cinalukast 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
leukotriene receptor antagonists	648	128312-51-6

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cinalukast
Ro 24-5913

Molecular weight: 412.55
Formula: C23H28N2O3S
CLOGP: 5.26
LIPINSKI: 1
HAC: 5
HDO: 2
TPSA: 79.29
ALOGS: -5.68
ROTB: 9

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:38070	antiarrhythmic agent
CHEBI has role	CHEBI:49159	leukotriene antagonists
CHEBI has role	CHEBI:49167	anti-asthmatic drugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	5.04	acidic
pKa2	12.68	acidic
pKa3	3.95	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Cysteinyl leukotriene receptor 1	GPCR	Q9Y271	CLTR1_HUMAN	ANTAGONIST				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE
Cysteinyl leukotriene receptor 1	GPCR		CLTR1_CAVPO		Ki	8.19		CHEMBL

External reference:

ID	Source
D02846	KEGG_DRUG
C0287390	UMLSCUI
CHEBI:126598	CHEBI
CHEMBL283754	ChEMBL_ID
DB00587	DRUGBANK_ID
C071436	MESH_SUPPLEMENTAL_RECORD_UI
6436135	PUBCHEM_CID
7094	INN_ID
5E1O433QAI	UNII

Pharmaceutical products:

None