alfacalcidol indications/contra

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 130 41294-56-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alfacalcidol
  • 1alpha-Hydroxycholecalciferol
  • alfarol
  • alphacalcidol
  • einsalpha
  • alpha-calcidol
  • 1-hydroxycholecalciferol
  • Molecular weight: 400.64
  • Formula: C27H44O2
  • CLOGP: 8.24
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -5.39
  • RINGS: 3
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.00 mg O
0.00 mg P

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1978 YEAR INTRODUCED

Pharmacologic Action:

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SourceCodeDescription
ATC A11CC03 Alimentary Tract And Metabolism
Vitamins
Vitamin A And D, Incl. Combinations Of The Two
Vitamin D and analogues
ATC M05BB06 Musculo-skeletal System
Drugs For Treatment Of Bone Diseases
Drugs Affecting Bone Structure And Mineralization
Bisphosphonates, combinations
MeSH PA D050071 Bone Density Conservation Agents
CHEBI has role CHEBI:50646 bone density conservation agent

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Renal osteodystrophy indication 16726004 DOID:13068
Hypoparathyroidism indication 36976004 DOID:11199
Hyperparathyroidism indication 66999008 DOID:13543
Neonatal hypocalcemia indication 268846006

Bioactivity Summary:

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TargetClassSwissprotActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor VDR_HUMAN AGONIST WOMBAT-PK KEGG DRUG
Sodium-dependent noradrenaline transporter Transporter SC6A2_HUMAN Ki 6 DRUG MATRIX

External reference:

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IDSource
CHEBI:31186 Chemical Entities of Biological Interest
CHEMBL1601669 ChEMBL DB Compound ID
DB01436 DrugBank ID
4489 Sequential number assigned by World Health Organization's International Nonproprietary Name (INN) Programme
D01518 KEGG DRUG Database ID
C008088 Medical Subject Headings (MeSH) Supplemental Record Unique ID
5282181 PubChem Compound Id
12062 RxNorm Vocabulary
329325000 US Edition of SNOMED CT
11984007 US Edition of SNOMED CT
URQ2517572 FDA Unique Ingredient Identifier Code

Pharmaceutical products:

None