methoxyflurane Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
halogenated compounds used as general inhalation anaesthetics 1754 76-38-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • methoxyflurane
  • methoflurane
  • methoxane
  • methoxyfluran
  • metofane
  • metoxfluran
  • metoxifluran
  • penthrane
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
  • Molecular weight: 164.96
  • Formula: C3H4Cl2F2O
  • CLOGP: 2.49
  • LIPINSKI: 0
  • HAC: 1
  • HDO: 0
  • TPSA: 9.23
  • ALOGS: -1.41
  • ROTB: 2

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA ABBOTT

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC N02BG09 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Other analgesics and antipyretics
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
CHEBI has role CHEBI:38870 inhalation anaesthetic
CHEBI has role CHEBI:35481 non-narcotic analgesic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
GABA-A receptor; anion channel Ion channel POSITIVE MODULATOR CHEMBL CHEMBL
Glycine receptor subunit alpha-1 Ion channel AGONIST DRUGBANK CHEMBL

External reference:

IDSource
4018733 VUID
N0000147038 NUI
C0025688 UMLSCUI
D00544 KEGG_DRUG
30905R8O7B UNII
1048 INN_ID
11136004 SNOMEDCT_US
4018733 VANDF
6857 RXNORM
5081 MMSL
d00291 MMSL
001401 NDDF
4116 PUBCHEM_CID
CHEBI:6843 CHEBI
CHEMBL1341 ChEMBL_ID
DB01028 DRUGBANK_ID
D008733 MESH_DESCRIPTOR_UI
7234 IUPHAR_LIGAND_ID

Pharmaceutical products:

None