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foscarbidopa 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| dopamine receptor agonists, dopamine derivatives, used as antiparkinsonism/prolactin inhibitors | 5725 | 1907685-81-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Foscarbidopa and foslevodopa combination (ABBV-951) was aproved by PMDA for the treatment of motor fluctuations in patients with advanced Parkinson’s disease. Foscarbidopa and foslevodopa are prodrugs of carbidopa and levodopa, respectively. They have higher solubility than their parent compounds, which allows them to be administered as a continuous subcutaneous infusion.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BMX,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CHUK,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHA2,EPHB4,ERBB2,FLT1,FLT3,GRK2,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,SRC,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 71 | |||
| kinase-selectivity-class | ACVR2B,AURKA,AURKB,AXL,BMX,BRAF,CDK1,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,IKBKB,IRAK3,JAK2,MAP2K6,MAP3K14,MAP3K2,MAPK7,MAPK8,PIK3CB,PIK3CD,PIK3CG,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 | 33 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pld-class | Phospholipidosis risk class (1 = positive, 0 = negative) | 0 | Moderate | 0.67 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Dec. 23, 2022 | PMDA | AbbVie GK |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| CHEBI has role | CHEBI:48407 | antiparkinson drug |
| CHEBI has role | CHEBI:50266 | prodrug |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Parkinson's disease | indication | 49049000 | DOID:14330 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
|---|---|---|---|---|---|---|---|---|---|---|
| 120MG/10ML;2400MG/10ML (12MG/ML;240MG/ML) | VYALEV | ABBVIE | N216962 | Oct. 16, 2024 | RX | SOLUTION | SUBCUTANEOUS | 10174061 | Oct. 21, 2035 | TREATMENT OF MOTOR FLUCTUATIONS IN ADULTS WITH ADVANCED PARKINSONS DISEASE |
| 120MG/10ML;2400MG/10ML (12MG/ML;240MG/ML) | VYALEV | ABBVIE | N216962 | Oct. 16, 2024 | RX | SOLUTION | SUBCUTANEOUS | 9446059 | Oct. 21, 2035 | TREATMENT OF MOTOR FLUCTUATIONS IN ADULTS WITH ADVANCED PARKINSONS DISEASE |
| 120MG/10ML;2400MG/10ML (12MG/ML;240MG/ML) | VYALEV | ABBVIE | N216962 | Oct. 16, 2024 | RX | SOLUTION | SUBCUTANEOUS | 12251365 | June 10, 2040 | TREATMENT OF MOTOR FLUCTUATIONS IN ADULTS WITH ADVANCED PARKINSONS DISEASE |
Orange Book exclusivity data (new drug applications)
| Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Exclusivity date | Description |
|---|---|---|---|---|---|---|---|---|---|
| 120MG/10ML;2400MG/10ML (12MG/ML;240MG/ML) | VYALEV | ABBVIE | N216962 | Oct. 16, 2024 | RX | SOLUTION | SUBCUTANEOUS | Oct. 16, 2027 | NEW PRODUCT |
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| CHEMBL4802240 | ChEMBL_ID |
| DB16171 | DRUGBANK_ID |
| 1332140007 | SNOMEDCT_US |
| 4043478 | VANDF |
| C5238148 | UMLSCUI |
| CHEBI:192512 | CHEBI |
| CHEMBL4594379 | ChEMBL_ID |
| 11007 | INN_ID |
| 121288738 | PUBCHEM_CID |
| 42572 | MMSL |
| d10165 | MMSL |
| 019434 | NDDF |
| D12057 | KEGG_DRUG |
| 5NT8HCA4OO | UNII |
| 2695774 | RXNORM |
| 5NT8HCA4OO | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Vyalev | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0074-0501 | INJECTION | 12 mg | SUBCUTANEOUS | NDA | 30 sections |