desoxycorticosterone pivalate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 822 808-48-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • desoxycorticosterone pivalate
  • deoxycorticosterone pivalate
  • deoxycorticosterone trimethylacetate
  • deoxycortone pivalate
  • deoxycortone trimethylacetate
  • desoxycorticosterone trimethylacetate
  • desoxycortisone pivalate
  • Molecular weight: 414.59
  • Formula: C26H38O4
  • CLOGP: 5.21
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 60.44
  • ALOGS: -5.47
  • ROTB: 5
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,ITK,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TTK,ZAP70 38
kinase-selectivity-class GRK2 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
None FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Mineralocorticoid deficit with primary adrenocortical insufficiency (Addisons disease) Indication

🐶 Veterinary products

ProductApplicantIngredients
Percorten-V Elanco US Inc. 1
Zycortal Suspension Dechra, Ltd. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mineralocorticoid receptor Nuclear hormone receptor AGONIST EC50 11 WOMBAT-PK CHEMBL

External reference:

IDSource
4018521 VUID
N0000179098 NUI
D03699 KEGG_DRUG
22537 RXNORM
4018521 VANDF
4019710 VANDF
C0057420 UMLSCUI
CHEBI:50782 CHEBI
CHEMBL1200592 ChEMBL_ID
CHEMBL1401691 ChEMBL_ID
DB01134 DRUGBANK_ID
11876263 PUBCHEM_CID
C019323 MESH_SUPPLEMENTAL_RECORD_UI
16665T4A2X UNII
002207 NDDF
002209 NDDF
116630009 SNOMEDCT_US
1336006 SNOMEDCT_US
75029008 SNOMEDCT_US
C0011710 UMLSCUI
DB15972 DRUGBANK_ID
6166 PUBCHEM_CID
387 INN_ID
CHEBI:16973 CHEBI
16665T4A2X INXIGHT DRUGS

Pharmaceutical products:

None