bilastine indications/contra

Stem definitionDrug idCAS RN
antihistaminics 4353 202189-78-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bellozal
  • F-96221-BM1
  • bilastine
  • bilaxten
  • Molecular weight: 463.62
  • Formula: C28H37N3O3
  • CLOGP: 1.95
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 67.59
  • ALOGS: -5.36
  • ROTB: 10

Drug dosage:

DoseUnitRoute
20 mg O

Approvals:

DateAgencyCompanyOrphan
None PMDA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Overdose 12.03 0 3 12 33975 3351869

Pharmacologic Action:

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SourceCodeDescription
ATC R06AX29 RESPIRATORY SYSTEM
ANTIHISTAMINES FOR SYSTEMIC USE
ANTIHISTAMINES FOR SYSTEMIC USE
Other antihistamines for systemic use

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Allergic rhinitis indication 61582004
Urticaria indication 126485001

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.42 acidic
pKa2 7.88 Basic
pKa3 5.11 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST Ki 7.19 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

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IDSource
D09570 KEGG_DRUG
C445659 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL1742423 ChEMBL_ID
013709 NDDF
697973006 SNOMEDCT_US
714622001 SNOMEDCT_US
185460 PUBCHEM_CID
PA1123N395 UNII
7905 INN_ID
DB11591 DRUGBANK_ID
CHEBI:135954 CHEBI

Pharmaceutical products:

None