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brensocatib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| cathepsin inhibitors | 5791 | 1802148-05-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Brensocatib is a competitive and reversible inhibitor of dipeptidyl peptidase 1 (DPP1). DPP1 activates pro-inflammatory neutrophil serine proteases (NSPs) during neutrophil maturation in the bone marrow. Brensocatib reduces the activity of NSPs implicated in the pathogenesis of bronchiectasis, including neutrophil elastase, cathepsin G and proteinase 3.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 18, 2025 | EMA | Insmed Netherlands B.V. | |
| Aug. 12, 2025 | FDA | Insmed Inc. |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:22587 | antiviral agent |
| CHEBI has role | CHEBI:231911 | renoprotective agent |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Non-cystic fibrosis bronchiectasis | indication | 12295008 | DOID:9563 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 10287258 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 10669245 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11655221 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11655222 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11655223 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11655224 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11673871 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11773069 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11814359 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 12054465 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 9815805 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 10287258 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 10669245 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11655221 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11655222 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11655223 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11655224 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11673871 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11773069 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 11814359 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 12054465 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | 9815805 | Jan. 21, 2035 | TREATMENT OF NON-CYSTIC FIBROSIS BRONCHIECTASIS IN PATIENTS 12 YEARS OF AGE AND OLDER |
Orange Book exclusivity data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
|---|---|---|---|---|---|---|---|---|---|
| 10MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | Aug. 12, 2030 | NEW CHEMICAL ENTITY |
| 25MG | BRINSUPRI | INSMED INC | N217673 | Aug. 12, 2025 | RX | TABLET | ORAL | Aug. 12, 2030 | NEW CHEMICAL ENTITY |
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 1 | Enzyme | INHIBITOR | IC50 | 8.40 | DRUG LABEL | DRUG LABEL | |||
| Dipeptidyl peptidase 1 | Enzyme | INHIBITOR | IC50 | 7.70 | IUPHAR | ||||
| Dipeptidyl peptidase 1 | Enzyme | INHIBITOR | IC50 | 7.60 | IUPHAR |
External reference:
| ID | Source |
|---|---|
| CHEMBL3900409 | ChEMBL_ID |
| C000619932 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB15638 | DRUGBANK_ID |
| 4044180 | VANDF |
| C5242458 | UMLSCUI |
| CHEBI:755968 | CHEBI |
| 11097 | INN_ID |
| D12120 | KEGG_DRUG |
| 118253852 | PUBCHEM_CID |
| 397078 | MMSL |
| 44328 | MMSL |
| d10303 | MMSL |
| 020194 | NDDF |
| 9412 | IUPHAR_LIGAND_ID |
| 25CG88L0BB | UNII |
| 2721880 | RXNORM |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Brinsupri | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71558-001 | TABLET | 10 mg | ORAL | NDA | 27 sections |
| Brinsupri | HUMAN PRESCRIPTION DRUG LABEL | 1 | 71558-002 | TABLET | 25 mg | ORAL | NDA | 27 sections |