methylprednisolone aceponate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 1769 86401-95-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methylprednisolone aceponate
  • advantan
  • Molecular weight: 472.58
  • Formula: C27H36O7
  • CLOGP: 3.35
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -4.87
  • ROTB: 7

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
S (Water solubility) 0.12 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Steroid withdrawal syndrome 74.15 43.24 11 552 534 63487925
Coagulation test abnormal 62.63 43.24 10 553 788 63487671
Euphoric mood 61.34 43.24 13 550 4874 63483585
Pelvic venous thrombosis 61.29 43.24 11 552 1744 63486715
Erythrodermic psoriasis 60.20 43.24 10 553 1008 63487451
Stupor 51.52 43.24 11 552 4264 63484195
Pulmonary embolism 43.61 43.24 21 542 116663 63371796

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Steroid withdrawal syndrome 39.42 32.88 6 437 240 34956248

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Steroid withdrawal syndrome 67.94 29.50 11 925 710 79742742
Coagulation test abnormal 54.58 29.50 10 926 1335 79742117
Erythrodermic psoriasis 51.91 29.50 10 926 1748 79741704
Euphoric mood 51.73 29.50 13 923 7713 79735739
Pelvic venous thrombosis 49.56 29.50 10 926 2215 79741237
Stupor 43.21 29.50 11 925 6861 79736591
Pulmonary embolism 32.82 29.50 22 914 171632 79571820

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D07AC14 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D018696 Neuroprotective Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:37962 adrenergic agents
CHEBI has role CHEBI:50919 antiemetico
CHEBI has role CHEBI:63726 neuroprotective agents
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.17 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07203 KEGG_DRUG
4018068 VANDF
C0174938 UMLSCUI
CHEBI:135762 CHEBI
CHEBI:6888 CHEBI
CHEMBL1697782 ChEMBL_ID
DB14643 DRUGBANK_ID
C078007 MESH_SUPPLEMENTAL_RECORD_UI
5524 INN_ID
ET54W9J4U2 UNII
63019 PUBCHEM_CID
DB00959 DRUGBANK_ID
62136 RXNORM
1041 MMSL
5093 MMSL
d00293 MMSL
002160 NDDF
006227 NDDF
116593003 SNOMEDCT_US
27242001 SNOMEDCT_US
708199003 SNOMEDCT_US
C0025815 UMLSCUI
732 INN_ID
6741 PUBCHEM_CID
D008775 MESH_DESCRIPTOR_UI

Pharmaceutical products:

None