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cicloprolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| beta-adrenoreceptor antagonists | 637 | 94651-09-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP2K6,MAPK7,MET,NTRK2,PDK2,PDK4,PRKDC,TEK,TGFBR1 | 25 | |||
| kinase-selectivity-class | CDK4,EIF2AK3 | 2 | |||
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 0.789 | High | 0.80 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| rat-kpuu-brain | Rat brain Kpuu | 0.243 | % | High | 0.80 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.19 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Beta-1 adrenergic receptor | GPCR | Ki | 8 | WOMBAT-PK | |||||
| Beta-2 adrenergic receptor | GPCR | Ki | 6.20 | WOMBAT-PK |
External reference:
| ID | Source |
|---|---|
| D03490 | KEGG_DRUG |
| 63659-12-1 | SECONDARY_CAS_RN |
| C0055713 | UMLSCUI |
| CHEBI:135377 | CHEBI |
| CHEMBL255015 | ChEMBL_ID |
| CHEMBL2110772 | ChEMBL_ID |
| CHEMBL399938 | ChEMBL_ID |
| CHEMBL2105976 | ChEMBL_ID |
| C053708 | MESH_SUPPLEMENTAL_RECORD_UI |
| 146294 | PUBCHEM_CID |
| 552 | IUPHAR_LIGAND_ID |
| 5250 | INN_ID |
| 63686-79-3 | SECONDARY_CAS_RN |
| 1K2ACH4U3R | UNII |
Pharmaceutical products:
None