cicaprost 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prostaglandins	631	94079-80-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cicaprost dihydrochloride
ZK-96480
cicaprost betadex
cicaprost

Molecular weight: 374.48
Formula: C22H30O5
CLOGP: 2.03
LIPINSKI: 0
HAC: 5
HDO: 3
TPSA: 86.99
ALOGS: -4.23
ROTB: 10

Drug dosage:

None

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	99 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	0.08 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	3.80 mL/min/kg	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	1.10 hours	Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
MeSH PA	D000970	Antineoplastic Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.64	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Prostaglandin E2 receptor EP1 subtype	GPCR	P34995	PE2R1_HUMAN		Ki	5.90		WOMBAT-PK
Prostaglandin E2 receptor EP3 subtype	GPCR	P43115	PE2R3_HUMAN		Ki	6.60		WOMBAT-PK
Prostacyclin receptor	GPCR	P43119	PI2R_HUMAN		Ki	7.80		WOMBAT-PK
Prostaglandin E2 receptor EP4 subtype	GPCR	P35408	PE2R4_HUMAN		Ki	7.40		WOMBAT-PK
Prostaglandin D2 receptor	GPCR	Q13258	PD2R_HUMAN		Ki	5.87		PDSP
Prostaglandin F2-alpha receptor	GPCR	P43088	PF2R_HUMAN		Ki	5.87		PDSP
Prostaglandin E2 receptor EP2 subtype	GPCR		PE2R2_MOUSE	AGONIST	Ki	5.90		IUPHAR
Prostaglandin E2 receptor EP3 subtype	GPCR		PE2R3_MOUSE	AGONIST	Ki	6.77		IUPHAR
Prostacyclin receptor	GPCR		PI2R_MOUSE	AGONIST	Ki	8		IUPHAR

External reference:

ID	Source
C0055705	UMLSCUI
CHEBI:135578	CHEBI
CHEMBL160629	ChEMBL_ID
C043867	MESH_SUPPLEMENTAL_RECORD_UI
5311044	PUBCHEM_CID
1917	IUPHAR_LIGAND_ID
5826	INN_ID
NE94J8CAMD	UNII

Pharmaceutical products:

None