dexloxiglumide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
cholecystokinine antagonists, antiulcer, anxiolytic agents 834 119817-90-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexloxiglumide
  • D-Loxiglumide
a CCK receptor antagonist; structure given in first source
  • Molecular weight: 461.38
  • Formula: C21H30Cl2N2O5
  • CLOGP: 4.39
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 95.94
  • ALOGS: -4.92
  • ROTB: 14

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Bocci G, Oprea TI, Benet LZ
BA (Bioavailability) 48 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.18 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 3.70 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 1.20 hours Lombardo F, Berellini G, Obach RS
S (Water solubility) 0.53 mg/mL Bocci G, Oprea TI, Benet LZ

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK14,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,ZAP70 36
kinase-selectivity-class AXL,BRAF,EIF2AK3,EPHB4,GRK2,PDK4 6
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 4.831 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
rat-kpuu-brain Rat brain Kpuu 0.056 % High 1

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:53784 antispasmodic drug

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.19 acidic
pKa2 13.75 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Cholecystokinin receptor type A GPCR IC50 6.89 WOMBAT-PK

External reference:

IDSource
C0533979 UMLSCUI
CHEBI:135747 CHEBI
CHEMBL550781 ChEMBL_ID
DB04856 DRUGBANK_ID
C103490 MESH_SUPPLEMENTAL_RECORD_UI
889 IUPHAR_LIGAND_ID
6782 INN_ID
69DY40RH9B UNII
65937 PUBCHEM_CID
69DY40RH9B INXIGHT DRUGS

Pharmaceutical products:

None