 187727 12920 90427796
Gout 15.14 10.55 8 187723 16851 90423865
Escherichia infection 15.09 10.55 7 187724 15888 90424828
Urethral caruncle 14.95 10.55 6 187725 85 90440631
Mite allergy 14.88 10.55 13 187718 827 90439889
Cardiomyopathy 14.87 10.55 12 187719 20194 90420522
Barrett's oesophagus 14.85 10.55 11 187720 552 90440164
Hemiparesis 14.82 10.55 27 187704 31792 90408924
Joint injury 14.74 10.55 117 187614 32547 90408169
Acute generalised exanthematous pustulosis 14.70 10.55 5 187726 13698 90427018
Lung adenocarcinoma stage IV 14.66 10.55 10 187721 440 90440276
Paraesthesia oral 14.62 10.55 27 187704 31632 90409084
Urine output decreased 14.60 10.55 4 187727 12599 90428117
Cerumen impaction 14.60 10.55 15 187716 1171 90439545
Skin irritation 14.53 10.55 5 187726 13598 90427118
Edentulous 14.48 10.55 8 187723 240 90440476
Flatulence 14.47 10.55 41 187690 41326 90399390
Granulomatosis with polyangiitis 14.44 10.55 22 187709 2563 90438153
Monoclonal gammopathy 14.43 10.55 13 187718 862 90439854
Bronchopulmonary aspergillosis 14.42 10.55 3 187728 11395 90429321
Gingival swelling 14.40 10.55 32 187699 4981 90435735
Balance disorder 14.40 10.55 130 187601 96950 90343766
Hospitalisation 14.37 10.55 183 187548 127917 90312799
Mood altered 14.16 10.55 9 187722 17135 90423581
Clostridium difficile infection 14.15 10.55 34 187697 36211 90404505
Bone hypertrophy 14.13 10.55 10 187721 467 90440249
Injection site haemorrhage 14.13 10.55 23 187708 28295 90412421
Erythema 14.12 10.55 364 187367 228882 90211834
Palmoplantar pustulosis 14.00 10.55 11 187720 603 90440113
Akathisia 13.99 10.55 3 187728 11156 90429560
Pneumococcal infection 13.99 10.55 15 187716 1230 90439486
Troponin increased 13.99 10.55 5 187726 13276 90427440
Duodenal ulcer perforation 13.98 10.55 576 187155 220712 90220004
Blood glucose increased 13.93 10.55 128 187603 95118 90345598
Surgery 13.92 10.55 47 187684 44840 90395876
Contusion 13.90 10.55 645 187086 250571 90190145
Purulence 13.86 10.55 17 187714 1612 90439104
Nocturnal dyspnoea 13.86 10.55 16 187715 1424 90439292
Pre-eclampsia 13.79 10.55 3 187728 11045 90429671
Blood pressure increased 13.78 10.55 519 187212 196698 90244018
Hallucination, auditory 13.73 10.55 8 187723 15967 90424749
Hyperaesthesia teeth 13.61 10.55 20 187711 2257 90438459
Intraocular pressure test 13.60 10.55 5 187726 55 90440661
Oedema peripheral 13.59 10.55 659 187072 257256 90183460
Hypoaesthesia 13.58 10.55 788 186943 313422 90127294
Lumbar vertebral fracture 13.50 10.55 40 187691 7418 90433298
Caecum operation 13.47 10.55 3 187728 3 90440713
Skeletal injury 13.46 10.55 15 187716 1284 90439432
Haematuria 13.46 10.55 33 187698 34904 90405812
Traumatic ulcer 13.44 10.55 5 187726 57 90440659
Osteomyelitis chronic 13.38 10.55 10 187721 509 90440207
Abortion induced 13.36 10.55 4 187727 11884 90428832
Full blood count abnormal 13.33 10.55 125 187606 36472 90404244
Gangrene 13.30 10.55 5 187726 12871 90427845
Pain in jaw 13.27 10.55 155 187576 47830 90392886
Atopy 13.26 10.55 8 187723 284 90440432
Urine calcium/creatinine ratio increased 13.21 10.55 6 187725 117 90440599
Pulmonary congestion 13.20 10.55 77 187654 19356 90421360
Plasma cell myeloma 13.18 10.55 42 187689 40786 90399930
Medical device removal 13.15 10.55 15 187716 1318 90439398
Muscle strain 13.07 10.55 47 187684 9640 90431076
Osteitis 13.07 10.55 26 187705 3747 90436969
Acidosis 13.07 10.55 5 187726 12731 90427985
Oliguria 13.03 10.55 3 187728 10621 90430095
Inner ear inflammation 13.01 10.55 3 187728 4 90440712
Cerebral haemorrhage 12.99 10.55 33 187698 34489 90406227
Gingival recession 12.95 10.55 17 187714 1726 90438990
Product dose omission in error 12.94 10.55 14 187717 20489 90420227
Bacterial infection 12.88 10.55 88 187643 23356 90417360
Throat tightness 12.87 10.55 26 187705 29458 90411258
Bone pain 12.87 10.55 190 187541 61793 90378923
Nodal osteoarthritis 12.86 10.55 13 187718 995 90439721
Intensive care unit acquired weakness 12.83 10.55 13 187718 998 90439718
Influenza like illness 12.82 10.55 106 187625 80505 90360211
Hyperparathyroidism 12.79 10.55 24 187707 3313 90437403
Injection site induration 12.75 10.55 3 187728 10465 90430251
Pulmonary toxicity 12.74 10.55 4 187727 11527 90429189
Muscle twitching 12.70 10.55 19 187712 24183 90416533
Product administration error 12.69 10.55 22 187709 26401 90414315
Hypotonia 12.56 10.55 4 187727 11422 90429294
Muscle rigidity 12.54 10.55 7 187724 14302 90426414
Pain of skin 12.54 10.55 9 187722 16073 90424643
Salpingo-oophorectomy bilateral 12.52 10.55 9 187722 431 90440285
Haemorrhage intracranial 12.47 10.55 8 187723 15154 90425562
Nightmare 12.46 10.55 16 187715 21709 90419007
Irritable bowel syndrome 12.43 10.55 537 187194 206911 90233805
Exposed bone in jaw 12.42 10.55 22 187709 2904 90437812
Breast cancer metastatic 12.42 10.55 8 187723 15124 90425592
Blood sodium decreased 12.36 10.55 24 187707 27589 90413127
Aplastic anaemia 12.36 10.55 6 187725 13263 90427453
Adverse reaction 12.30 10.55 27 187704 29685 90411031
Peripheral sensorimotor neuropathy 12.28 10.55 18 187713 2027 90438689
Cockroach allergy 12.20 10.55 5 187726 75 90440641
Myoclonus 12.19 10.55 13 187718 19155 90421561
Rectal haemorrhage 12.18 10.55 111 187620 82633 90358083
Schizophrenia 12.09 10.55 8 187723 14906 90425810
Jaw cyst 12.08 10.55 6 187725 144 90440572
Toxic skin eruption 12.07 10.55 9 187722 15765 90424951
Renal cyst 12.04 10.55 56 187675 12894 90427822
Blood calcium decreased 12.03 10.55 28 187703 30154 90410562
Infusion related reaction 12.02 10.55 1011 186720 415769 90024947
Therapeutic response shortened 11.97 10.55 18 187713 22861 90417855
Scapula fracture 11.79 10.55 9 187722 473 90440243
Ilium fracture 11.78 10.55 6 187725 152 90440564
Hypothermia 11.77 10.55 9 187722 15566 90425150
Cardiac failure acute 11.72 10.55 5 187726 11924 90428792
Left ventricular dysfunction 11.71 10.55 8 187723 14661 90426055
Tardive dyskinesia 11.71 10.55 4 187727 10926 90429790
Vascular skin disorder 11.66 10.55 3 187728 8 90440708
Gingivectomy 11.66 10.55 3 187728 8 90440708
Actinomycosis 11.57 10.55 13 187718 1123 90439593
Proteinuria 11.54 10.55 19 187712 23272 90417444
Enterococcus test positive 11.52 10.55 14 187717 1315 90439401
Oral discharge 11.50 10.55 6 187725 160 90440556
Conjunctival oedema 11.47 10.55 12 187719 957 90439759
Intervertebral disc degeneration 11.45 10.55 68 187663 17206 90423510
Necrotising ulcerative gingivostomatitis 11.40 10.55 4 187727 38 90440678
Diabetes mellitus inadequate control 11.40 10.55 72 187659 18612 90422104
Thinking abnormal 11.40 10.55 5 187726 11727 90428989
Deep vein thrombosis 11.38 10.55 128 187603 91492 90349224
Tendinous contracture 11.30 10.55 6 187725 166 90440550
Sweat gland tumour 11.30 10.55 6 187725 166 90440550
Central nervous system lesion 11.26 10.55 5 187726 11641 90429075
Hypoxia 11.15 10.55 96 187635 72303 90368413
Premature labour 11.08 10.55 7 187724 13369 90427347
Dysuria 11.07 10.55 43 187688 39358 90401358
Adrenal suppression 11.06 10.55 12 187719 997 90439719
Bone fissure 11.06 10.55 9 187722 519 90440197
Rubella 11.04 10.55 6 187725 174 90440542
Feeding disorder 11.00 10.55 12 187719 17500 90423216
Hydronephrosis 10.97 10.55 6 187725 12396 90428320
Kyphoscoliosis 10.96 10.55 9 187722 526 90440190
Polychondritis 10.95 10.55 10 187721 675 90440041
Blood thyroid stimulating hormone 10.95 10.55 3 187728 11 90440705
Blood cholinesterase increased 10.88 10.55 4 187727 44 90440672
Infusion site pain 10.85 10.55 15 187716 19723 90420993
Wrist deformity 10.84 10.55 22 187709 3216 90437500
Renal disorder 10.84 10.55 41 187690 37818 90402898
COVID-19 pneumonia 10.83 10.55 13 187718 18164 90422552
Small intestinal obstruction 10.83 10.55 17 187714 21217 90419499
Iron deficiency anaemia 10.81 10.55 85 187646 23577 90417139
Blood glucose decreased 10.80 10.55 20 187711 23409 90417307
Second primary malignancy 10.77 10.55 4 187727 10374 90430342
Dermatitis allergic 10.75 10.55 12 187719 17315 90423401
Blood magnesium decreased 10.72 10.55 10 187721 15683 90425033
Face oedema 10.67 10.55 20 187711 23298 90417418
Accidental overdose 10.66 10.55 27 187704 28246 90412470
Carbuncle 10.66 10.55 14 187717 1422 90439294
Blood bilirubin increased 10.64 10.55 50 187681 43420 90397296
Hyperbilirubinaemia 10.60 10.55 8 187723 13928 90426788
Dental plaque 10.58 10.55 5 187726 107 90440609
Intervertebral disc disorder 10.58 10.55 30 187701 5430 90435286
Knee arthroplasty 10.55 10.55 236 187495 82946 90357770

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood pressure systolic increased 139.78 13.32 110 19371 27858 42573996
Rheumatoid arthritis 102.24 13.32 111 19370 42329 42559525
Atypical femur fracture 81.12 13.32 21 19460 337 42601517
Heart rate decreased 78.44 13.32 90 19391 36442 42565412
Blood pressure increased 75.81 13.32 153 19328 101775 42500079
Sleep disorder due to general medical condition, insomnia type 73.43 13.32 27 19454 1442 42600412
Body temperature decreased 68.36 13.32 55 19426 14358 42587496
Pemphigus 65.27 13.32 27 19454 1979 42599875
Blood pressure systolic abnormal 54.35 13.32 33 19448 5495 42596359
Toxicity to various agents 50.17 13.32 21 19460 229115 42372739
Infusion related reaction 49.67 13.32 95 19386 60711 42541143
Mobility decreased 48.93 13.32 70 19411 35236 42566618
Arthralgia 47.82 13.32 203 19278 205035 42396819
Blood pressure diastolic abnormal 46.35 13.32 31 19450 6097 42595757
Drug interaction 46.08 13.32 33 19448 266966 42334888
Cystitis escherichia 46.04 13.32 12 19469 198 42601656
Lacrimal disorder 44.94 13.32 13 19468 321 42601533
Blood pressure fluctuation 42.76 13.32 57 19424 26851 42575003
Oxygen saturation decreased 42.10 13.32 92 19389 64595 42537259
Joint injury 41.78 13.32 42 19439 14634 42587220
Nerve degeneration 41.52 13.32 11 19470 194 42601660
Femur fracture 41.42 13.32 35 19446 9777 42592077
Impaired work ability 40.82 13.32 38 19443 12053 42589801
Bone density decreased 40.77 13.32 20 19461 2186 42599668
Osteoporosis 39.43 13.32 41 19440 14865 42586989
Pain 37.57 13.32 215 19266 244633 42357221
Death 37.47 13.32 102 19379 471083 42130771
Embolic stroke 36.93 13.32 25 19456 5015 42596839
Bronchial obstruction 35.96 13.32 17 19464 1712 42600142
Blood pressure diastolic decreased 35.78 13.32 33 19448 10342 42591512
Vein disorder 35.72 13.32 18 19463 2084 42599770
Breath sounds abnormal 35.15 13.32 35 19446 12058 42589796
Preterm premature rupture of membranes 34.21 13.32 8 19473 82 42601772
Musculoskeletal stiffness 34.06 13.32 79 19402 57686 42544168
Hernia pain 33.13 13.32 10 19471 287 42601567
Wound 33.12 13.32 40 19441 17077 42584777
Renal neoplasm 32.21 13.32 15 19466 1460 42600394
Hernia 32.09 13.32 32 19449 11041 42590813
Localised infection 30.61 13.32 42 19439 20331 42581523
Completed suicide 30.53 13.32 4 19477 96461 42505393
Osteonecrosis of jaw 29.72 13.32 40 19441 19009 42582845
Thrombocytopenia 29.67 13.32 26 19455 190253 42411601
Cataract 29.00 13.32 51 19430 30553 42571301
Oesophageal rupture 28.96 13.32 10 19471 444 42601410
Pulmonary function test decreased 27.44 13.32 22 19459 5710 42596144
Blood pressure diastolic increased 27.35 13.32 23 19458 6382 42595472
Acute kidney injury 27.33 13.32 82 19399 367255 42234599
Gynaecomastia 27.02 13.32 31 19450 12536 42589318
Nasopharyngitis 26.87 13.32 92 19389 83904 42517950
Osteomyelitis 26.52 13.32 37 19444 18186 42583668
Tibia fracture 26.30 13.32 14 19467 1814 42600040
Weight increased 26.02 13.32 108 19373 107875 42493979
Febrile neutropenia 25.91 13.32 28 19453 185675 42416179
Pyelonephritis acute 24.77 13.32 15 19466 2485 42599369
Nocturia 24.58 13.32 29 19452 12083 42589771
Heart rate increased 24.22 13.32 66 19415 53189 42548665
Scleritis 23.63 13.32 10 19471 776 42601078
Fall 22.76 13.32 184 19297 234336 42367518
Fracture displacement 22.15 13.32 7 19474 235 42601619
Post infection glomerulonephritis 22.13 13.32 6 19475 116 42601738
Ureteric stenosis 22.08 13.32 11 19470 1243 42600611
Foot fracture 21.95 13.32 20 19461 6171 42595683
Respiratory rate increased 21.64 13.32 26 19455 11036 42590818
Joint swelling 21.31 13.32 74 19407 67948 42533906
Osteonecrosis 21.30 13.32 31 19450 15834 42586020
Stress fracture 21.18 13.32 10 19471 1004 42600850
Pulmonary fibrosis 20.93 13.32 41 19440 26640 42575214
Lung neoplasm malignant 20.91 13.32 34 19447 19113 42582741
Middle ear effusion 20.35 13.32 9 19472 777 42601077
Hand fracture 20.31 13.32 14 19467 2892 42598962
Interstitial lung disease 20.10 13.32 80 19401 78382 42523472
Arthritis 20.00 13.32 53 19428 42012 42559842
Fibula fracture 19.94 13.32 10 19471 1146 42600708
Abdominal rigidity 19.78 13.32 11 19470 1554 42600300
Balance disorder 19.65 13.32 57 19424 47588 42554266
Lower respiratory tract congestion 19.55 13.32 11 19470 1589 42600265
Cardiac arrest 19.50 13.32 13 19468 109307 42492547
Arterial occlusive disease 19.03 13.32 16 19465 4437 42597417
Rheumatoid lung 18.96 13.32 9 19472 915 42600939
Panniculitis 18.86 13.32 12 19469 2169 42599685
Injection site haemorrhage 18.85 13.32 25 19456 11711 42590143
Disease progression 18.58 13.32 23 19458 143633 42458221
Infection 18.18 13.32 100 19381 111968 42489886
Arthritis infective 18.06 13.32 15 19466 4091 42597763
Nasal neoplasm 17.96 13.32 5 19476 107 42601747
Anaemia 17.78 13.32 67 19414 280211 42321643
Hyperintensity in brain deep nuclei 17.70 13.32 5 19476 113 42601741
Autism spectrum disorder 17.66 13.32 13 19468 2975 42598879
Wheezing 17.51 13.32 60 19421 54721 42547133
Renal mass 17.27 13.32 11 19470 1991 42599863
Nasal disorder 17.24 13.32 11 19470 1998 42599856
Intestinal prolapse 17.22 13.32 5 19476 125 42601729
Lymphocele 17.20 13.32 10 19471 1537 42600317
Asthma 17.15 13.32 65 19416 62249 42539605
Phlebosclerosis 17.11 13.32 5 19476 128 42601726
Distal intestinal obstruction syndrome 17.09 13.32 7 19474 500 42601354
Impaired healing 16.91 13.32 29 19452 17024 42584830
Product dose omission issue 16.73 13.32 28 19453 154337 42447517
Lower respiratory tract infection 16.71 13.32 49 19432 41157 42560697
Multifocal motor neuropathy 16.65 13.32 5 19476 141 42601713
Sensory disturbance 16.25 13.32 18 19463 7005 42594849
Therapy partial responder 15.99 13.32 31 19450 19990 42581864
Bronchomalacia 15.96 13.32 5 19476 163 42601691
Seizure 15.91 13.32 19 19462 120542 42481312
Arthropathy 15.84 13.32 39 19442 29558 42572296
Gastrointestinal disorder 15.70 13.32 52 19429 46601 42555253
Extraskeletal ossification 15.58 13.32 4 19477 62 42601792
Atypical fracture 15.56 13.32 5 19476 177 42601677
Stress 15.53 13.32 50 19431 44162 42557692
Epididymitis 15.29 13.32 12 19469 3022 42598832
Cough 15.28 13.32 136 19345 177967 42423887
Deafness 15.26 13.32 24 19457 13116 42588738
Diverticulum 15.21 13.32 18 19463 7523 42594331
Joint effusion 15.20 13.32 16 19465 5881 42595973
Elbow deformity 15.00 13.32 5 19476 199 42601655
Musculoskeletal discomfort 14.94 13.32 20 19461 9456 42592398
Fracture nonunion 14.93 13.32 5 19476 202 42601652
Rales 14.91 13.32 22 19459 11378 42590476
Granulomatosis with polyangiitis 14.90 13.32 9 19472 1483 42600371
Red blood cell sedimentation rate 14.78 13.32 8 19473 1072 42600782
Ulna fracture 14.74 13.32 6 19475 422 42601432
Herpes zoster 14.60 13.32 45 19436 38832 42563022
Noninfective encephalitis 14.57 13.32 5 19476 218 42601636
Central nervous system inflammation 14.44 13.32 5 19476 224 42601630
Hypoxia 14.30 13.32 7 19474 69779 42532075
Purpura 14.22 13.32 22 19459 11857 42589997
Granuloma 14.22 13.32 13 19468 4028 42597826
Fracture 14.17 13.32 18 19463 8085 42593769
Granuloma skin 14.15 13.32 8 19473 1167 42600687
Gastrooesophageal reflux disease 14.11 13.32 49 19432 44974 42556880
Oesophageal dilatation 13.91 13.32 5 19476 250 42601604
Spinal fracture 13.88 13.32 19 19462 9171 42592683
Low turnover osteopathy 13.78 13.32 4 19477 100 42601754
Hyperkalaemia 13.77 13.32 10 19471 80448 42521406
Immunoglobulin G4 related disease 13.74 13.32 5 19476 259 42601595
Product substitution issue 13.64 13.32 21 19460 11269 42590585
Genital lesion 13.61 13.32 5 19476 266 42601588
Mononeuropathy multiplex 13.60 13.32 6 19475 515 42601339
Skin cancer 13.40 13.32 21 19460 11441 42590413

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Oedema 715.77 11.44 1259 180910 208717 110198413
Rheumatoid arthritis 706.69 11.44 1538 180631 298075 110109055
Asthma 636.44 11.44 1325 180844 248966 110158164
Wheezing 633.69 11.44 1338 180831 253892 110153238
Atypical femur fracture 617.25 11.44 268 181901 5951 110401179
Toxicity to various agents 490.19 11.44 98 182071 480457 109926673
Femur fracture 475.47 11.44 469 181700 44000 110363130
Drug hypersensitivity 473.75 11.44 1733 180436 452357 109954773
Death 451.13 11.44 299 181870 698570 109708560
Mobility decreased 384.23 11.44 1055 181114 236367 110170763
Acute kidney injury 373.36 11.44 300 181869 635130 109772000
Pulmonary fibrosis 353.97 11.44 617 181552 101425 110305705
Stress fracture 351.23 11.44 191 181978 7030 110400100
Completed suicide 345.62 11.44 12 182157 242369 110164761
Drug interaction 323.81 11.44 213 181956 499970 109907160
Nasal oedema 316.37 11.44 175 181994 6664 110400466
Osteoarthritis 310.91 11.44 827 181342 181796 110225334
Rheumatoid factor positive 305.50 11.44 672 181497 130968 110276162
Neutropenia 296.39 11.44 123 182046 374497 110032633
Arthropathy 294.88 11.44 1092 181077 286430 110120700
Fracture displacement 281.85 11.44 102 182067 1370 110405760
Osteonecrosis of jaw 278.64 11.44 369 181800 47648 110359482
Low turnover osteopathy 278.06 11.44 110 182059 1912 110405218
Febrile neutropenia 267.19 11.44 94 182075 316673 110090457
Synovitis 261.22 11.44 1017 181152 273075 110134055
Lower limb fracture 257.90 11.44 453 181716 74895 110332235
Drug abuse 248.71 11.44 10 182159 177401 110229729
Disease progression 246.03 11.44 51 182118 243983 110163147
Blood pressure systolic increased 226.70 11.44 453 181716 82538 110324592
Cardiac arrest 211.43 11.44 35 182134 196718 110210412
Musculoskeletal stiffness 208.90 11.44 964 181205 278858 110128272
Sepsis 206.85 11.44 143 182026 327203 110079927
Anti-cyclic citrullinated peptide antibody positive 198.98 11.44 706 181463 181278 110225852
Arthralgia 198.85 11.44 2059 180110 777573 109629557
Swollen joint count increased 198.48 11.44 431 181738 83230 110323900
Type 2 diabetes mellitus 197.59 11.44 692 181477 176540 110230590
Foot deformity 191.82 11.44 311 181858 48169 110358961
Intentional overdose 190.82 11.44 6 182163 132495 110274635
Fibromyalgia 190.26 11.44 667 181502 170242 110236888
Anaemia 181.92 11.44 394 181775 546692 109860438
Deep vein thrombosis postoperative 180.69 11.44 339 181830 58952 110348178
Osteoporosis 180.04 11.44 425 181744 86727 110320403
Thrombocytopenia 179.29 11.44 186 181983 348699 110058431
Liver injury 178.77 11.44 600 181569 149813 110257317
Joint swelling 177.46 11.44 1293 180876 441552 109965578
Contraindicated product administered 176.26 11.44 843 181326 247424 110159706
Pathological fracture 173.46 11.44 150 182019 11882 110395248
Joint range of motion decreased 173.20 11.44 517 181652 121315 110285815
Gastrooesophageal reflux disease 172.31 11.44 669 181500 179307 110227823
Malignant neoplasm progression 170.81 11.44 39 182130 174528 110232602
Psoriatic arthropathy 170.50 11.44 709 181460 196052 110211078
Pemphigus 159.91 11.44 739 181430 213831 110193299
Somnolence 159.21 11.44 153 182016 297296 110109834
Rheumatoid nodule 158.20 11.44 181 181988 20115 110387015
Foot fracture 157.02 11.44 202 181967 25344 110381786
Nodule 149.54 11.44 224 181945 32407 110374723
Blood cholesterol increased 148.61 11.44 651 181518 184134 110222996
Product dose omission issue 148.55 11.44 187 181982 321595 110085535
Autoimmune disorder 148.13 11.44 331 181838 65152 110341978
Rheumatic fever 146.55 11.44 490 181679 122089 110285041
Respiratory tract infection 145.49 11.44 347 181822 71270 110335860
Seizure 144.56 11.44 93 182076 221092 110186038
Jaw disorder 144.38 11.44 96 182073 5116 110402014
Overdose 140.02 11.44 108 182061 233686 110173444
Sciatica 138.87 11.44 400 181769 91999 110315131
Lip dry 137.80 11.44 420 181749 99663 110307467
Adjustment disorder with depressed mood 137.58 11.44 254 181915 43629 110363501
Impaired healing 137.44 11.44 665 181504 196052 110211078
Respiratory failure 137.40 11.44 93 182076 215239 110191891
COVID-19 137.11 11.44 121 182048 244939 110162191
Fracture nonunion 135.75 11.44 61 182108 1473 110405657
C-reactive protein abnormal 133.95 11.44 494 181675 129201 110277929
Bone disorder 132.50 11.44 169 182000 21023 110386107
Wound infection 132.05 11.44 404 181765 96061 110311069
Bursitis 130.96 11.44 491 181678 129427 110277703
Drug intolerance 128.87 11.44 1125 181044 405387 110001743
Peripheral venous disease 128.21 11.44 366 181803 83751 110323379
Myelosuppression 126.76 11.44 7 182162 94333 110312797
Dehydration 125.32 11.44 166 182003 279345 110127785
Red blood cell sedimentation rate abnormal 125.03 11.44 177 181992 24332 110382798
Drug tolerance 124.38 11.44 145 182024 16440 110390690
Atypical fracture 123.22 11.44 51 182118 1001 110406129
Injection site pain 117.36 11.44 74 182095 177848 110229282
Osteomyelitis 116.19 11.44 213 181956 36387 110370743
Platelet count decreased 115.93 11.44 125 182044 230318 110176812
Night sweats 114.61 11.44 481 181688 133502 110273628
Pancytopenia 114.27 11.44 106 182063 209507 110197623
Blood parathyroid hormone decreased 112.77 11.44 123 182046 12966 110394164
Prescribed overdose 112.68 11.44 359 181810 87222 110319908
Infusion related reaction 112.66 11.44 1039 181130 380123 110027007
Joint destruction 112.47 11.44 113 182056 10830 110396300
Breast cancer stage III 110.77 11.44 334 181835 78783 110328347
Osteonecrosis 110.46 11.44 199 181970 33542 110373588
Multiple organ dysfunction syndrome 110.25 11.44 56 182113 151654 110255476
Dislocation of vertebra 109.15 11.44 230 181939 43491 110363639
C-reactive protein 108.50 11.44 186 181983 30145 110376985
Blood pressure diastolic abnormal 108.14 11.44 170 181999 25645 110381485
Treatment failure 107.20 11.44 803 181366 276431 110130699
Obesity 106.53 11.44 419 181750 112932 110294198
Suicide attempt 103.35 11.44 22 182147 103372 110303758
Systemic lupus erythematosus rash 102.23 11.44 55 182114 1980 110405150
Pain 102.15 11.44 2170 179999 952785 109454345
Hyperkalaemia 101.90 11.44 48 182121 135748 110271382
Osteopenia 101.11 11.44 152 182017 22057 110385073
Renal failure 101.10 11.44 135 182034 226439 110180691
Ankle arthroplasty 101.09 11.44 59 182110 2492 110404638
Lactic acidosis 100.82 11.44 16 182153 92795 110314335
Blood pressure diastolic decreased 100.51 11.44 198 181971 35687 110371443
Blood pressure systolic abnormal 100.45 11.44 161 182008 24689 110382441
Inflammation 100.14 11.44 602 181567 192636 110214494
Drug tolerance decreased 99.99 11.44 170 181999 27370 110379760
Infection 99.41 11.44 972 181197 361228 110045902
Lower respiratory tract infection 98.46 11.44 712 181457 242394 110164736
Cytokine release syndrome 98.38 11.44 4 182165 70302 110336828
Loss of personal independence in daily activities 98.25 11.44 498 181671 149522 110257608
White blood cell count decreased 97.04 11.44 142 182027 229248 110177882
Hand deformity 96.73 11.44 654 181515 217852 110189278
Fracture delayed union 95.48 11.44 54 182115 2147 110404983
Panniculitis 95.43 11.44 123 182046 15459 110391671
Discomfort 95.27 11.44 643 181526 214064 110193066
Tachycardia 94.22 11.44 142 182027 226503 110180627
Hypotension 93.75 11.44 494 181675 523355 109883775
Ulcer haemorrhage 93.67 11.44 148 182021 22423 110384707
Presbyacusis 93.10 11.44 58 182111 2761 110404369
Dry mouth 93.06 11.44 606 181563 199342 110207788
Pericarditis 92.95 11.44 649 181520 218465 110188665
Granuloma skin 91.98 11.44 103 182066 11180 110395950
Coma 91.03 11.44 40 182129 117829 110289301
Musculoskeletal pain 90.30 11.44 563 181606 182460 110224670
Tooth disorder 90.24 11.44 169 182000 29340 110377790
Therapeutic product effect decreased 89.60 11.44 699 181470 243617 110163513
Lung disorder 89.55 11.44 555 181614 179492 110227638
Neutrophil count decreased 88.84 11.44 44 182125 120897 110286233
Bradycardia 87.92 11.44 76 182093 155441 110251689
Cardiac failure 87.63 11.44 108 182061 187518 110219612
Prescribed underdose 87.36 11.44 271 181898 64903 110342227
Injury 87.27 11.44 545 181624 176720 110230410
Depressed level of consciousness 86.88 11.44 38 182131 112240 110294890
Road traffic accident 86.78 11.44 379 181790 107019 110300111
Wound 86.11 11.44 671 181498 233766 110173364
Red blood cell sedimentation rate increased 85.70 11.44 304 181865 77998 110329132
Constipation 85.00 11.44 303 181866 357483 110049647
Eosinophilic bronchitis 84.52 11.44 33 182136 553 110406577
Bone sequestrum 84.24 11.44 41 182128 1192 110405938
Syncope 84.08 11.44 127 182042 202409 110204721
Pleural fibrosis 83.86 11.44 64 182105 4244 110402886
Bedridden 83.83 11.44 107 182062 13318 110393812
Liver disorder 83.41 11.44 458 181711 141785 110265345
Intentional product misuse 82.64 11.44 59 182110 132845 110274285
Polyarthritis 82.39 11.44 127 182042 18836 110388294
Mucosal inflammation 81.90 11.44 28 182141 96113 110311017
Anaphylactic reaction 81.84 11.44 43 182126 114257 110292873
Duodenal ulcer perforation 81.73 11.44 537 181632 177163 110229967
Glossodynia 81.30 11.44 635 181534 221369 110185761
Sedation 80.41 11.44 10 182159 69673 110337457
Foot operation 79.76 11.44 78 182091 7235 110399895
Taste disorder 79.56 11.44 263 181906 65124 110342006
Muscle injury 78.99 11.44 448 181721 140359 110266771
Blepharospasm 77.19 11.44 232 181937 54619 110352511
Abdominal pain upper 77.13 11.44 897 181272 348214 110058916
Ill-defined disorder 77.05 11.44 482 181687 156371 110250759
Drug reaction with eosinophilia and systemic symptoms 77.04 11.44 20 182149 82075 110325055
Electrocardiogram QT prolonged 76.54 11.44 42 182127 108918 110298212
Off label use 76.47 11.44 1886 180283 1498299 108908831
Suicidal ideation 75.57 11.44 30 182139 93907 110313223
Osteogenesis imperfecta 75.04 11.44 33 182136 756 110406374
Drug ineffective for unapproved indication 74.65 11.44 38 182131 102800 110304330
Adverse event 73.92 11.44 365 181804 108444 110298686
Agitation 73.20 11.44 48 182121 113003 110294127
Injection site erythema 72.66 11.44 32 182137 94144 110312986
Gait inability 72.65 11.44 428 181741 135948 110271182
Swelling 72.30 11.44 890 181279 350151 110056979
Live birth 71.99 11.44 265 181904 69219 110337911
Irritable bowel syndrome 71.75 11.44 490 181679 163725 110243405
Systemic lupus erythematosus 70.93 11.44 685 181484 253653 110153477
Malaise 70.81 11.44 1524 180645 670295 109736835
Pulmonary embolism 70.70 11.44 155 182014 214319 110192811
Arthritis 70.24 11.44 495 181674 167091 110240039
Wrong technique in product usage process 70.09 11.44 28 182141 87320 110319810
Chest pain 69.82 11.44 936 181233 375439 110031691
Blood pressure fluctuation 69.82 11.44 276 181893 74548 110332582
Pelvic fracture 68.94 11.44 100 182069 14054 110393076
Drug resistance 67.79 11.44 7 182162 56367 110350763
Acute respiratory failure 67.52 11.44 20 182149 75240 110331890
Dysarthria 67.44 11.44 27 182142 84094 110323036
Pleural thickening 67.28 11.44 51 182118 3348 110403782
Salpingo-oophorectomy unilateral 67.09 11.44 31 182138 800 110406330
Serotonin syndrome 67.02 11.44 9 182160 59144 110347986
Contusion 66.80 11.44 632 181537 232729 110174401
Blister 66.69 11.44 619 181550 226757 110180373
Pain in extremity 66.63 11.44 1150 181019 485968 109921162
Pyrexia 66.60 11.44 1060 181109 897205 109509925
Accidental exposure to product 66.29 11.44 4 182165 50004 110357126
Neoplasm progression 66.10 11.44 13 182156 64582 110342548
Breast cancer stage II 66.01 11.44 142 182027 27233 110379897
Hallucination 65.76 11.44 43 182126 101389 110305741
Skin exfoliation 65.73 11.44 31 182138 87620 110319510
Alanine aminotransferase abnormal 65.68 11.44 79 182090 9255 110397875
Abdominal discomfort 65.60 11.44 961 181208 392897 110014233
Total lung capacity decreased 65.06 11.44 69 182100 7045 110400085
Adverse drug reaction 64.66 11.44 344 181825 105215 110301915
Hepatic enzyme increased 63.68 11.44 808 181361 320084 110087046
Amnesia 62.86 11.44 341 181828 105067 110302063
Dry skin 62.82 11.44 51 182118 107602 110299528
Osteosclerosis 62.49 11.44 55 182114 4460 110402670
Metabolic acidosis 62.37 11.44 44 182125 99700 110307430
Skin necrosis 61.83 11.44 120 182049 21392 110385738
Hypocholesterolaemia 61.80 11.44 64 182105 6357 110400773
Sleep disorder 61.41 11.44 547 181622 198097 110209033
Peripheral swelling 60.81 11.44 969 181200 403065 110004065
Helicobacter infection 60.49 11.44 509 181660 181368 110225762
Dental caries 60.41 11.44 89 182080 12684 110394446
Hypertension 59.91 11.44 1176 180993 508908 109898222
Anaemia postoperative 59.62 11.44 38 182131 1883 110405247
Cardio-respiratory arrest 59.16 11.44 62 182107 115774 110291356
Folliculitis 58.33 11.44 474 181695 167179 110239951
Obstructive airways disorder 58.28 11.44 188 181981 45961 110361169
Periodontal disease 57.84 11.44 38 182131 1984 110405146
Blood magnesium increased 57.83 11.44 49 182120 3774 110403356
Cytomegalovirus infection 57.76 11.44 10 182159 54434 110352696
Therapy non-responder 57.60 11.44 450 181719 156857 110250273
Hyponatraemia 57.39 11.44 176 181993 217477 110189653
X-ray abnormal 57.24 11.44 165 182004 37952 110369178
Neuropathy peripheral 57.10 11.44 132 182037 179145 110227985
Cardiac failure congestive 56.77 11.44 101 182068 150899 110256231
Product quality issue 55.88 11.44 264 181905 77035 110330095
Therapy cessation 55.44 11.44 5 182164 44852 110362278
Aggression 54.47 11.44 15 182154 59195 110347935
Encephalopathy 54.42 11.44 33 182136 81022 110326108
Colitis 54.27 11.44 53 182116 102270 110304860
Gastrointestinal haemorrhage 54.23 11.44 120 182049 165398 110241732
Lupus vulgaris 54.13 11.44 150 182019 33733 110373397
Hyperhidrosis 54.12 11.44 145 182024 187153 110219977
Bronchopulmonary aspergillosis allergic 53.95 11.44 68 182101 8358 110398772
Red blood cell sedimentation rate 53.88 11.44 54 182115 5160 110401970
Angioedema 53.43 11.44 50 182119 98450 110308680
Migraine 53.22 11.44 473 181696 171179 110235951
Basal cell carcinoma 53.22 11.44 180 181989 45090 110362040
Respiratory arrest 53.20 11.44 15 182154 58284 110348846
Therapy interrupted 53.19 11.44 9 182160 49813 110357317
Peri-implantitis 53.07 11.44 18 182151 197 110406933
Hip arthroplasty 52.98 11.44 207 181962 55606 110351524
Haematuria 52.72 11.44 36 182133 82969 110324161
Hypervolaemia 52.66 11.44 9 182160 49451 110357679
Ulna fracture 52.25 11.44 30 182139 1228 110405902
Sinusitis fungal 52.05 11.44 40 182129 2680 110404450
Feeling abnormal 51.38 11.44 141 182028 180570 110226560
Wheelchair user 51.34 11.44 64 182105 7778 110399352
Nerve injury 51.18 11.44 75 182094 10638 110396492
Bone density decreased 50.46 11.44 93 182076 15949 110391181
Walking aid user 50.37 11.44 121 182048 24954 110382176
Ulcer 50.30 11.44 171 181998 42945 110364185
Cardiogenic shock 50.06 11.44 16 182153 57322 110349808
Pruritus 49.74 11.44 667 181502 580893 109826237
Mental status changes 49.71 11.44 32 182137 76090 110331040
Intentional self-injury 49.60 11.44 3 182166 37426 110369704
Palmar-plantar erythrodysaesthesia syndrome 49.57 11.44 5 182164 41020 110366110
Coagulopathy 49.40 11.44 5 182164 40906 110366224
Injection site pruritus 49.04 11.44 12 182157 51246 110355884
Nasopharyngitis 48.93 11.44 917 181252 393444 110013686
Pancreatitis acute 48.89 11.44 19 182150 60255 110346875
Diverticulum 48.82 11.44 90 182079 15436 110391694
Intentional product use issue 48.64 11.44 623 181546 247283 110159847
Comminuted fracture 48.48 11.44 23 182146 631 110406499
Facet joint syndrome 48.44 11.44 299 181870 96529 110310601
Vomiting 48.37 11.44 1895 180274 908780 109498350
Hypoaesthesia 48.16 11.44 756 181413 313467 110093663
Ascites 48.16 11.44 49 182120 92759 110314371
Fear of injection 47.90 11.44 66 182103 8845 110398285
Leukopenia 47.83 11.44 109 182060 148682 110258448
Cerebrovascular accident 47.50 11.44 147 182022 181137 110225993
Exostosis 47.38 11.44 175 181994 45781 110361349
Rales 47.17 11.44 117 182052 24622 110382508
Weight increased 47.07 11.44 961 181208 418683 109988447
Haemoglobin decreased 47.01 11.44 230 181939 248497 110158633
Heart rate decreased 46.85 11.44 264 181905 82492 110324638
Lethargy 46.76 11.44 51 182118 93525 110313605
Resorption bone increased 46.76 11.44 30 182139 1504 110405626
Abnormal behaviour 46.55 11.44 5 182164 39034 110368096
Bone erosion 46.49 11.44 175 181994 46196 110360934
Osteonecrosis of external auditory canal 46.14 11.44 17 182152 241 110406889
Rash maculo-papular 46.07 11.44 33 182136 74189 110332941
Breath sounds abnormal 45.16 11.44 117 182052 25287 110381843
Tooth infection 44.41 11.44 107 182062 22109 110385021
Immunodeficiency 44.40 11.44 153 182016 38685 110368445
Muscle fatigue 44.19 11.44 43 182126 3964 110403166
Bone marrow failure 44.08 11.44 20 182149 57828 110349302
Acute myocardial infarction 43.73 11.44 44 182125 83733 110323397
Product prescribing error 43.63 11.44 15 182154 51316 110355814
Ventricular tachycardia 43.58 11.44 14 182155 49995 110357135
Periodontitis 43.23 11.44 48 182121 5160 110401970
Pulmonary oedema 42.85 11.44 62 182107 100597 110306533
Atrial fibrillation 42.45 11.44 214 181955 229428 110177702
Tachypnoea 42.32 11.44 7 182162 39388 110367742
Altered state of consciousness 42.26 11.44 21 182148 57605 110349525
Bone cyst 42.26 11.44 40 182129 3563 110403567
Gingival ulceration 41.99 11.44 26 182143 1224 110405906
Psychotic disorder 41.41 11.44 16 182153 50921 110356209
Knee arthroplasty 41.38 11.44 214 181955 64734 110342396
Deafness neurosensory 41.20 11.44 64 182105 9555 110397575
Hypoxia 40.72 11.44 96 182073 129419 110277711
Disturbance in attention 40.57 11.44 26 182143 61969 110345161
Dyskinesia 40.45 11.44 17 182152 51429 110355701
Hypersensitivity 40.41 11.44 910 181259 403088 110004042
Inappropriate schedule of product administration 40.41 11.44 185 181984 203452 110203678
Sopor 40.37 11.44 6 182163 36540 110370590
Blood pressure inadequately controlled 40.23 11.44 56 182113 7577 110399553
Withdrawal syndrome 40.16 11.44 3 182166 31377 110375753
Hepatic enzyme 40.16 11.44 46 182123 5117 110402013
Sputum discoloured 40.07 11.44 119 182050 27826 110379304
Generalised tonic-clonic seizure 39.99 11.44 20 182149 54660 110352470
Loose tooth 39.85 11.44 37 182132 3216 110403914
Exostosis of jaw 39.75 11.44 25 182144 1210 110405920
Hepatic failure 39.56 11.44 33 182136 68706 110338424
Vision blurred 39.48 11.44 97 182072 128925 110278205
Limb discomfort 39.16 11.44 152 182017 40702 110366428
Blood pressure diastolic increased 39.13 11.44 92 182077 18715 110388415
Hypoglycaemia 39 11.44 83 182086 116021 110291109
Unresponsive to stimuli 38.76 11.44 29 182140 63761 110343369
Renal impairment 38.72 11.44 169 182000 188276 110218854
Haemorrhage 38.64 11.44 73 182096 106619 110300511
Injection site bruising 38.63 11.44 18 182151 51245 110355885
Oral cavity fistula 38.57 11.44 20 182149 667 110406463
Lung opacity 38.49 11.44 69 182100 11583 110395547
Gait disturbance 38.41 11.44 658 181511 277550 110129580
International normalised ratio increased 38.38 11.44 52 182117 86720 110320410
Dental fistula 38.34 11.44 19 182150 575 110406555
Bronchopulmonary aspergillosis 37.81 11.44 3 182166 29860 110377270
Nail disorder 37.68 11.44 192 181977 57743 110349387
Flushing 37.64 11.44 72 182097 104664 110302466
Irritability 37.27 11.44 16 182153 47793 110359337
Thrombosis 37.07 11.44 77 182092 108585 110298545
Therapeutic response decreased 36.96 11.44 279 181890 96220 110310910
Labelled drug-drug interaction medication error 36.94 11.44 3 182166 29299 110377831
Sleep disorder due to general medical condition, insomnia type 36.90 11.44 299 181870 105344 110301786
Adrenal insufficiency 36.86 11.44 153 182016 42237 110364893
Haematochezia 36.82 11.44 85 182084 115439 110291691
Bacteraemia 36.70 11.44 12 182157 42378 110364752
Tubulointerstitial nephritis 36.58 11.44 22 182147 54262 110352868
Blood pressure increased 36.36 11.44 613 181556 257760 110149370
Extrapyramidal disorder 36.27 11.44 3 182166 28864 110378266
Gastrointestinal disorder 36.25 11.44 580 181589 241372 110165758
Vitamin B12 decreased 36.19 11.44 44 182125 5213 110401917
Respiratory distress 36.15 11.44 36 182133 68838 110338292
Epistaxis 36.11 11.44 103 182066 130269 110276861
Bone density abnormal 35.95 11.44 38 182131 3865 110403265
Nausea 35.75 11.44 1668 180501 1234022 109173108
Septic shock 35.67 11.44 136 182033 157392 110249738
Deep vein thrombosis 35.54 11.44 115 182054 139772 110267358
Exercise tolerance decreased 35.52 11.44 68 182101 11999 110395131
Fistula discharge 35.49 11.44 26 182143 1620 110405510
Grip strength decreased 35.46 11.44 240 181929 79934 110327196
Status epilepticus 35.30 11.44 5 182164 31566 110375564
Bunion operation 35.26 11.44 21 182148 921 110406209
Acute respiratory distress syndrome 35.24 11.44 22 182147 53176 110353954
Hepatic cytolysis 34.79 11.44 24 182145 55029 110352101
Memory impairment 34.52 11.44 485 181684 196459 110210671
Posterior reversible encephalopathy syndrome 34.26 11.44 7 182162 33854 110373276
Alopecia 34.12 11.44 814 181355 363939 110043191
Thrombotic microangiopathy 34.08 11.44 4 182165 29145 110377985
Lymphopenia 33.69 11.44 12 182157 40158 110366972
Limb asymmetry 33.66 11.44 18 182151 640 110406490
C-reactive protein increased 33.63 11.44 525 181644 217394 110189736
Anti-cyclic citrullinated peptide antibody 33.50 11.44 90 182079 19874 110387256
Bone formation decreased 33.41 11.44 11 182158 109 110407021
Jaw fracture 33.19 11.44 33 182136 3123 110404007
Epigastric discomfort 33.19 11.44 56 182113 8959 110398171
Fracture 33.14 11.44 103 182066 24685 110382445
Myocarditis 33.05 11.44 5 182164 30050 110377080
Impaired quality of life 32.99 11.44 5 182164 30012 110377118
Sinus tachycardia 32.95 11.44 16 182153 44477 110362653
Injection site swelling 32.77 11.44 32 182137 61758 110345372
General physical health deterioration 32.77 11.44 925 181244 424370 109982760
Hypercalcaemia 32.74 11.44 158 182011 46499 110360631
Rhabdomyolysis 32.70 11.44 96 182073 120305 110286825
Pneumonia aspiration 32.68 11.44 52 182117 81181 110325949
Gingivitis 32.63 11.44 60 182109 10271 110396859
Brain oedema 32.37 11.44 6 182163 31092 110376038
Gingival disorder 32.30 11.44 37 182132 4116 110403014
Blood calcium increased 31.98 11.44 83 182086 17957 110389173
Tendonitis 31.80 11.44 105 182064 25978 110381152
Tremor 31.65 11.44 199 181970 202033 110205097
Urinary retention 31.59 11.44 41 182128 69642 110337488
Chronic kidney disease 31.49 11.44 48 182121 76243 110330887
Pallor 31.41 11.44 28 182141 56439 110350691
Tooth fracture 31.40 11.44 68 182101 13099 110394031
Hunger 31.21 11.44 46 182123 6558 110400572
Body temperature decreased 31.09 11.44 132 182037 36803 110370327
Acute myeloid leukaemia 30.93 11.44 12 182157 38098 110369032
Dysgeusia 30.89 11.44 42 182127 69943 110337187
Skin ulcer 30.87 11.44 195 181974 63450 110343680
Pneumonitis 30.78 11.44 49 182120 76482 110330648
Cough 30.44 11.44 985 181184 460656 109946474
Pulmonary arterial hypertension 30.43 11.44 8 182161 32560 110374570
Acute hepatic failure 30.41 11.44 11 182158 36457 110370673
Bone loss 30.40 11.44 31 182138 3024 110404106
Purulent discharge 30.16 11.44 47 182122 7036 110400094
Drug dependence 30.06 11.44 23 182146 49997 110357133
Swollen tongue 30.05 11.44 33 182136 60329 110346801
Product use issue 29.88 11.44 698 181471 310997 110096133
Tibia fracture 29.87 11.44 45 182124 6540 110400590
Sinusitis 29.87 11.44 669 181500 296019 110111111
Embolism venous 29.74 11.44 39 182130 4984 110402146
Hyperbilirubinaemia 29.69 11.44 7 182162 30664 110376466
Therapeutic product effect variable 29.66 11.44 29 182140 2689 110404441
Premature delivery 29.64 11.44 7 182162 30625 110376505
Disorientation 29.62 11.44 44 182125 70627 110336503
Oral infection 29.62 11.44 44 182125 6317 110400813
Metaphyseal corner fracture 29.53 11.44 8 182161 37 110407093
Shock 29.30 11.44 27 182142 53561 110353569
Dystonia 29.06 11.44 4 182165 25801 110381329
Hepatotoxicity 29.06 11.44 37 182132 63363 110343767
Haemophagocytic lymphohistiocytosis 29.02 11.44 8 182161 31551 110375579
Neuroleptic malignant syndrome 28.86 11.44 10 182159 34049 110373081
Tooth extraction 28.62 11.44 65 182104 12926 110394204
Carpal tunnel syndrome 28.45 11.44 92 182077 22518 110384612
Diabetic ketoacidosis 28.40 11.44 17 182152 42041 110365089
Ejection fraction decreased 28.35 11.44 16 182153 40864 110366266
Illness 28.22 11.44 58 182111 82113 110325017
Enthesopathy 28.12 11.44 63 182106 12415 110394715
Thoracic vertebral fracture 28.11 11.44 44 182125 6611 110400519
Full blood count decreased 27.94 11.44 9 182160 32090 110375040
Rash erythematous 27.90 11.44 58 182111 81774 110325356
Emotional distress 27.75 11.44 20 182149 44827 110362303
Cerebral haemorrhage 27.67 11.44 40 182129 64928 110342202
Tongue disorder 27.66 11.44 68 182101 14230 110392900
Stevens-Johnson syndrome 27.63 11.44 22 182147 46879 110360251
Blue toe syndrome 27.49 11.44 16 182153 672 110406458
Abortion spontaneous 27.48 11.44 11 182158 34271 110372859
Groin pain 27.36 11.44 71 182098 15357 110391773
Cyst 27.32 11.44 74 182095 16422 110390708
Toxic epidermal necrolysis 27.16 11.44 32 182137 56695 110350435
Nephropathy toxic 27.14 11.44 6 182163 27472 110379658
Acute phase reaction 27.05 11.44 14 182155 465 110406665
Metastases to bone 26.95 11.44 9 182160 31363 110375767
Plasma cell myeloma 26.55 11.44 39 182130 62897 110344233
COVID-19 pneumonia 26.54 11.44 14 182155 37129 110370001
Muscle spasticity 26.47 11.44 13 182156 35902 110371228
Incorrect dose administered 26.47 11.44 85 182084 103556 110303574
Device malfunction 26.45 11.44 5 182164 25553 110381577
Aphasia 26.45 11.44 35 182134 58962 110348168
Rheumatoid lung 26.39 11.44 34 182135 4270 110402860
Drug withdrawal syndrome 26.24 11.44 15 182154 38039 110369091
Sinus bradycardia 26.14 11.44 8 182161 29475 110377655
Bone fragmentation 26.04 11.44 16 182153 743 110406387
Deformity 26.00 11.44 54 182115 10106 110397024
Hiatus hernia 25.88 11.44 102 182067 27504 110379626
Vaginal haemorrhage 25.75 11.44 5 182164 25069 110382061
Miosis 25.74 11.44 3 182166 21980 110385150
Unevaluable event 25.68 11.44 36 182133 59191 110347939
Sputum increased 25.66 11.44 39 182130 5712 110401418
Joint injury 25.63 11.44 132 182037 39862 110367268
Restlessness 25.61 11.44 33 182136 56226 110350904
Pericardial effusion 25.60 11.44 34 182135 57183 110349947
Circulatory collapse 25.54 11.44 20 182149 42973 110364157
Poisoning deliberate 25.51 11.44 6 182163 26325 110380805
Skin haemorrhage 25.39 11.44 5 182164 24822 110382308
Arteriovenous fistula occlusion 25.26 11.44 14 182155 535 110406595
Ataxia 25.24 11.44 9 182160 30099 110377031
Spinal compression fracture 25.13 11.44 77 182092 18315 110388815
Polymyalgia rheumatica 25.03 11.44 41 182128 6401 110400729
Right ventricular failure 24.98 11.44 6 182163 25948 110381182
Splenomegaly 24.92 11.44 5 182164 24493 110382637
Fracture malunion 24.86 11.44 9 182160 121 110407009
Endometrial disorder 24.80 11.44 15 182154 677 110406453
Surgery 24.78 11.44 19 182150 41264 110365866
Disability 24.66 11.44 107 182062 30116 110377014
Nightmare 24.48 11.44 17 182152 38846 110368284
Fracture pain 24.45 11.44 18 182151 1130 110406000
Multiple sclerosis relapse 24.42 11.44 28 182141 50212 110356918
Urosepsis 24.33 11.44 10 182159 30665 110376465
Nerve degeneration 24.13 11.44 11 182158 275 110406855
Accidental overdose 24.01 11.44 30 182139 51804 110355326
Coordination abnormal 23.95 11.44 6 182163 25222 110381908
Escherichia infection 23.93 11.44 5 182164 23811 110383319
Coronary artery disease 23.45 11.44 52 182117 71638 110335492
Immobile 23.41 11.44 44 182125 7658 110399472
Swelling face 23.38 11.44 76 182093 92245 110314885
Pregnancy 23.26 11.44 154 182015 50913 110356217
Periprosthetic fracture 23.20 11.44 15 182154 762 110406368
Stomatitis 23.14 11.44 596 181573 269646 110137484
Oral herpes 23.06 11.44 119 182050 35961 110371169
Hemiparesis 22.98 11.44 23 182146 43880 110363250
Presyncope 22.96 11.44 28 182141 48859 110358271
Abscess jaw 22.94 11.44 21 182148 1793 110405337
Bone graft 22.92 11.44 15 182154 778 110406352
Temporomandibular joint syndrome 22.85 11.44 30 182139 3839 110403291
Lacrimal disorder 22.85 11.44 13 182156 523 110406607
Dental necrosis 22.67 11.44 9 182160 158 110406972
Hypercholesterolaemia 22.57 11.44 239 181930 90598 110316532
Tuberculin test positive 22.53 11.44 29 182140 3639 110403491
Product use in unapproved indication 22.45 11.44 563 181606 446814 109960316
Fatigue 22.32 11.44 1713 180456 1214245 109192885
Leukocytosis 22.09 11.44 34 182135 53794 110353336
Granulomatosis with polyangiitis 22.08 11.44 28 182141 3462 110403668
Device issue 21.90 11.44 15 182154 34520 110372610
Hypothermia 21.82 11.44 8 182161 26294 110380836
Lip swelling 21.77 11.44 31 182138 50636 110356494
Diarrhoea 21.75 11.44 1600 180569 1137905 109269225
Gout 21.73 11.44 17 182152 36549 110370581
Rotator cuff syndrome 21.73 11.44 69 182100 16725 110390405
Pulmonary hypertension 21.60 11.44 36 182133 55184 110351946
Drug eruption 21.60 11.44 157 182012 53502 110353628
Polyneuropathy 21.53 11.44 13 182156 31999 110375131
Granuloma 21.48 11.44 48 182121 9442 110397688
Mass excision 21.10 11.44 11 182158 371 110406759
Renal tubular necrosis 21.03 11.44 12 182157 30463 110376667
Multiple drug therapy 20.98 11.44 43 182126 7971 110399159
Hyperthyroidism 20.95 11.44 11 182158 29250 110377880
Diastolic dysfunction 20.90 11.44 56 182113 12348 110394782
Aplastic anaemia 20.84 11.44 7 182162 24301 110382829
Gingival swelling 20.81 11.44 34 182135 5296 110401834
Eye injury 20.77 11.44 42 182127 7713 110399417
Mental disorder 20.67 11.44 20 182149 38771 110368359
Meniscus injury 20.62 11.44 42 182127 7751 110399379
Mood swings 20.57 11.44 6 182163 22806 110384324
Klebsiella infection 20.53 11.44 4 182165 20005 110387125
Cardiac failure acute 20.52 11.44 7 182162 24071 110383059
Giant cell arteritis 20.50 11.44 28 182141 3721 110403409
Muscle rigidity 20.46 11.44 7 182162 24024 110383106
Urticaria 20.39 11.44 678 181491 318179 110088951
Palpitations 20.37 11.44 166 182003 159046 110248084
Dysuria 20.27 11.44 43 182126 60188 110346942
Dysphagia 20.18 11.44 159 182010 153441 110253689
Malocclusion 20.16 11.44 9 182160 214 110406916
Pneumonia 20.15 11.44 1691 180478 875023 109532107
Troponin increased 20.15 11.44 12 182157 29754 110377376
Disseminated intravascular coagulation 20.08 11.44 23 182146 41263 110365867
Spinal disorder 19.81 11.44 53 182116 11675 110395455
Eosinophilia 19.80 11.44 41 182128 57895 110349235
Mydriasis 19.67 11.44 6 182163 22151 110384979
Injection site rash 19.63 11.44 7 182162 23412 110383718
Influenza 19.55 11.44 181 181988 168920 110238210
Lung adenocarcinoma stage IV 19.50 11.44 12 182157 559 110406571
Hysterectomy 19.46 11.44 42 182127 8072 110399058
Cytomegalovirus viraemia 19.43 11.44 3 182166 17761 110389369
Tenosynovitis 19.36 11.44 65 182104 16218 110390912
Bronchospasm 19.35 11.44 13 182156 30226 110376904
Vein disorder 19.28 11.44 36 182133 6234 110400896
Gastroenteritis viral 19.28 11.44 102 182067 31124 110376006
Schizophrenia 19.21 11.44 6 182163 21820 110385310
Urinary tract infection 19.06 11.44 401 181768 325881 110081249
Staphylococcal infection 18.82 11.44 56 182113 69888 110337242
Pleuritic pain 18.81 11.44 64 182105 16076 110391054
Myoclonus 18.79 11.44 16 182153 32982 110374148
Pulmonary alveolar haemorrhage 18.73 11.44 5 182164 20145 110386985
Oliguria 18.58 11.44 4 182165 18653 110388477
Akathisia 18.47 11.44 3 182166 17110 110390020
Erectile dysfunction 18.43 11.44 4 182165 18552 110388578
Immune thrombocytopenia 18.39 11.44 7 182162 22487 110384643
Lumbar vertebral fracture 18.27 11.44 44 182125 9087 110398043
Blood bilirubin increased 18.24 11.44 64 182105 75908 110331222
Product dose omission in error 18.12 11.44 8 182161 23504 110383626
Metastases to liver 18.00 11.44 19 182150 35367 110371763
Parkinsonism 17.98 11.44 7 182162 22180 110384950
Staphylococcal bacteraemia 17.85 11.44 3 182166 16685 110390445
Cholestasis 17.84 11.44 51 182118 64467 110342663
Melaena 17.83 11.44 56 182113 68701 110338429
Bronchiectasis 17.82 11.44 112 182057 36381 110370749
Glomerular filtration rate decreased 17.80 11.44 13 182156 28943 110378187
Second primary malignancy 17.74 11.44 4 182165 18064 110389066
Motor dysfunction 17.74 11.44 9 182160 24397 110382733
Diplopia 17.64 11.44 26 182143 41868 110365262
Chills 17.57 11.44 215 181954 190365 110216765
Burning sensation 17.51 11.44 57 182112 69155 110337975
Blood glucose increased 17.48 11.44 137 182032 132359 110274771
Barrett's oesophagus 17.45 11.44 12 182157 676 110406454
Toxic skin eruption 17.38 11.44 12 182157 27503 110379627
Urethral caruncle 17.34 11.44 6 182163 70 110407060
Tooth loss 17.27 11.44 40 182129 8056 110399074
No adverse event 17.20 11.44 63 182106 73776 110333354
Arteriosclerosis coronary artery 17.18 11.44 10 182159 25108 110382022
Device related infection 17.15 11.44 24 182145 39495 110367635
Blood triglycerides increased 17.12 11.44 9 182160 23917 110383213
Blood uric acid increased 17.11 11.44 7 182162 21522 110385608
Shock haemorrhagic 17.06 11.44 12 182157 27235 110379895
Rheumatoid factor 17.05 11.44 11 182158 557 110406573
Ventricular fibrillation 17.04 11.44 26 182143 41287 110365843
Coeliac disease 17.04 11.44 28 182141 43159 110363971
Pseudarthrosis 16.99 11.44 9 182160 314 110406816
Paraesthesia 16.92 11.44 585 181584 275936 110131194
Haematemesis 16.88 11.44 46 182123 59062 110348068
Staphylococcal sepsis 16.86 11.44 4 182165 17450 110389680
Abdominal distension 16.73 11.44 196 181973 174907 110232223
Renal injury 16.73 11.44 5 182164 18708 110388422
Food allergy 16.66 11.44 6 182163 19942 110387188
Urine output decreased 16.56 11.44 6 182163 19870 110387260
Haemorrhage intracranial 16.56 11.44 14 182155 28955 110378175
Edentulous 16.52 11.44 8 182161 230 110406900
Hypotonia 16.47 11.44 3 182166 15742 110391388
Sneezing 16.46 11.44 17 182152 31967 110375163
Rash macular 16.29 11.44 24 182145 38662 110368468
Radius fracture 16.28 11.44 26 182143 3974 110403156
Ankylosing spondylitis 16.27 11.44 3 182166 15609 110391521
Episcleral hyperaemia 16.23 11.44 3 182166 0 110407130
Respiratory rate increased 16.22 11.44 83 182086 25000 110382130
Anuria 16.21 11.44 10 182159 24331 110382799
Subarachnoid haemorrhage 16.20 11.44 15 182154 29687 110377443
Cold sweat 16.20 11.44 8 182161 22023 110385107
Polychondritis 16.17 11.44 13 182156 930 110406200
Myopathy toxic 16.10 11.44 15 182154 1310 110405820
Skeletal injury 16.05 11.44 16 182153 1519 110405611
Anhedonia 16.01 11.44 3 182166 15425 110391705
Spondylitis 15.99 11.44 48 182121 11290 110395840
Blood creatine phosphokinase increased 15.95 11.44 64 182105 73013 110334117
Cystitis escherichia 15.91 11.44 12 182157 782 110406348
Drug-induced liver injury 15.90 11.44 124 182045 119943 110287187
Face oedema 15.90 11.44 19 182150 33450 110373680
Pain in jaw 15.84 11.44 141 182028 51036 110356094
Device failure 15.81 11.44 36 182133 7171 110399959
Oxygen saturation decreased 15.79 11.44 354 181815 156628 110250502
Orthostatic hypotension 15.78 11.44 56 182113 66193 110340937
Polyp 15.76 11.44 44 182125 9936 110397194
Acute generalised exanthematous pustulosis 15.73 11.44 8 182161 21656 110385474
Hernia pain 15.70 11.44 10 182159 495 110406635
Jaw cyst 15.54 11.44 7 182162 170 110406960
Vascular device infection 15.53 11.44 4 182165 16508 110390622
Cytopenia 15.51 11.44 16 182153 30100 110377030
End stage renal disease 15.48 11.44 8 182161 21465 110385665
Blood test abnormal 15.44 11.44 90 182079 28464 110378666
Haemodialysis 15.37 11.44 5 182164 17714 110389416
Lower respiratory tract congestion 15.33 11.44 28 182141 4768 110402362
Skin irritation 15.26 11.44 4 182165 16315 110390815
Atelectasis 15.24 11.44 23 182146 36689 110370441
Embolism 15.22 11.44 4 182165 16285 110390845
Atrioventricular block complete 15.21 11.44 7 182162 20075 110387055
Hypothyroidism 15.20 11.44 65 182104 72834 110334296
Seronegative arthritis 15.14 11.44 52 182117 13125 110394005
Ear pain 15.13 11.44 144 182025 53082 110354048
Hypomagnesaemia 15.07 11.44 50 182119 60320 110346810
Immune effector cell-associated neurotoxicity syndrome 15.07 11.44 3 182166 14779 110392351
Ilium fracture 15.05 11.44 8 182161 281 110406849
Epstein-Barr virus infection 15.04 11.44 6 182163 18732 110388398
Blood creatine phosphokinase MB 15.04 11.44 4 182165 17 110407113
Blood sodium decreased 14.97 11.44 25 182144 38294 110368836
Injection site warmth 14.94 11.44 5 182164 17400 110389730
Tooth abscess 14.93 11.44 66 182103 18723 110388407
Cerumen impaction 14.90 11.44 15 182154 1441 110405689
Foetal death 14.88 11.44 4 182165 16041 110391089
Patellofemoral pain syndrome 14.87 11.44 10 182159 543 110406587
Carbuncle 14.80 11.44 15 182154 1452 110405678
Wrist deformity 14.76 11.44 22 182147 3167 110403963
Rash 14.63 11.44 1159 181010 819805 109587325
Mania 14.62 11.44 8 182161 20788 110386342
Clostridium difficile infection 14.57 11.44 41 182128 52088 110355042
Hepatic encephalopathy 14.56 11.44 15 182154 28241 110378889
Skin burning sensation 14.49 11.44 9 182160 21816 110385314
Exposed bone in jaw 14.46 11.44 24 182145 3787 110403343
Fibrosis 14.42 11.44 36 182133 7606 110399524
Oesophageal rupture 14.38 11.44 12 182157 905 110406225
Subcutaneous drug absorption impaired 14.37 11.44 36 182133 7623 110399507
Ischaemic stroke 14.27 11.44 29 182140 41234 110365896
Salpingo-oophorectomy bilateral 14.26 11.44 8 182161 313 110406817
Hypoalbuminaemia 14.24 11.44 16 182153 28958 110378172
Cardiotoxicity 14.23 11.44 5 182164 16876 110390254
Bone pain 14.19 11.44 167 182002 64966 110342164
Drug use disorder 14.16 11.44 6 182163 18068 110389062
Myelodysplastic syndrome 14.15 11.44 25 182144 37459 110369671
Hepatomegaly 13.98 11.44 9 182160 21405 110385725
Psychomotor hyperactivity 13.97 11.44 8 182161 20269 110386861
Proteinuria 13.95 11.44 28 182141 39990 110367140
Femoral neck fracture 13.92 11.44 49 182120 12518 110394612
Oropharyngeal pain 13.88 11.44 149 182020 135127 110272003
Weight bearing difficulty 13.87 11.44 23 182146 3628 110403502
Respiratory symptom 13.83 11.44 55 182114 14890 110392240
Apical granuloma 13.83 11.44 5 182164 67 110407063
Skin fissures 13.76 11.44 12 182157 24446 110382684
Pulmonary toxicity 13.73 11.44 6 182163 17740 110389390
Toxic encephalopathy 13.72 11.44 4 182165 15210 110391920
Polyuria 13.72 11.44 6 182163 17732 110389398
Uterine disorder 13.68 11.44 18 182151 2308 110404822
Pain of skin 13.66 11.44 8 182161 20021 110387109
Skin reaction 13.65 11.44 9 182160 21135 110385995
Thinking abnormal 13.62 11.44 4 182165 15136 110391994
Pharyngeal oedema 13.62 11.44 5 182164 16423 110390707
Hallucination, auditory 13.62 11.44 14 182155 26383 110380747
Gangrene 13.50 11.44 5 182164 16336 110390794
Hepatitis cholestatic 13.50 11.44 6 182163 17560 110389570
Swollen joint count 13.46 11.44 38 182131 8636 110398494
Nocturnal dyspnoea 13.41 11.44 16 182153 1859 110405271
Failure to thrive 13.34 11.44 3 182166 13571 110393559
Arrhythmia 13.33 11.44 64 182105 69511 110337619
Inappropriate antidiuretic hormone secretion 13.30 11.44 22 182147 33829 110373301
Aspiration 13.26 11.44 91 182078 30442 110376688
Dental alveolar anomaly 13.25 11.44 4 182165 29 110407101
Lymphocyte count decreased 13.22 11.44 49 182120 57194 110349936
Emphysema 13.21 11.44 66 182103 19690 110387440
Toothache 13.20 11.44 75 182094 23500 110383630
Urine calcium/creatinine ratio increased 13.20 11.44 6 182163 149 110406981
Progressive multifocal leukoencephalopathy 13.15 11.44 13 182156 24943 110382187
Post infection glomerulonephritis 13.09 11.44 6 182163 152 110406978
Pharyngeal paraesthesia 13.05 11.44 24 182145 4108 110403022
Feeling jittery 13.04 11.44 4 182165 14718 110392412
Cardiomyopathy 12.98 11.44 22 182147 33503 110373627
Cyanosis 12.97 11.44 18 182151 29723 110377407
Pollakiuria 12.92 11.44 34 182135 44161 110362969
Hypokalaemia 12.89 11.44 217 181952 182231 110224899
Atrophy 12.87 11.44 18 182151 2446 110404684
Drug ineffective 12.85 11.44 2257 179912 1518283 108888847
Rash pruritic 12.82 11.44 230 181939 97839 110309291
Spinal fracture 12.67 11.44 72 182097 22561 110384569
Mood altered 12.62 11.44 10 182159 21365 110385765
Oral disorder 12.62 11.44 46 182123 11957 110395173
Tinnitus 12.61 11.44 54 182115 60486 110346644
Nodal osteoarthritis 12.60 11.44 11 182158 882 110406248
Decreased appetite 12.57 11.44 928 181241 474918 109932212
Feeling cold 12.53 11.44 23 182146 33964 110373166
Sudden death 12.52 11.44 13 182156 24382 110382748
Myocardial infarction 12.44 11.44 232 181937 191851 110215279
Rubella 12.37 11.44 6 182163 173 110406957
Inner ear inflammation 12.35 11.44 3 182166 8 110407122
Intraocular pressure test 12.33 11.44 5 182164 93 110407037
Nasal congestion 12.33 11.44 103 182066 98179 110308951
Liver function test abnormal 12.31 11.44 65 182104 68885 110338245
Drug level increased 12.28 11.44 39 182130 47680 110359450
Nocturia 12.25 11.44 58 182111 16932 110390198
Paraesthesia oral 12.22 11.44 23 182146 33648 110373482
Hypersomnia 12.22 11.44 17 182152 28044 110379086
Kyphoscoliosis 12.20 11.44 7 182162 286 110406844
Blindness 12.20 11.44 26 182143 36333 110370797
Pneumococcal infection 12.16 11.44 15 182154 1804 110405326
Neutrophilia 12.08 11.44 41 182128 10288 110396842
Bone hypertrophy 12.07 11.44 10 182159 747 110406383
Hallucination, visual 11.94 11.44 30 182139 39575 110367555
Hospitalisation 11.94 11.44 164 182005 142329 110264801
Hepatic function abnormal 11.93 11.44 92 182077 89203 110317927
Bone resorption test abnormal 11.85 11.44 3 182166 10 110407120
Poor venous access 11.81 11.44 75 182094 24447 110382683
Delusion 11.81 11.44 13 182156 23742 110383388
Eosinophil count increased 11.80 11.44 67 182102 20991 110386139
Rash papular 11.78 11.44 17 182152 27622 110379508
Pancreatitis 11.74 11.44 98 182071 93435 110313695
Tender joint count 11.74 11.44 13 182156 1394 110405736
Blood calcium decreased 11.72 11.44 26 182143 35819 110371311
Palmoplantar pustulosis 11.67 11.44 11 182158 975 110406155
Appendicitis 11.66 11.44 18 182151 28446 110378684
Oedema peripheral 11.59 11.44 657 181512 328003 110079127
Kidney infection 11.54 11.44 77 182092 25522 110381608
Bundle branch block right 11.52 11.44 3 182166 12288 110394842
Sensory loss 11.51 11.44 11 182158 21446 110385684
Tardive dyskinesia 11.48 11.44 4 182165 13575 110393555
Multiple allergies 11.48 11.44 3 182166 12260 110394870
Traumatic ulcer 11.47 11.44 5 182164 112 110407018

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M05BA07 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates
ATC M05BB02 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB07 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
FDA CS M0006519 Diphosphonates
FDA EPC N0000175579 Bisphosphonate
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D050071 Bone Density Conservation Agents
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:50779 appetite enhancer
CHEBI has role CHEBI:35480 analgesic

Related Drugs by ATC class:

M05BA Bisphosphonates 7 drugs
alendronic acidclodronic acidetidronic acidibandronic acidpamidronic acidtiludronic acidzoledronic acid
M05BB Bisphosphonates, combinations 6 drugs
alendronic acidalfacalcidolcolecalciferoletidronic acidibandronic acidzoledronic acid

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteitis deformans indication 2089002 DOID:5408
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009
Glucocorticoid Induced Osteoporosis indication
Prevention of Glucocorticoid-Induced Osteoporosis indication
Gastritis contraindication 4556007 DOID:4029
Hypocalcemia contraindication 5291005
Bone pain contraindication 12584003
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Stricture of esophagus contraindication 63305008
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Muscle pain contraindication 68962001
Fracture of femur contraindication 71620000
Duodenitis contraindication 72007001 DOID:8643
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Bed-ridden contraindication 160685001
Osteolysis contraindication 203522001
Esophageal dysmotility contraindication 266434009 DOID:9192
Aseptic necrosis of bone of jaw contraindication 441809006




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.35 acidic
pKa2 6.42 acidic
pKa3 7.4 acidic
pKa4 11.47 acidic
pKa5 12.45 acidic
pKa6 4.27 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
35MG ATELVIA APIL N022560 Oct. 8, 2010 RX TABLET, DELAYED RELEASE ORAL 7645459 Jan. 9, 2028 TREATMENT OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN
35MG ATELVIA APIL N022560 Oct. 8, 2010 RX TABLET, DELAYED RELEASE ORAL 7645460 Jan. 9, 2028 TREATMENT OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme INHIBITOR Ki 9.44 CHEMBL CHEMBL
Butyrophilin subfamily 3 member A1 Antibody EC50 7.10 CHEMBL
Farnesyl pyrophosphate synthase Enzyme Ki 7.77 CHEMBL
Farnesyl diphosphate synthase Enzyme IC50 7.13 CHEMBL
Farnesyl diphosphate synthase Enzyme IC50 7.57 CHEMBL
Farnesyl pyrophosphate synthase, EC 2.5.1.1, EC 2.5.1.10 Enzyme Ki 7.80 CHEMBL

External reference:

IDSource
D00942 KEGG_DRUG
329003-65-8 SECONDARY_CAS_RN
353228-19-0 SECONDARY_CAS_RN
115436-72-1 SECONDARY_CAS_RN
4021112 VANDF
4024121 VANDF
C0140610 UMLSCUI
CHEBI:8869 CHEBI
RIS PDB_CHEM_ID
CHEMBL923 ChEMBL_ID
CHEMBL1654 ChEMBL_ID
DB00884 DRUGBANK_ID
D000068296 MESH_DESCRIPTOR_UI
5245 PUBCHEM_CID
6522 INN_ID
KM2Z91756Z UNII
1356127 RXNORM
107688 MMSL
11659 MMSL
5428 MMSL
d04300 MMSL
007620 NDDF
007621 NDDF
1269159002 SNOMEDCT_US
387064005 SNOMEDCT_US
387582001 SNOMEDCT_US
61901000087108 SNOMEDCT_US
734872006 SNOMEDCT_US
768538005 SNOMEDCT_US
768539002 SNOMEDCT_US
3176 IUPHAR_LIGAND_ID
KM2Z91756Z INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3098 TABLET, FILM COATED 35 mg ORAL ANDA 28 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3099 TABLET, FILM COATED 5 mg ORAL ANDA 28 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0093-3100 TABLET, FILM COATED 30 mg ORAL ANDA 28 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0115-1426 TABLET, DELAYED RELEASE 35 mg ORAL ANDA 30 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0470 TABLET, FILM COATED 25.80 mg ORAL NDA 32 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0470 TABLET, FILM COATED 4.20 mg ORAL NDA 32 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0471 TABLET, FILM COATED 0.70 mg ORAL NDA 32 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0471 TABLET, FILM COATED 4.30 mg ORAL NDA 32 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0472 TABLET, FILM COATED 4.90 mg ORAL NDA 32 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0472 TABLET, FILM COATED 30.10 mg ORAL NDA 32 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0477 TABLET, FILM COATED 64.50 mg ORAL NDA 32 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0477 TABLET, FILM COATED 10.50 mg ORAL NDA 32 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0478 TABLET, FILM COATED 129 mg ORAL NDA 32 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 2 0430-0478 TABLET, FILM COATED 21 mg ORAL NDA 32 sections
Atelvia HUMAN PRESCRIPTION DRUG LABEL 2 0430-0979 TABLET, DELAYED RELEASE 4.90 mg ORAL NDA 33 sections
Atelvia HUMAN PRESCRIPTION DRUG LABEL 2 0430-0979 TABLET, DELAYED RELEASE 30.10 mg ORAL NDA 33 sections
Risedronate Sodium Human Prescription Drug Label 1 33342-107 TABLET, FILM COATED 5 mg ORAL ANDA 28 sections
Risedronate Sodium Human Prescription Drug Label 1 33342-108 TABLET, FILM COATED 30 mg ORAL ANDA 28 sections
Risedronate Sodium Human Prescription Drug Label 1 33342-109 TABLET, FILM COATED 35 mg ORAL ANDA 28 sections
risedronate sodium Human Prescription Drug Label 1 47335-666 TABLET, FILM COATED 5 mg ORAL ANDA 30 sections
risedronate sodium Human Prescription Drug Label 1 47335-667 TABLET, FILM COATED 30 mg ORAL ANDA 30 sections
risedronate sodium Human Prescription Drug Label 1 47335-668 TABLET, FILM COATED 35 mg ORAL ANDA 30 sections
risedronate sodium Human Prescription Drug Label 1 47335-727 TABLET, FILM COATED 75 mg ORAL ANDA 30 sections
risedronate sodium Human Prescription Drug Label 1 47335-928 TABLET, FILM COATED 150 mg ORAL ANDA 30 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 1 54868-4386 TABLET, FILM COATED 5 mg ORAL NDA 28 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 1 54868-4671 TABLET, FILM COATED 35 mg ORAL NDA 28 sections
Actonel HUMAN PRESCRIPTION DRUG LABEL 1 54868-6069 TABLET, FILM COATED 150 mg ORAL NDA 28 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 2 59762-0405 TABLET, FILM COATED 30.10 mg ORAL NDA authorized generic 32 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 2 59762-0405 TABLET, FILM COATED 4.90 mg ORAL NDA authorized generic 32 sections
Risedronate Sodium HUMAN PRESCRIPTION DRUG LABEL 2 59762-0406 TABLET, FILM COATED 129 mg ORAL NDA authorized generic 32 sections