drostanolone propionate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
steroids not used as glucocorticosteroids 965 521-12-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • medrotestron
  • metholone
  • dromostanolone propionate
  • emdisterone
  • medrotestron propionate
  • medrotestrone propanoate
  • medrotestrone propionate
  • prometholone
  • permastril
  • drostanolone propionate
synthetic anabolic androgenic steroid used to lower plasma cholesterol & as antineoplastic agent in advanced breast neoplasms; major descriptor (66-86); on-line search ANDROSTANOLS (80-86); ANDROSTANES (68-86); INDEX MEDICUS search DROMOSTANOLONE (66-86); RN given refers to (2alpha,5alpha,17beta)-isomer
  • Molecular weight: 360.54
  • Formula: C23H36O3
  • CLOGP: 5.55
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 43.37
  • ALOGS: -5.76
  • ROTB: 3
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PRKDC,STK33,TEK,TGFBR1 24
kinase-selectivity-class EIF2AK3,GRK2 2
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA LILLY

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:36413 anabolic agent
CHEBI has role CHEBI:50113 androgen

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Malignant neoplasm of breast indication 254837009 DOID:1612




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Androgen receptor Nuclear hormone receptor AGONIST DRUGBANK CHEMBL

External reference:

IDSource
D01534 KEGG_DRUG
CHEBI:31523 CHEBI
CHEMBL1201048 ChEMBL_ID
DB14655 DRUGBANK_ID
DB00858 DRUGBANK_ID
23678 RXNORM
002664 NDDF
004822 NDDF
417263004 SNOMEDCT_US
420633004 SNOMEDCT_US
420908004 SNOMEDCT_US
C0058758 UMLSCUI
C0058753 UMLSCUI
CHEMBL1582 ChEMBL_ID
224004 PUBCHEM_CID
6011 PUBCHEM_CID
6947 IUPHAR_LIGAND_ID
C007561 MESH_SUPPLEMENTAL_RECORD_UI
C100263 MESH_SUPPLEMENTAL_RECORD_UI
X20UZ57G4O UNII
CHEBI:34838 CHEBI
X20UZ57G4O INXIGHT DRUGS

Pharmaceutical products:

None