alfacalcidol indications/contra

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 130 41294-56-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alfacalcidol
  • 1alpha-Hydroxycholecalciferol
  • alfarol
  • alphacalcidol
  • einsalpha
  • alpha-calcidol
  • 1-hydroxycholecalciferol
  • Molecular weight: 400.64
  • Formula: C27H44O2
  • CLOGP: 8.24
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -5.39
  • RINGS: 3
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.00 mg O
0.00 mg P

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1978 YEAR INTRODUCED

Pharmacologic Action:

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SourceCodeDescription
ATC A11CC03 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC M05BB06 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
MeSH PA D050071 Bone Density Conservation Agents
CHEBI has role CHEBI:50646 bone density conservation agent

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Renal osteodystrophy indication 16726004 DOID:13068
Hypoparathyroidism indication 36976004 DOID:11199
Hyperparathyroidism indication 66999008 DOID:13543
Neonatal hypocalcemia indication 268846006

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST WOMBAT-PK KEGG DRUG
Sodium-dependent noradrenaline transporter Transporter Ki 6 DRUG MATRIX

External reference:

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IDSource
003501 NDDF
12062 RXNORM
11984007 SNOMEDCT_US
329325000 SNOMEDCT_US
DB01436 DRUGBANK_ID
C008088 MESH_SUPPLEMENTAL_RECORD_UI
D01518 KEGG_DRUG
4489 INN_ID
URQ2517572 UNII
CHEBI:31186 CHEBI
5282181 PUBCHEM_CID
CHEMBL1601669 ChEMBL_ID
C0044410 UMLSCUI

Pharmaceutical products:

None