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colfosceril palmitate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 730 | 63-89-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
used in the treatment of unilateral pulmonary interstitial emphysema; component of Exosurf
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.11 | g | Inhal.powder |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 59 | |||
| kinase-selectivity-class | AXL,CAMK2A,CAMK2D,CDK4,EIF2AK3,EPHB4,GRK2,INSR,MAP2K6,MAPK10,MAPK7,MTOR,PDK4,PLK1,PRKCD,PTK2,SIK2,STK33,SYK,TEK,ZAP70 | 21 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 2, 1990 | FDA | GLAXOSMITHKLINE |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | R07AA01 | RESPIRATORY SYSTEM OTHER RESPIRATORY SYSTEM PRODUCTS OTHER RESPIRATORY SYSTEM PRODUCTS Lung surfactants |
| CHEBI has role | CHEBI:35195 | surfactant |
| CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Respiratory distress syndrome in the newborn | indication | 46775006 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 0.51 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| 4019552 | VUID |
| N0000179368 | NUI |
| D03585 | KEGG_DRUG |
| 69782 | RXNORM |
| C0216971 | UMLSCUI |
| CHEBI:72999 | CHEBI |
| CHEMBL1200737 | ChEMBL_ID |
| DB09114 | DRUGBANK_ID |
| C081581 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2799 | IUPHAR_LIGAND_ID |
| 6728 | INN_ID |
| 319X2NFW0A | UNII |
| 452110 | PUBCHEM_CID |
| 7409 | MMSL |
| 003549 | NDDF |
| 386883008 | SNOMEDCT_US |
| PCF | PDB_CHEM_ID |
| 4019552 | VANDF |
Pharmaceutical products:
None