beclometasone dipropionate Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 294 5534-09-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • rhinocort
  • beclometasone dipropionate
  • beclomethasone dipropionate
  • beclomethasone dipropionate monohydrate
An anti-inflammatory, synthetic glucocorticoid. It is used topically as an anti-inflammatory agent and in aerosol form for the treatment of ASTHMA.
  • Molecular weight: 521.05
  • Formula: C28H37ClO7
  • CLOGP: 4.26
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 106.97
  • ALOGS: -5.40
  • ROTB: 8

Drug dosage:

DoseUnitRoute
0.40 mg N
0.80 mg Inhal.aerosol
0.80 mg Inhal.powder
1.50 mg Inhal.solution

Approvals:

DateAgencyCompanyOrphan
May 12, 1976 FDA

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Nasal discomfort 283.79 38.79 45 792 1056 4637099
Asthma 173.91 38.79 48 789 17326 4620829
Epistaxis 107.20 38.79 34 803 19609 4618546
Sneezing 85.30 38.79 20 817 3708 4634447
Drug ineffective 73.83 38.79 52 785 186009 4452146
Nasal septum perforation 70.18 38.79 11 826 234 4637921
Exposure during pregnancy 65.28 38.79 27 810 32944 4605211
Cough 51.80 38.79 27 810 55560 4582595
Anosmia 50.60 38.79 11 826 1446 4636709
Burning sensation 46.35 38.79 16 821 11856 4626299
Device malfunction 42.95 38.79 13 824 6351 4631804
Dyspnoea 41.73 38.79 33 804 138952 4499203

Pharmacologic Action:

SourceCodeDescription
ATC A07EA07 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC D07AC15 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
ATC D07CC04 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, potent, combinations with antibiotics
ATC R01AD01 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03AK08 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AK13 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with corticosteroids or other drugs, excl. anticholinergics
ATC R03AL09 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Adrenergics in combination with anticholinergics incl. triple combinations with corticosteroids
ATC R03BA01 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
FDA EPC N0000175576 Corticosteroid
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:49167 anti-asthmatic drug
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:35472 anti-inflammatory drug

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Vasomotor rhinitis indication 8229003 DOID:4730
Nasal polyp indication 52756005
Allergic rhinitis indication 61582004
Rhinitis indication 70076002 DOID:4483
Asthma indication 195967001 DOID:2841
Asthma management indication 406162001
Severe chronic obstructive pulmonary disease off-label use 313299006
Mycosis contraindication 3218000 DOID:1564
Ocular hypertension contraindication 4210003 DOID:9282
Inactive tuberculosis contraindication 11999007
Epistaxis contraindication 12441001
Measles contraindication 14189004 DOID:8622
Disease caused by parasite contraindication 17322007
Glaucoma contraindication 23986001 DOID:1686
Acute tuberculosis contraindication 25629007
Perforation of nasal septum contraindication 80142000
Bacterial infectious disease contraindication 87628006
Mycobacteriosis contraindication 88415009
Operation on nose contraindication 88733004
Bilateral cataracts contraindication 95722004
Ophthalmic herpes simplex contraindication 186542001
Disease of liver contraindication 235856003 DOID:409
Varicella-zoster virus infection contraindication 309465005
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Exposure to varicella contraindication 444453009
Nasal Trauma contraindication
Nasal Candidiasis contraindication
Nasal Septal Ulcers contraindication
Uncontrolled Bacterial Infections contraindication
Untreated Fungal Infection contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.01 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST Ki 8.43 DRUG MATRIX CHEMBL
Matrix metalloproteinase-9 Enzyme IC50 5.70 CHEMBL
Interleukin-5 Cytokine IC50 4.57 CHEMBL
Glucocorticoid receptor Transcription factor IC50 8.54 CHEMBL
Interleukin-5 Unclassified IC50 4.58 CHEMBL
Progesterone receptor Transcription factor Ki 7.57 CHEMBL
Androgen receptor Transcription factor Ki 5.96 CHEMBL

External reference:

IDSource
D001507 MESH_DESCRIPTOR_UI
C0678163 UMLSCUI
D00689 KEGG_DRUG
4H7L9AI22I UNII
77011-63-3 SECONDARY_CAS_RN
116575004 SNOMEDCT_US
1348 RXNORM
4249 MMSL
4018793 VANDF
71834 MMSL
002179 NDDF
CHEMBL1370 ChEMBL_ID
DB00394 DRUGBANK_ID
CHEMBL1586 ChEMBL_ID
CHEMBL1200500 ChEMBL_ID
2307 INN_ID
CHEBI:3002 CHEBI
5894 IUPHAR_LIGAND_ID
21700 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
BECONASE HUMAN PRESCRIPTION DRUG LABEL 1 16590-030 SPRAY, SUSPENSION 42 ug NASAL NDA 13 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 16590-860 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 14 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 50090-1342 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 50090-3033 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 17 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 50090-3459 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 15 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 53002-2436 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 15 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 53002-3477 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 15 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 54868-5857 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 13 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 54868-5858 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 13 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-302 AEROSOL, METERED 40 ug RESPIRATORY (INHALATION) NDA 15 sections
QVAR REDIHALER HUMAN PRESCRIPTION DRUG LABEL 1 59310-304 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 15 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-406 AEROSOL, METERED 40 ug NASAL NDA 18 sections
QNASL HUMAN PRESCRIPTION DRUG LABEL 1 59310-410 AEROSOL, METERED 80 ug NASAL NDA 18 sections
QVAR HUMAN PRESCRIPTION DRUG LABEL 1 68788-7025 AEROSOL, METERED 80 ug RESPIRATORY (INHALATION) NDA 16 sections