colforsin daropate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
729 138605-00-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • colforsin dapropate hydrochloride
  • colforsin dapropate
  • colforsin daropate hydrochloride
  • colforsin daropate
  • colforsin dapropate HCl
  • colforsin daropate HCl
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.
  • Molecular weight: 509.64
  • Formula: C27H43NO8
  • CLOGP: 2.52
  • LIPINSKI: 1
  • HAC: 9
  • HDO: 2
  • TPSA: 122.60
  • ALOGS: -3.33
  • ROTB: 8

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000276 Adjuvants, Immunologic
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D002316 Cardiotonic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D020011 Protective Agents
MeSH PA D019141 Respiratory System Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:38147 cardiotonic drugs
CHEBI has role CHEBI:78548 adenylate cyclase agonists
CHEBI has role CHEBI:50427 platelet aggregation inhibitors
CHEBI has role CHEBI:64946 anti-AIDS agent
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:78547 protein kinase A agonists

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.82 acidic
pKa2 8.74 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Adenylate cyclase type 1 Enzyme IC50 7.39 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.22 CHEMBL
Solute carrier family 2, facilitated glucose transporter member 1 Transporter Kd 5.30 CHEMBL
Adenylate cyclase type 8 Enzyme EC50 7.03 CHEMBL
Adenylate cyclase type 1 Enzyme Kd 7.54 CHEMBL

External reference:

IDSource
D01697 KEGG_DRUG
113462-26-3 SECONDARY_CAS_RN
4033874 VANDF
CHEBI:31429 CHEBI
CHEBI:42471 CHEBI
C122001 MESH_SUPPLEMENTAL_RECORD_UI
DB02587 DRUGBANK_ID
007852 NDDF
C0909725 UMLSCUI
C0917964 UMLSCUI
CHEMBL52606 ChEMBL_ID
444029 PUBCHEM_CID
5326 INN_ID
66575-29-9 SECONDARY_CAS_RN
47936 PUBCHEM_CID
D005576 MESH_DESCRIPTOR_UI
1196KQZ976 UNII
1F7A44V6OU UNII

Pharmaceutical products:

None