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coumafos 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| insecticides, anthelminthics, pesticides etc., phosphorous derivatives | 5667 | 56-72-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A organothiophosphorus cholinesterase inhibitor that is used as an anthelmintic, insecticide, and as nematocide
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70 | 70 | |||
| kinase-selectivity-class | AURKA,AXL,BRAF,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,IRAK3,MAP2K6,MAPK12,MAPK7,MAPK8,MARK4,MTOR,PDK4,PIK3CB,PIK3CD,PRKDC,SIK2,STK33,SYK,TEK,TTK,ZAP70 | 26 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000871 | Anthelmintics |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000969 | Antinematodal Agents |
| MeSH PA | D000977 | Antiparasitic Agents |
| MeSH PA | D002800 | Cholinesterase Inhibitors |
| MeSH PA | D004791 | Enzyme Inhibitors |
| MeSH PA | D007306 | Insecticides |
| MeSH PA | D010575 | Pesticides |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018678 | Cholinergic Agents |
| CHEBI has role | CHEBI:22153 | acaricide |
| CHEBI has role | CHEBI:33286 | agrochemical |
| CHEBI has role | CHEBI:33289 | avicide |
| CHEBI has role | CHEBI:35444 | antinematodal drug |
| CHEBI has role | CHEBI:37733 | EC 3.1.1.8 (cholinesterase) inhibitor |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Chickens | Control of capillary worms (Capillaria obsignata) | Indication |
| Chickens | Control of common round worm, Ascaridia galli | Indication |
| Chickens | Control of cecal worm (Heterakis gallinae) | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Meldane 2 | Elanco US Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 1 | Enzyme | Ki | 4.21 | CHEMBL | |||||
| Carbonic anhydrase 4 | Enzyme | Ki | 5.26 | CHEMBL | |||||
| Carbonic anhydrase 9 | Enzyme | Ki | 5.19 | CHEMBL | |||||
| Carbonic anhydrase 12 | Enzyme | Ki | 5.02 | CHEMBL | |||||
| Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 5.29 | CHEMBL | |||||
| Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 5.47 | CHEMBL | |||||
| Carbonic anhydrase 7 | Enzyme | Ki | 5.33 | CHEMBL | |||||
| Carbonic anhydrase 3 | Enzyme | Ki | 5.33 | CHEMBL | |||||
| Carbonic anhydrase 6 | Enzyme | Ki | 5.65 | CHEMBL | |||||
| Carbonic anhydrase 14 | Enzyme | Ki | 5.38 | CHEMBL | |||||
| Carbonic anhydrase 13 | Enzyme | Ki | 5.37 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| WZ0 | PDB_CHEM_ID |
| CHEMBL251680 | ChEMBL_ID |
| DB11390 | DRUGBANK_ID |
| 96128001 | SNOMEDCT_US |
| C0010203 | UMLSCUI |
| CHEBI:3903 | CHEBI |
| D07750 | KEGG_DRUG |
| 2871 | PUBCHEM_CID |
| 1705 | INN_ID |
| 2745582 | RXNORM |
| D003372 | MESH_DESCRIPTOR_UI |
| L08SZ5Z5JC | UNII |
Pharmaceutical products:
None