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ceftiofur 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, cefalosporanic acid derivatives | 5663 | 80370-57-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -0.486 | Moderate | 0.75 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 5.929 | Moderate | 0.75 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 1.472 | 10^-6 cm/s | Moderate | 0.75 |
| dh-clint | Dog hepatocyte intrinsic clearance | 5.662 | uL/min/10^6 cells | Moderate | 0.75 |
| dppb | Dog plasma protein binding (% unbound) | 14.350 | % | Moderate | 0.75 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 8.830 | % | Moderate | 0.75 |
| herg | hERG pIC50 | 4.324 | pIC50 | Moderate | 0.75 |
| hh-clint | Human hepatocyte intrinsic clearance | 8.241 | uL/min/10^6 cells | Moderate | 0.75 |
| hlm-clint | Human liver microsomal intrinsic clearance | 19.588 | uL/min/mg protein | Moderate | 0.75 |
| hppb | Human plasma protein binding (% unbound) | 3.220 | % | Moderate | 0.75 |
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 18.750 | Moderate | 0.75 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 2.851 | Moderate | 0.75 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 41.976 | Moderate | 0.75 | |
| mppb | Mouse plasma protein binding (% unbound) | 8.830 | Moderate | 0.75 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 2.410 | Moderate | 0.75 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 7.740 | % | Moderate | 0.75 |
| rat-kpuu-brain | Rat brain Kpuu | 0.011 | % | Moderate | 0.75 |
| rh-clint | Rat hepatocyte intrinsic clearance | 24.099 | uL/min/10^6 cells | Moderate | 0.75 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 85.790 | % | Moderate | 0.75 |
| rppb | Rat plasma protein binding (% unbound) | 3.510 | % | Moderate | 0.75 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 756.833 | uM | Moderate | 0.75 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000900 | Anti-Bacterial Agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cattle | Acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum | Indication |
| Cattle | Bovine respiratory disease (BRD) associated with Mannheimia haemolytica | Indication |
| Cattle | Bovine respiratory disease (BRD) associated with Pasteurella multocida | Indication |
| Cattle | Bovine respiratory disease (BRD) associated with Histophilus somni | Indication |
| Cattle | Clinical mastitis associated with coagulase-negative staphylococci | Indication |
| Cattle | Subclinical mastitis associated with coagulase-negative staphylococci | Indication |
| Cattle | Clinical mastitis associated with Streptococcus dysgalactiae | Indication |
| Cattle | Clinical mastitis associated with Escherichia coli | Indication |
| Cattle | Subclinical mastitis associated with coagulase-negative staphylococci Streptococcus dysgalactiae | Indication |
| Cattle | Acute bovine interdigital necrobacillosis (foot rot, pododermatitis) associated with Bacteroides melaninogenicus | Indication |
| Chickens | Control of early mortality associated with Escherichia coli | Indication |
| Dogs | Urinary tract infections caused by Escherichia coli | Indication |
| Dogs | Urinary Tract Infections caused by Proteus mirabilis | Indication |
| Goats | Respiratory disease associated with M haemolytica | Indication |
| Goats | Respiratory disease associated with Pasteurella multocida | Indication |
| Horses | Respiratory infections associated with Streptococcus zooepidemicus | Indication |
| Sheep | Respiratory disease associated with M haemolytica | Indication |
| Sheep | Respiratory disease associated with Pasteurella multocida | Indication |
| Swine | Bacterial respiratory disease associated with Actinobacillus (Haemophilus) pleuropneumoniae | Indication |
| Swine | Bacterial respiratory disease associated with Pasteurella multocida | Indication |
| Swine | Bacterial respiratory disease associated with Salmonella choleraesuis | Indication |
| Swine | Bacterial respiratory disease associated with Streptococcus suis | Indication |
| Turkeys | Control of early mortality associated with Escherichia coli | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Naxcel Sterile Powder | Zoetis Inc. | 1 |
| Excenel Sterile Suspension, Excenel RTU, Excenel Sterile Powder | Zoetis Inc. | 1 |
| EXCEDE | Zoetis Inc. | 1 |
| EXCEDE FOR SWINE | Zoetis Inc. | 1 |
| Spectramast LC Sterile Suspension | Zoetis Inc. | 1 |
| Spectramast DC Sterile Suspension | Zoetis Inc. | 1 |
| EXCENEL RTU EZ | Zoetis Inc. | 1 |
| Ceftiofur Sodium Sterile Powder | Cephazone Pharma LLC | 1 |
| Cefenil RTU | Norbrook Laboratories, Ltd. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| CHEBI:747894 | CHEBI |
| CHEMBL222913 | ChEMBL_ID |
| C053503 | MESH_SUPPLEMENTAL_RECORD_UI |
| 13653 | IUPHAR_LIGAND_ID |
| DB11485 | DRUGBANK_ID |
| 373556003 | SNOMEDCT_US |
| 96044008 | SNOMEDCT_US |
| 96045009 | SNOMEDCT_US |
| 96046005 | SNOMEDCT_US |
| C0882426 | UMLSCUI |
| CHEMBL2105998 | ChEMBL_ID |
| CHEMBL2106486 | ChEMBL_ID |
| 5703 | INN_ID |
| 104010-37-9 | SECONDARY_CAS_RN |
| 103980-44-5 | SECONDARY_CAS_RN |
| D07657 | KEGG_DRUG |
| 6328657 | PUBCHEM_CID |
| 018137 | NDDF |
| 018138 | NDDF |
| 83JL932I1C | UNII |
| 1311520 | RXNORM |
Pharmaceutical products:
None