glafenine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
analgesics, glafenine derivatives (subgroup of fenamic acid group) 1297 3820-67-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • glafenine
  • alcidon
  • dolomate
  • glafenin
  • glaphenin
  • glaphenine
  • glicafan
  • glifanan
  • glifanar
  • glycerylaminophenaquine
  • privadol
  • glafenine hydrochloride
  • glafenine HCl
An anthranilic acid derivative with analgesic properties used for the relief of all types of pain.
  • Molecular weight: 372.81
  • Formula: C19H17ClN2O4
  • CLOGP: 4.04
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 3
  • TPSA: 91.68
  • ALOGS: -4.04
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.80 g O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Hosey CM, Chan R, Benet LZ
S (Water solubility) 0.02 mg/mL Bocci G, Oprea TI, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02BG03 NERVOUS SYSTEM
ANALGESICS
OTHER ANALGESICS AND ANTIPYRETICS
Other analgesics and antipyretics
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D002491 Central Nervous System Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35222 inhibitor
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.75 acidic
pKa2 6.97 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Bile salt export pump Transporter IC50 4.65 CHEMBL
Bile salt export pump Transporter IC50 4.49 CHEMBL

External reference:

IDSource
D01351 KEGG_DRUG
C0017592 UMLSCUI
CHEBI:31653 CHEBI
CHEMBL146095 ChEMBL_ID
DB08963 DRUGBANK_ID
D005897 MESH_DESCRIPTOR_UI
3474 PUBCHEM_CID
1890 INN_ID
65513-72-6 SECONDARY_CAS_RN
46HL4I09AH UNII
006856 NDDF

Pharmaceutical products:

None