ebrotidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
histamine-H2-receptor antagonists, cimetidine derivatives 979 100981-43-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • FI-3542
  • ebrotidine
  • ebrodin
  • ulsanic
an H2-receptor antagonist and gastric mucosa protector
  • Molecular weight: 477.41
  • Formula: C14H17BrN6O2S3
  • CLOGP: 1.12
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 4
  • TPSA: 133.32
  • ALOGS: -4.25
  • ROTB: 7

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Hosey CM, Chan R, Benet LZ

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000897 Anti-Ulcer Agents
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D018494 Histamine Agents
MeSH PA D006633 Histamine Antagonists
MeSH PA D006635 Histamine H2 Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.63 Basic
pKa2 2.56 Basic
pKa3 0.47 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H2 receptor GPCR ANTAGONIST SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
C0169307 UMLSCUI
CHEBI:135774 CHEBI
CHEMBL1742471 ChEMBL_ID
C075156 MESH_SUPPLEMENTAL_RECORD_UI
6009 INN_ID
TMZ3IBW2OW UNII
65869 PUBCHEM_CID
D013392 MESH_DESCRIPTOR_UI
CHEMBL3989780 ChEMBL_ID

Pharmaceutical products:

None