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vornorexant 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| orexin receptor antagonists | 5782 | 2265899-49-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Vornorexant acts as a dual orexin OX1 and OX2 receptor antagonist (DORA) which is used in the treatment of insomnia in Japan.
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 25, 2025 | PMDA | Taisho Pharmaceutical |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Insomnia | indication | 193462001 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Orexin receptor type 1 | GPCR | ANTAGONIST | IC50 | 8.98 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Orexin receptor type 2 | GPCR | ANTAGONIST | IC50 | 8.90 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| A1MCY | PDB_CHEM_ID |
| C000732022 | MESH_SUPPLEMENTAL_RECORD_UI |
| C5670523 | UMLSCUI |
| CHEBI:758399 | CHEBI |
| CHEMBL4650522 | ChEMBL_ID |
| 11740 | INN_ID |
| D12611 | KEGG_DRUG |
| 137419776 | PUBCHEM_CID |
| 14430 | IUPHAR_LIGAND_ID |
| ZY54BP1CK3 | UNII |
| C000723815 | MESH_SUPPLEMENTAL_RECORD_UI |
Pharmaceutical products:
None