DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
Scroll
All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
doxifluridine ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
uridine derivatives used as antiviral agents and as antineoplastics
958
3094-09-5
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
5-DFUR
doxifluridine
flutron
furtulon
Molecular weight: 246.19
Formula: C9H11FN2O5
CLOGP: -1.19
LIPINSKI: 0
HAC: 7
HDO: 3
TPSA: 99.10
ALOGS: -0.81
ROTB: 1
Drug dosage:
None
ADMET properties:
Show
10
25
50
100
entries
Search:
Property
Value
Reference
MRTD (Maximum Recommended Therapeutic Daily Dose)
69.63 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)
40 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)
11 mL/min/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.61 %
Lombardo F, Berellini G, Obach RS
t_half (Half-life)
0.35 hours
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.28 L/kg
Lombardo F, Berellini G, Obach RS
Showing 1 to 6 of 6 entries
Previous
1
Next
Approvals:
Show
10
25
50
100
entries
Search:
Date
Agency
Company
Orphan
Jan. 1, 1987
YEAR INTRODUCED
Showing 1 to 1 of 1 entries
Previous
1
Next
FDA Adverse Event Reporting System (Female)
Show
10
25
50
100
entries
Search:
MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Dermatitis acneiform
86.28
82.70
16
333
4980
63483693
Showing 1 to 1 of 1 entries
Previous
1
Next
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
Show
10
25
50
100
entries
Search:
MedDRA adverse event term
Likelihood ratio
Likelihood ratio threshold
Patients taking drug having adverse event
Patients taking drug not having adverse event
Patients not taking drug having adverse event
Patients not taking drug not having adverse event
Dermatitis acneiform
148.50
92.38
29
495
9964
79733900
Showing 1 to 1 of 1 entries
Previous
1
Next
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
Show
10
25
50
100
entries
Search:
Source
Code
Description
CHEBI has role
CHEBI:35221
antimetabolite
CHEBI has role
CHEBI:35610
antineoplastic agents
CHEBI has role
CHEBI:50266
Prodrugs
MeSH PA
D000963
Antimetabolites
MeSH PA
D000964
Antimetabolites, Antineoplastic
MeSH PA
D000970
Antineoplastic Agents
MeSH PA
D019167
Appetite Stimulants
MeSH PA
D002491
Central Nervous System Agents
MeSH PA
D000697
Central Nervous System Stimulants
MeSH PA
D007155
Immunologic Factors
Showing 1 to 10 of 12 entries
Previous
1
2
Next
Drug Use
| Suggest Off label Use Form|
|View source of the data|
Show
10
25
50
100
entries
Search:
Disease
Relation
SNOMED_ID
DOID
Primary malignant neoplasm of gastrointestinal tract
indication
363745004
Showing 1 to 1 of 1 entries
Previous
1
Next
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
Show
10
25
50
100
entries
Search:
Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
7.88
acidic
pKa2
13.11
acidic
pKa3
13.83
acidic
Showing 1 to 3 of 3 entries
Previous
1
Next
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
Show
10
25
50
100
entries
Search:
Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Thymidylate synthase
Enzyme
P04818
TYSY_HUMAN
WOMBAT-PK
Showing 1 to 1 of 1 entries
Previous
1
Next
External reference:
Show
10
25
50
100
entries
Search:
ID
Source
010903
NDDF
18343
PUBCHEM_CID
4913
INN_ID
C0048808
UMLSCUI
C025034
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:31521
CHEBI
CHEMBL1130
ChEMBL_ID
D01309
KEGG_DRUG
DB12947
DRUGBANK_ID
V1JK16Y2JP
UNII
Showing 1 to 10 of 10 entries
Previous
1
Next
Pharmaceutical products:
None
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
doxifluridine