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2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
dexloxiglumide 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
cholecystokinine antagonists, antiulcer, anxiolytic agents
834
119817-90-2
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
dexloxiglumide
D-Loxiglumide
a CCK receptor antagonist; structure given in first source
Molecular weight: 461.38
Formula: C21H30Cl2N2O5
CLOGP: 4.39
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 95.94
ALOGS: -4.92
ROTB: 14
Drug dosage:
None
ADMET properties:
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Property
Value
Reference
BA (Bioavailability)
48 %
Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
CL (Clearance)
3.70 mL/min/kg
Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)
2
Bocci G, Oprea TI, Benet LZ
t_half (Half-life)
1.20 hours
Lombardo F, Berellini G, Obach RS
S (Water solubility)
0.53 mg/mL
Bocci G, Oprea TI, Benet LZ
Vd (Volume of distribution)
0.18 L/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.02 %
Lombardo F, Berellini G, Obach RS
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Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
4.19
acidic
pKa2
13.75
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Cholecystokinin receptor type A
GPCR
P32238
CCKAR_HUMAN
IC50
6.89
WOMBAT-PK
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External reference:
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ID
Source
65937
PUBCHEM_CID
6782
INN_ID
69DY40RH9B
UNII
889
IUPHAR_LIGAND_ID
C0533979
UMLSCUI
C103490
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135747
CHEBI
CHEMBL550781
ChEMBL_ID
DB04856
DRUGBANK_ID
Showing 1 to 9 of 9 entries
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Pharmaceutical products:
None
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dexloxiglumide