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cefovecin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, cefalosporanic acid derivatives | 5662 | 234096-34-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -1.483 | Moderate | 0.71 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 2.109 | Moderate | 0.71 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 1.230 | 10^-6 cm/s | Moderate | 0.71 |
| dh-clint | Dog hepatocyte intrinsic clearance | 2.158 | uL/min/10^6 cells | Moderate | 0.71 |
| dppb | Dog plasma protein binding (% unbound) | 60.550 | % | Moderate | 0.71 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 39.840 | % | Moderate | 0.71 |
| herg | hERG pIC50 | 4.155 | pIC50 | Moderate | 0.71 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.552 | uL/min/10^6 cells | Moderate | 0.71 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.681 | uL/min/mg protein | Moderate | 0.71 |
| hppb | Human plasma protein binding (% unbound) | 33.850 | % | Moderate | 0.71 |
| mdck-mdr1-bcrp-efflux | MDCK-MDR1-BCRP efflux ratio | 15.205 | Moderate | 0.69 | |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 1.849 | Moderate | 0.71 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 4.955 | Moderate | 0.71 | |
| mppb | Mouse plasma protein binding (% unbound) | 48.620 | Moderate | 0.71 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 2.477 | Moderate | 0.71 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 38.520 | % | Moderate | 0.71 |
| rat-kpuu-brain | Rat brain Kpuu | 0.010 | % | Moderate | 0.69 |
| rh-clint | Rat hepatocyte intrinsic clearance | 2.109 | uL/min/10^6 cells | Moderate | 0.71 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 89.620 | % | Moderate | 0.71 |
| rppb | Rat plasma protein binding (% unbound) | 28.290 | % | Moderate | 0.71 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 937.562 | uM | Moderate | 0.71 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Cats | Skin infections caused by Pasteurella multocida | Indication |
| Dogs | Skin infections caused by Staphylococcus intermedius | Indication |
| Dogs | Skin infections caused by Streptococcus canis | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| Convenia | Zoetis Inc. | 1 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| CHEBI:754438 | CHEBI |
| CHEMBL2110625 | ChEMBL_ID |
| C516253 | MESH_SUPPLEMENTAL_RECORD_UI |
| 13654 | IUPHAR_LIGAND_ID |
| DB11505 | DRUGBANK_ID |
| 439183007 | SNOMEDCT_US |
| 439199001 | SNOMEDCT_US |
| C1869686 | UMLSCUI |
| CHEMBL2104475 | ChEMBL_ID |
| 8225 | INN_ID |
| 141195-77-9 | SECONDARY_CAS_RN |
| KEGG_DRUG | |
| 6336480 | PUBCHEM_CID |
| 018148 | NDDF |
| 018149 | NDDF |
| 0D1OL46ZIE | UNII |
| 1591901 | RXNORM |
Pharmaceutical products:
None