cicloprolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 637 94651-09-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • cicloprolol
  • cicloprolol hydrochloride
  • cycloprolol
  • cicloprolol HCl
  • Molecular weight: 323.43
  • Formula: C18H29NO4
  • CLOGP: 2.39
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 59.95
  • ALOGS: -3.69
  • ROTB: 12

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR Ki 8 WOMBAT-PK
Beta-2 adrenergic receptor GPCR Ki 6.20 WOMBAT-PK

External reference:

IDSource
D03490 KEGG_DRUG
C0055713 UMLSCUI
CHEBI:135377 CHEBI
CHEMBL255015 ChEMBL_ID
CHEMBL2110772 ChEMBL_ID
CHEMBL399938 ChEMBL_ID
C053708 MESH_SUPPLEMENTAL_RECORD_UI
146294 PUBCHEM_CID
552 IUPHAR_LIGAND_ID
5250 INN_ID
63686-79-3 SECONDARY_CAS_RN
1K2ACH4U3R UNII
CHEMBL2105976 ChEMBL_ID
63659-12-1 SECONDARY_CAS_RN

Pharmaceutical products:

None