lodoxamide indications/contra

Stem definitionDrug idCAS RN
3325 53882-12-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lodoxamide
  • lodoxamide tromethamine
  • lodoxamide trometamol
  • alomide
  • U 42585E
  • U-42,585E
  • Molecular weight: 311.63
  • Formula: C11H6ClN3O6
  • CLOGP: -2.24
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 4
  • TPSA: 156.59
  • ALOGS: -3.94
  • ROTB: 4

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 23, 1993 FDA ALCON

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC S01GX05 SENSORY ORGANS
OPHTHALMOLOGICALS
DECONGESTANTS AND ANTIALLERGICS
Other antiallergics
FDA PE N0000175628 Decreased Histamine Release
FDA EPC N0000175630 Mast Cell Stabilizer
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006634 Histamine H1 Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Vernal keratoconjunctivitis indication 317349009
Vernal conjunctivitis indication 318316003 DOID:2474
Vernal Keratitis indication
Giant papillary conjunctivitis off-label use 231857004 DOID:2457
Allergic conjunctivitis off-label use 473460002 DOID:11204
Allergic Keratoconjunctivitis off-label use

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 0.9 acidic
pKa2 1.5 acidic
pKa3 11.86 acidic
pKa4 12.46 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
G-protein coupled receptor 35 GPCR AGONIST EC50 8.79 SCIENTIFIC LITERATURE

External reference:

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IDSource
4020849 VUID
N0000148358 NUI
C0126120 UMLSCUI
D04762 KEGG_DRUG
50LV9A548L UNII
63610-09-3 SECONDARY_CAS_RN
4020849 VANDF
N0000148358 NDFRT
52151 RXNORM
108859008 SNOMEDCT_US
372552005 SNOMEDCT_US
003991 NDDF
44564 PUBCHEM_CID
CHEMBL1201175 ChEMBL_ID
CHEMBL1201266 ChEMBL_ID
DB06794 DRUGBANK_ID
CHEMBL2107161 ChEMBL_ID
4351 INN_ID
C022028 MESH_SUPPLEMENTAL_RECORD_UI
C021702 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135333 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
ALOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 0065-0345 SOLUTION/ DROPS 1 mg OPHTHALMIC NDA 12 sections