clofibric acid ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
695 882-09-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clofibric acid
  • chlorfibrinic acid
  • chlorofibrinic acid
  • chlorophibrinic acid
  • clofibrilic acid
  • clofibrin
  • clofibrinic acid
An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
  • Molecular weight: 214.65
  • Formula: C10H11ClO3
  • CLOGP: 2.82
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 46.53
  • ALOGS: -2.95
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 45 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 5.70 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 155.14 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1963 YEAR INTRODUCED

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000924 Anticholesteremic Agents
MeSH PA D000963 Antimetabolites
MeSH PA D000960 Hypolipidemic Agents
MeSH PA D057847 Lipid Regulating Agents
CHEBI has role CHEBI:24527 herbicides
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:35679 antilipemic drugs
CHEBI has role CHEBI:35821 anticholesteremic drugs
CHEBI has role CHEBI:70782 PPAR-alpha agonist
CHEBI has role CHEBI:83399 marine xenobiotic metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.71 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Lipoprotein lipase Enzyme WOMBAT-PK
Peroxisome proliferator-activated receptor alpha Nuclear hormone receptor EC50 4.40 CHEMBL
Peroxisome proliferator-activated receptor alpha Transcription factor EC50 7.38 CHEMBL

External reference:

IDSource
D07723 KEGG_DRUG
C0009003 UMLSCUI
CHEBI:34648 CHEBI
CHEMBL683 ChEMBL_ID
D002995 MESH_DESCRIPTOR_UI
2797 PUBCHEM_CID
2439 INN_ID
53PF01Q249 UNII
E0O PDB_CHEM_ID
DB13780 DRUGBANK_ID

Pharmaceutical products:

None