diethazine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
872 60-91-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • diethazine
  • dolisina
  • eazamine
  • eazaminum
  • parkazin
phenothiazine derivative anti-Parkinson agent with anticholinergic and antihistaminic actions; is effective against Parkinson tremor; minor descriptor (75-86); on-line & INDEX MEDICUS search PHENOTHIAZINES (75-86); RN given refers to cpd without isomeric designation
  • Molecular weight: 298.45
  • Formula: C18H22N2S
  • CLOGP: 5.35
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 6.48
  • ALOGS: -4.41
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.33 Basic
pKa2 3.55 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Pleiotropic ABC efflux transporter of multiple drugs Transporter IC50 4.99 CHEMBL

External reference:

IDSource
D07823 KEGG_DRUG
C0057921 UMLSCUI
CHEBI:135265 CHEBI
CHEMBL1620412 ChEMBL_ID
C100260 MESH_SUPPLEMENTAL_RECORD_UI
65535 PUBCHEM_CID
1539 INN_ID
28B5CG0RU3 UNII

Pharmaceutical products:

None