lutetium (177Lu) chloride 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5682 16434-14-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lutetium (177Lu) chloride
  • lumark
  • illuzyce
Lutetium (177 Lu) chloride is a radiopharmaceutical precursor, and it is not intended for direct use in patients. It is to be used only for the radiolabelling of carrier molecules that have been specifically developed and authorised for radiolabelling with lutetium (177 Lu) chloride.
  • Molecular weight: 283.29
  • Formula: Cl3Lu
  • CLOGP: -1.32
  • LIPINSKI: 0
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS: -0.86
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
June 18, 2015 EMA I.D.B. Radiopharmacy B.V.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 4354.59 9.82 2473 281663 51118 90293193
White blood cell count decreased 1227.14 9.82 2015 282121 165094 90179217
Pemphigus 1000.43 9.82 4 284132 326860 90017451
Hand deformity 866.44 9.82 12 284124 296350 90047961
Systemic lupus erythematosus 813.40 9.82 92 284044 361804 89982507
Glossodynia 778.27 9.82 61 284075 321718 90022593
Duodenal ulcer perforation 664.95 9.82 5 284131 221283 90123028
Pericarditis 659.45 9.82 49 284087 270102 90074209
Joint swelling 652.36 9.82 385 283751 502915 89841396
Helicobacter infection 639.19 9.82 15 284121 226835 90117476
Contraindicated product administered 632.33 9.82 119 284017 320020 90024291
Wound 612.70 9.82 106 284030 302874 90041437
Neutrophil count decreased 612.24 9.82 926 283210 70606 90273705
Arthropathy 593.32 9.82 204 283932 366038 89978273
Drug ineffective 572.98 9.82 2322 281814 1381976 88962335
Synovitis 563.71 9.82 167 283969 329585 90014726
Alopecia 544.64 9.82 452 283684 494619 89849692
Drug intolerance 543.27 9.82 369 283767 447222 89897089
Folliculitis 535.26 9.82 25 284111 204328 90139983
Rheumatoid arthritis 512.65 9.82 248 283888 362366 89981945
Therapeutic product effect decreased 501.72 9.82 126 284010 277445 90066866
Muscle injury 500.25 9.82 11 284125 176643 90167668
Psoriatic arthropathy 446.21 9.82 87 284049 228248 90116063
Hereditary angioedema 445.43 9.82 308 283828 9057 90335254
Irritable bowel syndrome 436.28 9.82 65 284071 207383 90136928
Treatment failure 421.72 9.82 213 283923 303715 90040596
Hepatic enzyme increased 406.86 9.82 321 283815 360415 89983896
Musculoskeletal stiffness 394.95 9.82 219 283917 296313 90047998
Hypokalaemia 377.02 9.82 1082 283054 130034 90214277
Infective pulmonary exacerbation of cystic fibrosis 355.53 9.82 279 283857 10000 90334311
Swelling 348.71 9.82 483 283653 418575 89925736
Hepatic function abnormal 342.98 9.82 561 283575 45727 90298584
Impaired healing 341.88 9.82 153 283983 234046 90110265
Lower respiratory tract infection 333.91 9.82 185 283951 250474 90093837
Abdominal discomfort 333.31 9.82 618 283518 476710 89867601
Swollen joint count increased 326.99 9.82 4 284132 111202 90233109
Chills 321.96 9.82 1028 283108 130953 90213358
Chest discomfort 312.63 9.82 1050 283086 137315 90206996
Cardiac failure congestive 311.83 9.82 843 283293 97851 90246460
Blood cholesterol increased 311.37 9.82 131 284005 207881 90136430
Type 2 diabetes mellitus 310.71 9.82 124 284012 203120 90141191
Joint range of motion decreased 298.18 9.82 37 284099 135606 90208705
Ill-defined disorder 295.67 9.82 105 284031 184786 90159525
Blister 282.24 9.82 231 283905 254767 90089544
Sleep disorder due to general medical condition, insomnia type 280.72 9.82 36 284100 128658 90215653
Maternal exposure during pregnancy 278.93 9.82 436 283700 359627 89984684
Facet joint syndrome 275.13 9.82 7 284129 98382 90245929
Drug hypersensitivity 271.18 9.82 663 283473 462946 89881365
Death 267.23 9.82 2388 281748 454163 89890148
Discomfort 264.21 9.82 282 283854 274053 90070258
C-reactive protein abnormal 260.89 9.82 43 284093 127386 90216925
Hyperkalaemia 258.72 9.82 606 283530 64358 90279953
Platelet count decreased 258.57 9.82 980 283156 135989 90208322
Sepsis 258.27 9.82 1183 282953 178631 90165680
Hypervolaemia 257.69 9.82 408 283728 32349 90311962
Granulocyte count decreased 253.87 9.82 133 284003 2319 90341992
Hypersensitivity 250.65 9.82 670 283466 454007 89890304
Peritonitis bacterial 250.48 9.82 172 283964 4999 90339312
Stomatitis 248.59 9.82 297 283839 274401 90069910
Dehydration 246.50 9.82 1234 282902 193213 90151098
Bursitis 245.12 9.82 56 284080 131598 90212713
Mobility decreased 244.51 9.82 255 283881 250479 90093832
Grip strength decreased 243.38 9.82 11 284125 92565 90251746
Anaemia 235.14 9.82 1900 282236 350902 89993409
Dyspnoea 233.88 9.82 3967 280169 876988 89467323
Agranulocytosis 233.74 9.82 405 283731 34597 90309714
Injury 226.89 9.82 172 283964 197177 90147134
Lip dry 225.68 9.82 26 284110 100929 90243382
Hypotension 223.14 9.82 1764 282372 323633 90020678
Fibromyalgia 218.27 9.82 195 283941 206074 90138237
Arthralgia 218.01 9.82 1488 282648 777034 89567277
Nausea 216.31 9.82 4769 279367 1105547 89238764
Inflammation 211.33 9.82 151 283985 178441 90165870
Macular degeneration 203.98 9.82 400 283736 37570 90306741
Hypercholesterolaemia 197.92 9.82 38 284098 100854 90243457
Pulmonary hypertension 194.28 9.82 419 283717 42104 90302207
Blood potassium decreased 191.98 9.82 447 283689 47280 90297031
Pneumonia 191.71 9.82 2934 281202 635125 89709186
Urinary tract infection 190.20 9.82 1621 282515 304011 90040300
Atrial fibrillation 188.79 9.82 875 283261 132736 90211575
Product use issue 187.15 9.82 479 283657 329440 90014871
Temperature intolerance 183.21 9.82 207 283929 11823 90332488
Osteoarthritis 177.68 9.82 211 283925 195519 90148792
Sleep disorder 174.98 9.82 218 283918 197812 90146499
Hyperpyrexia 172.85 9.82 133 284003 4628 90339683
Acute kidney injury 164.76 9.82 1631 282505 318756 90025555
Pulmonary fibrosis 163.55 9.82 66 284070 107437 90236874
Gastrointestinal haemorrhage 159.06 9.82 632 283504 89616 90254695
Night sweats 156.11 9.82 106 284030 128660 90215651
Peripheral venous disease 153.62 9.82 37 284099 83884 90260427
Wound infection 149.79 9.82 73 284063 106329 90237982
Acute respiratory failure 148.14 9.82 379 283757 42539 90301772
Hypoxia 147.44 9.82 531 283605 71868 90272443
Tachypnoea 146.78 9.82 250 283886 21059 90323252
Plasma cell myeloma 144.52 9.82 364 283772 40464 90303847
Psoriasis 144.27 9.82 150 283986 147604 90196707
General physical health deterioration 142.28 9.82 601 283535 354514 89989797
Cytokine release syndrome 142.21 9.82 288 283848 27685 90316626
Peritoneal dialysis complication 141.61 9.82 73 284063 1229 90343082
Hip arthroplasty 138.71 9.82 34 284102 76174 90268137
Vomiting 137.78 9.82 3337 280799 784956 89559355
Hyponatraemia 136.31 9.82 799 283337 132739 90211572
Obesity 135.93 9.82 81 284055 105426 90238885
Pain 135.21 9.82 2255 281881 994086 89350225
Condition aggravated 134.77 9.82 1206 282930 594339 89749972
Autoimmune disorder 134.41 9.82 37 284099 76707 90267604
Respiratory failure 134.39 9.82 729 283407 117689 90226622
Intentional product use issue 133.13 9.82 302 283834 216590 90127721
Gait inability 131.70 9.82 159 283977 146297 90198014
Prescribed overdose 131.43 9.82 71 284065 97554 90246757
Blepharospasm 127.17 9.82 13 284123 55432 90288879
Infusion site pain 124.80 9.82 223 283913 19515 90324796
Toxicity to various agents 124.21 9.82 473 283663 287373 90056938
Chronic obstructive pulmonary disease 122.13 9.82 507 283629 73322 90270989
Rash 121.68 9.82 1761 282375 794339 89549972
Dry mouth 121.51 9.82 246 283890 183813 90160498
Live birth 119.62 9.82 49 284087 79058 90265253
Colitis microscopic 118.25 9.82 160 283976 10999 90333312
Coeliac disease 118.24 9.82 5 284131 44605 90299706
Knee arthroplasty 117.19 9.82 57 284079 83125 90261186
Cardiac arrest 117.05 9.82 643 283493 104292 90240019
Liver injury 114.28 9.82 226 283910 170341 90173970
Cystic fibrosis 113.19 9.82 96 284040 3845 90340466
Exposure during pregnancy 109.95 9.82 381 283755 238029 90106282
Asthenia 109.49 9.82 2312 281824 531439 89812872
Bronchitis 109.04 9.82 837 283299 152090 90192221
Bone erosion 108.26 9.82 18 284118 53003 90291308
Device expulsion 106.99 9.82 5 284131 40881 90303430
Nail disorder 106.24 9.82 27 284109 59040 90285271
Lower limb fracture 105.71 9.82 68 284068 84945 90259366
Confusional state 104.38 9.82 745 283391 385460 89958851
Pleural effusion 103.44 9.82 653 283483 111338 90232973
Ovarian hyperstimulation syndrome 103.43 9.82 109 284027 5753 90338558
Pyrexia 102.58 9.82 2753 281383 657732 89686579
Onychomadesis 102.41 9.82 12 284124 45986 90298325
Diarrhoea 101.97 9.82 3748 280388 935442 89408869
Oedema peripheral 101.69 9.82 1246 282890 256669 90087642
Paraesthesia oral 101.51 9.82 272 283864 31387 90312924
Prescribed underdose 98.89 9.82 56 284080 74963 90269348
Liver disorder 98.45 9.82 142 283994 121127 90223184
Sciatica 97.74 9.82 104 284032 101278 90243033
Toxic anterior segment syndrome 97.70 9.82 70 284066 2180 90342131
Breast cancer stage II 96.97 9.82 3 284133 35331 90308980
Pneumonia aspiration 96.22 9.82 315 283821 40625 90303686
Red blood cell sedimentation rate increased 96.14 9.82 71 284065 82524 90261787
Joint stiffness 94.91 9.82 64 284072 77978 90266333
Musculoskeletal pain 93.68 9.82 253 283883 170998 90173313
Flushing 93.22 9.82 534 283602 87957 90256354
Constipation 91.97 9.82 1310 282826 279085 90065226
Pulmonary oedema 91.68 9.82 412 283724 61668 90282643
Febrile neutropenia 91.68 9.82 827 283309 157522 90186789
Gastrointestinal disorder 91.66 9.82 453 283683 256234 90088077
Chronic sinusitis 91.44 9.82 219 283917 23583 90320728
Bone marrow failure 90.68 9.82 264 283872 31957 90312354
Fungal peritonitis 90.41 9.82 43 284093 603 90343708
Wheezing 90.38 9.82 411 283725 237669 90106642
Oxygen saturation decreased 90.30 9.82 612 283524 106871 90237440
Pulmonary arterial hypertension 90.10 9.82 231 283905 25956 90318355
Nasopharyngitis 89.95 9.82 829 283307 406275 89938036
Fall 89.85 9.82 2059 282077 479751 89864560
Peritonitis 89.80 9.82 194 283942 19511 90324800
Blood pressure decreased 87.62 9.82 465 283671 74430 90269881
Therapy non-responder 87.43 9.82 186 283950 136518 90207793
Finger deformity 86.16 9.82 4 284132 32893 90311418
Vaginal flatulence 85.37 9.82 147 283989 12491 90331820
Haemoglobin decreased 84.84 9.82 828 283308 161128 90183183
Lupus-like syndrome 84.69 9.82 24 284112 48822 90295489
Drug abuse 84.50 9.82 80 284056 82267 90262044
Right ventricular failure 84.03 9.82 186 283950 19019 90325292
Cardiac failure 82.38 9.82 607 283529 108889 90235422
Syncope 81.52 9.82 702 283434 131961 90212350
Road traffic accident 79.75 9.82 134 284002 107492 90236819
Hypernatraemia 79.51 9.82 121 284015 9266 90335045
Foot deformity 79.38 9.82 44 284092 59607 90284704
Lung disorder 79.32 9.82 225 283911 149658 90194653
Full blood count decreased 78.55 9.82 238 283898 29451 90314860
Onychomycosis 77.85 9.82 12 284124 37364 90306947
Colitis 77.59 9.82 428 283708 69514 90274797
Proctitis 77.44 9.82 157 283979 15102 90329209
Insurance issue 77.37 9.82 130 284006 10828 90333483
Arthritis 77.37 9.82 267 283869 167048 90177263
Exostosis 77.01 9.82 35 284101 53099 90291212
Vascular device infection 76.80 9.82 136 284000 11816 90332495
Incorrect drug administration rate 74.69 9.82 87 284049 5136 90339175
Device interaction 74.48 9.82 28 284108 208 90344103
Glaucoma 74.45 9.82 186 283950 20569 90323742
Hospitalisation 74.13 9.82 669 283467 127431 90216880
Abdominal distension 74.02 9.82 679 283457 129922 90214389
Renal failure 71.68 9.82 676 283460 130331 90213980
Female genital tract fistula 71.46 9.82 167 283969 17701 90326610
Diverticulitis 71.36 9.82 306 283830 44881 90299430
Granulocytopenia 69.24 9.82 93 284043 6348 90337963
Cardiac disorder 69.21 9.82 357 283779 56515 90287796
Aspartate aminotransferase increased 68.18 9.82 554 283582 102383 90241928
Blood sodium decreased 68.09 9.82 216 283920 27397 90316914
Procedural pain 67.32 9.82 244 283892 33116 90311195
Back injury 67.12 9.82 31 284105 46591 90297720
Infusion site extravasation 66.98 9.82 118 284018 10210 90334101
International normalised ratio increased 66.87 9.82 310 283826 47006 90297305
Radiculopathy 66.55 9.82 166 283970 18339 90325972
Deep vein thrombosis 65.58 9.82 502 283634 91118 90253193
Sensitisation 65.56 9.82 73 284063 4102 90340209
Multiple allergies 65.49 9.82 146 283990 15000 90329311
Cough 65.10 9.82 1565 282571 367397 89976914
Adverse event 64.56 9.82 173 283963 117245 90227066
Illness 64.29 9.82 459 283677 81510 90262801
Injection site reaction 64.28 9.82 119 284017 91961 90252350
Mental status changes 64.09 9.82 294 283842 44385 90299926
Dementia 62.87 9.82 191 283945 23670 90320641
Completed suicide 62.75 9.82 238 283898 144820 90199491
Infusion related reaction 62.40 9.82 925 283211 415855 89928456
Urticaria 61.84 9.82 654 283482 312080 90032231
Sopor 61.43 9.82 4 284132 24640 90319671
Oral candidiasis 61.41 9.82 247 283889 35208 90309103
Infection 60.85 9.82 785 283351 361309 89983002
Thrombosis 59.68 9.82 414 283722 72837 90271474
Abdominal pain 58.87 9.82 1641 282495 394080 89950231
Blood urea increased 58.48 9.82 219 283917 30194 90314117
Pregnancy 58.31 9.82 65 284071 61982 90282329
Productive cough 57.26 9.82 426 283710 76637 90267674
Fluid retention 57.20 9.82 472 283664 87619 90256692
Weight increased 57.01 9.82 944 283192 416983 89927328
Hypomagnesaemia 56.97 9.82 242 283894 35346 90308965
Disability 55.76 9.82 29 284107 40716 90303595
Infusion site swelling 55.26 9.82 117 284019 11603 90332708
Therapeutic response decreased 54.96 9.82 125 284011 89604 90254707
Initial insomnia 54.82 9.82 102 284034 9208 90335103
Peripheral swelling 54.75 9.82 938 283198 412168 89932143
Ejection fraction abnormal 54.40 9.82 52 284084 2439 90341872
Hepatitis 54.34 9.82 86 284050 70653 90273658
Liver function test increased 53.79 9.82 116 284020 84739 90259572
Back pain 53.72 9.82 1338 282798 315837 90028474
Pulmonary embolism 53.68 9.82 637 283499 130183 90214128
Drug tolerance decreased 53.50 9.82 17 284119 32113 90312198
Adverse drug reaction 53.42 9.82 187 283949 116514 90227797
Electrolyte imbalance 53.39 9.82 180 283956 23565 90320746
Haemarthrosis 52.94 9.82 64 284072 3930 90340381
Blood glucose increased 52.85 9.82 493 283643 94753 90249558
Blood alkaline phosphatase increased 52.51 9.82 293 283843 47786 90296525
Laryngitis 52.43 9.82 49 284087 50704 90293607
Insomnia 52.38 9.82 733 283403 332741 90011570
Therapeutic product effect incomplete 52.32 9.82 374 283762 193522 90150789
Walking aid user 52.06 9.82 23 284113 35483 90308828
Contusion 51.84 9.82 520 283616 250696 90093615
Pallor 51.38 9.82 228 283908 33937 90310374
Cardiogenic shock 51.11 9.82 181 283955 24287 90320024
Rheumatoid nodule 51.09 9.82 3 284133 20163 90324148
Polycystic ovaries 50.92 9.82 75 284061 5579 90338732
Osmotic demyelination syndrome 50.91 9.82 35 284101 1019 90343292
Hiatus hernia 50.76 9.82 185 283951 25176 90319135
Weight decreased 50.63 9.82 1554 282582 378356 89965955
Dyspnoea exertional 50.57 9.82 394 283742 71894 90272417
Vaginal discharge 50.53 9.82 155 283981 19309 90325002
Cellulitis 50.30 9.82 472 283664 90865 90253446
Intentional self-injury 49.78 9.82 15 284121 29319 90314992
Seasonal allergy 49.72 9.82 172 283964 22811 90321500
Cyanosis 49.64 9.82 154 283982 19301 90325010
Ejection fraction 49.62 9.82 54 284082 2957 90341354
Decreased appetite 48.80 9.82 1535 282601 375005 89969306
COVID-19 48.38 9.82 771 283365 168072 90176239
Product use in unapproved indication 48.32 9.82 752 283384 335484 90008827
Hypophagia 48.26 9.82 232 283904 35705 90308606
Hyponatraemic encephalopathy 47.88 9.82 22 284114 284 90344027
Suicide attempt 47.85 9.82 103 284033 75296 90269015
Pancytopenia 47.77 9.82 582 283554 119681 90224630
Device related infection 47.37 9.82 183 283953 25603 90318708
Taste disorder 47.11 9.82 75 284061 61471 90282840
Poor venous access 46.56 9.82 151 283985 19376 90324935
Blood bilirubin increased 46.21 9.82 263 283873 43207 90301104
Myocardial infarction 46.15 9.82 522 283614 105450 90238861
C-reactive protein increased 46.02 9.82 356 283780 181033 90163278
Wound infection pseudomonas 45.64 9.82 43 284093 1980 90342331
Metabolic alkalosis 45.63 9.82 56 284080 3493 90340818
Sleep apnoea syndrome 45.60 9.82 209 283927 31538 90312773
Blood fibrinogen decreased 45.38 9.82 34 284102 1136 90343175
Arrhythmia 44.92 9.82 256 283880 42076 90302235
Lymphatic fistula 44.88 9.82 37 284099 1424 90342887
Product dose omission issue 44.87 9.82 1215 282921 290472 90053839
Unresponsive to stimuli 44.79 9.82 237 283899 37884 90306427
Blood magnesium decreased 44.56 9.82 129 284007 15564 90328747
Cold sweat 44.15 9.82 120 284016 13961 90330350
Femoral hernia incarcerated 43.86 9.82 37 284099 1471 90342840
Acidosis hyperchloraemic 43.56 9.82 30 284106 876 90343435
Abdominal pain upper 43.53 9.82 757 283379 331917 90012394
Infusion site haemorrhage 43.38 9.82 68 284068 5343 90338968
Infusion site erythema 43.37 9.82 117 284019 13553 90330758
Muscle spasticity 42.90 9.82 29 284107 35293 90309018
Hypocalcaemia 42.87 9.82 253 283883 42115 90302196
Adverse reaction 42.39 9.82 20 284116 29692 90314619
Cardiovascular disorder 42.33 9.82 115 284021 13377 90330934
Respiratory distress 42.30 9.82 237 283899 38709 90305602
Ascites 41.99 9.82 275 283861 47465 90296846
Staphylococcal infection 41.98 9.82 278 283858 48161 90296150
Haemoptysis 41.82 9.82 211 283925 33109 90311202
Blood cholesterol decreased 41.58 9.82 40 284096 1891 90342420
Loss of personal independence in daily activities 41.52 9.82 253 283883 135852 90208459
Erythema 41.48 9.82 976 283160 228270 90116041
Cardiomegaly 41.26 9.82 142 283994 18783 90325528
Prothrombin time prolonged 40.91 9.82 93 284043 9679 90334632
Dermatitis contact 40.79 9.82 114 284022 13481 90330830
Polyarthritis 40.32 9.82 5 284131 18345 90325966
Product residue present 40.21 9.82 58 284078 4233 90340078
Epistaxis 39.67 9.82 425 283711 84700 90259611
Blood chloride decreased 39.44 9.82 71 284065 6248 90338063
Abortion spontaneous 39.40 9.82 68 284068 53988 90290323
Intentional overdose 39.26 9.82 156 283980 93678 90250633
Pancreatic steatosis 39.17 9.82 36 284100 1606 90342705
Cerebrovascular accident 38.80 9.82 573 283563 122960 90221351
Blood creatinine increased 38.69 9.82 487 283649 100899 90243412
Palpitations 38.65 9.82 623 283513 136105 90208206
Failure to thrive 38.55 9.82 83 284053 8328 90335983
Clostridium difficile colitis 38.50 9.82 176 283960 26530 90317781
Hypoaesthesia 37.96 9.82 725 283411 313485 90030826
Blood potassium increased 37.91 9.82 147 283989 20602 90323709
Coagulopathy 37.77 9.82 159 283977 23130 90321181
Ultrafiltration failure 37.68 9.82 18 284118 255 90344056
Malnutrition 37.67 9.82 136 284000 18422 90325889
Maternal exposure timing unspecified 37.25 9.82 12 284124 22471 90321840
Hypovolaemia 37.06 9.82 104 284032 12327 90331984
Off label use 37.05 9.82 2965 281171 1099287 89245024
Haematuria 36.89 9.82 211 283925 34726 90309585
Tetany 36.88 9.82 43 284093 2541 90341770
Septic shock 36.84 9.82 415 283721 83745 90260566
Atrial flutter 36.08 9.82 94 284042 10664 90333647
Arterial haemorrhage 36.03 9.82 42 284094 2481 90341830
Leukocytosis 35.96 9.82 192 283944 30798 90313513
Infusion site infection 35.87 9.82 43 284093 2617 90341694
Cor pulmonale 35.80 9.82 38 284098 2022 90342289
Suicidal ideation 35.39 9.82 116 284020 73739 90270572
Disorganised speech 34.96 9.82 36 284100 1849 90342462
Blood creatine increased 34.54 9.82 71 284065 6896 90337415
Tachycardia 34.50 9.82 690 283446 156983 90187328
Coronary artery disease 34.16 9.82 201 283935 33422 90310889
Seroma 34.15 9.82 45 284091 3015 90341296
Product administration error 33.64 9.82 168 283968 26255 90318056
Mitral valve incompetence 33.63 9.82 150 283986 22374 90321937
Oxygen consumption increased 33.14 9.82 55 284081 4534 90339777
Brain natriuretic peptide increased 33.14 9.82 64 284072 5941 90338370
Haematochezia 33.02 9.82 354 283782 70559 90273752
Alanine aminotransferase increased 33.00 9.82 538 283598 117800 90226511
Toxic epidermal necrolysis 32.75 9.82 194 283942 32334 90311977
Influenza 32.70 9.82 616 283520 138648 90205663
Product quality issue 32.48 9.82 133 284003 79192 90265119
Encapsulating peritoneal sclerosis 32.47 9.82 18 284118 353 90343958
Peripheral circulatory failure 32.25 9.82 32 284104 1572 90342739
Memory impairment 32.22 9.82 430 283706 196814 90147497
Catheter site haemorrhage 32.09 9.82 48 284088 3620 90340691
Hyperglycaemia 31.96 9.82 271 283865 50699 90293612
Tenosynovitis 31.93 9.82 4 284132 14563 90329748
Diverticulum intestinal 31.82 9.82 81 284055 9061 90335250
Hyperaldosteronism 31.62 9.82 17 284119 313 90343998
Hepatic cirrhosis 31.25 9.82 98 284038 63155 90281156
Thrombocytopenia 31.11 9.82 866 283270 207859 90136452
Pericardial effusion 31.08 9.82 210 283926 36623 90307688
Infusion site bruising 31.04 9.82 52 284084 4320 90339991
Drug reaction with eosinophilia and systemic symptoms 30.97 9.82 54 284082 42704 90301607
Post procedural complication 30.88 9.82 130 284006 18912 90325399
Pustular psoriasis 30.57 9.82 10 284126 18546 90325765
Neuropathy peripheral 30.50 9.82 601 283535 136369 90207942
Transfusion 30.41 9.82 122 284014 17366 90326945
Product distribution issue 30.31 9.82 47 284089 3658 90340653
Product preparation issue 30.13 9.82 37 284099 2309 90342002
Immune effector cell-associated neurotoxicity syndrome 30.05 9.82 60 284076 5708 90338603
General symptom 29.90 9.82 5 284131 14663 90329648
Haemorrhage 29.88 9.82 341 283795 69028 90275283
Blood albumin decreased 29.85 9.82 118 284018 16685 90327626
Gastric polyps 29.81 9.82 53 284083 4619 90339692
Electrocardiogram abnormal 29.57 9.82 85 284051 10213 90334098
Eructation 29.51 9.82 88 284048 10794 90333517
Foetal death 29.49 9.82 14 284122 20709 90323602
Device infusion issue 29.48 9.82 39 284097 2623 90341688
Hypoglycaemia 29.48 9.82 342 283794 69506 90274805
Blood loss anaemia 29.41 9.82 84 284052 10056 90334255
Procedural complication 29.26 9.82 60 284076 5818 90338493
Small intestinal obstruction 29.18 9.82 138 283998 21096 90323215
Metabolic encephalopathy 29.09 9.82 65 284071 6687 90337624
Blood pressure diastolic abnormal 28.96 9.82 13 284123 19868 90324443
Faecaloma 28.90 9.82 85 284051 10346 90333965
Dysphagia 28.59 9.82 503 283633 111775 90232536
Hypoalbuminaemia 28.53 9.82 112 284024 15785 90328526
Blood glucose decreased 28.45 9.82 147 283989 23282 90321029
Acute pulmonary oedema 28.41 9.82 80 284056 9500 90334811
Nephrectomy 28.33 9.82 33 284103 1948 90342363
Personality disorder 28.32 9.82 3 284133 12441 90331870
Atrioventricular block first degree 28.17 9.82 74 284062 8437 90335874
Renal disorder 27.96 9.82 209 283927 37650 90306661
Activated partial thromboplastin time prolonged 27.93 9.82 70 284066 7755 90336556
Myocardial reperfusion injury 27.81 9.82 12 284124 132 90344179
Generalised oedema 27.79 9.82 126 284010 18927 90325384
Cystic fibrosis respiratory infection suppression 27.76 9.82 16 284120 339 90343972
Neuroglycopenia 27.68 9.82 25 284111 1090 90343221
Asthma 27.64 9.82 564 283572 241596 90102715
Migraine 27.60 9.82 425 283711 189967 90154344
Suspected product quality issue 27.36 9.82 17 284119 415 90343896
Seizure 27.35 9.82 649 283487 151980 90192331
Lymphocyte count decreased 27.32 9.82 196 283940 34854 90309457
Gout 27.26 9.82 115 284021 16744 90327567
Chronic respiratory failure 27.09 9.82 38 284098 2703 90341608
Tricuspid valve incompetence 26.95 9.82 114 284022 16617 90327694
Pain in jaw 26.92 9.82 249 283887 47736 90296575
Hospice care 26.81 9.82 79 284057 9625 90334686
Overdose 26.79 9.82 341 283795 157368 90186943
Pneumonia staphylococcal 26.78 9.82 44 284092 3597 90340714
Electrocardiogram T wave peaked 26.47 9.82 14 284122 249 90344062
Hepatotoxicity 26.37 9.82 66 284070 45776 90298535
Maternal exposure during delivery 26.32 9.82 45 284091 3801 90340510
Joint destruction 26.06 9.82 5 284131 13282 90331029
Respiratory syncytial virus infection 25.86 9.82 82 284054 10398 90333913
Skin reaction 25.80 9.82 121 284015 18432 90325879
Blood pressure abnormal 25.79 9.82 126 284010 19519 90324792
Infusion site pruritus 25.72 9.82 62 284074 6703 90337608
Drug tolerance 25.65 9.82 12 284124 17904 90326407
Cardiac failure acute 25.57 9.82 89 284047 11840 90332471
Sinus tachycardia 25.53 9.82 165 283971 28348 90315963
Dysuria 25.51 9.82 211 283925 39190 90305121
Catheter site pain 25.50 9.82 55 284081 5524 90338787
Emphysema 25.46 9.82 90 284046 12065 90332246
Myositis 25.27 9.82 23 284113 24105 90320206
Red blood cell count decreased 25.25 9.82 239 283897 46112 90298199
Burning sensation 25.16 9.82 307 283829 63145 90281166
Encephalopathy 25.06 9.82 239 283897 46205 90298106
Haematocrit decreased 24.97 9.82 220 283916 41612 90302699
Atelectasis 24.85 9.82 146 283990 24263 90320048
Subcutaneous drug absorption impaired 24.73 9.82 6 284130 13539 90330772
Haemoglobin increased 24.71 9.82 65 284071 7416 90336895
Heart rate increased 24.67 9.82 494 283642 112408 90231903
Schizophrenia 24.64 9.82 8 284128 14906 90329405
Blood potassium abnormal 24.52 9.82 38 284098 2956 90341355
Acute left ventricular failure 24.49 9.82 25 284111 1271 90343040
Air embolism 24.44 9.82 15 284121 358 90343953
Bacteraemia 24.41 9.82 136 284000 22164 90322147
Aortic valve stenosis 24.40 9.82 46 284090 4194 90340117
Viral infection 24.30 9.82 217 283919 41197 90303114
Urosepsis 24.26 9.82 131 284005 21101 90323210
Product preparation error 24.15 9.82 79 284057 10182 90334129
Lethargy 23.96 9.82 303 283833 62836 90281475
Device related sepsis 23.95 9.82 49 284087 4744 90339567
Catheter site infection 23.88 9.82 54 284082 5600 90338711
Pulse absent 23.57 9.82 56 284080 5999 90338312
Arteriosclerosis coronary artery 23.57 9.82 75 284061 9528 90334783
Groin pain 23.52 9.82 88 284048 12125 90332186
Hypothyroidism 23.26 9.82 262 283874 52865 90291446
Delirium 23.21 9.82 212 283924 104147 90240164
Transient ischaemic attack 23.20 9.82 222 283914 42954 90301357
Pneumothorax spontaneous 23.09 9.82 21 284115 924 90343387
Cytopenia 22.96 9.82 112 284024 17337 90326974
Amnesia 22.61 9.82 224 283912 108281 90236030
Internal haemorrhage 22.58 9.82 56 284080 6164 90338147
Bradycardia 22.56 9.82 379 283757 83468 90260843
Infusion site rash 22.45 9.82 33 284103 2450 90341861
Neonatal gastrointestinal disorder 22.45 9.82 9 284127 81 90344230
Hepatocellular injury 22.43 9.82 35 284101 28923 90315388
Catheter site extravasation 22.43 9.82 15 284121 417 90343894
Drug ineffective for unapproved indication 22.41 9.82 120 284016 66524 90277787
Endophthalmitis 22.36 9.82 47 284089 4638 90339673
Dizziness 22.17 9.82 2140 281996 587144 89757167
Gastritis 22.10 9.82 214 283922 41539 90302772
Coma 22.06 9.82 335 283801 72297 90272014
Gastrooesophageal reflux disease 22.01 9.82 680 283456 165657 90178654
Impaired work ability 21.99 9.82 17 284119 19309 90325002
Supraventricular tachycardia 21.60 9.82 105 284031 16231 90328080
Hypertension 21.49 9.82 1194 282942 456338 89887973
Bloody peritoneal effluent 21.45 9.82 8 284128 58 90344253
Peritoneal cloudy effluent 21.38 9.82 13 284123 305 90344006
Intentional product misuse 21.27 9.82 179 283957 89425 90254886
Fluid replacement 21.22 9.82 17 284119 628 90343683
Ulcer haemorrhage 21.18 9.82 31 284105 26290 90318021
Ischaemic contracture of the left ventricle 21.17 9.82 10 284126 138 90344173
Blood test abnormal 21.12 9.82 125 284011 20827 90323484
Hypochloraemia 21.09 9.82 33 284103 2589 90341722
Blood pressure systolic abnormal 21.08 9.82 18 284118 19460 90324851
Spondylitis 21.08 9.82 9 284127 14169 90330142
Feeling cold 21.07 9.82 153 283983 27312 90316999
Catheter site erythema 20.96 9.82 47 284089 4847 90339464
Presyncope 20.95 9.82 171 283965 31634 90312677
Foetal exposure during pregnancy 20.94 9.82 67 284069 42908 90301403
Hypophosphataemia 20.75 9.82 97 284039 14757 90329554
Urinary retention 20.75 9.82 195 283941 37549 90306762
Discoloured vomit 20.74 9.82 22 284114 1170 90343141
Aortic arteriosclerosis 20.70 9.82 62 284074 7622 90336689
Agitation 20.58 9.82 310 283826 66788 90277523
Blood urea decreased 20.57 9.82 33 284103 2645 90341666
Heparin-induced thrombocytopenia 20.54 9.82 49 284087 5263 90339048
Alkalosis 20.52 9.82 16 284120 568 90343743
Maternal exposure before pregnancy 20.41 9.82 5 284131 11208 90333103
Clostridium difficile infection 20.29 9.82 188 283948 36057 90308254
Pseudomonal bacteraemia 20.24 9.82 28 284108 1966 90342345
Pulmonary function test decreased 20.20 9.82 44 284092 4450 90339861
Orthopnoea 20.20 9.82 57 284079 6778 90337533
Gastrointestinal infection 20.19 9.82 78 284058 10912 90333399
Head injury 20.18 9.82 167 283969 31021 90313290
Haematoma 20.11 9.82 199 283937 38849 90305462
Tachyarrhythmia 19.97 9.82 49 284087 5357 90338954
Nodule 19.97 9.82 33 284103 26653 90317658
Blood immunoglobulin M increased 19.86 9.82 23 284113 1349 90342962
Drug resistance 19.82 9.82 41 284095 30408 90313903
Rectal haemorrhage 19.76 9.82 367 283769 82377 90261934
Injection site pain 19.68 9.82 405 283731 173294 90171017
Product deposit 19.67 9.82 13 284123 354 90343957
Wound dehiscence 19.66 9.82 51 284085 5771 90338540
Suspected product contamination 19.48 9.82 8 284128 77 90344234
Blood parathyroid hormone decreased 19.40 9.82 7 284129 12209 90332102
Blood immunoglobulin G increased 19.33 9.82 34 284102 2938 90341373
Pseudomonas infection 19.27 9.82 95 284041 14770 90329541
Anaphylactic shock 19.24 9.82 167 283969 31450 90312861
Anaphylactoid reaction 19.24 9.82 43 284093 4425 90339886
Melaena 19.24 9.82 180 283956 34617 90309694
Thyroid disorder 19.16 9.82 108 284028 17677 90326634
Pneumothorax 19.09 9.82 114 284022 19053 90325258
Inappropriate schedule of product administration 19.06 9.82 610 283526 149323 90194988
Unevaluable event 19.05 9.82 259 283877 54589 90289722
Injection site granuloma 19.04 9.82 8 284128 82 90344229
Muscular weakness 18.91 9.82 498 283638 206168 90138143
Dysphoria 18.85 9.82 52 284084 6102 90338209
Ileus 18.85 9.82 102 284034 16444 90327867
Neck pain 18.76 9.82 248 283888 113715 90230596
Calcium deficiency 18.72 9.82 22 284114 1311 90343000
Upper respiratory tract infection 18.72 9.82 531 283605 127787 90216524
Infusion site discharge 18.69 9.82 30 284106 2405 90341906
Chronic kidney disease 18.68 9.82 240 283896 49951 90294360
Urine chloride decreased 18.62 9.82 8 284128 87 90344224
Meningitis aseptic 18.58 9.82 55 284081 6718 90337593
Suspected transmission of an infectious agent via product 18.51 9.82 13 284123 392 90343919
Serotonin syndrome 18.50 9.82 59 284077 37828 90306483
Skin candida 18.50 9.82 25 284111 1716 90342595
Ventricular fibrillation 18.38 9.82 90 284046 13954 90330357
Haemorrhoidal haemorrhage 18.36 9.82 47 284089 5276 90339035
Blood immunoglobulin A decreased 18.34 9.82 25 284111 1731 90342580
Complication of device insertion 18.33 9.82 5 284131 10431 90333880
Tonsillar haemorrhage 18.25 9.82 11 284125 254 90344057
Polyuria 18.23 9.82 71 284065 9969 90334342
Facial discomfort 18.12 9.82 12 284124 328 90343983
Extravasation 18.11 9.82 33 284103 2931 90341380
Hypercapnia 18.11 9.82 54 284082 6623 90337688
Chest pain 18.07 9.82 1198 282938 318447 90025864
Acute myocardial infarction 18.06 9.82 178 283958 34712 90309599
Laryngeal oedema 18.05 9.82 55 284081 6826 90337485
Affect lability 18.00 9.82 18 284118 18045 90326266
Left ventricular failure 17.99 9.82 54 284082 6646 90337665
Sedation complication 17.93 9.82 16 284120 16928 90327383
Feeling abnormal 17.90 9.82 667 283469 166568 90177743
Nasal congestion 17.89 9.82 364 283772 83050 90261261
Epilepsy 17.85 9.82 168 283968 82038 90262273
Injection site swelling 17.84 9.82 112 284024 59727 90284584
Respiratory rate increased 17.79 9.82 98 284038 15903 90328408
Cor pulmonale chronic 17.76 9.82 11 284125 267 90344044
Laryngospasm 17.76 9.82 35 284101 3298 90341013
Candida infection 17.75 9.82 174 283962 33883 90310428
Hepatic cyst 17.70 9.82 53 284083 6515 90337796
Eye infection 17.70 9.82 90 284046 14164 90330147
Disturbance in social behaviour 17.69 9.82 40 284096 4148 90340163
Infusion site discomfort 17.68 9.82 25 284111 1791 90342520
Product selection error 17.65 9.82 11 284125 270 90344041
Tension 17.64 9.82 37 284099 3645 90340666
Torsade de pointes 17.57 9.82 94 284042 15088 90329223
Catheter management 17.55 9.82 33 284103 3003 90341308
Rhinitis allergic 17.48 9.82 101 284035 16684 90327627
Injection site erythema 17.47 9.82 211 283925 98291 90246020
Osteoporosis 17.42 9.82 206 283930 96325 90247986
Product contamination 17.40 9.82 20 284116 1164 90343147
Immunodeficiency 17.38 9.82 73 284063 43161 90301150
Respiratory tract infection 17.37 9.82 271 283865 58807 90285504
Accidental exposure to product 17.36 9.82 71 284065 42295 90302016
Catheterisation cardiac 17.34 9.82 44 284092 4912 90339399
Haemorrhoids 17.29 9.82 143 283993 26559 90317752
Hyperlipidaemia 17.20 9.82 127 284009 22789 90321522
Rash vesicular 17.16 9.82 19 284117 18178 90326133
Upper gastrointestinal haemorrhage 17.06 9.82 127 284009 22849 90321462
Oxygen therapy 17.05 9.82 33 284103 3069 90341242
Transaminases increased 17.00 9.82 185 283951 37007 90307304
Device difficult to use 16.86 9.82 18 284118 17507 90326804
Infusion site irritation 16.83 9.82 21 284115 1332 90342979
Carbon dioxide decreased 16.83 9.82 31 284105 2777 90341534
Enterocolitis infectious 16.79 9.82 26 284110 2021 90342290
Escherichia infection 16.78 9.82 96 284040 15799 90328512
Therapy partial responder 16.74 9.82 27 284109 22016 90322295
Akathisia 16.72 9.82 7 284129 11152 90333159
Obstetric procedure complication 16.72 9.82 5 284131 16 90344295
Paraesthesia 16.65 9.82 629 283507 249697 90094614
Hydronephrosis 16.60 9.82 80 284056 12322 90331989
Excessive eye blinking 16.60 9.82 21 284115 1351 90342960
Cardiopulmonary failure 16.59 9.82 39 284097 4149 90340162
Bacterial infection 16.51 9.82 128 284008 23316 90320995
Stupor 16.48 9.82 46 284090 5436 90338875
Lung transplant 16.42 9.82 36 284100 3656 90340655
Hernia 16.39 9.82 88 284048 14143 90330168
Oesophageal spasm 16.37 9.82 34 284102 3327 90340984
Somnolence 16.33 9.82 807 283329 208277 90136034
Cystitis 16.31 9.82 297 283839 66421 90277890
Gastroenteritis viral 16.27 9.82 156 283980 30199 90314112
Lower gastrointestinal haemorrhage 16.24 9.82 63 284073 8829 90335482
Adjustment disorder 16.23 9.82 5 284131 9637 90334674
Blood pressure increased 16.21 9.82 765 283371 196452 90147859
Ear pain 16.19 9.82 110 284026 57592 90286719
Tremor 16.17 9.82 610 283526 152563 90191748
Catheter site swelling 16.13 9.82 24 284112 1801 90342510
Hypomania 16.13 9.82 4 284132 8893 90335418
Arteriovenous malformation 16.03 9.82 22 284114 1533 90342778
Rhinovirus infection 15.96 9.82 48 284088 5915 90338396
Body height decreased 15.94 9.82 77 284059 11872 90332439
Lymphoedema 15.81 9.82 85 284051 13668 90330643
Poisoning deliberate 15.79 9.82 17 284119 16469 90327842
Gastrointestinal toxicity 15.78 9.82 5 284131 9462 90334849
Neonatal respiratory depression 15.77 9.82 9 284127 187 90344124
Hypoaesthesia oral 15.68 9.82 93 284043 15507 90328804
Uveitis 15.68 9.82 16 284120 15887 90328424
Carbon dioxide increased 15.64 9.82 24 284112 1851 90342460
Injection site bruising 15.54 9.82 98 284038 52209 90292102
Feeding disorder 15.47 9.82 101 284035 17411 90326900
Postoperative wound infection 15.45 9.82 83 284053 13343 90330968
Dermatitis exfoliative 15.23 9.82 45 284091 5491 90338820
Overlap syndrome 15.19 9.82 4 284132 8544 90335767
Infusion site phlebitis 15.19 9.82 7 284129 91 90344220
Staphylococcal sepsis 15.17 9.82 64 284072 9319 90334992
Hyperhidrosis 15.16 9.82 546 283590 135759 90208552
Laryngeal discomfort 15.12 9.82 12 284124 437 90343874
Osteonecrosis of jaw 15.12 9.82 67 284069 39036 90305275
Multiple-drug resistance 15.10 9.82 3 284133 7773 90336538
Blood chloride increased 15.08 9.82 32 284104 3178 90341133
Haemorrhage subcutaneous 14.98 9.82 33 284103 3363 90340948
Rapid correction of hyponatraemia 14.94 9.82 8 284128 146 90344165
Carpal tunnel syndrome 14.88 9.82 127 284009 23801 90320510
Transplant rejection 14.80 9.82 11 284125 12747 90331564
Skin laceration 14.55 9.82 135 284001 25900 90318411
Haemodialysis complication 14.55 9.82 9 284127 218 90344093
Breast cancer stage I 14.48 9.82 6 284130 9618 90334693
Haemodialysis 14.40 9.82 60 284076 8687 90335624
Immune-mediated enterocolitis 14.38 9.82 40 284096 4717 90339594
Pneumonitis 14.30 9.82 206 283930 43964 90300347
Haematotoxicity 14.29 9.82 11 284125 12524 90331787
Nodal arrhythmia 14.29 9.82 19 284117 1284 90343027
Ventricular tachycardia 14.26 9.82 129 284007 24579 90319732
Urine sodium decreased 14.20 9.82 8 284128 162 90344149
Cataract operation complication 14.16 9.82 8 284128 163 90344148
Nail dystrophy 14.12 9.82 19 284117 1299 90343012
Heart rate abnormal 14.08 9.82 46 284090 5925 90338386
Micturition disorder 14.07 9.82 30 284106 2990 90341321
Catheter placement 14.05 9.82 27 284109 2497 90341814
Joint dislocation 14.05 9.82 82 284054 44500 90299811
Lung infiltration 14.03 9.82 89 284047 15193 90329118
Burkholderia test positive 13.95 9.82 9 284127 235 90344076
Multiple drug therapy 13.92 9.82 51 284085 6958 90337353
Aortic valve disease 13.81 9.82 19 284117 1327 90342984
Drug chemical incompatibility 13.79 9.82 7 284129 114 90344197
Panniculitis 13.74 9.82 15 284121 14443 90329868
Spinal fusion surgery 13.73 9.82 11 284125 12272 90332039
Product substitution issue 13.73 9.82 22 284114 17986 90326325
Confusion postoperative 13.72 9.82 9 284127 242 90344069
Anterior chamber inflammation 13.67 9.82 11 284125 409 90343902
Spontaneous haemorrhage 13.60 9.82 14 284122 719 90343592
Parkinsonism 13.59 9.82 83 284053 13982 90330329
Lip erosion 13.50 9.82 18 284118 1220 90343091
Hyperthyroidism 13.47 9.82 101 284035 18209 90326102
Eye injury 13.44 9.82 9 284127 11011 90333300
Electrocardiogram Q wave abnormal 13.42 9.82 8 284128 181 90344130
Hypotonia 13.40 9.82 71 284065 11355 90332956
Central venous catheterisation 13.35 9.82 28 284108 2758 90341553
Brain death 13.35 9.82 35 284101 3986 90340325
Occult blood positive 13.34 9.82 35 284101 3988 90340323
Neutropenic sepsis 13.34 9.82 100 284036 18030 90326281
Catheter site scab 13.31 9.82 9 284127 255 90344056
Gait disturbance 13.30 9.82 674 283462 259822 90084489
Urine output decreased 13.23 9.82 76 284060 12527 90331784
Coagulation time prolonged 13.22 9.82 21 284115 1669 90342642
Necrotic lymphadenopathy 13.21 9.82 7 284129 125 90344186
Haemorrhage intracranial 13.12 9.82 87 284049 15075 90329236
B-lymphocyte abnormalities 13.12 9.82 9 284127 261 90344050
Localised oedema 13.09 9.82 46 284090 6148 90338163
Neutropenia 13.07 9.82 845 283291 224059 90120252
Pulse pressure decreased 13.07 9.82 8 284128 190 90344121
Mental status changes postoperative 13.07 9.82 8 284128 190 90344121
Type V hyperlipidaemia 13.05 9.82 15 284121 873 90343438
Tongue coated 13.01 9.82 21 284115 1692 90342619
Pneumonia fungal 13.00 9.82 50 284086 6981 90337330
Blood phosphorus decreased 12.98 9.82 40 284096 4994 90339317
Posterior reversible encephalopathy syndrome 12.97 9.82 32 284104 22307 90322004
Metabolic acidosis 12.97 9.82 246 283890 55430 90288881
Pancreatitis chronic 12.96 9.82 28 284108 2815 90341496
Leukoplakia oral 12.88 9.82 9 284127 269 90344042
Obstruction 12.88 9.82 34 284102 3887 90340424
Cerebral haemorrhage 12.81 9.82 165 283971 34357 90309954
Suspected suicide 12.81 9.82 7 284129 9561 90334750
Peptic ulcer 12.75 9.82 42 284094 5433 90338878
Depression 12.74 9.82 792 283344 299809 90044502
Cardiac operation 12.73 9.82 34 284102 3915 90340396
Diverticulum 12.68 9.82 73 284063 12040 90332271
Creatinine renal clearance decreased 12.68 9.82 25 284111 18874 90325437
Ischaemia 12.67 9.82 41 284095 5254 90339057
Vulvovaginal mycotic infection 12.58 9.82 46 284090 6268 90338043
Injection site pruritus 12.57 9.82 108 284028 53726 90290585
Pulse abnormal 12.55 9.82 29 284107 3050 90341261
Bezoar 12.55 9.82 27 284109 2707 90341604
Paranasal sinus hypersecretion 12.53 9.82 37 284099 4514 90339797
Hyperdynamic left ventricle 12.43 9.82 9 284127 285 90344026
Enthesopathy 12.42 9.82 7 284129 9397 90334914
Dystonia 12.40 9.82 21 284115 16798 90327513
Skin dystrophy 12.28 9.82 5 284131 47 90344264
Deformity 12.28 9.82 12 284124 12158 90332153
Pre-eclampsia 12.22 9.82 10 284126 11038 90333273
Deficiency anaemia 12.19 9.82 5 284131 48 90344263
Sinus node dysfunction 12.14 9.82 41 284095 5371 90338940
Ankylosing spondylitis 12.07 9.82 14 284122 13119 90331192
Coronary artery occlusion 12.05 9.82 56 284080 8498 90335813
Rales 12.04 9.82 88 284048 15739 90328572
Incision site pain 12.01 9.82 18 284118 1360 90342951
Interleukin level increased 11.99 9.82 13 284123 709 90343602
Device wireless communication issue 11.97 9.82 6 284130 95 90344216
Hypoxic-ischaemic encephalopathy 11.95 9.82 37 284099 4631 90339680
Pulmonary arterial pressure increased 11.91 9.82 33 284103 3883 90340428
Injection site warmth 11.90 9.82 23 284113 17492 90326819
Blood pressure fluctuation 11.86 9.82 106 284030 52307 90292004
Adenocarcinoma 11.84 9.82 29 284107 3167 90341144
Escherichia test positive 11.84 9.82 26 284110 2644 90341667
Device occlusion 11.80 9.82 59 284077 9223 90335088
Mental disorder 11.80 9.82 154 283982 32164 90312147
Wrong patient 11.80 9.82 14 284122 843 90343468
Myocardial necrosis marker increased 11.76 9.82 23 284113 2155 90342156
Congestive hepatopathy 11.75 9.82 28 284108 3005 90341306
Infusion site mass 11.68 9.82 23 284113 2166 90342145
Paracentesis 11.68 9.82 15 284121 980 90343331
Sodium retention 11.64 9.82 7 284129 161 90344150
Device related bacteraemia 11.61 9.82 10 284126 409 90343902
Product availability issue 11.58 9.82 50 284086 7354 90336957
Distal intestinal obstruction syndrome 11.58 9.82 11 284125 512 90343799
Pharyngitis streptococcal 11.57 9.82 74 284062 12668 90331643
Intestinal obstruction 11.56 9.82 172 283964 36959 90307352
Device alarm issue 11.54 9.82 21 284115 1864 90342447
Sedation 11.53 9.82 96 284040 48075 90296236
Chronic left ventricular failure 11.50 9.82 12 284124 626 90343685
Inability to afford medication 11.49 9.82 31 284105 3591 90340720
Cardioactive drug level increased 11.47 9.82 24 284112 2360 90341951
Nephrolithiasis 11.47 9.82 217 283919 48868 90295443
Pneumonia bacterial 11.44 9.82 74 284062 12716 90331595
Impaired gastric emptying 11.39 9.82 74 284062 12735 90331576
Weight abnormal 11.36 9.82 21 284115 1886 90342425
Blood electrolytes abnormal 11.36 9.82 16 284120 1142 90343169
Nephropathy 11.25 9.82 58 284078 9177 90335134
Cardiac aneurysm 11.24 9.82 15 284121 1017 90343294
Subdural haematoma 11.24 9.82 90 284046 16555 90327756
Protein total decreased 11.19 9.82 48 284088 7041 90337270
Gestational diabetes 11.19 9.82 10 284126 10572 90333739
Multiple organ dysfunction syndrome 11.16 9.82 287 283849 68049 90276262
Faeces discoloured 11.15 9.82 109 284027 21211 90323100
Acute sinusitis 11.12 9.82 34 284102 4227 90340084
Dependence on respirator 11.12 9.82 7 284129 175 90344136
Oliguria 11.11 9.82 64 284072 10560 90333751
Emotional distress 11.09 9.82 169 283967 36493 90307818
Visual impairment 11.06 9.82 323 283813 132042 90212269
Administration site phlebitis 11.03 9.82 3 284133 6 90344305
Renal cyst 11.02 9.82 74 284062 12876 90331435
Intensive care 11.02 9.82 17 284119 1317 90342994
Hyperphosphataemia 11.02 9.82 31 284105 3680 90340631
Post transplant lymphoproliferative disorder 11.01 9.82 4 284132 6945 90337366
Oxygen saturation abnormal 10.99 9.82 34 284102 4254 90340057
Kidney infection 10.98 9.82 127 284009 25789 90318522
Pelvic fluid collection 10.94 9.82 15 284121 1044 90343267
Pulmonary thrombosis 10.94 9.82 60 284076 9722 90334589
Blood pressure immeasurable 10.93 9.82 18 284118 1474 90342837
Deafness permanent 10.93 9.82 11 284125 550 90343761
Uterine perforation 10.91 9.82 5 284131 7549 90336762
Gadolinium deposition disease 10.90 9.82 6 284130 116 90344195
Multiple sclerosis relapse 10.89 9.82 108 284028 52197 90292114
Food allergy 10.88 9.82 42 284094 25436 90318875
Oral papilloma 10.85 9.82 5 284131 65 90344246
Thyroxine decreased 10.79 9.82 12 284124 673 90343638
Genital erosion 10.75 9.82 10 284126 453 90343858
Stevens-Johnson syndrome 10.73 9.82 140 283996 29236 90315075
Staphylococcus test positive 10.72 9.82 34 284102 4311 90340000
Blood pressure systolic increased 10.72 9.82 124 284012 58221 90286090
Rash rubelliform 10.72 9.82 3 284133 7 90344304
Incorrect product formulation administered 10.71 9.82 7 284129 187 90344124
Azotaemia 10.69 9.82 39 284097 5309 90339002
Serratia infection 10.66 9.82 15 284121 1070 90343241
Rheumatic disorder 10.64 9.82 29 284107 3379 90340932
Diffuse large B-cell lymphoma 10.63 9.82 7 284129 8638 90335673
Administration site extravasation 10.62 9.82 16 284120 1214 90343097
Hip fracture 10.60 9.82 154 283982 32923 90311388
Nephrocalcinosis 10.60 9.82 16 284120 1216 90343095
PCO2 abnormal 10.59 9.82 6 284130 123 90344188
Oesophageal pain 10.59 9.82 34 284102 4340 90339971
Infusion site warmth 10.57 9.82 22 284114 2156 90342155
Cholelithiasis 10.57 9.82 227 283909 52279 90292032
Infective exacerbation of bronchiectasis 10.55 9.82 10 284126 464 90343847
Retching 10.54 9.82 99 284037 19060 90325251
Gastrostomy tube site complication 10.46 9.82 5 284131 71 90344240
Adult failure to thrive 10.45 9.82 7 284129 195 90344116
Full blood count abnormal 10.43 9.82 167 283969 36430 90307881
Respiration abnormal 10.40 9.82 51 284085 7912 90336399
Neutrophil percentage abnormal 10.38 9.82 4 284132 32 90344279
Vascular compression 10.38 9.82 8 284128 279 90344032
Infusion site urticaria 10.36 9.82 19 284117 1696 90342615
Device maintenance issue 10.33 9.82 7 284129 199 90344112
Hemiplegia 10.31 9.82 22 284114 16138 90328173
Fatigue 10.24 9.82 3351 280785 1150672 89193639
Atrioventricular block second degree 10.23 9.82 34 284102 4418 90339893
Supraventricular extrasystoles 10.23 9.82 38 284098 5219 90339092
Basal cell carcinoma 10.21 9.82 62 284074 33327 90310984
Milk-alkali syndrome 10.21 9.82 16 284120 1257 90343054
Dysgeusia 10.18 9.82 226 283910 52334 90291977
Abortion incomplete complicated 10.17 9.82 3 284133 9 90344302
Abdominal injury 10.11 9.82 8 284128 290 90344021
Catheter removal 10.11 9.82 9 284127 385 90343926
Neuroleptic malignant syndrome 10.10 9.82 20 284116 15076 90329235
Hypoproteinaemia 10.08 9.82 27 284109 3115 90341196
Shock 10.04 9.82 136 284000 28642 90315669
Blood albumin abnormal 10 9.82 15 284121 1134 90343177
Bradykinesia 9.98 9.82 45 284091 6743 90337568
Wisdom teeth removal 9.96 9.82 12 284124 734 90343577
Cataract operation 9.93 9.82 42 284094 6121 90338190
Drug use disorder 9.93 9.82 7 284129 8336 90335975
Ventricular arrhythmia 9.93 9.82 33 284103 4288 90340023
International normalised ratio decreased 9.91 9.82 35 284101 4689 90339622
Tuberculosis 9.88 9.82 15 284121 12534 90331777
Peripheral coldness 9.87 9.82 76 284060 13816 90330495
Blood sodium increased 9.86 9.82 27 284109 3155 90341156
Ageusia 9.83 9.82 85 284051 15991 90328320

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 1258.30 10.34 1164 176091 39297 42404783
Drug ineffective 462.87 10.34 1234 176021 628963 41815117
Drug abuse 280.07 10.34 49 177206 104722 42339358
Infective pulmonary exacerbation of cystic fibrosis 256.52 10.34 232 177023 7586 42436494
Peritonitis bacterial 254.46 10.34 219 177036 6696 42437384
Toxicity to various agents 211.84 10.34 394 176861 228742 42215338
Peritoneal dialysis complication 175.76 10.34 106 177149 1821 42442259
White blood cell count decreased 175.01 10.34 914 176341 109482 42334598
Hypokalaemia 173.31 10.34 673 176582 71048 42373032
Drug interaction 147.45 10.34 591 176664 266408 42177672
Temperature intolerance 141.42 10.34 134 177121 4654 42439426
Cytokine release syndrome 134.05 10.34 449 176806 44078 42400002
Chills 131.01 10.34 752 176503 93314 42350766
Fungal peritonitis 126.96 10.34 67 177188 878 42443202
Tachypnoea 119.85 10.34 273 176982 21389 42422691
Granulocyte count decreased 119.54 10.34 77 177178 1493 42442587
Therapeutic product effect incomplete 117.44 10.34 75 177180 70864 42373216
Treatment failure 102.58 10.34 67 177188 62557 42381523
Dyspnoea 99.65 10.34 2475 174780 440146 42003934
Hypervolaemia 96.83 10.34 262 176993 22863 42421217
Pneumonia 96.34 10.34 2365 174890 419784 42024296
Toxic anterior segment syndrome 94.59 10.34 64 177191 1352 42442728
Suicide attempt 93.92 10.34 37 177218 46063 42398017
Neutrophil count decreased 93.57 10.34 515 176740 62900 42381180
Hereditary angioedema 91.99 10.34 64 177191 1417 42442663
Osmotic demyelination syndrome 90.58 10.34 55 177200 957 42443123
Cystic fibrosis 85.77 10.34 70 177185 1985 42442095
Peritonitis 85.03 10.34 218 177037 18415 42425665
Rheumatoid arthritis 84.93 10.34 35 177220 42405 42401675
Pyrexia 82.60 10.34 2183 175072 391859 42052221
Chest discomfort 78.56 10.34 493 176762 63123 42380957
Hyperpyrexia 77.02 10.34 84 177171 3456 42440624
Psoriasis 74.32 10.34 56 177199 48548 42395532
Abdominal distension 74.21 10.34 532 176723 71203 42372877
Hypotension 71.97 10.34 1486 175769 256145 42187935
Arthralgia 70.33 10.34 532 176723 204706 42239374
Platelet count decreased 70.32 10.34 883 176372 137698 42306382
Blood potassium decreased 67.14 10.34 212 177043 20172 42423908
Intentional overdose 65.83 10.34 70 177185 51386 42392694
Ventricular fibrillation 65.77 10.34 274 176981 29849 42414231
Sepsis 65.24 10.34 1178 176077 198156 42245924
Appendicolith 64.07 10.34 160 177095 13296 42430784
Cardiac failure congestive 60.22 10.34 582 176673 85020 42359060
Infusion related reaction 57.79 10.34 442 176813 60364 42383716
Rapid correction of hyponatraemia 56.90 10.34 23 177232 154 42443926
Sedation 56.49 10.34 28 177227 30447 42413633
Off label use 56.22 10.34 2131 175124 636204 41807876
Atrial fibrillation 55.98 10.34 853 176402 138740 42305340
Drug resistance 55.59 10.34 37 177218 34211 42409869
Hyponatraemia 55.13 10.34 655 176600 100807 42343273
Drug reaction with eosinophilia and systemic symptoms 54.09 10.34 57 177198 42018 42402062
Hypernatraemia 53.90 10.34 125 177130 9907 42434173
Sputum increased 53.61 10.34 66 177189 3097 42440983
Drug dependence 53.52 10.34 27 177228 29067 42415013
Foetal exposure during pregnancy 53.43 10.34 71 177184 47240 42396840
Suicidal ideation 52.66 10.34 74 177181 48087 42395993
Cardiogenic shock 52.25 10.34 289 176966 35351 42408729
Infusion site extravasation 51.00 10.34 86 177169 5395 42438685
Infusion site pain 50.66 10.34 85 177170 5310 42438770
Serotonin syndrome 50.61 10.34 22 177233 25823 42418257
Device interaction 50.28 10.34 31 177224 555 42443525
Dysphoria 45.50 10.34 57 177198 2723 42441357
Flushing 45.10 10.34 286 176969 36742 42407338
Therapeutic product effect decreased 44.98 10.34 58 177197 39092 42404988
Acute respiratory failure 44.80 10.34 296 176959 38562 42405518
Blood phosphorus increased 44.72 10.34 134 177121 12391 42431689
Disorganised speech 44.16 10.34 41 177214 1387 42442693
Ultrafiltration failure 44.15 10.34 23 177232 293 42443787
Injection site pain 43.65 10.34 111 177144 57687 42386393
Death 42.69 10.34 2380 174875 468805 41975275
Hepatic function abnormal 42.04 10.34 362 176893 51205 42392875
Appendicitis 41.53 10.34 183 177072 20430 42423650
Dysbiosis 41.48 10.34 31 177224 770 42443310
Overdose 41.36 10.34 262 176993 105002 42339078
Acidosis hyperchloraemic 41.33 10.34 29 177226 651 42443429
Intentional self-injury 40.83 10.34 7 177248 15195 42428885
Haemarthrosis 40.25 10.34 65 177190 3933 42440147
Hyperphosphataemia 39.88 10.34 132 177123 12872 42431208
Obstructive airways disorder 39.84 10.34 27 177228 24732 42419348
Loss of personal independence in daily activities 39.72 10.34 93 177162 49723 42394357
Angioedema 39.17 10.34 73 177182 42404 42401676
Psoriatic arthropathy 39.15 10.34 28 177227 24939 42419141
Intentional product use issue 38.89 10.34 160 177095 71673 42372407
Ascites 38.69 10.34 383 176872 56295 42387785
Myasthenia gravis 38.58 10.34 151 177104 15986 42428094
Monocyte chemotactic protein-1 increased 38.17 10.34 22 177233 346 42443734
Incorrect drug administration rate 38.12 10.34 46 177209 2114 42441966
Interleukin level increased 37.98 10.34 31 177224 879 42443201
Alpha tumour necrosis factor increased 37.90 10.34 22 177233 351 42443729
Incision site pain 37.70 10.34 43 177212 1860 42442220
Bacterial infection 37.53 10.34 221 177034 27658 42416422
Depression 37.46 10.34 290 176965 111073 42333007
Air embolism 37.32 10.34 19 177236 230 42443850
Oedema peripheral 37.28 10.34 783 176472 135293 42308787
Fluid retention 37.14 10.34 242 177013 31377 42412703
Encapsulating peritoneal sclerosis 36.97 10.34 26 177229 586 42443494
Joint swelling 36.52 10.34 152 177103 67870 42376210
Arthritis 36.45 10.34 75 177180 41990 42402090
Hypophosphataemia 36.34 10.34 178 177077 20767 42423313
Psychotic disorder 35.96 10.34 41 177214 29167 42414913
Spinal muscular atrophy 35.68 10.34 22 177233 394 42443686
Hepatocellular injury 35.28 10.34 28 177227 23650 42420430
Disturbance in attention 34.56 10.34 44 177211 29822 42414258
Chronic obstructive pulmonary disease 34.51 10.34 408 176847 62706 42381374
Insurance issue 33.64 10.34 61 177194 4055 42440025
Prostate cancer 33.51 10.34 86 177169 44557 42399523
Infusion site erythema 32.60 10.34 56 177199 3566 42440514
Cardiac failure 31.96 10.34 623 176632 106233 42337847
Eosinophilia 31.72 10.34 55 177200 32844 42411236
Noninfectious peritonitis 31.61 10.34 15 177240 154 42443926
Product contamination 31.61 10.34 29 177226 966 42443114
Completed suicide 31.60 10.34 253 177002 96212 42347868
Myalgia 31.47 10.34 252 177003 95828 42348252
Hypoxia 31.32 10.34 435 176820 69351 42374729
Vasculitis 31.04 10.34 19 177236 18375 42425705
Catheter site infection 30.87 10.34 50 177205 3033 42441047
Arthropathy 30.86 10.34 47 177208 29550 42414530
Blood pressure fluctuation 30.77 10.34 40 177215 26868 42417212
Therapeutic response decreased 30.39 10.34 68 177187 36944 42407136
Product packaging confusion 30.09 10.34 13 177242 105 42443975
Blood urea increased 29.83 10.34 236 177019 32557 42411523
Hyperkalaemia 29.70 10.34 485 176770 79973 42364107
Blood chloride decreased 29.67 10.34 58 177197 4081 42439999
Polyneuropathy 29.17 10.34 21 177234 18640 42425440
Eosinophil count 29.15 10.34 15 177240 186 42443894
Dehydration 29.12 10.34 784 176471 140983 42303097
Activated partial thromboplastin time prolonged 28.92 10.34 137 177118 15766 42428314
Neuroleptic malignant syndrome 28.84 10.34 28 177227 21444 42422636
Disease complication 28.34 10.34 48 177207 3022 42441058
Blood fibrinogen decreased 28.06 10.34 34 177221 1569 42442511
Vocal cord dysfunction 28.00 10.34 15 177240 203 42443877
Aortic stenosis 27.93 10.34 90 177165 8655 42435425
C-reactive protein abnormal 27.86 10.34 3 177252 9258 42434822
Sleep disorder therapy 27.75 10.34 77 177178 6817 42437263
Cytomegalovirus infection 27.65 10.34 58 177197 32248 42411832
Pulmonary fibrosis 27.21 10.34 43 177212 26638 42417442
Vomiting 27.03 10.34 1468 175787 288255 42155825
Aggression 26.73 10.34 94 177161 44069 42400011
Peritoneal cloudy effluent 26.53 10.34 18 177237 382 42443698
Sopor 26.23 10.34 11 177244 13191 42430889
Oxygen saturation decreased 25.78 10.34 395 176860 64292 42379788
Analgesic therapy 25.41 10.34 72 177183 6452 42437628
Meningitis aseptic 25.36 10.34 57 177198 4425 42439655
Administration site extravasation 25.32 10.34 23 177232 756 42443324
Poisoning 25.06 10.34 15 177240 14684 42429396
Faecal volume decreased 24.99 10.34 14 177241 208 42443872
Cardiovascular disorder 24.94 10.34 116 177139 13249 42430831
Infusion site reaction 24.83 10.34 29 177226 1287 42442793
Increased bronchial secretion 24.80 10.34 39 177216 2307 42441773
Respiratory failure 24.46 10.34 702 176553 127430 42316650
Cardiac arrest 24.31 10.34 611 176644 108709 42335371
Mental status changes 24.24 10.34 275 176980 41840 42402240
Disease progression 24.17 10.34 436 176819 143220 42300860
Bloody peritoneal effluent 24.06 10.34 11 177244 103 42443977
Diaphragmatic spasm 23.88 10.34 11 177244 105 42443975
Traumatic haemorrhage 23.86 10.34 28 177227 1249 42442831
Insomnia 23.84 10.34 347 176908 117906 42326174
Upper respiratory tract infection 23.65 10.34 274 176981 41899 42402181
Infusion site swelling 23.44 10.34 46 177209 3246 42440834
Incorrect route of product administration 23.26 10.34 177 177078 24128 42419952
Product substitution issue 23.09 10.34 9 177246 11281 42432799
Extrapyramidal disorder 22.51 10.34 21 177234 16391 42427689
Product preparation issue 22.51 10.34 25 177230 1050 42443030
Cough 22.46 10.34 930 176325 177173 42266907
Cataract operation complication 22.41 10.34 10 177245 88 42443992
Failure to thrive 22.39 10.34 88 177167 9334 42434746
Eczema 22.38 10.34 70 177185 34016 42410064
Cardiac disorder 22.35 10.34 306 176949 48626 42395454
Immune effector cell-associated neurotoxicity syndrome 22.19 10.34 88 177167 9373 42434707
Peritoneal effluent abnormal 22.17 10.34 9 177246 61 42444019
Liver injury 22.15 10.34 146 177109 19002 42425078
Heparin-induced thrombocytopenia 22.08 10.34 69 177186 6528 42437552
Interstitial lung disease 22.07 10.34 214 177041 78248 42365832
Tubulointerstitial nephritis 22.00 10.34 63 177192 31485 42412595
Mucosal inflammation 21.99 10.34 118 177137 49256 42394824
Drug ineffective for unapproved indication 21.87 10.34 108 177147 46055 42398025
Injection site swelling 21.80 10.34 23 177232 16950 42427130
Right ventricular failure 21.71 10.34 88 177167 9467 42434613
Suffocation feeling 21.70 10.34 20 177235 670 42443410
Accidental overdose 21.70 10.34 54 177201 28276 42415804
Neoplasm progression 21.66 10.34 56 177199 28944 42415136
Therapy partial responder 21.64 10.34 31 177224 19990 42424090
Chronic respiratory failure 21.59 10.34 31 177224 1691 42442389
Vertigo 21.53 10.34 72 177183 34275 42409805
Heart rate increased 21.53 10.34 326 176929 52929 42391151
Blood uric acid increased 21.41 10.34 124 177131 15423 42428657
Antacid therapy 21.32 10.34 55 177200 4662 42439418
Asthenia 21.31 10.34 1397 175858 279396 42164684
Erectile dysfunction 21.09 10.34 45 177210 24868 42419212
Oxygen therapy 20.89 10.34 27 177228 1331 42442749
Blood pressure systolic increased 20.89 10.34 54 177201 27914 42416166
Disease recurrence 20.89 10.34 59 177196 29619 42414461
Pancreatic enzyme abnormality 20.88 10.34 10 177245 105 42443975
Renal phospholipidosis 20.79 10.34 11 177244 145 42443935
Stoma closure 20.76 10.34 14 177241 294 42443786
Drug therapy 20.68 10.34 66 177189 6314 42437766
Second primary malignancy 20.66 10.34 7 177248 9568 42434512
Product prescribing error 20.61 10.34 49 177206 26063 42418017
Leukoplakia oral 20.59 10.34 11 177244 148 42443932
Pemphigoid 20.56 10.34 11 177244 11456 42432624
Glomerular filtration rate 20.48 10.34 10 177245 110 42443970
Transurethral resection syndrome 20.46 10.34 7 177248 27 42444053
Gout 20.33 10.34 192 177063 27863 42416217
Pulse absent 20.10 10.34 65 177190 6262 42437818
Sinusitis 20.10 10.34 292 176963 47000 42397080
Catheter site swelling 20.04 10.34 18 177237 583 42443497
Epilepsy 19.91 10.34 181 177074 25990 42418090
Dry skin 19.65 10.34 119 177136 48219 42395861
Musculoskeletal stiffness 19.61 10.34 150 177105 57615 42386465
Anticoagulant therapy 19.60 10.34 52 177203 4483 42439597
Blood creatine decreased 19.49 10.34 13 177242 268 42443812
Pneumococcal sepsis 19.43 10.34 27 177228 1428 42442652
Progressive multifocal leukoencephalopathy 19.35 10.34 12 177243 11524 42432556
Cholestasis 19.22 10.34 71 177184 32808 42411272
Paranoia 19.17 10.34 18 177237 14008 42430072
Motor neurone disease 19.15 10.34 17 177238 542 42443538
Infectious crystalline keratopathy 19.14 10.34 8 177247 59 42444021
Haemoglobin decreased 19.11 10.34 702 176553 131769 42312311
Post transplant lymphoproliferative disorder 19.10 10.34 7 177248 9113 42434967
Schizophrenia 19.09 10.34 10 177245 10540 42433540
Product use in unapproved indication 19.04 10.34 603 176652 183853 42260227
Haematotoxicity 19.03 10.34 11 177244 10974 42433106
Device related infection 19.02 10.34 147 177108 20132 42423948
Thrombotic microangiopathy 19.02 10.34 20 177235 14762 42429318
Complication associated with device 18.89 10.34 66 177189 6615 42437465
Acute graft versus host disease in skin 18.70 10.34 4 177251 7420 42436660
Miosis 18.68 10.34 17 177238 13429 42430651
Device infusion issue 18.59 10.34 23 177232 1085 42442995
Substance abuse 18.38 10.34 7 177248 8898 42435182
Pulmonary function test decreased 18.31 10.34 59 177196 5673 42438407
Mobility decreased 18.26 10.34 80 177175 35226 42408854
Respiratory alkalosis 18.23 10.34 34 177221 2310 42441770
Hallucination, auditory 18.15 10.34 21 177234 14843 42429237
Blood bilirubin increased 18 10.34 261 176994 41991 42402089
Blood sodium abnormal 18.00 10.34 17 177238 588 42443492
Vascular device infection 17.83 10.34 61 177194 6049 42438031
Infusion site discharge 17.77 10.34 14 177241 377 42443703
Procalcitonin decreased 17.76 10.34 12 177243 253 42443827
Hepatotoxicity 17.74 10.34 50 177205 25117 42418963
Skin toxicity 17.62 10.34 3 177252 6546 42437534
Poor venous access 17.45 10.34 68 177187 7184 42436896
Hypovolaemia 17.41 10.34 94 177161 11391 42432689
Supraventricular extrasystoles 17.38 10.34 46 177209 3960 42440120
Cystic fibrosis respiratory infection suppression 17.35 10.34 12 177243 263 42443817
Injection site reaction 17.33 10.34 24 177231 15697 42428383
Gynaecomastia 17.33 10.34 16 177239 12551 42431529
Neurological symptom 17.31 10.34 10 177245 9981 42434099
Eosinophil percentage decreased 17.27 10.34 12 177243 265 42443815
Swelling 17.08 10.34 322 176933 54563 42389517
Post procedural complication 17.07 10.34 100 177155 12490 42431590
Frequent bowel movements 17.03 10.34 40 177215 21367 42422713
Cyanosis 17.02 10.34 114 177141 14917 42429163
Blood albumin decreased 16.95 10.34 116 177139 15286 42428794
Product preparation error 16.95 10.34 51 177204 4727 42439353
Cytomegalovirus infection reactivation 16.93 10.34 13 177242 11165 42432915
Tardive dyskinesia 16.90 10.34 4 177251 6920 42437160
Basal cell carcinoma 16.90 10.34 44 177211 22689 42421391
Product distribution issue 16.87 10.34 30 177225 1964 42442116
Withdrawal syndrome 16.85 10.34 22 177233 14753 42429327
Condition aggravated 16.75 10.34 900 176355 259854 42184226
Delusion 16.75 10.34 22 177233 14712 42429368
Atrial septal defect 16.72 10.34 6 177249 7913 42436167
Lymphoma 16.67 10.34 21 177234 14300 42429780
Lymphadenectomy 16.67 10.34 15 177240 487 42443593
Blood creatine phosphokinase increased 16.65 10.34 125 177130 48213 42395867
Pathogen resistance 16.48 10.34 14 177241 11436 42432644
Troponin T increased 16.45 10.34 36 177219 2744 42441336
Uveitis 16.42 10.34 9 177246 9249 42434831
Rales 16.41 10.34 92 177163 11308 42432772
Immune reconstitution inflammatory syndrome 16.40 10.34 11 177244 10132 42433948
Burkholderia test positive 16.35 10.34 21 177234 1029 42443051
Pneumocystis jirovecii pneumonia 16.33 10.34 52 177203 25129 42418951
Drug intolerance 16.20 10.34 236 177019 80188 42363892
Abdominal pain 16.15 10.34 957 176298 189514 42254566
Catheter site extravasation 16.12 10.34 10 177245 181 42443899
Prothrombin time prolonged 16.09 10.34 80 177175 9389 42434691
Hepatocellular carcinoma 16 10.34 7 177248 8187 42435893
Body temperature decreased 15.89 10.34 22 177233 14391 42429689
Pulmonary arterial hypertension 15.87 10.34 84 177171 10103 42433977
Illness 15.82 10.34 166 177089 24764 42419316
Mucormycosis 15.80 10.34 5 177250 7138 42436942
Blood pressure decreased 15.74 10.34 335 176920 57997 42386083
Colitis ulcerative 15.64 10.34 56 177199 26119 42417961
Accidental exposure to product 15.52 10.34 39 177216 20354 42423726
Electrolyte imbalance 15.51 10.34 123 177132 16978 42427102
Congestive hepatopathy 15.43 10.34 32 177223 2350 42441730
Spinal meningeal cyst 15.42 10.34 8 177247 101 42443979
Coagulation time prolonged 15.41 10.34 24 177231 1408 42442672
Hyponatraemic encephalopathy 15.36 10.34 7 177248 65 42444015
Suspected product contamination 15.34 10.34 10 177245 198 42443882
Atelectasis 15.29 10.34 135 177120 19226 42424854
Nightmare 15.29 10.34 53 177202 24959 42419121
Red blood cells urine positive 15.22 10.34 28 177227 1882 42442198
Respiratory depression 15.22 10.34 35 177220 18833 42425247
Haemoglobin increased 15.22 10.34 52 177203 5154 42438926
Lower respiratory tract infection bacterial 15.18 10.34 15 177240 549 42443531
Contraindicated product administered 15.15 10.34 54 177201 25218 42418862
Visual impairment 15.09 10.34 111 177144 43002 42401078
Neuralgia 15.00 10.34 168 177087 25479 42418601
Pulmonary alveolar haemorrhage 14.99 10.34 24 177231 14792 42429288
Skin warm 14.97 10.34 35 177220 2788 42441292
Therapy non-responder 14.80 10.34 146 177109 53213 42390867
Hyperchloraemia 14.74 10.34 15 177240 569 42443511
Therapeutic response shortened 14.64 10.34 21 177234 13533 42430547
Muscle haemorrhage 14.60 10.34 44 177211 4081 42439999
Lung infiltration 14.60 10.34 104 177151 13885 42430195
Tumour lysis syndrome 14.57 10.34 149 177106 22082 42421998
Tendonitis 14.36 10.34 12 177243 9882 42434198
Blood loss anaemia 14.30 10.34 79 177176 9657 42434423
Syringe issue 14.21 10.34 9 177246 8547 42435533
Exposure during pregnancy 14.19 10.34 9 177246 8539 42435541
Forced expiratory volume decreased 14.15 10.34 7 177248 7623 42436457
Haematochezia 14.15 10.34 165 177090 58271 42385809
Scrotal oedema 14.09 10.34 27 177228 1872 42442208
Dyskinesia 14.08 10.34 56 177199 25334 42418746
Peri-implantitis 14.04 10.34 8 177247 123 42443957
Blood sodium decreased 14.02 10.34 126 177129 18036 42426044
Lymphocyte count decreased 13.99 10.34 177 177078 27632 42416448
Osteonecrosis 13.98 10.34 28 177227 15837 42428243
Cognitive disorder 13.96 10.34 84 177171 34088 42409992
Systemic lupus erythematosus 13.92 10.34 11 177244 9313 42434767
Fibrin D dimer increased 13.88 10.34 49 177206 4936 42439144
Urine output decreased 13.87 10.34 85 177170 10788 42433292
Electrocardiogram T wave amplitude decreased 13.85 10.34 12 177243 370 42443710
Epstein-Barr virus infection 13.85 10.34 12 177243 9706 42434374
Visual acuity reduced 13.80 10.34 33 177222 17517 42426563
Impaired work ability 13.80 10.34 18 177237 12073 42432007
Tetany 13.64 10.34 20 177235 1112 42442968
Dystonia 13.63 10.34 20 177235 12770 42431310
Therapeutic product effect prolonged 13.63 10.34 11 177244 307 42443773
Full blood count decreased 13.57 10.34 138 177117 20422 42423658
Hyperlipidaemia 13.53 10.34 143 177112 21373 42422707
Atrial flutter 13.48 10.34 120 177135 17131 42426949
Bladder cancer 13.45 10.34 32 177223 17015 42427065
Drug level decreased 13.41 10.34 13 177242 9964 42434116
Photosensitivity reaction 13.40 10.34 20 177235 12682 42431398
Intercepted product preparation error 13.38 10.34 7 177248 7382 42436698
Coagulopathy 13.34 10.34 146 177109 22016 42422064
Blood glucose false positive 13.33 10.34 6 177249 54 42444026
Conjunctivitis allergic 13.32 10.34 4 177251 5907 42438173
Agitation 13.21 10.34 188 177067 64126 42379954
Iron deficiency 13.19 10.34 85 177170 10976 42433104
Suspected transmission of an infectious agent via product 13.19 10.34 18 177237 936 42443144
Pulmonary hypertension 13.16 10.34 153 177102 23416 42420664
Gangrene 13.10 10.34 49 177206 5077 42439003
Bronchial disorder 13.09 10.34 22 177233 1376 42442704
Endotracheal intubation 13.05 10.34 40 177215 3745 42440335
Cellulitis 13.04 10.34 342 176913 61243 42382837
Malignant neoplasm progression 13.03 10.34 347 176908 108053 42336027
Blood sodium increased 13.01 10.34 36 177219 3182 42440898
Blood immunoglobulin M abnormal 12.98 10.34 7 177248 96 42443984
Sexual dysfunction 12.90 10.34 6 177249 6769 42437311
SARS-CoV-2 test negative 12.88 10.34 25 177230 1750 42442330
Febrile bone marrow aplasia 12.85 10.34 14 177241 10167 42433913
Anal fissure 12.84 10.34 3 177252 5236 42438844
Vocal cord paralysis 12.83 10.34 20 177235 1174 42442906
Cauda equina syndrome 12.81 10.34 18 177237 962 42443118
Blood immunoglobulin G abnormal 12.80 10.34 7 177248 99 42443981
Obsessive-compulsive disorder 12.79 10.34 6 177249 6737 42437343
International normalised ratio increased 12.79 10.34 276 176979 47892 42396188
Plasma cell myeloma 12.76 10.34 273 176982 47305 42396775
Steroid dependence 12.72 10.34 6 177249 6716 42437364
Ventricular tachycardia 12.72 10.34 186 177069 29974 42414106
Delirium 12.71 10.34 297 176958 52222 42391858
Alkalosis 12.70 10.34 8 177247 149 42443931
Blood calcium increased 12.68 10.34 69 177186 8385 42435695
Generalised oedema 12.67 10.34 108 177147 15228 42428852
Aspartate aminotransferase increased 12.64 10.34 415 176840 76748 42367332
Oesophageal carcinoma 12.61 10.34 13 177242 9683 42434397
Bronchial hyperreactivity 12.60 10.34 26 177229 1903 42442177
Diabetes insipidus 12.58 10.34 39 177216 3674 42440406
Anaemia 12.52 10.34 1340 175915 278938 42165142
Alopecia 12.47 10.34 71 177184 29205 42414875
Acute coronary syndrome 12.46 10.34 27 177228 14838 42429242
Blood gases abnormal 12.44 10.34 11 177244 349 42443731
Metabolic disorder 12.43 10.34 46 177209 4742 42439338
Rhabdomyolysis 12.42 10.34 239 177016 77780 42366300
Resuscitation 12.39 10.34 25 177230 1800 42442280
BK virus infection 12.33 10.34 11 177244 8773 42435307
Dysarthria 12.30 10.34 106 177149 39701 42404379
Gait disturbance 12.23 10.34 312 176943 97688 42346392
Catheter site bruise 12.21 10.34 6 177249 67 42444013
Mood altered 12.18 10.34 16 177239 10702 42433378
Neutropenia neonatal 12.18 10.34 17 177238 903 42443177
Memory impairment 12.09 10.34 142 177113 50080 42394000
Chest pain 12.00 10.34 702 176553 138828 42305252
Haematocrit decreased 11.98 10.34 208 177047 34700 42409380
Hernia 11.95 10.34 83 177172 10990 42433090
Influenza 11.95 10.34 341 176914 61834 42382246
Heparin-induced thrombocytopenia test 11.95 10.34 8 177247 166 42443914
Sensory integrative dysfunction 11.95 10.34 5 177250 37 42444043
Thirst decreased 11.95 10.34 5 177250 37 42444043
Sinus congestion 11.88 10.34 59 177196 6921 42437159
Myocardial necrosis marker increased 11.86 10.34 25 177230 1857 42442223
Euphoric mood 11.85 10.34 6 177249 6447 42437633
Angina pectoris 11.84 10.34 84 177171 32812 42411268
Gastric cancer 11.83 10.34 7 177248 6896 42437184
Herpes zoster 11.80 10.34 104 177151 38773 42405307
Gastrointestinal haemorrhage 11.78 10.34 508 176747 97218 42346862
Salivary hypersecretion 11.77 10.34 17 177238 10926 42433154
Body temperature increased 11.74 10.34 133 177122 20225 42423855
Toxic epidermal necrolysis 11.69 10.34 166 177089 26584 42417496
Wrong technique in product usage process 11.68 10.34 117 177138 42518 42401562
Drug withdrawal syndrome 11.65 10.34 48 177207 21501 42422579
Poisoning deliberate 11.65 10.34 15 177240 10119 42433961
Deafness permanent 11.63 10.34 9 177246 236 42443844
Pericarditis 11.62 10.34 24 177231 13420 42430660
Blood potassium abnormal 11.58 10.34 24 177231 1762 42442318
Poor quality product administered 11.58 10.34 28 177227 2280 42441800
Type IIa hyperlipidaemia 11.55 10.34 10 177245 308 42443772
Anaphylactic shock 11.54 10.34 149 177106 23368 42420712
Foetal disorder 11.49 10.34 18 177237 1061 42443019
Infusion site rash 11.45 10.34 14 177241 652 42443428
Procedural pain 11.41 10.34 51 177204 5728 42438352
Depressed level of consciousness 11.40 10.34 136 177119 47834 42396246
Alpha-1 antitrypsin deficiency 11.39 10.34 4 177251 17 42444063
Oedema 11.36 10.34 290 176965 51711 42392369
Shoshin beriberi 11.34 10.34 6 177249 79 42444001
Haemorrhage 11.32 10.34 331 176924 60232 42383848
Product storage error 11.31 10.34 18 177237 11122 42432958
Stress 11.31 10.34 252 177003 43960 42400120
Fungal sepsis 11.31 10.34 18 177237 1076 42443004
Urinary tract infection 11.28 10.34 513 176742 98771 42345309
Apathy 11.24 10.34 11 177244 8395 42435685
Osteonecrosis of jaw 11.22 10.34 41 177214 19008 42425072
Hepatitis 11.21 10.34 67 177188 27233 42416847
Catatonia 11.16 10.34 6 177249 6233 42437847
Catheter site pain 11.14 10.34 23 177232 1684 42442396
Metabolic alkalosis 11.09 10.34 26 177229 2075 42442005
Anal fistula 11.08 10.34 6 177249 6207 42437873
Multiple sclerosis relapse 11.07 10.34 27 177228 14237 42429843
Blindness 11.05 10.34 38 177217 17940 42426140
Blood uric acid abnormal 11.00 10.34 9 177246 256 42443824
Ankylosing spondylitis 10.95 10.34 8 177247 7048 42437032
Endocrine ophthalmopathy 10.94 10.34 8 177247 192 42443888
Extravasation 10.94 10.34 28 177227 2362 42441718
Renin decreased 10.94 10.34 3 177252 4 42444076
Ventricular extrasystoles 10.91 10.34 94 177161 13296 42430784
Neutropenia 10.88 10.34 699 176556 198732 42245348
Peritoneal effluent leukocyte count increased 10.86 10.34 4 177251 20 42444060
Respiratory rate increased 10.83 10.34 81 177174 10981 42433099
Euglycaemic diabetic ketoacidosis 10.79 10.34 5 177250 5655 42438425
Injury 10.78 10.34 141 177114 22175 42421905
Dyspnoea paroxysmal nocturnal 10.77 10.34 22 177233 1598 42442482
Burns second degree 10.71 10.34 6 177249 6090 42437990
Respiratory tract infection fungal 10.64 10.34 15 177240 804 42443276
Troponin I increased 10.61 10.34 33 177222 3113 42440967
Respiratory tract infection 10.58 10.34 161 177094 26161 42417919
Emotional disorder of childhood 10.57 10.34 5 177250 51 42444029
Peripheral vascular disorder 10.55 10.34 47 177208 5270 42438810
Ischaemic stroke 10.54 10.34 52 177203 22181 42421899
Squamous cell carcinoma 10.54 10.34 24 177231 12958 42431122
Infusion site haemorrhage 10.53 10.34 19 177236 1258 42442822
Osteoarthritis 10.50 10.34 59 177196 24346 42419734
Chronic graft versus host disease 10.48 10.34 6 177249 6019 42438061
Injection site bruising 10.45 10.34 20 177235 11505 42432575
Atrial enlargement 10.45 10.34 14 177241 715 42443365
Dry mouth 10.43 10.34 228 177027 39651 42404429
Right ventricular dysfunction 10.41 10.34 20 177235 1389 42442691
Unresponsive to stimuli 10.38 10.34 186 177069 31217 42412863

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Myelosuppression 6233.00 9.76 3946 378604 90394 110116355
White blood cell count decreased 1492.78 9.76 2771 379779 226619 109980130
Drug ineffective 742.03 9.76 2739 379811 1517801 108688948
Neutrophil count decreased 724.02 9.76 1411 381139 119530 110087219
Pemphigus 703.30 9.76 7 382543 214563 109992186
Hand deformity 699.05 9.76 11 382539 218495 109988254
Systemic lupus erythematosus 613.65 9.76 78 382472 254260 109952489
Joint swelling 584.44 9.76 409 382141 442436 109764313
Duodenal ulcer perforation 568.16 9.76 9 382541 177691 110029058
Pericarditis 546.42 9.76 60 382490 219054 109987695
Helicobacter infection 540.66 9.76 20 382530 181857 110024892
Glossodynia 530.93 9.76 70 382480 221934 109984815
Synovitis 522.39 9.76 150 382400 273942 109932807
Hypokalaemia 509.62 9.76 1588 380962 180860 110025889
Infective pulmonary exacerbation of cystic fibrosis 507.62 9.76 416 382134 14355 110192394
Arthropathy 506.07 9.76 181 382369 287341 109919408
Rheumatoid arthritis 482.56 9.76 216 382334 299397 109907352
Wound 462.30 9.76 120 382430 234317 109972432
Therapeutic product effect decreased 457.70 9.76 138 382412 244178 109962571
Muscle injury 442.46 9.76 9 382541 140798 110065951
Contraindicated product administered 439.08 9.76 155 382395 248112 109958637
Folliculitis 430.70 9.76 41 382509 167612 110039137
Chills 420.07 9.76 1532 381018 189048 110017701
Psoriatic arthropathy 417.19 9.76 86 382464 196675 110010074
Drug intolerance 413.55 9.76 478 382072 406034 109800715
Treatment failure 407.06 9.76 226 382324 277008 109929741
Granulocyte count decreased 406.60 9.76 221 382329 3753 110202996
Hepatic function abnormal 397.84 9.76 924 381626 88371 110118378
Alopecia 392.95 9.76 409 382141 364344 109842405
Irritable bowel syndrome 389.69 9.76 53 382497 164162 110042587
Peritonitis bacterial 373.22 9.76 302 382248 10231 110196518
Platelet count decreased 349.92 9.76 1652 380898 228791 109977958
Chest discomfort 347.84 9.76 1355 381195 172493 110034256
Temperature intolerance 343.23 9.76 325 382225 13625 110193124
Musculoskeletal stiffness 338.79 9.76 282 382268 279540 109927209
C-reactive protein abnormal 305.02 9.76 43 382507 129652 110077097
Facet joint syndrome 304.96 9.76 6 382544 96822 110109927
Hereditary angioedema 302.02 9.76 227 382323 6887 110199862
Cytokine release syndrome 294.16 9.76 710 381840 69596 110137153
Drug abuse 291.71 9.76 124 382426 177287 110029462
Hypervolaemia 290.88 9.76 573 381977 48887 110157862
Impaired healing 287.77 9.76 161 382389 196556 110010193
Toxicity to various agents 287.11 9.76 788 381762 479767 109726982
Joint range of motion decreased 285.10 9.76 41 382509 121791 110084958
Arthralgia 281.34 9.76 1566 380984 778066 109428683
Tachypnoea 279.94 9.76 495 382055 38900 110167849
Dyspnoea 275.04 9.76 5360 377190 1101512 109105237
Hepatic enzyme increased 274.75 9.76 428 382122 320464 109886285
Swollen joint count increased 268.38 9.76 4 382546 83657 110123092
Bursitis 264.80 9.76 62 382488 129856 110076893
Ill-defined disorder 262.12 9.76 107 382443 156746 110050003
Sepsis 256.36 9.76 1974 380576 325372 109881377
Lip dry 255.64 9.76 25 382525 100058 110106691
Cardiac failure congestive 255.58 9.76 1118 381432 149882 110056867
Hyperpyrexia 249.86 9.76 214 382336 7855 110198894
Sleep disorder due to general medical condition, insomnia type 248.48 9.76 35 382515 105608 110101141
Mobility decreased 238.22 9.76 282 382268 237140 109969609
Hypotension 237.92 9.76 2814 379736 521035 109685714
Inflammation 237.23 9.76 192 382358 193046 110013703
Hyperkalaemia 234.07 9.76 1011 381539 134785 110071964
Lower respiratory tract infection 228.01 9.76 304 382246 242802 109963947
Grip strength decreased 227.75 9.76 12 382538 80162 110126587
Type 2 diabetes mellitus 222.72 9.76 172 382378 177060 110029689
Atrial fibrillation 214.49 9.76 1445 381105 228197 109978552
Blister 213.57 9.76 284 382266 227092 109979657
Abdominal discomfort 211.88 9.76 678 381872 393180 109813569
Pneumonia 209.76 9.76 4223 378327 872491 109334258
Osteoarthritis 204.26 9.76 198 382352 182425 110024324
Pyrexia 201.84 9.76 4287 378263 893978 109312771
Stomatitis 201.65 9.76 393 382157 269849 109936900
Fibromyalgia 197.37 9.76 180 382370 170729 110036020
Drug hypersensitivity 197.03 9.76 854 381696 453236 109753513
Intentional product use issue 196.04 9.76 348 382202 247558 109959191
Maternal exposure during pregnancy 189.88 9.76 371 382179 254512 109952237
Hyponatraemia 188.75 9.76 1345 381205 216308 109990441
Hypersensitivity 182.53 9.76 748 381802 403250 109803499
Psoriasis 182.15 9.76 131 382419 139862 110066887
Blood potassium decreased 181.52 9.76 503 382047 53611 110153138
Anaemia 180.67 9.76 2775 379775 544311 109662438
Cystic fibrosis 176.89 9.76 140 382410 4591 110202158
Nausea 176.73 9.76 5553 376997 1230137 108976612
Peritoneal dialysis complication 176.56 9.76 110 382440 2436 110204313
Dehydration 176.34 9.76 1606 380944 277905 109928844
Acute respiratory failure 174.18 9.76 615 381935 74645 110132104
Peripheral venous disease 167.76 9.76 42 382508 84075 110122674
Toxic anterior segment syndrome 164.20 9.76 118 382432 3336 110203413
Hypoxia 158.97 9.76 875 381675 128640 110078109
Night sweats 158.43 9.76 138 382412 133845 110072904
Swelling 156.64 9.76 653 381897 350388 109856361
Pulmonary hypertension 153.41 9.76 480 382070 54740 110152009
Obesity 151.52 9.76 103 382447 113248 110093501
Blood cholesterol increased 150.06 9.76 255 382295 184530 110022219
Blepharospasm 147.46 9.76 11 382539 54840 110151909
Pulmonary fibrosis 147.06 9.76 85 382465 101957 110104792
Vomiting 146.55 9.76 4154 378396 906521 109300228
Live birth 141.89 9.76 33 382517 69451 110137298
Agranulocytosis 140.61 9.76 502 382048 61258 110145491
Osmotic demyelination syndrome 140.21 9.76 88 382462 1975 110204774
Dislocation of vertebra 136.51 9.76 3 382547 43718 110163031
Death 132.24 9.76 3257 379293 695612 109511137
Hypercholesterolaemia 130.43 9.76 76 382474 90761 110115988
Wound infection 129.82 9.76 87 382463 96378 110110371
Abdominal distension 129.78 9.76 1043 381507 174060 110032689
Onychomadesis 129.17 9.76 7 382543 45656 110161093
Discomfort 128.83 9.76 351 382199 214356 109992393
Gastrointestinal haemorrhage 128.77 9.76 997 381553 164521 110042228
Hypernatraemia 126.58 9.76 224 382326 17609 110189140
Injury 125.19 9.76 266 382284 176999 110029750
Respiratory failure 124.64 9.76 1215 381335 214117 109992632
Gait inability 124.32 9.76 174 382376 136202 110070547
Musculoskeletal pain 123.21 9.76 282 382268 182741 110024008
Chronic obstructive pulmonary disease 123.10 9.76 721 381829 108437 110098312
Nail disorder 121.35 9.76 26 382524 57909 110148840
Fungal peritonitis 119.99 9.76 68 382482 1257 110205492
Cardiac arrest 116.25 9.76 1115 381435 195638 110011111
Lower limb fracture 115.54 9.76 58 382492 75290 110131459
Autoimmune disorder 115.48 9.76 41 382509 65442 110141307
Nasopharyngitis 113.84 9.76 847 381703 393514 109813235
Sleep disorder 113.81 9.76 332 382218 198312 110008437
Arthritis 112.17 9.76 259 382291 167327 110039422
Flushing 111.84 9.76 682 381868 104054 110102695
Product use issue 111.58 9.76 627 381923 311068 109895681
Lung disorder 109.77 9.76 292 382258 179755 110026994
Cardiogenic shock 109.00 9.76 440 382110 56898 110149851
Prescribed overdose 107.47 9.76 87 382463 87494 110119255
Ventricular fibrillation 107.37 9.76 351 382199 40962 110165787
Coeliac disease 107.16 9.76 12 382538 43175 110163574
Suicide attempt 106.68 9.76 120 382430 103274 110103475
Haemoglobin decreased 105.63 9.76 1320 381230 247407 109959342
Febrile neutropenia 104.84 9.76 1608 380942 315159 109891590
Bone erosion 103.06 9.76 18 382532 46353 110160396
Ovarian hyperstimulation syndrome 102.63 9.76 109 382441 5251 110201498
Acute kidney injury 102.12 9.76 2899 379651 632531 109574218
Peritonitis 100.49 9.76 294 382256 32313 110174436
Sciatica 100.05 9.76 103 382447 92296 110114453
Urinary tract infection 99.57 9.76 1634 380916 324648 109882101
Exposure during pregnancy 99.46 9.76 275 382275 167149 110039600
Oedema peripheral 98.48 9.76 1641 380909 327019 109879730
Therapeutic product effect incomplete 96.88 9.76 421 382129 223384 109983365
Hip arthroplasty 96.64 9.76 36 382514 55777 110150972
Knee arthroplasty 96.61 9.76 52 382498 64896 110141853
Injection site reaction 95.64 9.76 100 382450 88970 110117779
Oxygen saturation decreased 95.39 9.76 895 381655 156087 110050662
Liver disorder 95.06 9.76 220 382330 142023 110064726
Full blood count decreased 94.73 9.76 285 382265 31814 110174935
Finger deformity 93.83 9.76 5 382545 33087 110173662
Bone marrow failure 93.05 9.76 422 382128 57426 110149323
Pain 91.98 9.76 2558 379992 952397 109254352
Condition aggravated 91.21 9.76 1894 380656 732942 109473807
Red blood cell sedimentation rate increased 90.93 9.76 82 382468 78220 110128529
Device interaction 90.75 9.76 47 382503 720 110206029
Pregnancy 90.01 9.76 32 382518 51035 110155714
Device expulsion 89.73 9.76 4 382546 30887 110175862
Intentional self-injury 88.95 9.76 12 382538 37417 110169332
Plasma cell myeloma 88.78 9.76 442 382108 62494 110144255
Infusion site pain 88.48 9.76 190 382360 17229 110189520
Road traffic accident 87.36 9.76 148 382402 107250 110099499
Haemarthrosis 87.29 9.76 117 382433 7212 110199537
Onychomycosis 85.54 9.76 15 382535 38516 110168233
Blood pressure decreased 84.41 9.76 684 381866 114407 110092342
Ascites 84.18 9.76 580 381970 92228 110114521
Cardiac failure 84.08 9.76 1006 381544 186620 110020129
Right ventricular failure 83.84 9.76 238 382312 25716 110181033
Appendicolith 83.62 9.76 165 382385 14090 110192659
Dysphoria 83.36 9.76 107 382443 6321 110200428
Asthenia 82.96 9.76 3037 379513 685962 109520787
Exostosis 82.37 9.76 28 382522 45928 110160821
Aspartate aminotransferase increased 81.34 9.76 879 381671 159057 110047692
Completed suicide 81.16 9.76 498 382052 241883 109964866
Intentional overdose 79.92 9.76 216 382334 132285 110074464
Insomnia 79.89 9.76 829 381721 359761 109846988
Colitis microscopic 79.73 9.76 156 382394 13238 110193511
Pulmonary arterial hypertension 79.56 9.76 271 382279 32297 110174452
Blood urea increased 78.97 9.76 388 382162 54569 110152180
Therapy non-responder 78.87 9.76 279 382271 157028 110049721
Joint stiffness 78.58 9.76 70 382480 67173 110139576
Drug interaction 78.46 9.76 1237 381313 498946 109707803
Breast cancer stage II 78.05 9.76 4 382546 27371 110179378
Pleural effusion 77.96 9.76 949 381601 176760 110029989
Vaginal flatulence 77.90 9.76 146 382404 11998 110194751
Drug reaction with eosinophilia and systemic symptoms 77.58 9.76 102 382448 81993 110124756
Therapeutic response decreased 77.56 9.76 134 382416 96365 110110384
Disorganised speech 77.55 9.76 75 382475 3228 110203521
Sopor 77.36 9.76 16 382534 36530 110170219
Wheezing 76.58 9.76 542 382008 254688 109952061
Rash 76.45 9.76 2209 380341 818755 109387994
Suicidal ideation 75.90 9.76 130 382420 93807 110112942
Mental status changes 75.84 9.76 487 382063 75635 110131114
Dry mouth 75.49 9.76 395 382155 199553 110007196
Back injury 74.93 9.76 35 382515 47364 110159385
Adverse drug reaction 74.85 9.76 158 382392 105401 110101348
Bronchitis 74.82 9.76 852 381698 156180 110050569
Foot deformity 74.81 9.76 37 382513 48443 110158306
Vascular device infection 74.74 9.76 172 382378 16340 110190409
Blood fibrinogen decreased 72.93 9.76 66 382484 2609 110204140
Acidosis hyperchloraemic 72.70 9.76 53 382497 1533 110205216
Paraesthesia oral 72.67 9.76 269 382281 33402 110173347
Confusional state 70.86 9.76 1167 381383 467513 109739236
Constipation 70.67 9.76 1678 380872 356108 109850641
Prescribed underdose 70.16 9.76 73 382477 65101 110141648
Granulocytopenia 69.60 9.76 143 382407 12572 110194177
Insurance issue 68.59 9.76 128 382422 10484 110196265
Hepatitis 67.95 9.76 130 382420 89924 110116825
Pulmonary oedema 67.84 9.76 587 381963 100072 110106677
Blood bilirubin increased 67.25 9.76 472 382078 75500 110131249
Chronic sinusitis 66.88 9.76 215 382335 24869 110181880
Hypophosphataemia 66.58 9.76 259 382291 32923 110173826
General physical health deterioration 65.93 9.76 1054 381496 424241 109782508
Loss of personal independence in daily activities 65.64 9.76 281 382269 149739 110057010
Infusion site extravasation 65.05 9.76 132 382418 11502 110195247
Injection site pain 64.66 9.76 356 382194 177566 110029183
Macular degeneration 64.56 9.76 193 382357 21466 110185283
Abdominal pain 63.83 9.76 2270 380280 510719 109696030
International normalised ratio increased 63.78 9.76 516 382034 86256 110120493
Cyanosis 63.68 9.76 237 382313 29504 110177245
Fluid retention 63.57 9.76 550 382000 93757 110112992
Proctitis 63.48 9.76 164 382386 16763 110189986
Lupus-like syndrome 63.14 9.76 31 382519 40761 110165988
Radiculopathy 63.13 9.76 178 382372 19158 110187591
Product use in unapproved indication 63.08 9.76 1128 381422 446249 109760500
Female genital tract fistula 62.93 9.76 161 382389 16358 110190391
Activated partial thromboplastin time prolonged 62.64 9.76 195 382355 22173 110184576
Migraine 62.63 9.76 343 382207 171309 110035440
Cardiac disorder 62.39 9.76 465 382085 75815 110130934
Rapid correction of hyponatraemia 61.67 9.76 25 382525 208 110206541
Gastrointestinal disorder 61.33 9.76 538 382012 241414 109965335
Taste disorder 61.01 9.76 82 382468 65305 110141444
Hyponatraemic encephalopathy 60.76 9.76 29 382521 369 110206380
Drug tolerance decreased 60.53 9.76 11 382539 27529 110179220
Abdominal pain upper 59.30 9.76 850 381700 348261 109858488
Memory impairment 59.18 9.76 418 382132 196526 110010223
Blood sodium decreased 58.27 9.76 275 382275 38044 110168705
Urticaria 57.86 9.76 766 381784 318091 109888658
Appendicitis 57.78 9.76 223 382327 28241 110178508
Hyperphosphataemia 57.65 9.76 155 382395 16226 110190523
Hospitalisation 57.39 9.76 749 381801 141744 110065005
Electrolyte imbalance 56.50 9.76 266 382284 36762 110169987
Procedural pain 56.12 9.76 258 382292 35307 110171442
Drug resistance 55.39 9.76 68 382482 56306 110150443
Atrial flutter 55.04 9.76 197 382353 24065 110182684
Blood phosphorus increased 54.90 9.76 152 382398 16188 110190561
Unresponsive to stimuli 54.53 9.76 393 382157 63397 110143352
Muscle spasticity 54.53 9.76 28 382522 35887 110170862
Lymphocyte count decreased 53.84 9.76 361 382189 56882 110149867
Failure to thrive 53.48 9.76 134 382416 13440 110193309
Encapsulating peritoneal sclerosis 53.23 9.76 35 382515 853 110205896
Porphyria acute 52.74 9.76 3 382547 18777 110187972
Interleukin level increased 52.25 9.76 44 382506 1577 110205172
Sensitisation 52.11 9.76 68 382482 4083 110202666
Glaucoma 52.08 9.76 184 382366 22333 110184416
Blood creatinine increased 51.75 9.76 905 381645 181984 110024765
Maternal exposure timing unspecified 51.73 9.76 6 382544 21007 110185742
Metabolic alkalosis 51.48 9.76 79 382471 5516 110201233
Serotonin syndrome 51.42 9.76 78 382472 59075 110147674
Sputum increased 51.23 9.76 80 382470 5671 110201078
Pneumonia aspiration 50.76 9.76 466 382084 80767 110125982
Product preparation issue 50.55 9.76 55 382495 2724 110204025
Device related infection 50.49 9.76 270 382280 39249 110167500
Diarrhoea 50.23 9.76 4584 377966 1134921 109071828
Immune effector cell-associated neurotoxicity syndrome 50.15 9.76 138 382412 14644 110192105
Hepatocellular injury 49.85 9.76 61 382489 50581 110156168
Rheumatoid nodule 49.46 9.76 6 382544 20290 110186459
Infusion site swelling 49.32 9.76 107 382443 9770 110196979
Bacterial infection 49.27 9.76 300 382250 45736 110161013
Vaginal discharge 49.12 9.76 155 382395 17753 110188996
Blood glucose increased 49.05 9.76 686 381864 131810 110074939
Gout 48.90 9.76 253 382297 36313 110170436
Hypomagnesaemia 48.79 9.76 367 382183 60003 110146746
Incision site pain 48.43 9.76 57 382493 3078 110203671
Tetany 48.33 9.76 61 382489 3543 110203206
Myasthenia gravis 48.23 9.76 174 382376 21337 110185412
Adverse reaction 48.11 9.76 21 382529 29573 110177176
Infusion site erythema 48.11 9.76 119 382431 11840 110194909
Oral candidiasis 47.47 9.76 291 382259 44469 110162280
Polycystic ovaries 47.37 9.76 70 382480 4726 110202023
Coagulopathy 47.26 9.76 272 382278 40639 110166110
Contusion 47.06 9.76 548 382002 232813 109973936
Laryngitis 46.22 9.76 47 382503 42364 110164385
Multiple allergies 46.18 9.76 119 382431 12144 110194605
Overdose 46.00 9.76 552 381998 233242 109973507
Administration site extravasation 45.84 9.76 42 382508 1687 110205062
Thrombosis 45.79 9.76 576 381974 108086 110098663
Cellulitis 45.67 9.76 650 381900 125366 110081383
Sedation 45.56 9.76 109 382441 69574 110137175
Adverse event 45.07 9.76 208 382342 108601 110098148
Hypovolaemia 44.98 9.76 171 382379 21503 110185246
Syncope 44.67 9.76 965 381585 201571 110005178
Tenosynovitis 44.53 9.76 3 382547 16280 110190469
Off label use 44.51 9.76 4529 378021 1495656 108711093
Chronic respiratory failure 44.50 9.76 61 382489 3842 110202907
Weight increased 44.48 9.76 1108 381442 418536 109788213
Prothrombin time prolonged 44.26 9.76 146 382404 17115 110189634
Alanine aminotransferase increased 43.92 9.76 886 381664 182887 110023862
Product contamination 43.75 9.76 43 382507 1888 110204861
Heparin-induced thrombocytopenia 43.16 9.76 111 382439 11313 110195436
Hyperlipidaemia 43.16 9.76 241 382309 35607 110171142
Lymphatic fistula 42.96 9.76 38 382512 1457 110205292
Depression 42.85 9.76 806 381744 316529 109890220
Ultrafiltration failure 42.50 9.76 23 382527 387 110206362
Blood chloride decreased 42.42 9.76 96 382454 9019 110197730
Ejection fraction abnormal 42.38 9.76 56 382494 3404 110203345
Hypocalcaemia 42.38 9.76 378 382172 64988 110141761
Blood alkaline phosphatase increased 42.35 9.76 403 382147 70532 110136217
Respiratory distress 41.97 9.76 393 382157 68481 110138268
Monocyte chemotactic protein-1 increased 41.97 9.76 22 382528 346 110206403
Peripheral swelling 41.69 9.76 1071 381479 402963 109803786
Spinal muscular atrophy 41.62 9.76 23 382527 404 110206345
Pallor 41.61 9.76 336 382214 56131 110150618
Catheter site infection 41.48 9.76 88 382462 7912 110198837
Ejection fraction 41.20 9.76 51 382499 2904 110203845
Wound infection pseudomonas 40.89 9.76 46 382504 2365 110204384
Colitis 40.84 9.76 537 382013 101786 110104963
Hepatotoxicity 40.80 9.76 100 382450 63300 110143449
Blood pressure fluctuation 40.72 9.76 128 382422 74696 110132053
Cough 40.72 9.76 1970 380580 459671 109747078
Femoral hernia incarcerated 40.68 9.76 37 382513 1472 110205277
Tachycardia 40.54 9.76 1049 381501 225596 109981153
Air embolism 40.26 9.76 26 382524 614 110206135
Drug use disorder 40.20 9.76 7 382543 18067 110188682
Infection 39.83 9.76 951 381599 361249 109845500
Anaphylactic shock 39.78 9.76 310 382240 51236 110155513
Sleep disorder therapy 39.69 9.76 83 382467 7388 110199361
Alpha tumour necrosis factor increased 39.63 9.76 22 382528 390 110206359
Cardiovascular disorder 39.60 9.76 170 382380 22590 110184159
Dyspnoea exertional 39.42 9.76 541 382009 103519 110103230
Blood pressure diastolic abnormal 39.38 9.76 20 382530 25795 110180954
Injection site swelling 39.34 9.76 98 382452 61692 110145057
Initial insomnia 39.31 9.76 101 382449 10288 110196461
Injection site erythema 39.02 9.76 180 382370 93996 110112753
Blood loss anaemia 38.89 9.76 144 382406 17881 110188868
Product administration error 38.86 9.76 241 382309 36976 110169773
Heart rate increased 38.65 9.76 706 381844 143128 110063621
Infusion site haemorrhage 38.26 9.76 62 382488 4536 110202213
C-reactive protein increased 38.25 9.76 527 382023 217392 109989357
Aggression 37.63 9.76 94 382456 59116 110147633
Incorrect drug administration rate 37.57 9.76 68 382482 5440 110201309
Drug ineffective for unapproved indication 37.23 9.76 206 382344 102632 110104117
Blood pressure systolic abnormal 36.80 9.76 20 382530 24830 110181919
Toxic epidermal necrolysis 36.76 9.76 328 382222 56399 110150350
Analgesic therapy 36.48 9.76 79 382471 7205 110199544
Hypoalbuminaemia 36.37 9.76 197 382353 28777 110177972
Schizophrenia 36.26 9.76 15 382535 21811 110184938
Generalised oedema 36.03 9.76 205 382345 30499 110176250
Ventricular tachycardia 36.00 9.76 296 382254 49713 110157036
Malnutrition 35.96 9.76 188 382362 27091 110179658
Walking aid user 35.96 9.76 21 382529 25054 110181695
Pulse absent 35.94 9.76 103 382447 11189 110195560
Productive cough 35.76 9.76 575 381975 113730 110093019
Amnesia 35.56 9.76 216 382334 105192 110101557
Haemorrhage 35.39 9.76 542 382008 106150 110100599
Cataract operation complication 35.27 9.76 18 382532 267 110206482
Akathisia 35.19 9.76 8 382542 17105 110189644
Therapy partial responder 35.06 9.76 46 382504 37015 110169734
Diverticulitis 34.95 9.76 310 382240 53212 110153537
Atelectasis 34.81 9.76 232 382318 36480 110170269
Blood magnesium decreased 34.52 9.76 149 382401 19847 110186902
Fall 34.46 9.76 2477 380073 601005 109605744
Product preparation error 34.40 9.76 99 382451 10780 110195969
Asthma 34.00 9.76 635 381915 249656 109957093
Impaired work ability 33.99 9.76 25 382525 26394 110180355
Blood potassium increased 33.90 9.76 214 382336 33035 110173714
Neck pain 33.80 9.76 268 382282 122862 110083887
Epistaxis 33.67 9.76 636 381914 129736 110077013
Disease complication 33.64 9.76 67 382483 5760 110200989
Oxygen consumption increased 33.58 9.76 66 382484 5619 110201130
Blood pressure systolic increased 33.57 9.76 160 382390 82831 110123918
Catheter site haemorrhage 33.21 9.76 67 382483 5813 110200936
Oxygen therapy 33.20 9.76 55 382495 4098 110202651
Angioedema 33.15 9.76 202 382348 98298 110108451
Product quality issue 33.07 9.76 146 382404 77153 110129596
Pancreatic steatosis 33.04 9.76 36 382514 1786 110204963
Blood creatine increased 32.78 9.76 101 382449 11420 110195329
Illness 32.69 9.76 431 382119 81740 110125009
Cor pulmonale 32.64 9.76 40 382510 2254 110204495
Eosinophil count 32.50 9.76 15 382535 176 110206573
Enthesopathy 32.17 9.76 3 382547 12475 110194274
Ileus 32.09 9.76 199 382351 30530 110176219
Blood albumin decreased 32.04 9.76 184 382366 27468 110179281
Poisoning 32.01 9.76 32 382518 29073 110177676
Cold sweat 31.97 9.76 156 382394 21875 110184874
Diaphragmatic spasm 31.78 9.76 13 382537 111 110206638
Transaminases increased 31.57 9.76 347 382203 63043 110143706
Extrapyramidal disorder 31.45 9.76 32 382518 28835 110177914
Suspected transmission of an infectious agent via product 31.40 9.76 31 382519 1369 110205380
Injection site bruising 31.33 9.76 83 382467 51180 110155569
Post procedural complication 31.29 9.76 178 382372 26480 110180269
Dementia 31.15 9.76 202 382348 31471 110175278
Hypophagia 30.93 9.76 298 382252 52328 110154421
Blood uric acid increased 30.92 9.76 152 382398 21377 110185372
Deep vein thrombosis 30.67 9.76 666 381884 139221 110067528
Metabolic encephalopathy 30.58 9.76 96 382454 10964 110195785
Accidental exposure to product 30.54 9.76 81 382469 49927 110156822
Complication associated with device 30.48 9.76 144 382406 19929 110186820
Alkalosis 30.45 9.76 24 382526 782 110205967
Pneumonia staphylococcal 30.43 9.76 66 382484 6025 110200724
Hypochloraemia 30.40 9.76 49 382501 3569 110203180
Obstructive airways disorder 30.32 9.76 72 382478 46077 110160672
Blood cholesterol decreased 30.29 9.76 42 382508 2674 110204075
Hyperaldosteronism 30.28 9.76 22 382528 633 110206116
Pulmonary embolism 30.15 9.76 963 381587 213511 109993238
Paraesthesia 30.12 9.76 727 381823 275794 109930955
Suspected product contamination 30.00 9.76 16 382534 261 110206488
Thrombotic microangiopathy 29.88 9.76 34 382516 29115 110177634
Drug therapy 29.81 9.76 73 382477 7218 110199531
Multiple-drug resistance 29.71 9.76 5 382545 13230 110193519
Hyperglycaemia 29.67 9.76 436 382114 84654 110122095
Neuroleptic malignant syndrome 29.51 9.76 45 382505 34014 110172735
Nightmare 29.40 9.76 56 382494 38807 110167942
Endophthalmitis 29.35 9.76 78 382472 8109 110198640
Blood potassium abnormal 29.32 9.76 51 382499 3954 110202795
Cytomegalovirus infection 29.02 9.76 94 382456 54350 110152399
Catheter site pain 29.01 9.76 67 382483 6379 110200370
Small intestinal obstruction 29.01 9.76 201 382349 32012 110174737
Post transplant lymphoproliferative disorder 28.88 9.76 9 382541 15604 110191145
Haematotoxicity 28.38 9.76 19 382531 21063 110185686
Sleep apnoea syndrome 28.36 9.76 238 382312 40209 110166540
Electrocardiogram abnormal 28.25 9.76 134 382416 18575 110188174
Product substitution issue 28.17 9.76 23 382527 23038 110183711
Antacid therapy 28.06 9.76 60 382490 5424 110201325
Respiratory rate increased 27.82 9.76 165 382385 24918 110181831
Hiatus hernia 27.73 9.76 177 382373 27429 110179320
Product distribution issue 27.57 9.76 52 382498 4294 110202455
Aortic stenosis 27.07 9.76 103 382447 12956 110193793
Liver function test increased 27.04 9.76 187 382363 88361 110118388
Poor venous access 27.00 9.76 161 382389 24361 110182388
Cardiomegaly 26.97 9.76 183 382367 28947 110177802
Osteonecrosis of jaw 26.94 9.76 81 382469 47936 110158813
Vasculitis 26.87 9.76 52 382498 35821 110170928
Peritoneal cloudy effluent 26.79 9.76 21 382529 679 110206070
Seroma 26.77 9.76 44 382506 3257 110203492
Leukoplakia oral 26.77 9.76 18 382532 456 110206293
Anticoagulant therapy 26.68 9.76 58 382492 5303 110201446
Poisoning deliberate 26.68 9.76 31 382519 26300 110180449
Device infusion issue 26.63 9.76 42 382508 3003 110203746
Myocardial reperfusion injury 26.60 9.76 12 382538 133 110206616
Myocardial necrosis marker increased 26.59 9.76 48 382502 3832 110202917
Peripheral circulatory failure 26.34 9.76 32 382518 1787 110204962
Faecal volume decreased 26.08 9.76 17 382533 408 110206341
Catheter site swelling 26.01 9.76 36 382514 2288 110204461
Traumatic haemorrhage 25.99 9.76 32 382518 1812 110204937
Red blood cell count decreased 25.90 9.76 345 382205 65578 110141171
Basal cell carcinoma 25.66 9.76 76 382474 45194 110161555
Polyarthritis 25.64 9.76 17 382533 18946 110187803
Congestive hepatopathy 25.44 9.76 56 382494 5164 110201585
Staphylococcal infection 25.42 9.76 361 382189 69583 110137166
Abortion spontaneous 25.41 9.76 50 382500 34232 110172517
Bacteraemia 25.39 9.76 241 382309 42149 110164600
Neuroglycopenia 25.38 9.76 25 382525 1101 110205648
Dysbiosis 25.34 9.76 34 382516 2098 110204651
Polyneuropathy 25.22 9.76 45 382505 31967 110174782
Coagulation time prolonged 25.18 9.76 40 382510 2877 110203872
Suspected product quality issue 25.17 9.76 19 382531 580 110206169
Disability 25.17 9.76 41 382509 30182 110176567
Haematocrit decreased 25.14 9.76 344 382206 65773 110140976
Infusion site infection 25.14 9.76 35 382515 2237 110204512
Drug tolerance 25.07 9.76 13 382537 16572 110190177
Septic shock 25.01 9.76 718 381832 156810 110049939
Hypomania 24.92 9.76 3 382547 10207 110196542
COVID-19 24.89 9.76 1061 381489 243999 109962750
Osteoporosis 24.71 9.76 188 382362 86964 110119785
Progressive multifocal leukoencephalopathy 24.62 9.76 30 382520 24926 110181823
Arterial haemorrhage 24.60 9.76 46 382504 3773 110202976
Device related sepsis 24.58 9.76 70 382480 7577 110199172
Maternal exposure during delivery 24.30 9.76 44 382506 3521 110203228
Bloody peritoneal effluent 24.25 9.76 12 382538 166 110206583
Blood glucose false positive 24.17 9.76 9 382541 58 110206691
Dermatitis contact 24.11 9.76 104 382446 13849 110192900
Sedation complication 24.01 9.76 20 382530 19835 110186914
Visual impairment 23.97 9.76 324 382226 134104 110072645
Cystic fibrosis respiratory infection suppression 23.92 9.76 17 382533 472 110206277
Blood test abnormal 23.87 9.76 175 382375 28379 110178370
Liver injury 23.86 9.76 371 382179 150042 110056707
Clostridium difficile colitis 23.84 9.76 244 382306 43534 110163215
Catheter site extravasation 23.72 9.76 18 382532 554 110206195
Foetal death 23.64 9.76 13 382537 16032 110190717
Tumour lysis syndrome 23.63 9.76 185 382365 30616 110176133
Transfusion 23.57 9.76 160 382390 25312 110181437
Carbon dioxide decreased 23.39 9.76 51 382499 4673 110202076
Sinus tachycardia 23.29 9.76 246 382304 44247 110162502
Skin toxicity 23.27 9.76 6 382544 11777 110194972
Gait disturbance 23.24 9.76 759 381791 277449 109929300
Chest pain 23.22 9.76 1555 380995 374820 109831929
Hypercapnia 23.12 9.76 88 382462 11071 110195678
Injection site pruritus 23.04 9.76 95 382455 51163 110155586
Noninfectious peritonitis 23 9.76 14 382536 297 110206452
Arrhythmia 22.90 9.76 353 382197 69222 110137527
Suffocation feeling 22.82 9.76 32 382518 2059 110204690
Head injury 22.59 9.76 238 382312 42779 110163970
Encephalopathy 22.52 9.76 400 382150 80655 110126094
Nephrectomy 22.52 9.76 36 382514 2604 110204145
Panniculitis 22.42 9.76 13 382537 15569 110191180
Eczema 22.41 9.76 152 382398 72141 110134608
Procedural complication 22.37 9.76 72 382478 8333 110198416
Gastric polyps 22.26 9.76 55 382495 5468 110201281
Affect lability 22.26 9.76 19 382531 18618 110188131
Miosis 22.14 9.76 26 382524 21957 110184792
Tricuspid valve incompetence 22.12 9.76 150 382400 23723 110183026
Neurologic neglect syndrome 22.05 9.76 3 382547 9295 110197454
Diabetes insipidus 21.96 9.76 61 382489 6509 110200240
Acute left ventricular failure 21.89 9.76 33 382517 2268 110204481
Mitral valve incompetence 21.74 9.76 193 382357 33136 110173613
Poor quality product administered 21.73 9.76 49 382501 4592 110202157
Infusion related reaction 21.70 9.76 1087 381463 380075 109826674
Renal failure 21.68 9.76 975 381575 225599 109981150
Blood phosphorus decreased 21.63 9.76 67 382483 7598 110199151
Catheter management 21.63 9.76 43 382507 3692 110203057
Fibrin D dimer increased 21.53 9.76 79 382471 9766 110196983
Uveitis 21.52 9.76 26 382524 21684 110185065
Anaphylactoid reaction 21.47 9.76 62 382488 6764 110199985
Nodule 21.36 9.76 51 382499 32580 110174169
Psychotic disorder 21.31 9.76 97 382453 50840 110155909
Tachyarrhythmia 21.29 9.76 70 382480 8191 110198558
Catheterisation cardiac 21.20 9.76 58 382492 6133 110200616
Ankylosing spondylitis 21.11 9.76 14 382536 15598 110191151
Sinusitis 21.01 9.76 826 381724 295862 109910887
Upper respiratory tract infection 20.96 9.76 599 381951 130729 110076020
Pulmonary function test decreased 20.90 9.76 72 382478 8628 110198121
Leukocytosis 20.85 9.76 281 382269 53547 110153202
Ventricular extrasystoles 20.82 9.76 142 382408 22499 110184250
Prostate cancer 20.76 9.76 64 382486 37577 110169172
Infusion site bruising 20.76 9.76 42 382508 3652 110203097
Pericardial effusion 20.67 9.76 295 382255 56922 110149827
Haemoptysis 20.50 9.76 354 382196 71000 110135749
Eosinophilia 20.45 9.76 117 382433 57819 110148930
Supraventricular extrasystoles 20.45 9.76 68 382482 8005 110198744
Disturbance in attention 20.41 9.76 128 382422 61867 110144882
Rales 20.33 9.76 151 382399 24588 110182161
Urine output decreased 20.31 9.76 128 382422 19748 110187001
Pseudomonal bacteraemia 20.30 9.76 46 382504 4325 110202424
Drug chemical incompatibility 20.30 9.76 10 382540 137 110206612
Acute pulmonary oedema 20.29 9.76 114 382436 16882 110189867
Aortic valve stenosis 20.28 9.76 58 382492 6292 110200457
Blood pressure abnormal 20.24 9.76 140 382410 22284 110184465
Hernia 20.19 9.76 126 382424 19374 110187375
Pancreatic enzyme abnormality 20.17 9.76 11 382539 188 110206561
Right ventricular dysfunction 20.14 9.76 39 382511 3284 110203465
Pustular psoriasis 20.08 9.76 11 382539 13594 110193155
Infusion site rash 20.05 9.76 32 382518 2311 110204438
Pneumococcal sepsis 20.02 9.76 31 382519 2181 110204568
Multiple organ dysfunction syndrome 19.98 9.76 676 381874 151034 110055715
Electrocardiogram T wave amplitude decreased 19.95 9.76 19 382531 802 110205947
Urine chloride decreased 19.93 9.76 9 382541 100 110206649
Respiratory syncytial virus infection 19.91 9.76 101 382449 14383 110192366
Hypoaesthesia 19.89 9.76 886 381664 313337 109893412
Infusion site discharge 19.78 9.76 29 382521 1944 110204805
Deafness permanent 19.75 9.76 20 382530 911 110205838
Ischaemic contracture of the left ventricle 19.73 9.76 10 382540 146 110206603
Blood sodium abnormal 19.67 9.76 24 382526 1346 110205403
Decubitus ulcer 19.61 9.76 119 382431 18117 110188632
Erythema 19.58 9.76 1213 381337 290234 109916515
Therapeutic response shortened 19.56 9.76 46 382504 29537 110177212
Seasonal allergy 19.53 9.76 126 382424 19596 110187153
Wrong patient 19.51 9.76 25 382525 1474 110205275
Lung infiltration 19.49 9.76 149 382401 24479 110182270
Cytopenia 19.44 9.76 174 382376 29942 110176807
Haematuria 19.43 9.76 399 382151 82606 110124143
Mouth ulceration 19.35 9.76 253 382297 47885 110158864
Cardiac failure acute 19.24 9.76 146 382404 23932 110182817
Laryngeal oedema 19.23 9.76 76 382474 9731 110197018
Stoma closure 19.14 9.76 14 382536 407 110206342
Peritoneal effluent abnormal 19.08 9.76 7 382543 43 110206706
Respiratory alkalosis 19.00 9.76 53 382497 5668 110201081
Electrocardiogram T wave peaked 18.96 9.76 22 382528 1170 110205579
Transplant rejection 18.94 9.76 35 382515 24532 110182217
Hemiplegia 18.89 9.76 31 382519 22751 110183998
Decreased appetite 18.88 9.76 1901 380649 473945 109732804
Palpitations 18.88 9.76 701 381849 158511 110048238
Pain in extremity 18.83 9.76 1440 381110 485678 109721071
Dystonia 18.82 9.76 38 382512 25767 110180982
Blood parathyroid hormone decreased 18.72 9.76 11 382539 13078 110193671
Vertigo 18.68 9.76 201 382349 86669 110120080
Eructation 18.61 9.76 97 382453 13960 110192789
Hospice care 18.59 9.76 89 382461 12384 110194365
Infectious crystalline keratopathy 18.54 9.76 8 382542 79 110206670
Resuscitation 18.49 9.76 35 382515 2898 110203851
Cor pulmonale chronic 18.34 9.76 14 382536 435 110206314
Troponin increased 18.21 9.76 170 382380 29596 110177153
Orthopnoea 18.17 9.76 81 382469 10940 110195809
Cytomegalovirus infection reactivation 18.13 9.76 22 382528 18311 110188438
Motor neurone disease 18.06 9.76 17 382533 707 110206042
Epstein-Barr virus infection 17.99 9.76 23 382527 18715 110188034
Joint effusion 17.75 9.76 28 382522 20877 110185872
Hepatic cirrhosis 17.73 9.76 149 382401 67477 110139272
Glomerular filtration rate 17.64 9.76 10 382540 185 110206564
Gastric cancer 17.60 9.76 8 382542 11000 110195749
Calcium deficiency 17.45 9.76 21 382529 1161 110205588
COVID-19 pneumonia 17.44 9.76 201 382349 36942 110169807
Atrioventricular block first degree 17.37 9.76 96 382454 14129 110192620
Feeling cold 17.36 9.76 187 382363 33800 110172949
Hyperchloraemia 17.35 9.76 22 382528 1284 110205465
Scrotal oedema 17.28 9.76 25 382525 1656 110205093
Dyspnoea paroxysmal nocturnal 17.21 9.76 31 382519 2471 110204278
Drug dose omission by device 17.09 9.76 15 382535 14501 110192248
Injection site warmth 17.09 9.76 21 382529 17384 110189365
Spontaneous haemorrhage 17.08 9.76 21 382529 1187 110205562
Diverticulum intestinal 17.02 9.76 83 382467 11636 110195113
Subcutaneous drug absorption impaired 16.96 9.76 3 382547 7656 110199093
Dysphagia 16.96 9.76 671 381879 152929 110053820
Back pain 16.93 9.76 1497 381053 369499 109837250
Intentional product misuse 16.88 9.76 341 382209 132563 110074186
Wrong technique in product usage process 16.88 9.76 207 382343 87141 110119608
Disease recurrence 16.82 9.76 132 382418 60652 110146097
Hypoproteinaemia 16.80 9.76 52 382498 5893 110200856
Upper gastrointestinal haemorrhage 16.80 9.76 255 382295 49841 110156908
Rhinovirus infection 16.77 9.76 83 382467 11706 110195043
Photosensitivity reaction 16.75 9.76 40 382510 25549 110181200
Urine sodium decreased 16.73 9.76 11 382539 268 110206481
Influenza 16.69 9.76 730 381820 168371 110038378
Endotracheal intubation 16.69 9.76 53 382497 6091 110200658
Cognitive disorder 16.68 9.76 208 382342 87303 110119446
Dysuria 16.65 9.76 297 382253 59934 110146815
Injection site rash 16.64 9.76 35 382515 23384 110183365
Lung transplant 16.61 9.76 48 382502 5238 110201511
Gadolinium deposition disease 16.55 9.76 9 382541 153 110206596
Complication of device insertion 16.52 9.76 5 382545 8833 110197916
Muscular weakness 16.47 9.76 697 381853 247771 109958978
Arrhythmia supraventricular 16.43 9.76 30 382520 2416 110204333
Thrombocytopenia 16.42 9.76 1411 381139 347474 109859275
Malaise 16.42 9.76 2054 380496 669765 109536984
Multiple sclerosis relapse 16.40 9.76 104 382446 50136 110156613
Oesophageal spasm 16.39 9.76 38 382512 3628 110203121
Catheter site erythema 16.37 9.76 52 382498 5976 110200773
Brain death 16.32 9.76 55 382495 6518 110200231
Injection site granuloma 16.28 9.76 8 382542 109 110206640
Atrial enlargement 16.26 9.76 20 382530 1131 110205618
Blood sodium increased 16.26 9.76 49 382501 5474 110201275
Supraventricular tachycardia 16.23 9.76 142 382408 24280 110182469
Retching 16.19 9.76 134 382416 22548 110184201
Pemphigoid 16.17 9.76 27 382523 19680 110187069
Device difficult to use 16.15 9.76 25 382525 18780 110187969
Seizure 16.07 9.76 927 381623 220258 109986491
Hyperhidrosis 16.00 9.76 797 381753 186501 110020248
Middle insomnia 15.99 9.76 29 382521 20473 110186276
Blood albumin abnormal 15.92 9.76 17 382533 824 110205925
Postoperative wound infection 15.82 9.76 101 382449 15652 110191097
Pneumothorax spontaneous 15.80 9.76 25 382525 1792 110204957
Incorrect product formulation administered 15.79 9.76 10 382540 228 110206521
Lymphoedema 15.79 9.76 97 382453 14832 110191917
Substance abuse 15.77 9.76 12 382538 12451 110194298
Occult blood positive 15.66 9.76 59 382491 7386 110199363
Facial discomfort 15.66 9.76 12 382538 375 110206374
Sexual dysfunction 15.63 9.76 5 382545 8525 110198224
Carbon dioxide increased 15.58 9.76 32 382518 2812 110203937
Hypertension 15.55 9.76 1536 381014 508548 109698201
Blood chloride increased 15.54 9.76 53 382497 6319 110200430
Economic problem 15.46 9.76 40 382510 4091 110202658
Product contamination microbial 15.44 9.76 19 382531 1075 110205674
Hepatic haemorrhage 15.44 9.76 21 382529 1313 110205436
Overlap syndrome 15.42 9.76 6 382544 9053 110197696
Troponin T increased 15.41 9.76 41 382509 4265 110202484
Blood urea decreased 15.41 9.76 36 382514 3454 110203295
Blood pressure immeasurable 15.38 9.76 29 382521 2394 110204355
Left ventricular failure 15.36 9.76 79 382471 11310 110195439
Lip erosion 15.31 9.76 25 382525 1841 110204908
Coronary artery disease 15.29 9.76 340 382210 71350 110135399
Suspected suicide 15.28 9.76 18 382532 15181 110191568
Haemorrhage subcutaneous 15.24 9.76 48 382502 5491 110201258
Nail dystrophy 15.23 9.76 20 382530 1208 110205541
Extravasation 15.23 9.76 44 382506 4801 110201948
Mental disorder 15.23 9.76 203 382347 38588 110168161
Discoloured vomit 15.18 9.76 26 382524 1991 110204758
Gingival bleeding 15.13 9.76 119 382431 19720 110187029
Laryngeal discomfort 15.13 9.76 16 382534 767 110205982
Meningitis aseptic 15.13 9.76 71 382479 9799 110196950
Syringe issue 15.11 9.76 7 382543 9518 110197231
N-terminal prohormone brain natriuretic peptide increased 15.01 9.76 51 382499 6070 110200679
Ear pain 15.00 9.76 115 382435 53111 110153638
Haemorrhoids 14.98 9.76 189 382361 35483 110171266
Interstitial lung disease 14.98 9.76 367 382183 138967 110067782
Euglycaemic diabetic ketoacidosis 14.95 9.76 11 382539 11612 110195137
Heart rate abnormal 14.93 9.76 57 382493 7181 110199568
Muscle haemorrhage 14.92 9.76 55 382495 6814 110199935
Spinal meningeal cyst 14.92 9.76 8 382542 132 110206617
Blood immunoglobulin M increased 14.90 9.76 23 382527 1614 110205135
Gastrointestinal infection 14.82 9.76 91 382459 13914 110192835
Lower gastrointestinal haemorrhage 14.72 9.76 112 382438 18374 110188375
Oesophageal carcinoma 14.70 9.76 11 382539 11513 110195236
Bladder cancer 14.69 9.76 30 382520 20262 110186487
Burning sensation 14.68 9.76 328 382222 68884 110137865
Aortic aneurysm rupture 14.65 9.76 21 382529 1379 110205370
Brain natriuretic peptide increased 14.60 9.76 77 382473 11132 110195617
Acne 14.52 9.76 63 382487 33457 110173292
Immune reconstitution inflammatory syndrome 14.49 9.76 21 382529 16205 110190544
Sensory loss 14.48 9.76 33 382517 21424 110185325
Dissociation 14.46 9.76 8 382542 9834 110196915
Posterior reversible encephalopathy syndrome 14.45 9.76 64 382486 33797 110172952
Chronic left ventricular failure 14.39 9.76 20 382530 1276 110205473
Regurgitation 14.36 9.76 35 382515 3450 110203299
Red blood cells urine positive 14.33 9.76 45 382505 5140 110201609
Groin pain 14.33 9.76 97 382453 15331 110191418
Serratia infection 14.29 9.76 27 382523 2232 110204517
Unevaluable event 14.29 9.76 286 382264 58941 110147808
Pre-eclampsia 14.28 9.76 6 382544 8644 110198105
Transplant evaluation 14.27 9.76 24 382526 1811 110204938
Spondylitis 14.24 9.76 11 382539 11327 110195422
Vocal cord dysfunction 14.23 9.76 17 382533 933 110205816
Adjustment disorder 14.17 9.76 10 382540 10785 110195964
Aortic arteriosclerosis 14.15 9.76 75 382475 10863 110195886
Infusion site phlebitis 14.11 9.76 8 382542 148 110206601
Renal tubular acidosis 14.04 9.76 42 382508 4673 110202076
Breath sounds abnormal 14.03 9.76 142 382408 25262 110181487
Nervous system injury 14.01 9.76 3 382547 0 110206749
Haemodialysis complication 13.97 9.76 11 382539 358 110206391
SARS-CoV-2 test negative 13.95 9.76 26 382524 2127 110204622
Necrotic lymphadenopathy 13.92 9.76 9 382541 213 110206536
Troponin I increased 13.88 9.76 46 382504 5406 110201343
Pancytopenia 13.81 9.76 871 381679 208742 109998007
Emotional distress 13.80 9.76 225 382325 44622 110162127
COVID-19 treatment 13.77 9.76 12 382538 451 110206298
Infusion site oedema 13.76 9.76 21 382529 1459 110205290
Bradycardia 13.75 9.76 664 381886 154853 110051896
Tardive dyskinesia 13.74 9.76 16 382534 13563 110193186
Emphysema 13.72 9.76 116 382434 19640 110187109
Skin candida 13.72 9.76 27 382523 2301 110204448
Pain in jaw 13.67 9.76 251 382299 50926 110155823
Bilirubin conjugated increased 13.66 9.76 50 382500 6174 110200575
Creatinine renal clearance decreased 13.57 9.76 35 382515 21780 110184969
Wound dehiscence 13.49 9.76 59 382491 7903 110198846
Hallucination, visual 13.44 9.76 81 382469 39524 110167225
Neuralgia 13.38 9.76 239 382311 48239 110158510
Peripheral vascular disorder 13.37 9.76 62 382488 8514 110198235
Catheter placement 13.32 9.76 33 382517 3287 110203462
Infusion site thrombosis 13.29 9.76 10 382540 304 110206445
General symptom 13.28 9.76 7 382543 8839 110197910
Renal phospholipidosis 13.24 9.76 11 382539 387 110206362
Hiccups 13.23 9.76 83 382467 12786 110193963
Arteriovenous malformation 13.20 9.76 24 382526 1927 110204822
B-lymphocyte abnormalities 13.17 9.76 8 382542 169 110206580
Anal fissure 13.17 9.76 9 382541 9872 110196877
Disturbance in social behaviour 13.16 9.76 43 382507 5015 110201734
Blood glucose decreased 13.15 9.76 158 382392 29330 110177419
Electrocardiogram P wave abnormal 13.14 9.76 11 382539 391 110206358
Iron deficiency 13.10 9.76 109 382441 18367 110188382
Renal injury 13.06 9.76 110 382440 18603 110188146
Neutrophil count increased 13.06 9.76 180 382370 34472 110172277
Varicella zoster virus infection 13.05 9.76 3 382547 6365 110200384
Cerebrovascular accident 13.01 9.76 759 381791 180525 110026224
Internal haemorrhage 12.99 9.76 69 382481 10002 110196747
Asthma-chronic obstructive pulmonary disease overlap syndrome 12.98 9.76 3 382547 6341 110200408
Pathogen resistance 12.91 9.76 26 382524 17646 110189103
Product deposit 12.91 9.76 14 382536 691 110206058
Metastases to lung 12.87 9.76 39 382511 23024 110183725
Pulmonary arterial pressure increased 12.82 9.76 43 382507 5084 110201665
Haemodialysis 12.82 9.76 105 382445 17614 110189135
Staphylococcus test positive 12.78 9.76 55 382495 7315 110199434
Tubulointerstitial nephritis 12.75 9.76 123 382427 54161 110152588
Type IIa hyperlipidaemia 12.73 9.76 12 382538 500 110206249
Catheter site scab 12.66 9.76 9 382541 250 110206499
Product residue present 12.59 9.76 36 382514 3905 110202844
Tendonitis 12.58 9.76 47 382503 26036 110180713
Anaesthetic complication 12.57 9.76 34 382516 3572 110203177
Increased bronchial secretion 12.55 9.76 36 382514 3912 110202837
Enterocolitis infectious 12.54 9.76 33 382517 3411 110203338
Infusion site pruritus 12.52 9.76 42 382508 4966 110201783
Transurethral resection syndrome 12.50 9.76 4 382546 15 110206734
Alanine aminotransferase decreased 12.49 9.76 23 382527 1865 110204884
Anal inflammation 12.42 9.76 27 382523 2469 110204280
Breast cancer stage I 12.40 9.76 5 382545 7382 110199367
Fracture 12.39 9.76 44 382506 24744 110182005
Shoshin beriberi 12.39 9.76 6 382544 79 110206670
Metastases to bone 12.38 9.76 61 382489 31311 110175438
Viral infection 12.29 9.76 255 382295 52884 110153865
Steroid dependence 12.28 9.76 7 382543 8462 110198287
Blood gases abnormal 12.25 9.76 19 382531 1339 110205410
Hyperaesthesia 12.25 9.76 20 382530 14707 110192042
Spinal cord paralysis 12.20 9.76 8 382542 194 110206555
Spinal cord injury cervical 12.17 9.76 8 382542 195 110206554
Convulsions local 12.13 9.76 6 382544 83 110206666
Wrong product administered 12.09 9.76 72 382478 10888 110195861
Nasal obstruction 12.09 9.76 32 382518 3318 110203431
Cardiac pacemaker evaluation 12.09 9.76 7 382543 135 110206614
Synovial cyst 12.08 9.76 13 382537 11417 110195332
Right atrial pressure increased 12.08 9.76 10 382540 350 110206399
Product monitoring error 12.08 9.76 8 382542 8919 110197830
Skin reaction 12.07 9.76 119 382431 21025 110185724
Fungal sepsis 12.06 9.76 25 382525 2212 110204537
Infective exacerbation of bronchiectasis 12.02 9.76 15 382535 861 110205888
Injection site urticaria 12.01 9.76 26 382524 17189 110189560
Neonatal gastrointestinal disorder 11.99 9.76 5 382545 45 110206704
Hepatic necrosis 11.99 9.76 10 382540 9912 110196837
Dust allergy 11.96 9.76 3 382547 5998 110200751
Blood immunoglobulin G abnormal 11.95 9.76 7 382543 138 110206611
Lymphoproliferative disorder 11.93 9.76 5 382545 7213 110199536
Vitamin A increased 11.92 9.76 4 382546 18 110206731
Transplant dysfunction 11.91 9.76 7 382543 8321 110198428
Pneumonia klebsiella 11.90 9.76 50 382500 6582 110200167
Cardioactive drug level decreased 11.88 9.76 8 382542 203 110206546
Left ventricular dysfunction 11.88 9.76 129 382421 23364 110183385
Respiratory tract infection bacterial 11.87 9.76 26 382524 2390 110204359
End stage renal disease 11.84 9.76 120 382430 21353 110185396
Product selection error 11.84 9.76 11 382539 450 110206299
Coordination abnormal 11.82 9.76 46 382504 25182 110181567
Depressed mood 11.79 9.76 144 382406 60665 110146084
Burns second degree 11.78 9.76 6 382544 7727 110199022
Blood bicarbonate increased 11.77 9.76 19 382531 1385 110205364
Peri-implantitis 11.75 9.76 8 382542 207 110206542
Paradoxical drug reaction 11.73 9.76 10 382540 9807 110196942
Mania 11.72 9.76 35 382515 20761 110185988
Polyuria 11.71 9.76 103 382447 17635 110189114
Bacteroides infection 11.69 9.76 29 382521 2890 110203859
BK virus infection 11.66 9.76 17 382533 13089 110193660
Foetal heart rate disorder 11.62 9.76 5 382545 49 110206700
Ecchymosis 11.62 9.76 101 382449 17237 110189512
Aphthous ulcer 11.61 9.76 36 382514 21100 110185649
Blood immunoglobulin M abnormal 11.56 9.76 7 382543 147 110206602
Culture positive 11.55 9.76 17 382533 1144 110205605
Haemorrhage intracranial 11.54 9.76 152 382398 28817 110177932
Injection site haemorrhage 11.50 9.76 67 382483 32961 110173788
Mouth haemorrhage 11.47 9.76 83 382467 13405 110193344
Medication error 11.47 9.76 277 382273 105089 110101660
Tuberculosis 11.46 9.76 28 382522 17746 110189003
Thyroid disorder 11.45 9.76 99 382451 16870 110189879
Oxygen saturation abnormal 11.42 9.76 44 382506 5567 110201182
Neoplasm progression 11.40 9.76 156 382394 64439 110142310
Torsade de pointes 11.38 9.76 124 382426 22476 110184273
Epidermolysis bullosa 11.36 9.76 10 382540 381 110206368
Delusion 11.33 9.76 43 382507 23712 110183037
Ulcer haemorrhage 11.33 9.76 40 382510 22531 110184218
Injection site phlebitis 11.32 9.76 7 382543 153 110206596
Limb injury 11.27 9.76 188 382362 37448 110169301
Vulva cyst 11.27 9.76 4 382546 22 110206727
Nasal congestion 11.23 9.76 431 382119 97851 110108898
Second primary malignancy 11.23 9.76 29 382521 18039 110188710
Escherichia infection 11.23 9.76 129 382421 23687 110183062
Hepatic cyst 11.21 9.76 55 382495 7728 110199021
Skin fissures 11.20 9.76 45 382505 24413 110182336
Deposit eye 11.20 9.76 5 382545 54 110206695
Autoimmune haemolytic anaemia 11.19 9.76 12 382538 10555 110196194
Device use error 11.18 9.76 9 382541 9080 110197669
Hypoglycaemia 11.18 9.76 500 382050 115604 110091145
Heparin-induced thrombocytopenia test 11.17 9.76 8 382542 225 110206524
Neutrophil percentage decreased 11.15 9.76 15 382535 928 110205821
Peritoneal disorder 11.11 9.76 14 382536 812 110205937
Pneumonitis 11.10 9.76 345 382205 76186 110130563
Blood pressure diastolic increased 11.08 9.76 31 382519 18776 110187973
Enterobacter pneumonia 11.05 9.76 12 382538 593 110206156
Diffuse large B-cell lymphoma recurrent 11.01 9.76 4 382546 6295 110200454
Therapeutic product effect prolonged 11.00 9.76 13 382537 705 110206044
Embolism 10.97 9.76 95 382455 16194 110190555
Bronchial hyperreactivity 10.96 9.76 32 382518 3512 110203237
Cystic fibrosis hepatic disease 10.96 9.76 5 382545 57 110206692
Lower respiratory tract infection bacterial 10.95 9.76 16 382534 1069 110205680
Mucosal inflammation 10.95 9.76 251 382299 95890 110110859
Anhedonia 10.93 9.76 91 382459 15337 110191412
Neuritis 10.89 9.76 6 382544 7393 110199356
Uterine perforation 10.89 9.76 5 382545 6835 110199914
Anterior chamber disorder 10.89 9.76 7 382543 164 110206585
Weight decreased 10.88 9.76 1810 380740 466247 109740502
Gastroenteritis viral 10.88 9.76 160 382390 31066 110175683
Electrocardiogram ST segment abnormal 10.88 9.76 21 382529 1764 110204985
Oropharyngeal discomfort 10.86 9.76 67 382483 10260 110196489
Hypoaesthesia oral 10.85 9.76 98 382452 16904 110189845
Papule 10.82 9.76 66 382484 10067 110196682
Skin dystrophy 10.81 9.76 5 382545 59 110206690
Atypical femur fracture 10.78 9.76 4 382546 6215 110200534
Fluid replacement 10.78 9.76 15 382535 958 110205791
Unintentional medical device removal 10.78 9.76 9 382541 8914 110197835
Fistula 10.76 9.76 23 382527 15276 110191473
Burkholderia test positive 10.74 9.76 12 382538 612 110206137
Product design issue 10.74 9.76 3 382547 6 110206743
Implantable cardiac monitor insertion 10.74 9.76 3 382547 6 110206743
Administration site phlebitis 10.74 9.76 3 382547 6 110206743
Herpes zoster 10.70 9.76 289 382261 108090 110098659
Quadriplegia 10.66 9.76 35 382515 4092 110202657
Fatigue 10.65 9.76 3912 378638 1212046 108994703
Erectile dysfunction 10.63 9.76 31 382519 18525 110188224
Faecaloma 10.60 9.76 88 382462 14820 110191929
Deficiency anaemia 10.58 9.76 6 382544 111 110206638
Haematoma 10.54 9.76 271 382279 58205 110148544
Lymphadenectomy 10.52 9.76 19 382531 1517 110205232
Anxiety 10.52 9.76 1039 381511 344039 109862710
Tremor 10.49 9.76 824 381726 201408 110005341
Tension 10.48 9.76 40 382510 5038 110201711
Myalgia 10.47 9.76 646 381904 221735 109985014
Rash rubelliform 10.42 9.76 3 382547 7 110206742
Eye injury 10.42 9.76 7 382543 7748 110199001
Blood pressure diastolic decreased 10.37 9.76 77 382473 35808 110170941
Drug delivery system issue 10.36 9.76 8 382542 253 110206496
Pulse pressure decreased 10.35 9.76 10 382540 430 110206319
Small cell lung cancer extensive stage 10.34 9.76 4 382546 29 110206720
Catheter removal 10.31 9.76 12 382538 640 110206109
Blood lactate dehydrogenase abnormal 10.30 9.76 12 382538 641 110206108
Body temperature increased 10.29 9.76 255 382295 54458 110152291
Skin laceration 10.26 9.76 169 382381 33584 110173165
Hypercoagulation 10.26 9.76 30 382520 3296 110203453
Pickwickian syndrome 10.24 9.76 11 382539 537 110206212
Withdrawal syndrome 10.22 9.76 65 382485 31315 110175434
Acute hepatic failure 10.18 9.76 79 382471 36389 110170360
Apathy 10.15 9.76 26 382524 16213 110190536
Clostridium difficile infection 10.12 9.76 244 382306 51885 110154864
Bradypnoea 10.11 9.76 9 382541 8640 110198109
Cardioactive drug level increased 10.10 9.76 33 382517 3849 110202900
Bleeding time prolonged 10.09 9.76 17 382533 1285 110205464
Product dose omission issue 10.08 9.76 1266 381284 320516 109886233
Familial periodic paralysis 10.07 9.76 9 382541 350 110206399
Mycotic allergy 10.04 9.76 4 382546 5950 110200799
Inability to afford medication 10.03 9.76 34 382516 4042 110202707
Catheter site related reaction 9.98 9.76 18 382532 1436 110205313
Gastrooesophageal reflux disease 9.94 9.76 737 381813 179239 110027510
Device occlusion 9.94 9.76 88 382462 15097 110191652
Amylase abnormal 9.93 9.76 5 382545 72 110206677
Immune thrombocytopenia 9.92 9.76 42 382508 22452 110184297
Wisdom teeth removal 9.91 9.76 13 382537 785 110205964
Hepatitis fulminant 9.89 9.76 9 382541 8551 110198198
Post procedural erythema 9.88 9.76 3 382547 9 110206740
Abortion incomplete complicated 9.88 9.76 3 382547 9 110206740
Respiratory tract infection fungal 9.88 9.76 17 382533 1307 110205442
Rash erythematous 9.87 9.76 361 382189 81471 110125278
Right ventricular dilatation 9.87 9.76 24 382526 2363 110204386
Staphylococcal sepsis 9.85 9.76 98 382452 17356 110189393
Lung consolidation 9.81 9.76 66 382484 10410 110196339
Gynaecomastia 9.80 9.76 11 382539 9479 110197270
Eye infection intraocular 9.79 9.76 4 382546 34 110206715
PO2 abnormal 9.79 9.76 4 382546 34 110206715

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Radiolabelling of carrier molecules indication
Pregnancy, function contraindication 289908002




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
CHEBI:759745 CHEBI
CHEMBL5315062 ChEMBL_ID
CL PDB_CHEM_ID
CLO PDB_CHEM_ID
DB00761 DRUGBANK_ID
DB01164 DRUGBANK_ID
DB08913 DRUGBANK_ID
DB09129 DRUGBANK_ID
DB09316 DRUGBANK_ID
DB09498 DRUGBANK_ID
DB11056 DRUGBANK_ID
DB13569 DRUGBANK_ID
DB13987 DRUGBANK_ID
DB14206 DRUGBANK_ID
DB14533 DRUGBANK_ID
DB14547 DRUGBANK_ID
DB14550 DRUGBANK_ID
D10828 KEGG_DRUG
71587001 PUBCHEM_CID
4155 INN_ID
0EA6JO8O41 UNII
1JB99PM4G8 UNII
1SW3X68G1K UNII
3I8Y076A0E UNII
3X55YB10CW UNII
451W47IQ8X UNII
4W6QNK7DH4 UNII
4ZR792I587 UNII
53PH22NTYW UNII
660YQ98I10 UNII
73TYF012WF UNII
7VZ3JEC7N7 UNII
A71VE6C11B UNII
BB0UFP2VO5 UNII
BQC3E45EYF UNII
F0Z746KRKQ UNII
FAE9RL3AWX UNII
FM3JMK26RS UNII
G46PX623OB UNII
G4962QA067 UNII
JSA9HU7KJF UNII
N9214IR8N7 UNII
Q2A03W637H UNII
Q32ZN48698 UNII
Q65224GJ7F UNII
Q9BRS9C9G3 UNII
QTT17582CB UNII
U4M5Y13FGM UNII
VMP9781061 UNII
G4962QA067 INXIGHT DRUGS

Pharmaceutical products:

None