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dithiazanine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 930 | 7187-55-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium. A benzothiazole that was formerly used as an antinematodal agent and is currently used as a fluorescent dye.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT1,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FGFR1,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K1,MAP3K11,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MELK,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIM1,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 72 | |||
| kinase-selectivity-class | ACVR2A,ACVR2B,AXL,BRAF,CAMK2D,CDK4,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,MAP2K6,MAPK12,MAPK7,MARK4,MET,PDK4,SIK2,STK33,SYK,TEK,TTK,ZAP70 | 25 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000969 | Antinematodal Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D004396 | Coloring Agents |
| MeSH PA | D005456 | Fluorescent Dyes |
| MeSH PA | D007202 | Indicators and Reagents |
| MeSH PA | D049408 | Luminescent Agents |
| CHEBI has role | CHEBI:35443 | anthelminthic drug |
| CHEBI has role | CHEBI:51217 | fluorochrome |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Parasite infestations | Indication |
| Horses | Control of large roundworms, Parascaris equorum | Indication |
| Horses | Control of small strongyles | Indication |
| Horses | Control of large strongyles, Strongylus vulgaris | Indication |
| Horses | Control of pinworms, Oxyuris equi | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Dizan Tablets | Cronus Pharma Specialities India Private Limited | 1 |
| Dizan Powder | Cronus Pharma Specialities India Private Limited | 1 |
| Dizan Suspension With Piperazine | Cronus Pharma Specialities India Private Limited | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 4.05 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 514-73-8 | SECONDARY_CAS_RN |
| C0012783 | UMLSCUI |
| CHEBI:52787 | CHEBI |
| CHEMBL1185568 | ChEMBL_ID |
| CHEMBL421701 | ChEMBL_ID |
| DB11516 | DRUGBANK_ID |
| D004225 | MESH_DESCRIPTOR_UI |
| 5473758 | PUBCHEM_CID |
| 5L7E7IY5EH | UNII |
| 002981 | NDDF |
| 004970 | NDDF |
| 797929008 | SNOMEDCT_US |
| 89701003 | SNOMEDCT_US |
| 768 | INN_ID |
Pharmaceutical products:
None