dehydrocholic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
794 81-23-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dehydrocholic acid
  • cholepatin
  • decholin
  • dehystolin
  • ketocholanic acid
  • oxycholin
A semisynthetic bile acid made from cholic acid. It is used as a cholagogue, hydrocholeretic, diuretic, and as a diagnostic aid.
  • Molecular weight: 402.53
  • Formula: C24H34O5
  • CLOGP: 1.22
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 88.51
  • ALOGS: -4.76
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DYRK1B,EIF2AK3,ERBB2,GRK2,ITK,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,STK33,SYK,TEK,TGFBR1 25
kinase-selectivity-class EIF2AK3,GRK2,MAP2K6 3
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D002756 Cholagogues and Choleretics
MeSH PA D005765 Gastrointestinal Agents
CHEBI has role CHEBI:55324 gastrointestinal drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089
Disorder of biliary tract indication 105997008 DOID:9741
Incomplete passage of stool indication 249515001
Incontinence of feces contraindication 72042002
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal obstruction contraindication 126765001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.64 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4018426 VUID
N0000146752 NUI
D01693 KEGG_DRUG
216396 RXNORM
4018426 VANDF
C0011182 UMLSCUI
CHEBI:31459 CHEBI
CHEMBL514446 ChEMBL_ID
D003685 MESH_DESCRIPTOR_UI
DB11622 DRUGBANK_ID
6674 PUBCHEM_CID
157 INN_ID
NH5000009I UNII
4540 MMSL
6841 MMSL
857 MMSL
d01030 MMSL
001203 NDDF
001207 NDDF
387285003 SNOMEDCT_US
51752005 SNOMEDCT_US
NH5000009I INXIGHT DRUGS

Pharmaceutical products:

None