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motugivatrep 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| transient receptor potential antagonists | 5795 | 920332-28-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Motugivatrep is a selective TRPV1 antagonist designed for topical ophthalmic use. By inhibiting TRPV1 activation, the drug is hypothesized to reduce corneal nerve hypersensitivity and downstream discomfort signals associated with tear film instability.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 22, 2025 | PMDA | Senju Pharmaceutical Co., Ltd. |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Dry eye disease | indication | 46152009 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 1 | Ion channel | INHIBITOR | UNKNOWN | EXPERT CURATOR |
External reference:
| ID | Source |
|---|---|
| CHEMBL5095073 | ChEMBL_ID |
| C5707845 | UMLSCUI |
| CHEBI:758657 | CHEBI |
| 12048 | INN_ID |
| 137350798 | PUBCHEM_CID |
| 14510 | IUPHAR_LIGAND_ID |
| 7SHP2FH6HQ | UNII |
| D12841 | KEGG_DRUG |
Pharmaceutical products:
None