cyclovalone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
762 579-23-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cyclovalone
  • curcumoid
  • cyclovalon
  • cycvalon
  • cyqualon
  • vanilone
is a synthetic curcumin derivative
  • Molecular weight: 366.41
  • Formula: C22H22O5
  • CLOGP: 4.08
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.99
  • ALOGS: -5.09
  • ROTB: 4

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.18 acidic
pKa2 9.78 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Nuclear factor NF-kappa-B p105 subunit Cytosolic other IC50 5.38 CHEMBL
Transcription factor AP-1 Transcription factor IC50 5.14 CHEMBL
Integrase Enzyme IC50 4 CHEMBL

External reference:

IDSource
C2825423 UMLSCUI
CHEBI:135543 CHEBI
CHEMBL2362372 ChEMBL_ID
CHEMBL17205 ChEMBL_ID
C000598259 MESH_SUPPLEMENTAL_RECORD_UI
1550234 PUBCHEM_CID
C010704 MESH_SUPPLEMENTAL_RECORD_UI
1456 INN_ID
6M4YJ3FA16 UNII

Pharmaceutical products:

None