amcinonide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| steroids for topical use, acetal derivatives | 150 | 51022-69-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Oct. 18, 1979 | FDA | ASTELLAS |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D07AC11 | DERMATOLOGICALS CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS CORTICOSTEROIDS, PLAIN Corticosteroids, potent (group III) |
| FDA MoA | N0000175450 | Corticosteroid Hormone Receptor Agonists |
| FDA EPC | N0000175576 | Corticosteroid |
| MeSH PA | D005938 | Glucocorticoids |
| MeSH PA | D006728 | Hormones |
| CHEBI has role | CHEBI:35472 | anti-inflammatory drugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Atopic dermatitis | indication | 24079001 | DOID:3310 |
| Contact dermatitis | indication | 40275004 | DOID:2773 |
| Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
| Lichen simplex chronicus | indication | 53891004 | |
| Granuloma annulare | indication | 65508009 | DOID:3777 |
| Pruritus ani | indication | 90446007 | |
| Discoid lupus erythematosus | indication | 200938002 | |
| Plaque psoriasis | indication | 200965009 | |
| Scalp psoriasis | indication | 238608008 | |
| Pruritus of genital organs | indication | 267802000 | |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Primary cutaneous T-cell lymphoma | indication | 400122007 | |
| Glaucoma | contraindication | 23986001 | DOID:1686 |
| Diabetes mellitus type 2 | contraindication | 44054006 | DOID:9352 |
| Diabetes mellitus type 1 | contraindication | 46635009 | DOID:9744 |
| Tuberculosis of skin | contraindication | 66986005 | |
| Bilateral cataracts | contraindication | 95722004 | |
| Atrophoderma | contraindication | 399979006 | |
| Peripheral vascular disease | contraindication | 400047006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.08 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Nuclear hormone receptor | AGONIST | CHEMBL | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4017920 | VUID |
| N0000146271 | NUI |
| D01387 | KEGG_DRUG |
| 17652 | RXNORM |
| C0051556 | UMLSCUI |
| CHEBI:31199 | CHEBI |
| CHEMBL1200732 | ChEMBL_ID |
| DB00288 | DRUGBANK_ID |
| C012716 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7060 | IUPHAR_LIGAND_ID |
| 3755 | INN_ID |
| 423W026MA9 | UNII |
| 443958 | PUBCHEM_CID |
| 222 | MMSL |
| 4163 | MMSL |
| 44051 | MMSL |
| 420859004 | SNOMEDCT_US |
| 67980007 | SNOMEDCT_US |
| 4017920 | VANDF |
| 002202 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Amcinonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0278 | CREAM | 1 mg | TOPICAL | ANDA | 19 sections |
| Amcinonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0278 | CREAM | 1 mg | TOPICAL | ANDA | 19 sections |
| Amcinonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0279 | OINTMENT | 1 mg | TOPICAL | ANDA | 18 sections |
| amcinonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0168-0280 | LOTION | 1 mg | TOPICAL | ANDA | 18 sections |
| Amcinonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4054 | CREAM | 1 mg | TOPICAL | ANDA | 20 sections |
| Amcinonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51672-4060 | OINTMENT | 1 mg | TOPICAL | ANDA | 20 sections |
| Amcinonide | HUMAN PRESCRIPTION DRUG LABEL | 1 | 73308-407 | OINTMENT | 1 mg | TOPICAL | ANDA | 18 sections |