zoledronic acid Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 2868 118072-93-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • zoledronic acid
  • zoledronate
  • zoledronic acid monohydrate
  • zometa
  • zoledronic acid hydrate
An imidobisphosphonate inhibitor of BONE RESORPTION that is used for the treatment of malignancy-related HYPERCALCEMIA; OSTEITIS DEFORMANS; and OSTEOPOROSIS.
  • Molecular weight: 272.09
  • Formula: C5H10N2O7P2
  • CLOGP: -3.07
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 5
  • TPSA: 153.11
  • ALOGS: -1.92
  • ROTB: 4

Drug dosage:

DoseUnitRoute
4 mg P

Approvals:

DateAgencyCompanyOrphan
March 20, 2001 EMA
Aug. 20, 2001 FDA NOVARTIS

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Osteonecrosis of jaw 28821.24 31.51 5411 18424 8236 4606921
Osteonecrosis 27201.88 31.51 5087 18748 7377 4607780
Bone disorder 8568.70 31.51 1682 22153 3225 4611932
Tooth extraction 8400.55 31.51 1608 22227 2504 4612653
Pain in jaw 5972.26 31.51 1383 22452 7349 4607808
Exposed bone in jaw 5822.43 31.51 997 22838 361 4614796
Osteomyelitis 5459.59 31.51 1208 22627 5000 4610157
Pain 4430.78 31.51 1910 21925 90960 4524197
Impaired healing 3886.45 31.51 974 22861 7505 4607652
Bone sequestrum 2999.23 31.51 509 23326 142 4615015
Bone pain 2981.00 31.51 872 22963 12614 4602543
Pyrexia 2444.36 31.51 1335 22500 105809 4509348
Malignant neoplasm progression 2430.88 31.51 901 22934 28135 4587022
Purulent discharge 2367.47 31.51 473 23362 997 4614160
Metastases to bone 2252.76 31.51 552 23283 3794 4611363
Arthralgia 2238.50 31.51 1153 22682 80841 4534316
Debridement 2107.14 31.51 376 23459 264 4614893
Gingivitis 2099.49 31.51 458 23377 1713 4613444
Bone lesion 2008.19 31.51 399 23436 805 4614352
Jaw disorder 2005.34 31.51 429 23406 1427 4613730
Sequestrectomy 2002.35 31.51 346 23489 144 4615013
Swelling 1866.03 31.51 710 23125 23772 4591385
Myalgia 1832.59 31.51 817 23018 41231 4573926
Toothache 1823.56 31.51 454 23381 3352 4611805
Fistula 1765.32 31.51 423 23412 2604 4612553
Hypocalcaemia 1695.43 31.51 501 23334 7460 4607697
Osteitis 1681.22 31.51 339 23496 761 4614396
Influenza like illness 1565.54 31.51 585 23250 18568 4596589
Bone debridement 1504.74 31.51 254 23581 59 4615098
Tooth disorder 1497.79 31.51 427 23408 5551 4609606
Gingival swelling 1483.80 31.51 312 23523 929 4614228
Death 1441.57 31.51 1217 22618 196946 4418211
Tooth loss 1391.45 31.51 325 23510 1757 4613400
Osteolysis 1321.10 31.51 262 23573 519 4614638
Periodontitis 1247.02 31.51 262 23573 775 4614382
Pain in extremity 1161.82 31.51 689 23146 63050 4552107
Actinomycosis 1129.51 31.51 209 23626 224 4614933
Neoplasm malignant 1113.41 31.51 394 23441 10627 4604530
Back pain 1106.11 31.51 616 23219 49983 4565174
Jaw operation 1095.32 31.51 201 23634 197 4614960
Nausea 1085.07 31.51 989 22846 176344 4438813
Blood creatinine increased 997.06 31.51 468 23367 26432 4588725
Dental care 949.69 31.51 190 23645 401 4614756
Chills 941.89 31.51 460 23375 28379 4586778
Femur fracture 937.89 31.51 325 23510 8214 4606943
Fatigue 928.34 31.51 832 23003 144734 4470423
Tooth abscess 927.72 31.51 255 23580 2863 4612294
Dental operation 923.29 31.51 183 23652 360 4614797
Oral disorder 912.36 31.51 235 23600 2010 4613147
Oral surgery 906.83 31.51 180 23655 358 4614799
Asthenia 904.89 31.51 660 23175 85503 4529654
Oral cavity fistula 887.52 31.51 161 23674 138 4615019
Vomiting 875.03 31.51 740 23095 118959 4496198
Infection 860.54 31.51 466 23369 35676 4579481
General physical health deterioration 853.56 31.51 430 23405 28348 4586809
Pathological fracture 849.54 31.51 216 23619 1744 4613413
Metastases to liver 843.64 31.51 271 23564 5371 4609786
Dyspnoea 841.65 31.51 772 23063 138213 4476944
Surgery 834.70 31.51 306 23529 9141 4606016
Erythema 833.02 31.51 480 23355 41460 4573697
Neoplasm progression 831.45 31.51 300 23535 8555 4606602
Malaise 816.16 31.51 632 23203 89525 4525632
Loose tooth 812.20 31.51 181 23654 759 4614398
Inflammation 805.41 31.51 304 23531 9867 4605290
Oral pain 788.74 31.51 251 23584 4819 4610338
Osteosclerosis 766.86 31.51 155 23680 352 4614805
Headache 715.26 31.51 667 23168 121706 4493451
Abscess jaw 708.52 31.51 146 23689 379 4614778
Gingival pain 707.85 31.51 180 23655 1453 4613704
Dental caries 707.65 31.51 200 23635 2502 4612655
Blood calcium decreased 650.25 31.51 203 23632 3648 4611509
Acute kidney injury 641.43 31.51 496 23339 69935 4545222
Atypical femur fracture 627.87 31.51 156 23679 1133 4614024
Purulence 627.28 31.51 139 23696 564 4614593
Jaw fracture 622.66 31.51 140 23695 616 4614541
Metastases to lung 622.08 31.51 193 23642 3394 4611763
Fall 613.27 31.51 504 23331 77542 4537615
Soft tissue infection 613.20 31.51 137 23698 582 4614575
Chest pain 578.05 31.51 409 23426 50291 4564866
Decreased appetite 561.28 31.51 419 23416 55978 4559179
Gait disturbance 543.14 31.51 348 23487 36292 4578865
Anaemia 542.93 31.51 453 23382 71107 4544050
Periodontal disease 534.20 31.51 118 23717 470 4614687
Dental fistula 532.86 31.51 100 23735 123 4615034
Haemoglobin decreased 524.62 31.51 344 23491 37313 4577844
Osteotomy 520.21 31.51 92 23743 56 4615101
Diarrhoea 517.45 31.51 618 23217 149567 4465590
Gingival erythema 511.82 31.51 98 23737 145 4615012
Hypoaesthesia 509.91 31.51 317 23518 31348 4583809
Abscess 508.42 31.51 177 23658 4523 4610634
Renal failure 499.93 31.51 346 23489 41023 4574134
Breast cancer metastatic 496.56 31.51 148 23687 2256 4612901
Mouth ulceration 494.48 31.51 186 23649 5964 4609193
Neuropathy peripheral 490.83 31.51 279 23556 23390 4591767
Blood urea increased 487.55 31.51 203 23632 8547 4606610
Musculoskeletal pain 482.78 31.51 245 23590 16343 4598814
Bone swelling 470.42 31.51 95 23740 214 4614943
Hyperbaric oxygen therapy 463.44 31.51 77 23758 9 4615148
Breast cancer 453.59 31.51 203 23632 10208 4604949
Oedema peripheral 451.45 31.51 327 23508 41645 4573512
Breath odour 427.85 31.51 97 23738 446 4614711
Tooth infection 427.64 31.51 138 23697 2769 4612388
Eye pain 426.42 31.51 178 23657 7539 4607618
Hypophosphataemia 425.33 31.51 137 23698 2732 4612425
Tenderness 420.55 31.51 138 23697 2925 4612232
Dehydration 419.90 31.51 314 23521 41976 4573181
Terminal state 418.21 31.51 118 23717 1464 4613693
Wound closure 416.24 31.51 72 23763 30 4615127
Osteoarthritis 414.33 31.51 186 23649 9418 4605739
Disease progression 412.74 31.51 307 23528 40704 4574453
Mastication disorder 409.62 31.51 98 23737 594 4614563
C-reactive protein increased 404.43 31.51 200 23635 12612 4602545
Gingival ulceration 401.22 31.51 81 23754 182 4614975
Paraesthesia 396.67 31.51 282 23553 34851 4580306
Metastases to spine 393.80 31.51 98 23737 716 4614441
Haematocrit decreased 387.61 31.51 174 23661 8808 4606349
Wound treatment 385.74 31.51 70 23765 60 4615097
Pleural effusion 384.36 31.51 241 23594 24157 4591000
Metastases to central nervous system 380.35 31.51 138 23697 3986 4611171
Excessive granulation tissue 379.23 31.51 79 23756 220 4614937
Tooth fracture 375.82 31.51 119 23716 2240 4612917
Gingival disorder 371.62 31.51 97 23738 876 4614281
Weight decreased 364.08 31.51 321 23514 54143 4561014
Hypercalcaemia 356.14 31.51 138 23697 4800 4610357
Dizziness 352.91 31.51 417 23418 99454 4515703
Bone fistula 352.91 31.51 62 23773 34 4615123
Renal impairment 344.11 31.51 228 23607 25110 4590047
Joint swelling 342.41 31.51 223 23612 23855 4591302
Mucosal inflammation 337.10 31.51 170 23665 11173 4603984
Stomatitis 336.33 31.51 193 23642 16446 4598711
Blood alkaline phosphatase increased 335.67 31.51 175 23660 12332 4602825
Neck pain 328.35 31.51 168 23667 11384 4603773
Dysphagia 320.96 31.51 219 23616 25312 4589845
Metastases to lymph nodes 319.40 31.51 101 23734 1892 4613265
Lymphadenopathy 318.37 31.51 159 23676 10233 4604924
Atrial fibrillation 316.85 31.51 235 23600 30980 4584177
Muscle spasms 315.81 31.51 247 23588 35243 4579914
Muscular weakness 315.54 31.51 220 23615 26330 4588827
Red blood cell count decreased 314.72 31.51 147 23688 8156 4607001
Plastic surgery 311.91 31.51 57 23778 53 4615104
Musculoskeletal chest pain 310.31 31.51 117 23718 3771 4611386
Bone operation 307.11 31.51 60 23775 105 4615052
Cellulitis 306.26 31.51 182 23653 16550 4598607
Oral infection 302.48 31.51 86 23749 1098 4614059
Osteomyelitis chronic 302.44 31.51 62 23773 155 4615002
Bone trimming 300.20 31.51 51 23784 14 4615143
Prostatic specific antigen increased 298.06 31.51 103 23732 2569 4612588
Sinusitis 295.42 31.51 199 23636 22513 4592644
Wound dehiscence 294.32 31.51 88 23747 1355 4613802
Hypertension 293.55 31.51 276 23559 50522 4564635
Confusional state 289.23 31.51 269 23566 48565 4566592
Acute phase reaction 288.86 31.51 56 23779 92 4615065
Hypokalaemia 287.06 31.51 182 23653 18578 4596579
Fracture 280.01 31.51 113 23722 4380 4610777
Biopsy site unspecified abnormal 278.76 31.51 50 23785 37 4615120
Injury 277.87 31.51 140 23695 9178 4605979
Osteoporosis 277.55 31.51 125 23710 6370 4608787
Swelling face 275.71 31.51 163 23672 14677 4600480
Feeling abnormal 272.36 31.51 229 23606 36176 4578981
Anxiety 270.00 31.51 257 23578 47754 4567403
Exostosis 268.63 31.51 88 23747 1853 4613304
Pneumonia 258.65 31.51 363 23472 102452 4512705
Plasma cell myeloma 255.27 31.51 171 23664 19158 4595999
Rib fracture 254.99 31.51 106 23729 4436 4610721
Trismus 254.14 31.51 80 23755 1475 4613682
Cough 252.57 31.51 265 23570 55322 4559835
Biopsy bone abnormal 249.21 31.51 43 23792 17 4615140
Osteopenia 248.48 31.51 90 23745 2584 4612573
Hypoaesthesia oral 245.73 31.51 94 23741 3153 4612004
Spinal osteoarthritis 245.66 31.51 89 23746 2557 4612600
Alopecia 244.46 31.51 193 23642 27887 4587270
Oroantral fistula 240.34 31.51 45 23790 54 4615103
Deformity 239.84 31.51 64 23771 634 4614523
Abscess oral 239.55 31.51 57 23778 336 4614821
Urinary tract infection 236.55 31.51 226 23609 42164 4572993
Radioisotope scan 236.22 31.51 40 23795 10 4615147
Thrombocytopenia 234.10 31.51 237 23598 47436 4567721
Wound 233.45 31.51 100 23735 4512 4610645
Endodontic procedure 231.03 31.51 61 23774 578 4614579
Constipation 228.15 31.51 221 23614 41933 4573224
Gait inability 227.38 31.51 124 23711 9561 4605596
Movement disorder 226.76 31.51 99 23736 4680 4610477
Facial pain 223.20 31.51 75 23760 1713 4613444
Bacterial infection 222.97 31.51 97 23738 4546 4610611
Abscess drainage 220.12 31.51 50 23785 232 4614925
Parophthalmia 219.45 31.51 43 23792 77 4615080
Neutropenia 216.69 31.51 228 23607 47722 4567435
Bone loss 214.20 31.51 59 23776 665 4614492
Bone lesion excision 211.35 31.51 38 23797 29 4615128
Abdominal pain 210.50 31.51 250 23585 59774 4555383
Oedema 210.20 31.51 150 23685 18601 4596556
Aspartate aminotransferase increased 209.75 31.51 168 23667 24770 4590387
Wound drainage 209.49 31.51 49 23786 265 4614892
Palmar-plantar erythrodysaesthesia syndrome 204.63 31.51 113 23722 8928 4606229
Prostate cancer 203.12 31.51 93 23742 4923 4610234
Gingival bleeding 198.18 31.51 83 23752 3538 4611619
Hypophagia 198.10 31.51 105 23730 7643 4607514
Foot fracture 196.95 31.51 83 23752 3594 4611563
Oral mucosal erythema 196.73 31.51 49 23786 359 4614798
Arthritis 196.33 31.51 131 23704 14569 4600588
Intervertebral disc degeneration 195.63 31.51 73 23762 2283 4612874
X-ray abnormal 194.35 31.51 45 23790 231 4614926
Prostate cancer metastatic 193.17 31.51 58 23777 906 4614251
Mass 192.90 31.51 78 23757 3037 4612120
Gingival abscess 191.38 31.51 43 23792 188 4614969
Blood pressure increased 191.29 31.51 171 23664 29289 4585868
Blood lactate dehydrogenase increased 188.66 31.51 101 23734 7502 4607655
Chest discomfort 185.95 31.51 152 23683 23058 4592099
Stress fracture 185.01 31.51 63 23772 1500 4613657
Exostosis of jaw 184.81 31.51 46 23789 336 4614821
Blood sodium decreased 182.45 31.51 90 23745 5632 4609525
Insomnia 181.02 31.51 202 23633 45143 4570014
Red blood cell sedimentation rate increased 180.63 31.51 76 23759 3277 4611880
Bone erosion 180.39 31.51 53 23782 765 4614392
Bone fragmentation 180.12 31.51 39 23796 138 4615019
Atelectasis 179.09 31.51 80 23755 3995 4611162
Bone density decreased 178.28 31.51 64 23771 1789 4613368
Atypical fracture 175.57 31.51 39 23796 160 4614997
Musculoskeletal stiffness 171.09 31.51 133 23702 18769 4596388
Vision blurred 171.05 31.51 149 23686 24654 4590503
Lymph node pain 169.66 31.51 44 23791 386 4614771
Iritis 169.53 31.51 53 23782 954 4614203
Tetany 168.46 31.51 50 23785 749 4614408
Fistula discharge 167.41 31.51 42 23793 318 4614839
Iridocyclitis 166.95 31.51 53 23782 1005 4614152
Ocular hyperaemia 166.69 31.51 88 23747 6352 4608805
Tachycardia 164.14 31.51 161 23674 30984 4584173
Incisional drainage 163.53 31.51 37 23798 168 4614989
Pulpitis dental 163.16 31.51 38 23797 201 4614956
Computerised tomogram abnormal 162.81 31.51 50 23785 846 4614311
Blood glucose increased 162.09 31.51 143 23692 24061 4591096
Gastrooesophageal reflux disease 161.98 31.51 117 23718 14776 4600381
Alveolar osteitis 161.81 31.51 34 23801 100 4615057
Blood calcium increased 161.72 31.51 61 23774 1966 4613191
Platelet count decreased 160.83 31.51 168 23667 34834 4580323
Denture wearer 160.24 31.51 31 23804 50 4615107
Paraesthesia oral 159.47 31.51 69 23766 3189 4611968
Gingival recession 158.49 31.51 42 23793 404 4614753
Hip fracture 156.96 31.51 86 23749 6688 4608469
Blood phosphorus decreased 155.29 31.51 52 23783 1174 4613983
Renal tubular necrosis 154.88 31.51 72 23763 3946 4611211
Oedema mouth 153.62 31.51 52 23783 1215 4613942
Urine output decreased 152.12 31.51 66 23769 3071 4612086
Sepsis 151.01 31.51 179 23656 42660 4572497
Soft tissue inflammation 150.77 31.51 31 23804 79 4615078
Concomitant disease progression 150.29 31.51 49 23786 1015 4614142
Intervertebral disc protrusion 149.73 31.51 74 23761 4648 4610509
Syncope 149.35 31.51 158 23677 33237 4581920
Lymphocyte count decreased 148.89 31.51 80 23755 5983 4609174
White blood cell count increased 148.19 31.51 112 23723 15155 4600002
Depression 148.10 31.51 187 23648 47546 4567611
Metastasis 147.97 31.51 58 23777 2078 4613079
Chronic obstructive pulmonary disease 146.90 31.51 107 23728 13687 4601470
Glomerular filtration rate decreased 145.21 31.51 65 23770 3261 4611896
Dental discomfort 144.90 31.51 32 23803 127 4615030
Polyneuropathy 144.81 31.51 68 23767 3813 4611344
Creatinine renal clearance decreased 144.50 31.51 55 23780 1818 4613339
Respiratory failure 141.89 31.51 147 23688 30179 4584978
Maxillofacial operation 140.85 31.51 25 23810 16 4615141
Vitamin D deficiency 140.73 31.51 56 23779 2089 4613068
Tumour marker increased 139.22 31.51 45 23790 906 4614251
Hypotension 138.95 31.51 217 23618 67183 4547974
Discomfort 138.62 31.51 85 23750 8165 4606992
Dialysis 138.40 31.51 71 23764 4828 4610329
Lethargy 138.25 31.51 113 23722 17128 4598029
Product use in unapproved indication 137.55 31.51 133 23702 25140 4590017
Blood albumin decreased 136.93 31.51 64 23771 3550 4611607
Oedema mucosal 136.91 31.51 37 23798 386 4614771
Red cell distribution width increased 133.52 31.51 45 23790 1037 4614120
Dysgeusia 133.50 31.51 104 23731 14715 4600442
Bone scan abnormal 132.36 31.51 29 23806 110 4615047
Compression fracture 129.57 31.51 47 23788 1354 4613803
Spinal compression fracture 128.61 31.51 57 23778 2792 4612365
Internal fixation of fracture 126.11 31.51 32 23803 255 4614902
Rash 125.61 31.51 272 23563 108116 4507041
Bedridden 125.49 31.51 52 23783 2156 4613001
Tremor 125.27 31.51 150 23685 36109 4579048
Decubitus ulcer 125.11 31.51 54 23781 2480 4612677
Carbohydrate antigen 15-3 increased 125.06 31.51 28 23807 120 4615037
Joint effusion 124.45 31.51 50 23785 1913 4613244
Proteinuria 123.46 31.51 73 23762 6563 4608594
Neuralgia 123.08 31.51 64 23771 4476 4610681
Renal disorder 121.27 31.51 82 23753 9314 4605843
Oral discomfort 121.17 31.51 49 23786 1907 4613250
Alanine aminotransferase increased 121.12 31.51 131 23704 28242 4586915
Eating disorder 120.04 31.51 59 23776 3661 4611496
Dyspnoea exertional 119.28 31.51 84 23751 10188 4604969
Spinal fracture 118.06 31.51 60 23775 4000 4611157
Pulmonary mass 117.66 31.51 57 23778 3426 4611731
Necrosis 116.43 31.51 49 23786 2113 4613044
Spinal cord compression 116.43 31.51 43 23792 1305 4613852
Soft tissue disorder 115.73 31.51 32 23803 366 4614791
Scoliosis 115.62 31.51 43 23792 1331 4613826
Exophthalmos 114.81 31.51 34 23801 505 4614652
Uveitis 113.89 31.51 54 23781 3094 4612063
Body temperature increased 112.68 31.51 67 23768 6085 4609072
Palpitations 111.84 31.51 118 23717 24728 4590429
Peripheral swelling 111.77 31.51 122 23713 26570 4588587
Chronic papillomatous dermatitis 111.35 31.51 21 23814 27 4615130
Hepatic lesion 111.14 31.51 40 23795 1126 4614031
Gamma-glutamyltransferase increased 110.17 31.51 83 23752 11171 4603986
Mouth swelling 110.13 31.51 38 23797 942 4614215
Blood pressure decreased 108.47 31.51 100 23735 17800 4597357
Anhedonia 108.11 31.51 46 23789 2039 4613118
White blood cell count decreased 108.04 31.51 133 23702 32932 4582225
Eye swelling 107.43 31.51 67 23768 6630 4608527
Arthropathy 107.18 31.51 80 23755 10618 4604539
Tooth avulsion 107.02 31.51 21 23814 38 4615119
Sinus disorder 106.94 31.51 55 23780 3759 4611398
Blood potassium decreased 106.51 31.51 71 23764 7875 4607282
Leukopenia 106.42 31.51 108 23727 21628 4593529
Dysaesthesia 106.24 31.51 39 23796 1163 4613994
Dental implantation 104.94 31.51 29 23806 331 4614826
Physical disability 104.54 31.51 29 23806 336 4614821
Tibia fracture 103.97 31.51 38 23797 1119 4614038
Gingival erosion 103.88 31.51 22 23813 68 4615089
Face and mouth X-ray abnormal 103.69 31.51 18 23817 8 4615149
Renal cyst 103.52 31.51 46 23789 2267 4612890
Chronic sinusitis 103.21 31.51 35 23800 822 4614335
Localised infection 102.91 31.51 58 23777 4763 4610394
Emotional distress 102.87 31.51 64 23771 6306 4608851
Groin pain 102.22 31.51 45 23790 2168 4612989
Hypokinesia 102.04 31.51 50 23785 3081 4612076
Idiopathic orbital inflammation 101.83 31.51 19 23816 22 4615135
Urinary incontinence 101.47 31.51 67 23768 7313 4607844
Osteomyelitis acute 101.37 31.51 23 23812 106 4615051
Lung infiltration 101.17 31.51 57 23778 4677 4610480
Poor personal hygiene 100.92 31.51 24 23811 141 4615016
Osteoradionecrosis 100.71 31.51 22 23813 82 4615075
Tooth erosion 99.33 31.51 25 23810 192 4614965
Conjunctivitis 99.31 31.51 55 23780 4365 4610792
Pulmonary embolism 99.07 31.51 130 23705 34296 4580861
Thoracic vertebral fracture 98.57 31.51 34 23801 842 4614315
Dental prosthesis placement 97.54 31.51 20 23815 50 4615107
Scleritis 97.54 31.51 29 23806 437 4614720
Musculoskeletal discomfort 96.82 31.51 49 23786 3237 4611920
Ulcer 96.52 31.51 49 23786 3258 4611899
Cataract 96.33 31.51 72 23763 9574 4605583
Cardiomegaly 95.87 31.51 56 23779 4921 4610236
Mitral valve incompetence 95.86 31.51 55 23780 4673 4610484
Fanconi syndrome acquired 95.78 31.51 32 23803 717 4614440
Bone density increased 95.36 31.51 21 23814 82 4615075
X-ray dental 95.30 31.51 16 23819 3 4615154
Biopsy 95.05 31.51 24 23811 187 4614970
Dysstasia 94.58 31.51 55 23780 4792 4610365
Condition aggravated 94.00 31.51 168 23667 58003 4557154
Flank pain 93.78 31.51 45 23790 2648 4612509
Gingival operation 93.39 31.51 19 23816 45 4615112
Tubulointerstitial nephritis 92.60 31.51 59 23776 6060 4609097
Chronic kidney disease 92.17 31.51 73 23762 10572 4604585
Resorption bone increased 91.22 31.51 25 23810 276 4614881
Aortic arteriosclerosis 91.03 31.51 35 23800 1189 4613968
Speech disorder 91.03 31.51 75 23760 11487 4603670
Hydronephrosis 90.77 31.51 45 23790 2844 4612313
Skin toxicity 90.21 31.51 39 23796 1798 4613359
Ostectomy 89.65 31.51 17 23818 23 4615134
Loss of consciousness 89.42 31.51 126 23709 35556 4579601
Oral pustule 88.97 31.51 18 23817 41 4615116
Dysuria 88.81 31.51 64 23771 8046 4607111
Metastatic neoplasm 88.65 31.51 36 23799 1416 4613741
Mobility decreased 88.32 31.51 78 23757 13127 4602030
Eye inflammation 88.04 31.51 36 23799 1442 4613715
Feeding disorder 87.59 31.51 42 23793 2467 4612690
Platelet count increased 87.55 31.51 50 23785 4210 4610947
Hyperparathyroidism 86.89 31.51 30 23805 745 4614412
Feeling hot 86.87 31.51 70 23765 10391 4604766
Lip pain 86.77 31.51 27 23808 478 4614679
Hyperlipidaemia 86.40 31.51 53 23782 5092 4610065
Dental cleaning 86.20 31.51 17 23818 32 4615125
Systemic inflammatory response syndrome 85.85 31.51 38 23797 1855 4613302
Haemorrhage 85.39 31.51 104 23731 25458 4589699
Somnolence 84.96 31.51 137 23698 43523 4571634
Nephrolithiasis 84.80 31.51 65 23770 8974 4606183
Fracture nonunion 84.63 31.51 28 23807 608 4614549
Radiotherapy 84.48 31.51 24 23811 305 4614852
Pancytopenia 84.46 31.51 102 23733 24751 4590406
Edentulous 84.38 31.51 19 23816 84 4615073
Oral discharge 84.38 31.51 19 23816 84 4615073
Radiculopathy 83.71 31.51 33 23802 1200 4613957
Dental prosthesis user 83.34 31.51 17 23818 41 4615116
Hyponatraemia 83.24 31.51 101 23734 24629 4590528
Feeling cold 82.38 31.51 51 23784 4980 4610177
Hyperparathyroidism secondary 82.22 31.51 24 23811 338 4614819
Aminoaciduria 82.20 31.51 18 23817 68 4615089
Kyphosis 82.18 31.51 26 23809 487 4614670
Urinary retention 82.00 31.51 66 23769 9781 4605376
Lacrimation increased 81.86 31.51 49 23786 4504 4610653
Tricuspid valve incompetence 81.84 31.51 43 23792 3071 4612086
Local anaesthesia 81.52 31.51 14 23821 5 4615152
Bursitis 81.45 31.51 41 23794 2677 4612480
Diverticulum intestinal 81.24 31.51 33 23802 1299 4613858
Palatal disorder 81.09 31.51 21 23814 183 4614974
Dry mouth 80.93 31.51 74 23761 13027 4602130
Lymphocytic infiltration 80.74 31.51 25 23810 435 4614722
Mucosal ulceration 80.63 31.51 25 23810 437 4614720
Lumbar spinal stenosis 80.60 31.51 31 23804 1054 4614103
Fanconi syndrome 80.07 31.51 27 23808 623 4614534
Cardiac failure 79.98 31.51 104 23731 27184 4587973
Pulmonary oedema 79.88 31.51 78 23757 14908 4600249
Spinal pain 79.29 31.51 37 23798 2044 4613113
Pruritus 79.28 31.51 178 23657 72394 4542763
Blood potassium increased 79.27 31.51 50 23785 5045 4610112
Abdominal pain upper 79.24 31.51 118 23717 34997 4580160
Deep vein thrombosis 79.18 31.51 100 23735 25394 4589763
Multiple fractures 78.39 31.51 30 23805 1006 4614151
Rhinorrhoea 78.28 31.51 70 23765 11972 4603185
Metabolic acidosis 78.28 31.51 71 23764 12369 4602788
Blood parathyroid hormone increased 78.28 31.51 31 23804 1141 4614016
Heart rate increased 78.03 31.51 85 23750 18457 4596700
Cancer pain 77.73 31.51 27 23808 683 4614474
Cardiac failure congestive 77.70 31.51 113 23722 32809 4582348
Acute sinusitis 77.55 31.51 27 23808 688 4614469
Eyelid ptosis 77.28 31.51 36 23799 1981 4613176
Bone graft 77.27 31.51 22 23813 282 4614875
Pollakiuria 77.21 31.51 56 23779 7109 4608048
Myoglobinuria 76.99 31.51 22 23813 286 4614871
Abscess management 76.96 31.51 13 23822 3 4615154
Mental status changes 76.64 31.51 70 23765 12306 4602851
Haemorrhoids 76.25 31.51 47 23788 4554 4610603
Polymyalgia rheumatica 75.22 31.51 27 23808 754 4614403
Cellulitis orbital 75.03 31.51 20 23815 197 4614960
Hypothyroidism 74.69 31.51 57 23778 7817 4607340
Prosthesis user 74.67 31.51 14 23821 17 4615140
Hyperaesthesia teeth 74.66 31.51 25 23810 564 4614593
Conjunctival oedema 74.08 31.51 23 23812 404 4614753
Onycholysis 73.76 31.51 23 23812 410 4614747
Lymphoedema 73.34 31.51 33 23802 1675 4613482
Diplopia 73.14 31.51 52 23783 6399 4608758
Balance disorder 72.77 31.51 77 23758 16179 4598978
Bone formation increased 72.55 31.51 16 23819 63 4615094
Stem cell transplant 72.52 31.51 28 23807 962 4614195
Metastases to skin 72.25 31.51 22 23813 361 4614796
Spondylolisthesis 72.25 31.51 25 23810 625 4614532
Blood creatinine decreased 72.22 31.51 28 23807 973 4614184
Magnetic resonance imaging abnormal 72.18 31.51 30 23805 1253 4613904
Cachexia 71.74 31.51 34 23801 1945 4613212
Joint stiffness 71.74 31.51 50 23785 5961 4609196
Vertebral foraminal stenosis 70.93 31.51 19 23816 191 4614966
Chondrocalcinosis pyrophosphate 70.78 31.51 21 23814 314 4614843
Blood chloride decreased 70.66 31.51 30 23805 1322 4613835
Alveolar bone resorption 70.43 31.51 14 23821 28 4615129
Hiatus hernia 70.30 31.51 40 23795 3344 4611813
Single photon emission computerised tomogram abnormal 70.08 31.51 12 23823 4 4615153
Thrombosis 69.95 31.51 80 23755 18324 4596833
Skin ulcer 69.73 31.51 53 23782 7225 4607932
Visual impairment 69.63 31.51 82 23753 19378 4595779
Secretion discharge 69.37 31.51 33 23802 1904 4613253
Breast cancer recurrent 69.30 31.51 26 23809 825 4614332
Tooth deposit 69.28 31.51 16 23819 81 4615076
Hepatic failure 69.26 31.51 68 23767 13081 4602076
Metastases to meninges 68.75 31.51 25 23810 725 4614432
Oropharyngeal pain 68.74 31.51 77 23758 17242 4597915
Monocyte count increased 68.27 31.51 28 23807 1130 4614027
Radiation injury 67.85 31.51 20 23815 292 4614865
Sinus tachycardia 67.81 31.51 49 23786 6185 4608972
Lung neoplasm malignant 67.73 31.51 51 23784 6855 4608302
Prosthesis implantation 67.63 31.51 15 23820 61 4615096
Leukocytosis 67.48 31.51 53 23782 7581 4607576
Burning sensation 67.43 31.51 64 23771 11808 4603349
Upper limb fracture 67.28 31.51 40 23795 3630 4611527
Herpes zoster 67.24 31.51 73 23762 15790 4599367
Contusion 67.00 31.51 80 23755 19178 4595979
General anaesthesia 66.99 31.51 16 23819 96 4615061
Arteriosclerosis 66.67 31.51 39 23796 3435 4611722
Visual acuity reduced 66.58 31.51 59 23776 9971 4605186
Anuria 66.50 31.51 41 23794 3974 4611183
Dental alveolar anomaly 66.41 31.51 14 23821 42 4615115
Ankle fracture 66.18 31.51 37 23798 2990 4612167
Tooth discolouration 65.84 31.51 22 23813 493 4614664
Epistaxis 65.73 31.51 80 23755 19563 4595594
Seborrhoeic keratosis 65.39 31.51 22 23813 504 4614653
Mouth haemorrhage 64.58 31.51 32 23803 2020 4613137
Hypouricaemia 64.38 31.51 16 23819 116 4615041
Paralysis 64.20 31.51 38 23797 3421 4611736
Ear pain 63.99 31.51 39 23796 3703 4611454
Oral candidiasis 63.81 31.51 38 23797 3459 4611698
Pallor 63.45 31.51 51 23784 7541 4607616
Wrist fracture 63.44 31.51 32 23803 2098 4613059
Decreased interest 63.44 31.51 25 23810 908 4614249
Bone cancer 63.26 31.51 21 23814 461 4614696
Migraine 63.25 31.51 66 23769 13643 4601514
Febrile neutropenia 63.08 31.51 91 23744 26221 4588936
Lung neoplasm 63.08 31.51 30 23805 1730 4613427
Neoplasm 63.05 31.51 33 23802 2338 4612819
Poor venous access 62.96 31.51 27 23808 1220 4613937
Pelvic fracture 62.95 31.51 30 23805 1738 4613419
Rhabdomyolysis 62.77 31.51 78 23757 19480 4595677
Pelvic pain 62.75 31.51 33 23802 2361 4612796
Haematuria 62.65 31.51 64 23771 12906 4602251
Seizure 62.59 31.51 130 23705 50107 4565050
Eyelid oedema 62.32 31.51 40 23795 4159 4610998
Temporomandibular joint syndrome 61.72 31.51 24 23811 841 4614316
Deafness 61.32 31.51 43 23792 5176 4609981
Hypercholesterolaemia 61.05 31.51 35 23800 2968 4612189
Hyperkeratosis 60.82 31.51 28 23807 1499 4613658
Pneumonitis 60.78 31.51 54 23781 9156 4606001
Femoral neck fracture 60.42 31.51 30 23805 1902 4613255
Device failure 59.72 31.51 34 23801 2845 4612312
Hyperhidrosis 59.71 31.51 95 23740 29822 4585335
Amnesia 59.24 31.51 62 23773 12859 4602298
Tinnitus 59.18 31.51 53 23782 9080 4606077
Diverticulum 58.60 31.51 33 23802 2704 4612453
Candida infection 58.56 31.51 42 23793 5239 4609918
Jaw fistula 58.52 31.51 12 23823 30 4615127
Vertigo 58.51 31.51 66 23769 14890 4600267
Ascites 58.46 31.51 60 23775 12165 4602992
Intervertebral disc space narrowing 58.43 31.51 16 23819 176 4614981
Blood urine present 58.24 31.51 38 23797 4063 4611094
Malnutrition 58.20 31.51 36 23799 3509 4611648
General physical condition abnormal 58.19 31.51 27 23808 1472 4613685
Walking aid user 58.13 31.51 24 23811 985 4614172
Bronchitis 58.12 31.51 76 23759 19964 4595193
Sciatica 58.09 31.51 34 23801 2997 4612160
Hip arthroplasty 58.07 31.51 33 23802 2752 4612405
Liver function test abnormal 57.75 31.51 65 23770 14627 4600530
Influenza 57.65 31.51 77 23758 20646 4594511
Vein disorder 57.38 31.51 23 23812 874 4614283
Hyperkalaemia 57.09 31.51 67 23768 15770 4599387
Neutrophil count increased 57.04 31.51 40 23795 4815 4610342
Lumbar vertebral fracture 56.73 31.51 25 23810 1207 4613950
Synovial cyst 56.71 31.51 25 23810 1208 4613949
Metastases to the mediastinum 56.53 31.51 15 23820 145 4615012
Pericardial effusion 56.48 31.51 49 23786 8049 4607108
Ejection fraction decreased 56.38 31.51 42 23793 5554 4609603
Plasma cell myeloma recurrent 56.29 31.51 23 23812 919 4614238
Quality of life decreased 55.99 31.51 26 23809 1420 4613737
Cholelithiasis 55.92 31.51 52 23783 9350 4605807
Multiple organ dysfunction syndrome 55.75 31.51 72 23763 18684 4596473
Limb discomfort 55.71 31.51 40 23795 4998 4610159
Metaphyseal corner fracture 55.15 31.51 9 23826 0 4615157
Loss of personal independence in daily activities 54.44 31.51 48 23787 8057 4607100
Renal tubular disorder 54.30 31.51 26 23809 1522 4613635
Spinal stenosis 54.22 31.51 29 23806 2147 4613010
Metastases to bone marrow 54.13 31.51 15 23820 173 4614984
Blood magnesium decreased 54.02 31.51 29 23806 2163 4612994
Cyst 53.84 31.51 30 23805 2408 4612749
Swollen tongue 53.21 31.51 49 23786 8701 4606456
Hyperglycaemia 53.11 31.51 55 23780 11267 4603890
Dyspepsia 53.08 31.51 65 23770 15989 4599168
Dry skin 52.94 31.51 54 23781 10868 4604289
Anaesthesia 52.83 31.51 13 23822 90 4615067
Nail toxicity 52.58 31.51 13 23822 92 4615065
Radius fracture 52.47 31.51 21 23814 795 4614362
Disability 52.36 31.51 25 23810 1454 4613703
Hand fracture 52.08 31.51 23 23812 1116 4614041
Transient ischaemic attack 51.92 31.51 55 23780 11567 4603590
Vitamin D decreased 51.85 31.51 25 23810 1486 4613671
Blood pressure systolic increased 51.79 31.51 36 23799 4272 4610885
Diabetes mellitus 51.64 31.51 63 23772 15438 4599719
Gingival hypertrophy 51.54 31.51 21 23814 833 4614324
Gout 51.31 31.51 36 23799 4337 4610820
Photophobia 51.30 31.51 34 23801 3732 4611425
Upper respiratory tract infection 50.82 31.51 59 23776 13728 4601429
Electrolyte imbalance 50.79 31.51 34 23801 3795 4611362
Tooth impacted 50.75 31.51 13 23822 108 4615049
Alveoloplasty 50.56 31.51 9 23826 6 4615151
Humerus fracture 50.49 31.51 25 23810 1575 4613582
Disorientation 50.48 31.51 56 23779 12403 4602754
Dental plaque 50.38 31.51 12 23823 71 4615086
Life expectancy shortened 50.35 31.51 11 23824 41 4615116
Hypercalcaemia of malignancy 49.82 31.51 12 23823 75 4615082
Metastases to pelvis 49.72 31.51 13 23822 118 4615039
Poor dental condition 49.68 31.51 12 23823 76 4615081
Dental necrosis 49.62 31.51 13 23822 119 4615038
Azotaemia 49.21 31.51 24 23811 1463 4613694
Blindness 48.91 31.51 43 23792 7189 4607968
Abdominal distension 48.75 31.51 66 23769 17923 4597234
Post procedural complication 48.72 31.51 39 23796 5732 4609425
Eye movement disorder 48.69 31.51 27 23808 2147 4613010
Rales 48.67 31.51 27 23808 2149 4613008
Gingival oedema 48.60 31.51 11 23824 50 4615107
Emphysema 48.44 31.51 28 23807 2411 4612746
Protein total decreased 48.25 31.51 24 23811 1527 4613630
Nasal disorder 48.25 31.51 18 23817 562 4614595
Facet joint syndrome 48.24 31.51 13 23822 134 4615023
Dry eye 48.20 31.51 38 23797 5463 4609694
Intervertebral disc disorder 48.06 31.51 21 23814 993 4614164
Lower limb fracture 47.97 31.51 30 23805 2981 4612176
Osteitis deformans 47.92 31.51 12 23823 90 4615067
Fibula fracture 47.73 31.51 19 23816 709 4614448
Tachypnoea 47.56 31.51 36 23799 4875 4610282
Hepatic cyst 47.55 31.51 21 23814 1019 4614138
Aphthous ulcer 46.98 31.51 27 23808 2300 4612857
Rotator cuff syndrome 46.91 31.51 29 23806 2823 4612334
Left ventricular hypertrophy 46.82 31.51 24 23811 1628 4613529
Jaw lesion excision 46.48 31.51 8 23827 3 4615154
Oral dysaesthesia 46.34 31.51 11 23824 64 4615093
Gastritis 46.24 31.51 44 23791 8142 4607015
Bone infarction 46.22 31.51 13 23822 159 4614998
Eye disorder 45.90 31.51 36 23799 5138 4610019
Ulna fracture 45.80 31.51 15 23820 315 4614842
Aortic valve incompetence 45.72 31.51 24 23811 1710 4613447
Heart rate irregular 45.67 31.51 34 23801 4490 4610667
Vascular calcification 45.54 31.51 15 23820 321 4614836
Skin lesion 45.45 31.51 42 23793 7491 4607666
Subcutaneous abscess 45.41 31.51 24 23811 1734 4613423
Product use issue 45.21 31.51 76 23759 24960 4590197
Interstitial lung disease 45.20 31.51 66 23769 19219 4595938
Peri-implantitis 45.14 31.51 8 23827 5 4615152
Metastases to soft tissue 45.10 31.51 11 23824 73 4615084
Periodontal destruction 44.95 31.51 9 23826 19 4615138
Hyperplasia 44.69 31.51 15 23820 341 4614816
BRAF gene mutation 44.63 31.51 9 23826 20 4615137
Chronic inflammatory demyelinating polyradiculoneuropathy 44.41 31.51 14 23821 259 4614898
Fibrosis 44.39 31.51 20 23815 1018 4614139
Low turnover osteopathy 44.38 31.51 21 23814 1197 4613960
Breath sounds abnormal 44.23 31.51 22 23813 1400 4613757
Noninfective gingivitis 44.16 31.51 14 23821 264 4614893
Malignant pleural effusion 43.97 31.51 18 23817 723 4614434
Cerebral atrophy 43.93 31.51 23 23812 1630 4613527
Scar 43.82 31.51 28 23807 2888 4612269
Face oedema 43.69 31.51 39 23796 6651 4608506
Tooth resorption 43.57 31.51 10 23825 49 4615108
Fungal infection 43.43 31.51 42 23793 7927 4607230
Bone abscess 43.41 31.51 12 23823 137 4615020
Bone development abnormal 43.31 31.51 11 23824 88 4615069
Abdominal discomfort 43.24 31.51 80 23755 28328 4586829
Pulmonary fibrosis 43.22 31.51 36 23799 5594 4609563
Depressed level of consciousness 43.21 31.51 57 23778 15097 4600060
Hypoxia 43.18 31.51 53 23782 13068 4602089
Plasmacytoma 42.81 31.51 19 23816 933 4614224
Prostatic specific antigen abnormal 42.77 31.51 11 23824 93 4615064
Breast pain 42.59 31.51 23 23812 1736 4613421
Metastases to nervous system 42.45 31.51 10 23825 56 4615101
Circulatory collapse 42.37 31.51 41 23794 7744 4607413
Phlebitis 42.32 31.51 24 23811 1993 4613164
Thirst 42.29 31.51 28 23807 3068 4612089
Bone neoplasm 42.21 31.51 13 23822 222 4614935
Nasal septum deviation 42.16 31.51 15 23820 408 4614749
Large intestine polyp 42.07 31.51 25 23810 2266 4612891
Tooth injury 42.01 31.51 14 23821 311 4614846
Mean cell volume increased 41.99 31.51 17 23818 663 4614494
Uterine leiomyoma 41.80 31.51 22 23813 1576 4613581
Fistula repair 41.73 31.51 10 23825 61 4615096
Open reduction of fracture 41.68 31.51 15 23820 422 4614735
Renal atrophy 41.56 31.51 14 23821 322 4614835
Pericoronitis 41.53 31.51 9 23826 32 4615125
Spinal disorder 41.43 31.51 23 23812 1833 4613324
Device related infection 41.15 31.51 36 23799 5979 4609178
Productive cough 41.08 31.51 44 23791 9369 4605788
Tendonitis 40.87 31.51 30 23805 3878 4611279
Central nervous system lesion 40.55 31.51 28 23807 3287 4611870
Lymphadenopathy mediastinal 40.45 31.51 17 23818 730 4614427
Skin discolouration 40.26 31.51 42 23793 8676 4606481
Oliguria 40.18 31.51 26 23809 2741 4612416
Biopsy bone 40.11 31.51 9 23826 39 4615118
Asthma 40.05 31.51 59 23776 17315 4597842
Arrhythmia 39.99 31.51 52 23783 13580 4601577
Hip surgery 39.58 31.51 17 23818 771 4614386
Mean cell haemoglobin decreased 39.56 31.51 15 23820 490 4614667
Inappropriate schedule of product administration 39.19 31.51 67 23768 22303 4592854
Cranial nerve disorder 39.17 31.51 13 23822 285 4614872
Infusion site extravasation 39.02 31.51 21 23814 1574 4613583
Corneal endotheliitis 38.47 31.51 8 23827 22 4615135
Synovitis 38.44 31.51 28 23807 3577 4611580
Tonsillar disorder 38.34 31.51 13 23822 305 4614852
Streptococcal infection 38.29 31.51 21 23814 1634 4613523
Disease recurrence 38.28 31.51 38 23797 7403 4607754
Joint dislocation 38.24 31.51 23 23812 2131 4613026
Staphylococcal infection 38.16 31.51 45 23790 10643 4604514
Antibiotic prophylaxis 38.05 31.51 7 23828 7 4615150
Mitral valve calcification 38.02 31.51 12 23823 223 4614934
Sleep disorder 37.88 31.51 46 23789 11217 4603940
Sensory disturbance 37.80 31.51 30 23805 4355 4610802
Gastrointestinal disorder 37.68 31.51 55 23780 16006 4599151
Supraventricular extrasystoles 37.55 31.51 20 23815 1468 4613689
Pubis fracture 37.44 31.51 14 23821 440 4614717
Dementia 37.39 31.51 32 23803 5160 4609997
Anal incontinence 37.25 31.51 26 23809 3105 4612052
Second primary malignancy 37.24 31.51 25 23810 2803 4612354
Recurrent cancer 37.14 31.51 16 23819 731 4614426
Fibromyalgia 37.11 31.51 28 23807 3773 4611384
Atrophy 37.03 31.51 15 23820 586 4614571
Urinary tract obstruction 36.80 31.51 17 23818 917 4614240
Renal glycosuria 36.79 31.51 8 23827 29 4615128
Blood cholesterol increased 36.77 31.51 40 23795 8666 4606491
Foot deformity 36.67 31.51 24 23811 2579 4612578
Neutrophil count decreased 36.65 31.51 50 23785 13673 4601484
Onychomycosis 36.58 31.51 17 23818 930 4614227
Lung cancer metastatic 36.46 31.51 18 23817 1127 4614030
Dental cyst 36.37 31.51 8 23827 31 4615126
Disseminated intravascular coagulation 36.31 31.51 37 23798 7436 4607721
Lung disorder 35.99 31.51 47 23788 12324 4602833
Tongue ulceration 35.97 31.51 16 23819 790 4614367
Breast cancer stage IV 35.96 31.51 10 23825 117 4615040
Histology abnormal 35.57 31.51 10 23825 122 4615035
Sinus perforation 35.56 31.51 7 23828 13 4615144
Skin disorder 35.49 31.51 34 23801 6342 4608815
Calcinosis 35.46 31.51 14 23821 511 4614646
Periorbital oedema 35.46 31.51 21 23814 1892 4613265
Bone deformity 35.42 31.51 10 23825 124 4615033
Thyroid neoplasm 35.12 31.51 16 23819 836 4614321
Granuloma 35.08 31.51 18 23817 1223 4613934
Dyslipidaemia 35.04 31.51 20 23815 1681 4613476
Left atrial dilatation 35.03 31.51 14 23821 528 4614629
Concomitant disease aggravated 34.95 31.51 21 23814 1942 4613215
Metastases to ovary 34.90 31.51 9 23826 77 4615080
Albumin urine present 34.78 31.51 10 23825 133 4615024
Malocclusion 34.69 31.51 9 23826 79 4615078
Hot flush 34.61 31.51 42 23793 10233 4604924
Hilar lymphadenopathy 34.49 31.51 12 23823 305 4614852
Blood creatine phosphokinase increased 34.41 31.51 51 23784 15048 4600109
Coronary artery disease 34.34 31.51 53 23782 16199 4598958
Spinal deformity 34.27 31.51 12 23823 311 4614846
Unmasking of previously unidentified disease 34.00 31.51 11 23824 222 4614935
Sensory loss 33.94 31.51 21 23814 2047 4613110
Hypoacusis 33.91 31.51 33 23802 6276 4608881
Hypovolaemia 33.85 31.51 23 23812 2630 4612527
Radiotherapy to bone 33.70 31.51 6 23829 4 4615153
Blood testosterone decreased 33.55 31.51 17 23818 1125 4614032
Chondromalacia 33.55 31.51 9 23826 91 4615066
Stomatitis necrotising 33.55 31.51 9 23826 91 4615066
Calcium ionised decreased 33.46 31.51 9 23826 92 4615065
Urinary tract inflammation 33.35 31.51 8 23827 49 4615108
Weight bearing difficulty 33.34 31.51 14 23821 600 4614557
Oesophagitis 33.18 31.51 27 23808 4061 4611096
Pleural fibrosis 33.17 31.51 13 23822 465 4614692
Biopsy kidney abnormal 32.62 31.51 9 23826 102 4615055
Haematoma 32.53 31.51 40 23795 9876 4605281
Liver disorder 32.40 31.51 46 23789 13052 4602105
Hepatic steatosis 32.40 31.51 32 23803 6196 4608961
Hypoalbuminaemia 32.39 31.51 24 23811 3146 4612011
Cardiac arrest 32.26 31.51 79 23756 33928 4581229
Soft tissue mass 32.23 31.51 9 23826 107 4615050
Metastases to bladder 32.19 31.51 8 23827 58 4615099
Carcinoembryonic antigen increased 32.09 31.51 13 23822 508 4614649
Pyogenic granuloma 31.67 31.51 10 23825 186 4614971
Performance status decreased 31.67 31.51 18 23817 1501 4613656
Hypertrophy 31.57 31.51 10 23825 188 4614969

Pharmacologic Action:

SourceCodeDescription
ATC M05BA08 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates
ATC M05BB08 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
CHEBI has role CHEBI:50646 bone density conservation agent
MeSH PA D050071 Bone Density Conservation Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Osteitis deformans indication 2089002 DOID:5408
Humoral hypercalcemia of malignancy indication 47709007
Osteoporosis indication 64859006 DOID:11476
Postmenopausal osteoporosis indication 102447009
Bone Metastases of Solid Tumors indication
Glucocorticoid Induced Osteoporosis indication
Osteolytic Lesions of Multiple Myeloma indication
Hypogonadal Osteoporosis in Males indication
Prevention of Glucocorticoid-Induced Osteoporosis indication
Drug-induced osteoporosis off-label use 14651005
Intracranial hemorrhage contraindication 1386000
Anuria contraindication 2472002 DOID:2983
Hypophosphatemia contraindication 4996001
Hypocalcemia contraindication 5291005
Bone pain contraindication 12584003
Hyperkalemia contraindication 14140009
Hypovolemia contraindication 28560003
Dehydration contraindication 34095006
Hypoparathyroidism contraindication 36976004 DOID:11199
Hypernatremia contraindication 39355002
Chronic heart failure contraindication 48447003
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Pulmonary congestion contraindication 67599009
Muscle pain contraindication 68962001
Fracture of femur contraindication 71620000
Oliguria contraindication 83128009
Hyponatremia contraindication 89627008
Small intestine excision contraindication 107938000
Hypomagnesemia contraindication 190855004
Impaired renal function disorder contraindication 197663003
Tooth disorder contraindication 234947003 DOID:1091
Fragile capillaries contraindication 248726001
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Aseptic necrosis of bone of jaw contraindication 441809006
Severe dehydration contraindication 450316000
Invasive Dental Procedure contraindication
Thyroid Surgery contraindication
Malabsorption States contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.38 acidic
pKa2 5.45 acidic
pKa3 6.59 acidic
pKa4 10.35 acidic
pKa5 11.04 acidic
pKa6 5.92 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 5MG BASE/100ML RECLAST NOVARTIS N021817 April 16, 2007 RX INJECTABLE INTRAVENOUS 8052987 Oct. 27, 2023 TREATMENT AND PREVENTION OF POSTMENOPAUSAL OR GLUCOCORTICOID-INDUCED OSTEOPOROSIS AND TREATMENT TO INCREASE BONE MASS IN MEN WITH OSTEOPOROSIS
EQ 4MG BASE/100ML ZOMETA NOVARTIS N021223 June 17, 2011 RX INJECTABLE INTRAVENOUS 8324189 May 29, 2025 BONE METASTASES
EQ 4MG BASE/100ML ZOMETA NOVARTIS N021223 June 17, 2011 RX INJECTABLE INTRAVENOUS 8324189 May 29, 2025 HYPERCALCEMIA OF MALIGNANCY
EQ 4MG BASE/100ML ZOMETA NOVARTIS N021223 June 17, 2011 RX INJECTABLE INTRAVENOUS 8324189 May 29, 2025 MULTIPLE MYELOMA
EQ 4MG BASE/5ML ZOMETA NOVARTIS N021223 March 7, 2003 RX INJECTABLE INTRAVENOUS 8324189 May 29, 2025 BONE METASTASES
EQ 4MG BASE/5ML ZOMETA NOVARTIS N021223 March 7, 2003 RX INJECTABLE INTRAVENOUS 8324189 May 29, 2025 HYPERCALCEMIA OF MALIGNANCY
EQ 4MG BASE/5ML ZOMETA NOVARTIS N021223 March 7, 2003 RX INJECTABLE INTRAVENOUS 8324189 May 29, 2025 MULTIPLE MYELOMA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme INHIBITOR Ki 10.15 CHEMBL CHEMBL
72 kDa type IV collagenase Enzyme IC50 5.15 CHEMBL
Neutrophil collagenase Enzyme IC50 4.75 CHEMBL
Geranylgeranyl pyrophosphate synthase Enzyme Ki 5.57 CHEMBL
Carbonic anhydrase 2 Enzyme IC50 7.21 CHEMBL
Carbonic anhydrase 14 Enzyme IC50 7.04 CHEMBL
Carbonic anhydrase 12 Enzyme IC50 6.50 CHEMBL
Carbonic anhydrase 9 Enzyme IC50 5.27 CHEMBL
Matrix metalloproteinase-14 Enzyme IC50 4.90 CHEMBL
Matrix metalloproteinase-9 Enzyme IC50 4.28 CHEMBL
Geranylgeranyl pyrophosphate synthase Enzyme Ki 6.59 CHEMBL
Farnesyl pyrophosphate synthase Enzyme Ki 7.96 CHEMBL
Farnesyl diphosphate synthase Enzyme IC50 5.96 CHEMBL
Farnesyl pyrophosphate synthase Unclassified INHIBITOR IC50 6.30 IUPHAR

External reference:

IDSource
D000077211 MESH_DESCRIPTOR_UI
4021276 VUID
N0000179387 NUI
C0257685 UMLSCUI
D01968 KEGG_DRUG
6XC1PAD3KF UNII
165800-06-6 SECONDARY_CAS_RN
134600006 SNOMEDCT_US
008997 NDDF
199263 MMSL
d04708 MMSL
15839 MMSL
77655 RXNORM
4021276 VANDF
395926009 SNOMEDCT_US
CHEBI:46557 CHEBI
CHEMBL924 ChEMBL_ID
DB00399 DRUGBANK_ID
ZOL PDB_CHEM_ID
68740 PUBCHEM_CID
3177 IUPHAR_LIGAND_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Zometa HUMAN PRESCRIPTION DRUG LABEL 1 0078-0387 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS NDA 17 sections
Reclast HUMAN PRESCRIPTION DRUG LABEL 1 0078-0435 INJECTION, SOLUTION 5 mg INTRAVENOUS NDA 17 sections
Zometa HUMAN PRESCRIPTION DRUG LABEL 1 0078-0590 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS NDA 17 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0143-9642 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS ANDA 17 sections
ZOLEDRONIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0409-4215 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS ANDA 18 sections
ZOLEDRONIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 0409-4228 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 17 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 0409-4229 INJECTION, SOLUTION 4 mg INTRAVENOUS NDA 18 sections
Zoledronic acid HUMAN PRESCRIPTION DRUG LABEL 1 16714-815 INJECTION 4 mg INTRAVENOUS ANDA 17 sections
Zoledronic acid HUMAN PRESCRIPTION DRUG LABEL 1 16729-242 INJECTION 4 mg INTRAVENOUS ANDA 17 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 17478-324 SOLUTION 5 mg INTRAVENOUS ANDA 17 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 17478-327 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS ANDA 16 sections
Zoledronic acid HUMAN PRESCRIPTION DRUG LABEL 1 23155-170 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS ANDA 16 sections
Zoledronic acid HUMAN PRESCRIPTION DRUG LABEL 1 23155-186 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 17 sections
zoledronic acid HUMAN PRESCRIPTION DRUG LABEL 1 25021-801 INJECTION, SOLUTION, CONCENTRATE 0.80 mg INTRAVENOUS ANDA 17 sections
zoledronic acid HUMAN PRESCRIPTION DRUG LABEL 1 25021-826 INJECTION, SOLUTION 0.04 mg INTRAVENOUS NDA 16 sections
zoledronic acid HUMAN PRESCRIPTION DRUG LABEL 1 25021-830 INJECTION, SOLUTION 0.05 mg INTRAVENOUS ANDA 17 sections
Zoledronic acid HUMAN PRESCRIPTION DRUG LABEL 1 43598-255 INJECTION, SOLUTION 4 mg INTRAVENOUS ANDA 16 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 43598-330 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS ANDA 16 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 43598-331 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 18 sections
zoledronic acid HUMAN PRESCRIPTION DRUG LABEL 1 50742-416 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS ANDA 17 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 51991-064 INJECTION 5 mg INTRAVENOUS ANDA 17 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 51991-065 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS ANDA 18 sections
ZOLEDRONIC ACID HUMAN PRESCRIPTION DRUG LABEL 1 54288-100 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS ANDA 17 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 55111-685 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS ANDA 16 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 55111-688 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 18 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 55150-266 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS ANDA 17 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 55150-283 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 17 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 60505-6110 INJECTION, SOLUTION, CONCENTRATE 4 mg INTRAVENOUS ANDA 16 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 63323-961 INJECTION 4 mg INTRAVENOUS ANDA 17 sections
Zoledronic Acid HUMAN PRESCRIPTION DRUG LABEL 1 63323-966 INJECTION, SOLUTION 5 mg INTRAVENOUS ANDA 17 sections