denaverine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
spasmolytics with a papaverine-like action 805 3579-62-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • spasmalgan
  • denaverine hydrochloride
  • denaverine
  • Molecular weight: 383.53
  • Formula: C24H33NO3
  • CLOGP: 5.66
  • LIPINSKI: 1
  • HAC: 4
  • HDO: 0
  • TPSA: 38.77
  • ALOGS: -5.58
  • ROTB: 12

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 6.70 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 7.10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 5.70 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 34 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.13 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07787 KEGG_DRUG
3321-06-0 SECONDARY_CAS_RN
22503 RXNORM
C0057383 UMLSCUI
CHEBI:135601 CHEBI
CHEMBL1614656 ChEMBL_ID
C001967 MESH_SUPPLEMENTAL_RECORD_UI
71130 PUBCHEM_CID
3029 INN_ID
O14NF38MTL UNII
006845 NDDF
006846 NDDF

Pharmaceutical products:

None