clorprenaline 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
bronchodilators, phenethylamine derivatives	714	3811-25-4

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

clorprenaline
isoprofenamine
isoprophenamine
clorprenaline hydrochloride
clorprenaline HCl

Molecular weight: 213.71
Formula: C11H16ClNO
CLOGP: 2.13
LIPINSKI: 0
HAC: 2
HDO: 2
TPSA: 32.26
ALOGS: -2.35
ROTB: 4

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-selectivity-class	AXL,EIF2AK3,GRK2,PDK4	4
kinase-safety-class	ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,MAP2K6,MAP3K21,MAPK7,NTRK2,PDK2,PDK4,PIK3CB,PRKDC,SIK2,SIK3,SYK,TEK,TGFBR1	31
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	171.37	116.66	36	234	40904	90587273
Coma	150.81	116.66	36	234	72596	90555581
Underdose	123.39	116.66	29	241	53988	90574189
Gastrooesophageal reflux disease	121.23	116.66	36	234	166301	90461876

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Pneumonia aspiration	153.94	113.12	36	234	81197	110507832
Coma	140.61	113.12	36	234	117833	110471196
Gastrooesophageal reflux disease	125.51	113.12	36	234	179940	110409089
Underdose	124.44	113.12	29	241	63525	110525504

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D001993	Bronchodilator Agents
MeSH PA	D013566	Sympathomimetics
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018927	Anti-Asthmatic Agents
MeSH PA	D019141	Respiratory System Agents
CHEBI has role	CHEBI:35522	β-adrenergic agonist
CHEBI has role	CHEBI:35523	bronchodilator agent
CHEBI has role	CHEBI:35524	sympathomimetic agent

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.64	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN		Ki	5.83		DRUG MATRIX
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Ki	5.86		DRUG MATRIX

External reference:

ID	Source
D01835	KEGG_DRUG
C0055943	UMLSCUI
CHEBI:134887	CHEBI
CHEMBL1902627	ChEMBL_ID
CHEMBL3989576	ChEMBL_ID
2810	PUBCHEM_CID
C004350	MESH_SUPPLEMENTAL_RECORD_UI
1696	INN_ID
5588-22-7	SECONDARY_CAS_RN
3W4327W76O	UNII
008203	NDDF
008204	NDDF
96260001	SNOMEDCT_US
3W4327W76O	INXIGHT DRUGS

Pharmaceutical products:

None