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sepetaprost 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| prostaglandins | 5805 | 1262873-06-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Sepetaprost, a bicyclic prostaglandin derivative, which binds to and stimulates FP and EP3 receptors, promoting aqueous humor outflow and thereby lowering intraocular pressure (IOP).
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 25, 2025 | PMDA | Santen Pharmaceutical Co., Ltd. |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Glaucoma | indication | 23986001 | DOID:1686 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP3 subtype | GPCR | AGONIST | EC50 | 7.54 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Prostaglandin F2-alpha receptor | GPCR | AGONIST | EC50 | 7.65 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| CHEMBL4297633 | ChEMBL_ID |
| DB12043 | DRUGBANK_ID |
| C4519294 | UMLSCUI |
| CHEBI:757102 | CHEBI |
| 9850 | INN_ID |
| 50902259 | PUBCHEM_CID |
| 9875 | IUPHAR_LIGAND_ID |
| 79O7855J4G | UNII |
| D12617 | KEGG_DRUG |
Pharmaceutical products:
None