afoxolaner 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antagonists of GABA (gamma-aminobutyric acid) regulated chloride channels, antiparasitic agents 5660 1093861-60-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • afoxolaner
  • nexgard
  • AH252723
  • Molecular weight: 625.88
  • Formula: C26H17ClF9N3O3
  • CLOGP: 6.07
  • LIPINSKI: 2
  • HAC: 6
  • HDO: 2
  • TPSA: 79.79
  • ALOGS: -5.80
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

SpeciesUseRelation
Dogs Kill adult fleas, Ctenocephalides felis Indication
Dogs Treatment and control of black-legged tick (Ixodes scapularis) Indication
Dogs Treatment and control of tick infestations with Dermacentor variabilis (American dog tick) Indication
Dogs Treatment and control of tick infestations with Amblyomma americanum (lone star tick) Indication
Dogs Treatment and control of Brown Dog tick (Rhipicephalus sanguineus) infestations Indication

🐶 Veterinary products

ProductApplicantIngredients
NexGard Boehringer lngelheim Animal Health USA Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
CHEMBL2219412 ChEMBL_ID
C000589002 MESH_SUPPLEMENTAL_RECORD_UI
DB11369 DRUGBANK_ID
017740 NDDF
C3692449 UMLSCUI
CHEMBL2364610 ChEMBL_ID
9697 INN_ID
D10361 KEGG_DRUG
25154249 PUBCHEM_CID
1442093 RXNORM
02L07H6D0U UNII

Pharmaceutical products:

None