colfosceril palmitate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	730	63-89-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

colfosceril palmitate
L-Dipalmitoyl lecithin

used in the treatment of unilateral pulmonary interstitial emphysema; component of Exosurf

Molecular weight: 734.05
Formula: C40H80NO8P
CLOGP: 4
LIPINSKI: 1
HAC: 9
HDO: 0
TPSA: 111.19
ALOGS: -7.52
ROTB: 40

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.11	g	Inhal.powder

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 2, 1990	FDA	GLAXOSMITHKLINE

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	R07AA01	RESPIRATORY SYSTEM OTHER RESPIRATORY SYSTEM PRODUCTS OTHER RESPIRATORY SYSTEM PRODUCTS Lung surfactants
CHEBI has role	CHEBI:35195	surfactant
CHEBI has role	CHEBI:75771	Mus musculus metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Respiratory distress syndrome in the newborn	indication	46775006

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	0.51	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4019552	VUID
N0000179368	NUI
D03585	KEGG_DRUG
69782	RXNORM
4019552	VANDF
C0216971	UMLSCUI
CHEBI:72999	CHEBI
PCF	PDB_CHEM_ID
CHEMBL1200737	ChEMBL_ID
DB09114	DRUGBANK_ID
C081581	MESH_SUPPLEMENTAL_RECORD_UI
2799	IUPHAR_LIGAND_ID
6728	INN_ID
319X2NFW0A	UNII
452110	PUBCHEM_CID
7409	MMSL
003549	NDDF
386883008	SNOMEDCT_US

Pharmaceutical products:

None