flupirtine indications/contra

Stem definitionDrug idCAS RN
1215 56995-20-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • flupirtin maleate
  • flupirtine maleate
  • flupirtine
  • katadolon
  • Molecular weight: 304.33
  • Formula: C15H17FN4O2
  • CLOGP: 3.05
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 89.27
  • ALOGS: -3.62
  • ROTB: 6

Drug dosage:

DoseUnitRoute
0.40 g O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1986 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N02BG07 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Other analgesics and antipyretics
MeSH PA D000700 Analgesics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.83 acidic
pKa2 7.26 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Potassium voltage-gated channel subfamily KQT member 2 Ion channel ACTIVATOR EC50 5 IUPHAR
Potassium voltage-gated channel subfamily KQT member 3 Ion channel WOMBAT-PK

External reference:

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IDSource
2598 IUPHAR_LIGAND_ID
4025785 VUID
N0000179138 NUI
C0060583 UMLSCUI
D07978 KEGG_DRUG
0VCI53PK4A UNII
75507-68-5 SECONDARY_CAS_RN
4025785 VANDF
N0000176074 NDFRT
N0000179138 NDFRT
25193 RXNORM
006784 NDDF
CHEMBL255044 ChEMBL_ID
53276 PUBCHEM_CID
CHEBI:94646 CHEBI
CHEMBL1256752 ChEMBL_ID
C034161 MESH_SUPPLEMENTAL_RECORD_UI
DB06623 DRUGBANK_ID
3976 INN_ID

Pharmaceutical products:

None