alfacalcidol ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 130 41294-56-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alfacalcidol
  • 1alpha-Hydroxycholecalciferol
  • alfarol
  • alphacalcidol
  • einsalpha
  • alpha-calcidol
  • 1-hydroxycholecalciferol
  • Molecular weight: 400.65
  • Formula: C27H44O2
  • CLOGP: 8.24
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -5.39
  • ROTB: 6

Drug dosage:

DoseUnitRoute
1 mcg O
1 mcg P
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 8 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.00 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 71 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance) 0.82 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 48.60 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1978 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Muscle spasticity 476.39 14.88 191 17340 21603 63449888
Respiratory disorder 401.60 14.88 202 17329 38880 63432611
Ear pain 392.73 14.88 194 17337 35924 63435567
Body temperature increased 381.45 14.88 192 17339 37000 63434491
Night sweats 359.34 14.88 202 17329 48612 63422879
Urticaria 167.28 14.88 217 17314 165585 63305906
Lower respiratory tract infection 163.81 14.88 192 17339 132115 63339376
Hypocalcaemia 152.53 14.88 100 17431 31613 63439878
Insomnia 144.24 14.88 232 17299 215020 63256471
Back pain 129.33 14.88 248 17283 263897 63207594
Abdominal pain upper 115.01 14.88 205 17326 206239 63265252
Hypercalcaemia 109.36 14.88 78 17453 28244 63443247
Sinusitis 99.02 14.88 203 17328 226450 63245041
Hepatic function abnormal 96.79 14.88 81 17450 37061 63434430
Pruritus 92.40 14.88 263 17268 361190 63110301
Upper respiratory tract inflammation 91.20 14.88 32 17499 2491 63469000
Peripheral swelling 89.97 14.88 215 17316 265727 63205764
Osteonecrosis of jaw 88.24 14.88 75 17456 35048 63436443
Shunt stenosis 88.03 14.88 22 17509 518 63470973
Spinal compression fracture 83.55 14.88 51 17480 14232 63457259
Renal impairment 81.78 14.88 111 17420 88244 63383247
Drug ineffective 81.45 14.88 102 17429 1044663 62426828
Vomiting 69.75 14.88 322 17209 559295 62912196
Asthenia 68.62 14.88 247 17284 383357 63088134
Incorrect route of product administration 61.64 14.88 55 17476 27397 63444094
Diarrhoea 61.25 14.88 371 17160 714995 62756496
Fatigue 54.33 14.88 102 17429 887926 62583565
Drug intolerance 53.96 14.88 10 17521 308651 63162840
Joint swelling 51.08 14.88 202 17329 327464 63144027
Rash 49.23 14.88 293 17238 560578 62910913
Product dose omission issue 47 14.88 5 17526 234308 63237183
Drug hypersensitivity 44.78 14.88 15 17516 310672 63160819
Blood parathyroid hormone increased 44.28 14.88 20 17511 3018 63468473
Shunt occlusion 42.57 14.88 13 17518 652 63470839
Cerebral infarction 42.37 14.88 42 17489 23851 63447640
Interstitial lung disease 40.32 14.88 66 17465 61842 63409649
Atypical femur fracture 38.82 14.88 22 17509 5350 63466141
Enteritis infectious 34.22 14.88 15 17516 2109 63469382
Ileus 34.04 14.88 30 17501 14695 63456796
Hyperuricaemia 33.53 14.88 20 17511 5350 63466141
Iron deficiency anaemia 33.39 14.88 34 17497 19935 63451556
Abdominal discomfort 33.38 14.88 24 17507 320861 63150630
Cardiac failure 32.14 14.88 74 17457 89068 63382423
Toxoplasmosis 32.03 14.88 13 17518 1510 63469981
Alopecia 31.65 14.88 28 17503 337508 63133983
Lymph node palpable 31.05 14.88 7 17524 104 63471387
Nausea 28.78 14.88 130 17401 854341 62617150
Tetany 28.61 14.88 13 17518 1988 63469503
Large intestine polyp 28.15 14.88 21 17510 8136 63463355
Treatment failure 27.98 14.88 10 17521 199033 63272458
Anxiety 25.74 14.88 14 17517 217527 63253964
Gastroenteritis 25.48 14.88 34 17497 26556 63444935
Headache 25.13 14.88 276 17255 632965 62838526
Glossodynia 25.12 14.88 9 17522 178867 63292624
Toxicity to various agents 25.04 14.88 19 17512 247231 63224260
Anaemia 24.80 14.88 152 17379 293278 63178213
Nephrogenic anaemia 24.61 14.88 12 17519 2150 63469341
Death 24.57 14.88 41 17490 374340 63097151
Osteomyelitis 24.51 14.88 33 17498 25987 63445504
Milk-alkali syndrome 24.29 14.88 9 17522 819 63470672
Beta 2 microglobulin urine increased 23.91 14.88 5 17526 51 63471440
Arthropathy 23.83 14.88 18 17513 234774 63236717
Platelet count decreased 23.46 14.88 78 17453 116044 63355447
Therapeutic drug monitoring analysis incorrectly performed 23.20 14.88 7 17524 337 63471154
Peritonitis 23.02 14.88 26 17505 17128 63454363
Periodontitis 22.46 14.88 13 17518 3290 63468201
Hand deformity 22.42 14.88 8 17523 159449 63312042
Enterocolitis 22.26 14.88 18 17513 7840 63463651
Peripheral arterial occlusive disease 22.03 14.88 14 17517 4187 63467304
Haemodialysis complication 21.67 14.88 6 17525 212 63471279
Musculoskeletal stiffness 21.66 14.88 12 17519 184606 63286885
Rheumatoid arthritis 21.52 14.88 23 17508 253796 63217695
Chronic gastritis 21.52 14.88 12 17519 2829 63468662
Oncocytoma 21.30 14.88 4 17527 22 63471469
Immunosuppressant drug level increased 21.29 14.88 13 17518 3625 63467866
Disseminated intravascular coagulation 20.82 14.88 26 17505 19025 63452466
Calciphylaxis 20.65 14.88 12 17519 3060 63468431
Enterocolitis viral 20.43 14.88 6 17525 263 63471228
Marasmus 20.29 14.88 7 17524 518 63470973
Premature rupture of membranes 19.83 14.88 14 17517 4979 63466512
Infusion related reaction 18.93 14.88 24 17507 245497 63225994
Pneumonia aspiration 18.77 14.88 34 17497 34506 63436985
Pemphigus 18.75 14.88 14 17517 183712 63287779
Wound 18.60 14.88 11 17520 163252 63308239
Discomfort 18.07 14.88 12 17519 167362 63304129
Hyperhidrosis 17.77 14.88 4 17527 107832 63363659
Hypoalbuminaemia 17.76 14.88 19 17512 11786 63459705
Neuropsychiatric lupus 17.71 14.88 5 17526 190 63471301
Loss of personal independence in daily activities 17.30 14.88 3 17528 97287 63374204
Precocious puberty 16.94 14.88 5 17526 223 63471268
Shunt infection 16.87 14.88 4 17527 75 63471416
Colon cancer 16.84 14.88 17 17514 9861 63461630
Community acquired infection 16.76 14.88 3 17528 12 63471479
Liver disorder 16.58 14.88 42 17489 53645 63417846
Hypophosphataemia 16.51 14.88 18 17513 11408 63460083
Neurosis 16.14 14.88 5 17526 263 63471228
Muscle injury 16.06 14.88 47 17484 65298 63406193
Blood albumin decreased 15.89 14.88 20 17511 14746 63456745
Injection site pain 15.87 14.88 8 17523 129792 63341699
Autoimmune pancytopenia 15.78 14.88 4 17527 100 63471391
Oesophageal mucosal tear 15.75 14.88 3 17528 18 63471473
Feeling abnormal 15.54 14.88 11 17520 148381 63323110
Chills 15.41 14.88 6 17525 113372 63358119
Retinal haemorrhage 15.40 14.88 12 17519 4957 63466534
Hungry bone syndrome 15.34 14.88 4 17527 112 63471379
Immobilisation syndrome 15.22 14.88 5 17526 318 63471173
Pharyngitis 15.22 14.88 23 17508 20120 63451371
Hypotension 15.11 14.88 33 17498 272571 63198920

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Shunt stenosis 148.16 17.20 35 8378 747 34947771
Oesophageal perforation 119.02 17.20 32 8381 1167 34947351
Hypocalcaemia 117.42 17.20 73 8340 24216 34924302
Soft tissue mass 114.50 17.20 30 8383 989 34947529
Multimorbidity 111.97 17.20 29 8384 913 34947605
Shunt occlusion 109.34 17.20 28 8385 842 34947676
Immunosuppressant drug level increased 97.37 17.20 41 8372 6014 34942504
Superinfection 87.71 17.20 30 8383 2489 34946029
Transplant failure 81.22 17.20 31 8382 3522 34944996
Myocardial ischaemia 68.51 17.20 46 8367 17362 34931156
Inflammatory marker increased 67.58 17.20 30 8383 4998 34943520
Oesophageal carcinoma 63.53 17.20 35 8378 9269 34939249
Lung consolidation 62.81 17.20 30 8383 5906 34942612
Renal impairment 61.00 17.20 93 8320 94420 34854098
Labelled drug-drug interaction medication error 60.04 17.20 40 8373 14899 34933619
Cardiomegaly 51.82 17.20 37 8376 15401 34933117
Osteonecrosis of jaw 49.13 17.20 38 8375 17851 34930667
Rales 48.47 17.20 30 8383 9853 34938665
Hepatic function abnormal 42.70 17.20 53 8360 44310 34904208
Upper respiratory tract inflammation 42.69 17.20 16 8397 1728 34946790
Anti-erythropoietin antibody negative 42.61 17.20 10 8403 207 34948311
Procalcitonin abnormal 41.73 17.20 11 8402 371 34948147
Aplasia pure red cell 41.67 17.20 23 8390 6109 34942409
Hypercalcaemia 38.47 17.20 31 8382 15437 34933081
Drug level increased 38.22 17.20 36 8377 22060 34926458
Encephalomalacia 32.94 17.20 11 8402 847 34947671
Pleural effusion 32.59 17.20 65 8348 81481 34867037
Neuromyopathy 30.93 17.20 11 8402 1023 34947495
Drug ineffective 30.81 17.20 39 8374 456712 34491806
Calciphylaxis 30.35 17.20 11 8402 1081 34947437
Ascites 30.23 17.20 46 8367 46525 34901993
Dysphagia 28.95 17.20 53 8360 62328 34886190
Drug interaction 28.83 17.20 119 8294 225827 34722691
Lower respiratory tract infection 27.59 17.20 36 8377 31601 34916917
Fatigue 26.72 17.20 30 8383 370623 34577895
PO2 decreased 26.39 17.20 11 8402 1570 34946948
Haemoptysis 26.22 17.20 37 8376 34969 34913549
Retinopathy hypertensive 25.40 17.20 7 8406 280 34948238
PCO2 decreased 25.16 17.20 11 8402 1765 34946753
Cerebral infarction 25.13 17.20 32 8381 27423 34921095
Device related sepsis 24.94 17.20 13 8400 3080 34945438
Interstitial lung disease 24.84 17.20 51 8362 65231 34883287
Peripheral arterial occlusive disease 24.25 17.20 16 8397 5858 34942660
C-reactive protein increased 23.89 17.20 45 8368 54053 34894465
Pneumonia 22.76 17.20 157 8256 362470 34586048
Disseminated intravascular coagulation 22.49 17.20 27 8386 21789 34926729
Renal tubular acidosis 22.36 17.20 11 8402 2308 34946210
Lymphocyte count increased 21.17 17.20 12 8401 3353 34945165
Nephrotic syndrome 21.11 17.20 16 8397 7287 34941231
Acute kidney injury 20.89 17.20 135 8278 304853 34643665
Hypoglycaemia 19.97 17.20 42 8371 54598 34893920
Monocyte count increased 19.92 17.20 13 8400 4674 34943844
Hepatosplenomegaly neonatal 19.75 17.20 4 8409 40 34948478
Pyrexia 19.60 17.20 142 8271 332871 34615647
Bradycardia foetal 19.45 17.20 6 8407 358 34948160
Myeloperoxidase deficiency 19.40 17.20 4 8409 44 34948474
Extraskeletal ossification 18.86 17.20 4 8409 51 34948467
Hyperkalaemia 18.39 17.20 47 8366 69342 34879176
Immune thrombocytopenia 17.94 17.20 16 8397 9136 34939382
Low birth weight baby 17.89 17.20 15 8398 7890 34940628
Productive cough 17.37 17.20 32 8381 37781 34910737

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hypocalcaemia 235.60 13.24 160 23567 49764 79670897
Shunt stenosis 224.22 13.24 57 23670 1334 79719327
Muscle spasticity 203.97 13.24 108 23619 21367 79699294
Ear pain 166.21 13.24 110 23617 32759 79687902
Respiratory disorder 152.75 13.24 118 23609 44738 79675923
Body temperature increased 145.07 13.24 114 23613 44306 79676355
Shunt occlusion 144.71 13.24 41 23686 1463 79719198
Hypercalcaemia 139.44 13.24 105 23622 38325 79682336
Night sweats 137.24 13.24 118 23609 51977 79668684
Osteonecrosis of jaw 130.62 13.24 106 23621 43120 79677541
Hepatic function abnormal 128.02 13.24 132 23595 72975 79647686
Upper respiratory tract inflammation 126.61 13.24 47 23680 3988 79716673
Renal impairment 123.00 13.24 190 23537 157593 79563068
Oesophageal perforation 112.24 13.24 34 23693 1537 79719124
Spinal compression fracture 101.17 13.24 63 23664 16895 79703766
Soft tissue mass 96.87 13.24 29 23698 1259 79719402
Multimorbidity 89.50 13.24 28 23699 1411 79719250
Drug ineffective 89.25 13.24 115 23612 1080798 78639863
Lower respiratory tract infection 83.52 13.24 143 23584 129077 79591584
Immunosuppressant drug level increased 81.75 13.24 44 23683 8983 79711678
Fatigue 68.61 13.24 107 23620 929620 78791041
Transplant failure 66.85 13.24 31 23696 4610 79716051
Blood parathyroid hormone increased 62.36 13.24 27 23700 3418 79717243
Superinfection 62.19 13.24 30 23697 4872 79715789
Interstitial lung disease 61.71 13.24 116 23611 112484 79608177
Cerebral infarction 61.71 13.24 72 23655 45604 79675057
Aplasia pure red cell 56.90 13.24 33 23694 7777 79712884
Oesophageal carcinoma 48.64 13.24 34 23693 11050 79709611
Urticaria 48.64 13.24 143 23584 185058 79535603
Myocardial ischaemia 48.14 13.24 48 23679 25471 79695190
Inflammatory marker increased 47.26 13.24 33 23694 10707 79709954
Drug intolerance 46.05 13.24 11 23716 264108 79456553
Peripheral arterial occlusive disease 45.05 13.24 29 23698 8229 79712432
Insomnia 44.45 13.24 167 23560 245003 79475658
Incorrect route of product administration 43.78 13.24 53 23674 34876 79685785
Product dose omission issue 43.77 13.24 10 23717 247527 79473134
Labelled drug-drug interaction medication error 43.17 13.24 47 23680 27603 79693058
Lung consolidation 42.93 13.24 29 23698 8918 79711743
Disseminated intravascular coagulation 42.68 13.24 53 23674 35789 79684872
Platelet count decreased 42.51 13.24 141 23586 194523 79526138
Drug hypersensitivity 40.72 13.24 19 23708 298897 79421764
Hyperuricaemia 40.05 13.24 31 23696 11768 79708893
Procalcitonin abnormal 39.19 13.24 11 23716 379 79720282
Anti-erythropoietin antibody negative 36.31 13.24 10 23717 321 79720340
Anaemia 36.00 13.24 241 23486 444774 79275887
Back pain 35.83 13.24 182 23545 303998 79416663
Gastroenteritis 33.72 13.24 46 23681 34036 79686625
Completed suicide 32.88 13.24 16 23711 245751 79474910
Diarrhoea 32.53 13.24 402 23325 880087 78840574
Enteritis infectious 32.28 13.24 17 23710 3321 79717340
Hyperhidrosis 31.42 13.24 4 23723 151488 79569173
Calciphylaxis 30.34 13.24 17 23710 3753 79716908
Cardiac failure 30.16 13.24 108 23619 154734 79565927
Periodontitis 30.13 13.24 18 23709 4478 79716183
Large intestine polyp 29.87 13.24 27 23700 12681 79707980
Cardiomegaly 29.83 13.24 38 23689 26314 79694347
Tetany 29.57 13.24 15 23712 2713 79717948
Abdominal pain upper 28.53 13.24 137 23590 223682 79496979
Atypical femur fracture 27.76 13.24 18 23709 5171 79715490
Pruritus 27.38 13.24 206 23521 394442 79326219
Lymph node palpable 27.32 13.24 7 23720 169 79720492
Encephalomalacia 26.71 13.24 11 23716 1230 79719431
Chronic gastritis 26.52 13.24 16 23711 4052 79716609
Nausea 26.33 13.24 172 23555 957024 78763637
Hungry bone syndrome 26.30 13.24 7 23720 197 79720464
Pneumonia aspiration 26.10 13.24 60 23667 66907 79653754
Iron deficiency anaemia 25.93 13.24 35 23692 25637 79695024
Anxiety 25.33 13.24 22 23705 248490 79472171
Nephrotic syndrome 24.82 13.24 23 23704 11151 79709510
Treatment failure 24.52 13.24 10 23717 170476 79550185
Rales 24.49 13.24 30 23697 19971 79700690
Neuromyopathy 24.30 13.24 11 23716 1547 79719114
Liver disorder 24.06 13.24 61 23666 72356 79648305
Toxoplasmosis 24.01 13.24 13 23714 2684 79717977
Ileus 23.88 13.24 34 23693 26177 79694484
Beta 2 microglobulin urine increased 23.65 13.24 6 23721 139 79720522
Peritonitis 23.55 13.24 35 23692 28001 79692660
Hypophosphataemia 22.99 13.24 29 23698 19884 79700777
Haemoptysis 22.74 13.24 51 23676 55948 79664713
Ascites 22.40 13.24 61 23666 75501 79645160
Sinusitis 22.31 13.24 116 23611 195385 79525276
Pyrexia 22.10 13.24 303 23424 678406 79042255
Osteomyelitis 22.03 13.24 37 23690 32828 79687833
Enterocolitis viral 21.76 13.24 7 23720 386 79720275
Enterocolitis 21.49 13.24 24 23703 14488 79706173
Premature rupture of membranes 21.48 13.24 14 23713 4055 79716606
Retinopathy hypertensive 20.01 13.24 7 23720 500 79720161
Rash 19.97 13.24 261 23466 578097 79142564
Vomiting 19.97 13.24 293 23434 665535 79055126
Oncocytoma 19.93 13.24 4 23723 30 79720631
Concomitant disease aggravated 19.89 13.24 22 23705 13145 79707516
Injection site pain 19.70 13.24 7 23720 129831 79590830
Immobilisation syndrome 19.61 13.24 7 23720 531 79720130
Nephrogenic anaemia 19.57 13.24 13 23714 3889 79716772
Abdominal discomfort 19.21 13.24 28 23699 250699 79469962
Hypoglycaemia 19.04 13.24 70 23657 101524 79619137
Milk-alkali syndrome 18.95 13.24 9 23718 1411 79719250
Haemodialysis complication 18.92 13.24 6 23721 316 79720345
Pharyngitis 18.89 13.24 28 23699 22347 79698314
Death 18.63 13.24 96 23631 566418 79154243
Pleural effusion 18.55 13.24 89 23638 145173 79575488
Musculoskeletal stiffness 18.43 13.24 15 23712 174993 79545668
Marasmus 18.42 13.24 8 23719 1020 79719641
Renal tubular acidosis 18.03 13.24 12 23715 3602 79717059
Decreased appetite 18.00 13.24 168 23559 342250 79378411
Hyperphosphataemia 17.92 13.24 15 23712 6361 79714300
Premature delivery 17.88 13.24 28 23699 23439 79697222
Hypotension 17.85 13.24 69 23658 440248 79280413
Therapeutic drug monitoring analysis incorrectly performed 17.66 13.24 7 23720 709 79719952
PO2 decreased 17.65 13.24 11 23716 2952 79717709
Immune thrombocytopenia 17.56 13.24 24 23703 17781 79702880
Hyperkalaemia 17.54 13.24 74 23653 114324 79606337
Infusion related reaction 17.35 13.24 26 23701 230211 79490450
Intentional overdose 17.34 13.24 5 23722 105955 79614706
Neuropsychiatric lupus 17.29 13.24 5 23722 192 79720469
Haemorrhage subcutaneous 17.12 13.24 13 23714 4796 79715865
Drug level increased 17.10 13.24 37 23690 39614 79681047
PCO2 decreased 17.02 13.24 11 23716 3143 79717518
Shunt infection 16.93 13.24 5 23722 207 79720454
Pain in extremity 16.87 13.24 54 23673 364484 79356177
Depression 16.81 13.24 24 23703 216766 79503895
Calcium metabolism disorder 16.78 13.24 4 23723 71 79720590
Colon cancer 16.53 13.24 21 23706 14502 79706159
Loss of personal independence in daily activities 16.49 13.24 5 23722 102575 79618086
Pneumonia 16.19 13.24 281 23446 659965 79060696
Hyperparathyroidism secondary 16.16 13.24 10 23717 2650 79718011
Pneumonia bacterial 16.04 13.24 24 23703 19307 79701354
Oesophageal mucosal tear 15.83 13.24 3 23724 16 79720645
Skin erosion 15.79 13.24 12 23715 4433 79716228
Shunt malfunction 15.72 13.24 5 23722 266 79720395
Acute kidney injury 15.72 13.24 229 23498 519175 79201486
Femoral neck fracture 15.63 13.24 17 23710 9967 79710694
Sepsis 15.59 13.24 135 23592 269293 79451368
Cholangitis 15.38 13.24 19 23708 12757 79707904
Eczema asteatotic 15.21 13.24 6 23721 600 79720061
Feeling abnormal 15.14 13.24 15 23712 159184 79561477
Disease progression 14.70 13.24 20 23707 184342 79536319
Precocious puberty 14.68 13.24 5 23722 330 79720331
Community acquired infection 14.46 13.24 3 23724 27 79720634
Femur fracture 14.37 13.24 34 23693 38618 79682043
Calculus urinary 14.32 13.24 9 23718 2451 79718210
Thalamus haemorrhage 14.24 13.24 8 23719 1774 79718887
Aortic dissection 14.24 13.24 11 23716 4164 79716497
Device related sepsis 14.16 13.24 13 23714 6227 79714434
Pemphigoid 14.14 13.24 20 23707 15295 79705366
Idiopathic pulmonary fibrosis 14.11 13.24 11 23716 4217 79716444
Chronic obstructive pulmonary disease 14.03 13.24 4 23723 85415 79635246
Alopecia 13.95 13.24 30 23697 231325 79489336
Myeloperoxidase deficiency 13.92 13.24 3 23724 33 79720628
Memory impairment 13.86 13.24 8 23719 111726 79608935
Protein urine present 13.75 13.24 16 23711 10096 79710565
Suicidal ideation 13.65 13.24 3 23724 76337 79644324
Suicide attempt 13.41 13.24 4 23723 82928 79637733
Stag horn calculus 13.40 13.24 4 23723 172 79720489
Shunt aneurysm 13.39 13.24 3 23724 40 79720621
Neurosis 13.38 13.24 5 23722 432 79720229
Arthropathy 13.34 13.24 20 23707 177091 79543570

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CC03 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC M05BB06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
MeSH PA D050071 Bone Density Conservation Agents
CHEBI has role CHEBI:50646 antiosteoporotic

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Renal osteodystrophy indication 16726004 DOID:13068
Hypoparathyroidism indication 36976004 DOID:11199
Hyperparathyroidism indication 66999008 DOID:13543
Neonatal hypocalcemia indication 268846006




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.7 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST WOMBAT-PK KEGG DRUG
Sodium-dependent noradrenaline transporter Transporter Ki 6 DRUG MATRIX

External reference:

IDSource
D01518 KEGG_DRUG
12062 RXNORM
C0044410 UMLSCUI
CHEBI:31186 CHEBI
M9B PDB_CHEM_ID
CHEMBL1601669 ChEMBL_ID
DB01436 DRUGBANK_ID
C008088 MESH_SUPPLEMENTAL_RECORD_UI
5282181 PUBCHEM_CID
4489 INN_ID
URQ2517572 UNII
11984007 SNOMEDCT_US
329325000 SNOMEDCT_US
003501 NDDF

Pharmaceutical products:

None