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deracoxib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| selective cyclo-oxygenase inhibitors | 5672 | 169590-41-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 2.685 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.729 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 76.913 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 4.487 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 5.070 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 15.940 | % | High | 1 |
| herg | hERG pIC50 | 4.692 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 3.327 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 5.395 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 3.980 | % | High | 1 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 2.339 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 16.106 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 4.550 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 6.310 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 1 | |||
| pppb | Pig plasma protein binding (% unbound) | 11.720 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 7.962 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 39.890 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 5.810 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 4.375 | uM | High | 1 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000893 | Anti-Inflammatory Agents |
| MeSH PA | D000894 | Anti-Inflammatory Agents, Non-Steroidal |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D016861 | Cyclooxygenase Inhibitors |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018501 | Antirheumatic Agents |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D018712 | Analgesics, Non-Narcotic |
| CHEBI has role | CHEBI:35475 | non-steroidal anti-inflammatory drug |
| CHEBI has role | CHEBI:35481 | non-narcotic analgesic |
| CHEBI has role | CHEBI:50629 | cyclooxygenase 2 inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Dogs | Postoperative pain and inflammation associated with dental surgery | Indication |
| Dogs | Pain and inflammation associated with osteoarthritis | Indication |
| Dogs | Postoperative pain and inflammation associated with orthopedic surgery | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Deramaxx Chewable Tablets | Elanco US Inc. | 1 |
| Doxidyl | Ceva Sante Animale | 1 |
| Deracoxib Chewable Tablets | Felix Pharmaceuticals Pvt. Ltd. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Prostaglandin G/H synthase 2 | Enzyme | IC50 | 7.30 | CHEMBL | |||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.44 | CHEMBL | |||||
| Cyclooxygenase 2; Prostaglandin G/H synthase-2; Uncharacterized protein | Enzyme | IC50 | 6.20 | CHEMBL | |||||
| Prostaglandin G/H synthase 1 | Enzyme | IC50 | 4.64 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| CHEBI:73032 | CHEBI |
| CHEMBL28636 | ChEMBL_ID |
| C471996 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB11395 | DRUGBANK_ID |
| 423684002 | SNOMEDCT_US |
| 424281006 | SNOMEDCT_US |
| C1174840 | UMLSCUI |
| 7789 | INN_ID |
| D03689 | KEGG_DRUG |
| 3058754 | PUBCHEM_CID |
| 017762 | NDDF |
| VX29JB5XWV | UNII |
| 356834 | RXNORM |
| VX29JB5XWV | INXIGHT DRUGS |
Pharmaceutical products:
None