desoxycorticosterone acetate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
corticosteroids, except prednisolone derivatives 821 56-47-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • desoxycorticosterone acetate
  • cortexone acetate
  • decosteron
  • decosterone
  • deoxycorticosterone acetate
  • deoxycortone acetate
  • desoxycortone acetate
  • sincortex
The 21-acetate derivative of desoxycorticosterone.
  • Molecular weight: 372.51
  • Formula: C23H32O4
  • CLOGP: 3.98
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 60.44
  • ALOGS: -4.87
  • ROTB: 4
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAPK10,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,STK33,SYK,TEK 24
kinase-selectivity-class GRK2 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Aug. 17, 1939 FDA ORGANON USA INC

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D006728 Hormones
MeSH PA D008901 Mineralocorticoids
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Mineralocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

IDSource
4018520 VUID
N0000179711 NUI
D03698 KEGG_DRUG
258333 RXNORM
4018520 VANDF
4019710 VANDF
C0813203 UMLSCUI
CHEBI:34671 CHEBI
CHEMBL1200542 ChEMBL_ID
DB06780 DRUGBANK_ID
D064791 MESH_DESCRIPTOR_UI
5952 PUBCHEM_CID
6E0A168OB8 UNII
002207 NDDF
002208 NDDF
1336006 SNOMEDCT_US
56156001 SNOMEDCT_US
75029008 SNOMEDCT_US
C0011710 UMLSCUI
DB15972 DRUGBANK_ID
6166 PUBCHEM_CID
387 INN_ID
CHEBI:16973 CHEBI
6E0A168OB8 INXIGHT DRUGS

Pharmaceutical products:

None