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carbomycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, produced by Streptomyces strains | 5658 | 4564-87-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
From Streptomyces halstedii
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 1.358 | Moderate | 0.76 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 20.464 | Moderate | 0.76 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 6.223 | 10^-6 cm/s | Moderate | 0.76 |
| dh-clint | Dog hepatocyte intrinsic clearance | 10.740 | uL/min/10^6 cells | Moderate | 0.76 |
| dppb | Dog plasma protein binding (% unbound) | 58.210 | % | Moderate | 0.76 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 48.160 | % | Moderate | 0.76 |
| herg | hERG pIC50 | 4.279 | pIC50 | Moderate | 0.76 |
| hh-clint | Human hepatocyte intrinsic clearance | 7.063 | uL/min/10^6 cells | Moderate | 0.76 |
| hlm-clint | Human liver microsomal intrinsic clearance | 45.394 | uL/min/mg protein | Moderate | 0.76 |
| hppb | Human plasma protein binding (% unbound) | 57.480 | % | Moderate | 0.76 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 10 | Moderate | 0.76 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 34.514 | Moderate | 0.76 | |
| mppb | Mouse plasma protein binding (% unbound) | 50.810 | Moderate | 0.76 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 13.900 | Moderate | 0.76 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 55.620 | % | Moderate | 0.76 |
| rh-clint | Rat hepatocyte intrinsic clearance | 23.174 | uL/min/10^6 cells | Moderate | 0.76 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 83.010 | % | Moderate | 0.76 |
| rppb | Rat plasma protein binding (% unbound) | 54.990 | % | Moderate | 0.76 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 843.335 | uM | Moderate | 0.76 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
None
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
| Species | Use | Relation |
|---|---|---|
| Chicken | Air sacculitis (air-sac disease chronic respiratory disease) caused by Mycoplasma gallisepticum | Indication |
| Chicken | Secondary bacterial organisms associated with chronic respiratory disease such as Escherichia coli | Indication |
🐶 Veterinary products
| Product | Applicant | Ingredients |
|---|---|---|
| MAGNA-TERRAMYCIN Soluble Powder | Zoetis Inc. | 2 |
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| CHEBI:756054 | CHEBI |
| CAI | PDB_CHEM_ID |
| CHEMBL3989435 | ChEMBL_ID |
| C059423 | MESH_SUPPLEMENTAL_RECORD_UI |
| DB11383 | DRUGBANK_ID |
| 373551008 | SNOMEDCT_US |
| 96011002 | SNOMEDCT_US |
| C0054700 | UMLSCUI |
| 202 | INN_ID |
| KEGG_DRUG | |
| 5287879 | PUBCHEM_CID |
| 3952621T3O | UNII |
Pharmaceutical products:
None