nedocromil indications/contra

Stem definitionDrug idCAS RN
antiallergics, cromoglicic acid derivatives 1889 69049-73-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nedocromil
  • nedocromil sodium
A pyranoquinolone derivative that inhibits activation of inflammatory cells which are associated with ASTHMA, including eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.
  • Molecular weight: 371.35
  • Formula: C19H17NO7
  • CLOGP: 1.50
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 121.21
  • ALOGS: -3.91
  • ROTB: 5

Drug dosage:

DoseUnitRoute
10.40 mg N
8 mg Inhal.aerosol

Approvals:

DateAgencyCompanyOrphan
Dec. 30, 1992 FDA KING PHARMS

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC R01AC07 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Antiallergic agents, excl. corticosteroids
ATC R03BC03 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Antiallergic agents, excl. corticosteroids
ATC S01GX04 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Other antiallergics
FDA PE N0000175628 Decreased Histamine Release
FDA EPC N0000175630 Mast Cell Stabilizer
MeSH PA D018926 Anti-Allergic Agents
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:49167 anti-asthmatic drug
CHEBI has role CHEBI:50857 anti-allergic agent

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Asthma indication 195967001 DOID:2841
Asthma management indication 406162001
Allergic conjunctivitis indication 473460002 DOID:11204
Ocular Itching indication
Bronchospasm Prevention off-label use

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.51 acidic
pKa2 3.02 acidic
pKa3 4.8 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
G-protein coupled receptor 35 GPCR AGONIST EC50 6.01 SCIENTIFIC LITERATURE
Cysteinyl leukotriene receptor 1 GPCR WOMBAT-PK

External reference:

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IDSource
4023599 VUID
N0000021604 NUI
C0068483 UMLSCUI
7607 IUPHAR_LIGAND_ID
D00527 KEGG_DRUG
0B535E0BN0 UNII
5420 INN_ID
DB00716 DRUGBANK_ID
CHEMBL746 ChEMBL_ID
CHEMBL915 ChEMBL_ID
4023599 VANDF
N0000007491 NDFRT
N0000021604 NDFRT
31563 RXNORM
108627004 SNOMEDCT_US
372519004 SNOMEDCT_US
d03112 MMSL
003747 NDDF
50294 PUBCHEM_CID
69049-74-7 SECONDARY_CAS_RN
D017835 MESH_DESCRIPTOR_UI
CHEBI:7492 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
ALOCRIL HUMAN PRESCRIPTION DRUG LABEL 1 0023-8842 SOLUTION/ DROPS 20 mg OPHTHALMIC NDA 11 sections
Nedocromil Sodium HUMAN PRESCRIPTION DRUG LABEL 1 17478-066 SOLUTION/ DROPS 20 mg OPHTHALMIC ANDA 11 sections