alclofenac indications/contra

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibufenac derivatives 107 22131-79-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • 4-allyloxy-3-chlorophenylacetic acid
  • prinalgin
  • alclofenac
  • aclofenac
  • alclophenac
  • allopydin
  • medifenac
  • reufenac
  • Molecular weight: 226.66
  • Formula: C11H11ClO3
  • CLOGP: 2.73
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -2.90
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1.25 g O
1.25 g R

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1969 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC M01AB06 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Acetic acid derivatives and related substances
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory drug
CHEBI has role CHEBI:35481 non-narcotic analgesic
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D000894 Anti-Inflammatory Agents, Non-Steroidal
MeSH PA D018501 Antirheumatic Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Rheumatoid arthritis indication 69896004 DOID:7148

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.42 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 1 Enzyme WOMBAT-PK
Prostaglandin G/H synthase 2 Enzyme WOMBAT-PK

External reference:

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IDSource
D01252 KEGG_DRUG
30951 PUBCHEM_CID
CHEMBL94081 ChEMBL_ID
CHEBI:31183 CHEBI
C084615 MESH_SUPPLEMENTAL_RECORD_UI
M9CP5H21N8 UNII
2826 INN_ID
DB13167 DRUGBANK_ID

Pharmaceutical products:

None